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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
IWS1
Full Name:
Protein IWS1 homolog
Alias:
DKFZp761G0123; IWS1L; Protein IWS1 homolog: IWS1-like protein
Type:
Transcription protein
Mass (Da):
91955
Number AA:
819
UniProt ID:
Q96ST2
International Prot ID:
IPI00296432
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
D
S
E
Y
Y
S
G
D
Q
S
D
D
G
Site 2
S11
E
Y
Y
S
G
D
Q
S
D
D
G
G
A
T
P
Site 3
T17
Q
S
D
D
G
G
A
T
P
V
Q
D
E
R
D
Site 4
S25
P
V
Q
D
E
R
D
S
G
S
D
G
E
D
D
Site 5
S27
Q
D
E
R
D
S
G
S
D
G
E
D
D
V
N
Site 6
S38
D
D
V
N
E
Q
H
S
G
S
D
T
G
S
V
Site 7
S40
V
N
E
Q
H
S
G
S
D
T
G
S
V
E
R
Site 8
T42
E
Q
H
S
G
S
D
T
G
S
V
E
R
H
S
Site 9
S44
H
S
G
S
D
T
G
S
V
E
R
H
S
E
N
Site 10
S49
T
G
S
V
E
R
H
S
E
N
E
T
S
D
R
Site 11
T53
E
R
H
S
E
N
E
T
S
D
R
E
D
G
L
Site 12
S54
R
H
S
E
N
E
T
S
D
R
E
D
G
L
P
Site 13
T67
L
P
K
G
H
H
V
T
D
S
E
N
D
E
P
Site 14
S69
K
G
H
H
V
T
D
S
E
N
D
E
P
L
N
Site 15
S80
E
P
L
N
L
N
A
S
D
S
E
S
E
E
L
Site 16
S82
L
N
L
N
A
S
D
S
E
S
E
E
L
H
R
Site 17
S84
L
N
A
S
D
S
E
S
E
E
L
H
R
Q
K
Site 18
S93
E
L
H
R
Q
K
D
S
D
S
E
S
E
E
R
Site 19
S95
H
R
Q
K
D
S
D
S
E
S
E
E
R
A
E
Site 20
S97
Q
K
D
S
D
S
E
S
E
E
R
A
E
P
P
Site 21
S106
E
R
A
E
P
P
A
S
D
S
E
N
E
D
V
Site 22
S108
A
E
P
P
A
S
D
S
E
N
E
D
V
N
Q
Site 23
S118
E
D
V
N
Q
H
G
S
D
S
E
S
E
E
T
Site 24
S120
V
N
Q
H
G
S
D
S
E
S
E
E
T
R
K
Site 25
S122
Q
H
G
S
D
S
E
S
E
E
T
R
K
L
P
Site 26
T125
S
D
S
E
S
E
E
T
R
K
L
P
G
S
D
Site 27
S131
E
T
R
K
L
P
G
S
D
S
E
N
E
E
L
Site 28
S133
R
K
L
P
G
S
D
S
E
N
E
E
L
L
N
Site 29
S144
E
L
L
N
G
H
A
S
D
S
E
N
E
D
V
Site 30
S146
L
N
G
H
A
S
D
S
E
N
E
D
V
G
K
Site 31
S157
D
V
G
K
H
P
A
S
D
S
E
I
E
E
L
Site 32
S159
G
K
H
P
A
S
D
S
E
I
E
E
L
Q
K
Site 33
S167
E
I
E
E
L
Q
K
S
P
A
S
D
S
E
T
Site 34
S170
E
L
Q
K
S
P
A
S
D
S
E
T
E
D
A
Site 35
S172
Q
K
S
P
A
S
D
S
E
T
E
D
A
L
K
Site 36
T174
S
P
A
S
D
S
E
T
E
D
A
L
K
P
Q
Site 37
S183
D
A
L
K
P
Q
I
S
D
S
E
S
E
E
P
Site 38
S185
L
K
P
Q
I
S
D
S
E
S
E
E
P
P
R
Site 39
S187
P
Q
I
S
D
S
E
S
E
E
P
P
R
H
Q
Site 40
S196
E
P
P
R
H
Q
A
S
D
S
E
N
E
E
P
Site 41
S198
P
R
H
Q
A
S
D
S
E
N
E
E
P
P
K
Site 42
S209
E
P
P
K
P
R
M
S
D
S
E
S
E
E
L
Site 43
S211
P
K
P
R
M
S
D
S
E
S
E
E
L
P
K
Site 44
S213
P
R
M
S
D
S
E
S
E
E
L
P
K
P
Q
Site 45
S222
E
L
P
K
P
Q
V
S
D
S
E
S
E
E
P
Site 46
S224
P
K
P
Q
V
S
D
S
E
S
E
E
P
P
R
Site 47
S226
P
Q
V
S
D
S
E
S
E
E
P
P
R
H
Q
Site 48
S235
E
P
P
R
H
Q
A
S
D
S
E
N
E
E
L
Site 49
S237
P
R
H
Q
A
S
D
S
E
N
E
E
L
P
K
Site 50
S248
E
L
P
K
P
R
I
S
D
S
E
S
E
D
P
Site 51
S250
P
K
P
R
I
S
D
S
E
S
E
D
P
P
R
Site 52
S252
P
R
I
S
D
S
E
S
E
D
P
P
R
H
Q
Site 53
S261
D
P
P
R
H
Q
A
S
D
S
E
N
E
E
L
Site 54
S278
P
R
I
S
D
S
E
S
E
D
P
P
R
N
Q
Site 55
S287
D
P
P
R
N
Q
A
S
D
S
E
N
E
E
L
Site 56
S289
P
R
N
Q
A
S
D
S
E
N
E
E
L
P
K
Site 57
S300
E
L
P
K
P
R
V
S
D
S
E
S
E
G
P
Site 58
S302
P
K
P
R
V
S
D
S
E
S
E
G
P
Q
K
Site 59
S304
P
R
V
S
D
S
E
S
E
G
P
Q
K
G
P
Site 60
S313
G
P
Q
K
G
P
A
S
D
S
E
T
E
D
A
Site 61
S315
Q
K
G
P
A
S
D
S
E
T
E
D
A
S
R
Site 62
T317
G
P
A
S
D
S
E
T
E
D
A
S
R
H
K
Site 63
S321
D
S
E
T
E
D
A
S
R
H
K
Q
K
P
E
Site 64
S329
R
H
K
Q
K
P
E
S
D
D
D
S
D
R
E
Site 65
S333
K
P
E
S
D
D
D
S
D
R
E
N
K
G
E
Site 66
T342
R
E
N
K
G
E
D
T
E
M
Q
N
D
S
F
Site 67
S348
D
T
E
M
Q
N
D
S
F
H
S
D
S
H
M
Site 68
S351
M
Q
N
D
S
F
H
S
D
S
H
M
D
R
K
Site 69
S353
N
D
S
F
H
S
D
S
H
M
D
R
K
K
F
Site 70
S362
M
D
R
K
K
F
H
S
S
D
S
E
E
E
E
Site 71
S363
D
R
K
K
F
H
S
S
D
S
E
E
E
E
H
Site 72
S365
K
K
F
H
S
S
D
S
E
E
E
E
H
K
K
Site 73
S377
H
K
K
Q
K
M
D
S
D
E
D
E
K
E
G
Site 74
S398
K
R
K
A
A
V
L
S
D
S
E
D
E
E
K
Site 75
S400
K
A
A
V
L
S
D
S
E
D
E
E
K
A
S
Site 76
S407
S
E
D
E
E
K
A
S
A
K
K
S
R
V
V
Site 77
S411
E
K
A
S
A
K
K
S
R
V
V
S
D
A
D
Site 78
S415
A
K
K
S
R
V
V
S
D
A
D
D
S
D
S
Site 79
S420
V
V
S
D
A
D
D
S
D
S
D
A
V
S
D
Site 80
S422
S
D
A
D
D
S
D
S
D
A
V
S
D
K
S
Site 81
S426
D
S
D
S
D
A
V
S
D
K
S
G
K
R
E
Site 82
S429
S
D
A
V
S
D
K
S
G
K
R
E
K
T
I
Site 83
T435
K
S
G
K
R
E
K
T
I
A
S
D
S
E
E
Site 84
S438
K
R
E
K
T
I
A
S
D
S
E
E
E
A
G
Site 85
S440
E
K
T
I
A
S
D
S
E
E
E
A
G
K
E
Site 86
S449
E
E
A
G
K
E
L
S
D
K
K
N
E
E
K
Site 87
S461
E
E
K
D
L
F
G
S
D
S
E
S
G
N
E
Site 88
S463
K
D
L
F
G
S
D
S
E
S
G
N
E
E
E
Site 89
S465
L
F
G
S
D
S
E
S
G
N
E
E
E
N
L
Site 90
T489
D
E
E
E
E
E
F
T
G
F
N
Q
E
D
L
Site 91
T503
L
E
E
E
K
G
E
T
Q
V
K
E
A
E
D
Site 92
S511
Q
V
K
E
A
E
D
S
D
S
D
D
N
I
K
Site 93
S513
K
E
A
E
D
S
D
S
D
D
N
I
K
R
G
Site 94
S527
G
K
H
M
D
F
L
S
D
F
E
M
M
L
Q
Site 95
S538
M
M
L
Q
R
K
K
S
M
S
G
K
R
R
R
Site 96
S540
L
Q
R
K
K
S
M
S
G
K
R
R
R
N
R
Site 97
T551
R
R
N
R
D
G
G
T
F
I
S
D
A
D
D
Site 98
S554
R
D
G
G
T
F
I
S
D
A
D
D
V
V
S
Site 99
T589
K
P
A
L
K
K
L
T
L
L
P
A
V
V
M
Site 100
T606
K
K
Q
D
L
K
E
T
F
I
D
S
G
V
M
Site 101
S621
S
A
I
K
E
W
L
S
P
L
P
D
R
S
L
Site 102
S627
L
S
P
L
P
D
R
S
L
P
A
L
K
I
R
Site 103
S646
K
I
L
Q
E
L
P
S
V
S
Q
E
T
L
K
Site 104
S648
L
Q
E
L
P
S
V
S
Q
E
T
L
K
H
S
Site 105
T651
L
P
S
V
S
Q
E
T
L
K
H
S
G
I
G
Site 106
Y663
G
I
G
R
A
V
M
Y
L
Y
K
H
P
K
E
Site 107
Y665
G
R
A
V
M
Y
L
Y
K
H
P
K
E
S
R
Site 108
S686
G
K
L
I
N
E
W
S
R
P
I
F
G
L
T
Site 109
T693
S
R
P
I
F
G
L
T
S
N
Y
K
G
M
T
Site 110
S720
P
Q
R
R
R
M
N
S
T
G
G
Q
T
P
R
Site 111
T721
Q
R
R
R
M
N
S
T
G
G
Q
T
P
R
R
Site 112
T725
M
N
S
T
G
G
Q
T
P
R
R
D
L
E
K
Site 113
T735
R
D
L
E
K
V
L
T
G
E
E
K
A
L
R
Site 114
S758
R
A
R
V
P
M
P
S
N
K
D
Y
V
V
R
Site 115
Y762
P
M
P
S
N
K
D
Y
V
V
R
P
K
W
N
Site 116
S774
K
W
N
V
E
M
E
S
S
R
F
Q
A
T
S
Site 117
S775
W
N
V
E
M
E
S
S
R
F
Q
A
T
S
K
Site 118
S781
S
S
R
F
Q
A
T
S
K
K
G
I
S
R
L
Site 119
T796
D
K
Q
M
R
K
F
T
D
I
R
K
K
S
R
Site 120
S802
F
T
D
I
R
K
K
S
R
S
A
H
A
V
K
Site 121
S804
D
I
R
K
K
S
R
S
A
H
A
V
K
I
S
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation