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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SETDB2
Full Name:
Histone-lysine N-methyltransferase SETDB2
Alias:
Chronic lymphocytic leukemia deletion region gene 8 protein;Lysine N-methyltransferase 1F;SET domain bifurcated 2
Type:
Mass (Da):
81894
Number AA:
719
UniProt ID:
Q96T68
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T10
E
K
N
G
D
A
K
T
F
W
M
E
L
E
D
Site 2
S65
E
A
T
I
I
N
S
S
T
S
I
K
G
A
S
Site 3
S72
S
T
S
I
K
G
A
S
Q
K
E
V
N
A
Q
Site 4
S81
K
E
V
N
A
Q
S
S
D
P
M
P
V
T
Q
Site 5
T87
S
S
D
P
M
P
V
T
Q
K
E
Q
E
N
K
Site 6
S95
Q
K
E
Q
E
N
K
S
N
A
F
P
S
T
S
Site 7
S100
N
K
S
N
A
F
P
S
T
S
C
E
N
S
F
Site 8
T101
K
S
N
A
F
P
S
T
S
C
E
N
S
F
P
Site 9
S102
S
N
A
F
P
S
T
S
C
E
N
S
F
P
E
Site 10
S106
P
S
T
S
C
E
N
S
F
P
E
D
C
T
F
Site 11
T112
N
S
F
P
E
D
C
T
F
L
T
T
E
N
K
Site 12
T115
P
E
D
C
T
F
L
T
T
E
N
K
E
I
L
Site 13
S136
V
D
F
R
E
K
D
S
S
S
N
L
S
Y
Q
Site 14
S137
D
F
R
E
K
D
S
S
S
N
L
S
Y
Q
S
Site 15
S138
F
R
E
K
D
S
S
S
N
L
S
Y
Q
S
H
Site 16
S141
K
D
S
S
S
N
L
S
Y
Q
S
H
D
C
S
Site 17
Y142
D
S
S
S
N
L
S
Y
Q
S
H
D
C
S
G
Site 18
S144
S
S
N
L
S
Y
Q
S
H
D
C
S
G
A
C
Site 19
S148
S
Y
Q
S
H
D
C
S
G
A
C
L
M
K
M
Site 20
T180
F
Q
R
R
H
A
K
T
N
S
H
S
S
A
L
Site 21
S182
R
R
H
A
K
T
N
S
H
S
S
A
L
H
V
Site 22
S184
H
A
K
T
N
S
H
S
S
A
L
H
V
S
Y
Site 23
S185
A
K
T
N
S
H
S
S
A
L
H
V
S
Y
K
Site 24
Y191
S
S
A
L
H
V
S
Y
K
T
P
C
G
R
S
Site 25
T193
A
L
H
V
S
Y
K
T
P
C
G
R
S
L
R
Site 26
S198
Y
K
T
P
C
G
R
S
L
R
N
V
E
E
V
Site 27
Y208
N
V
E
E
V
F
R
Y
L
L
E
T
E
C
N
Site 28
Y227
D
N
F
S
F
N
T
Y
V
Q
L
A
R
N
Y
Site 29
Y234
Y
V
Q
L
A
R
N
Y
P
K
Q
K
E
V
V
Site 30
S242
P
K
Q
K
E
V
V
S
D
V
D
I
S
N
G
Site 31
Y271
R
K
L
P
Q
F
K
Y
R
K
T
V
W
P
R
Site 32
Y280
K
T
V
W
P
R
A
Y
N
L
T
N
F
S
S
Site 33
T311
K
C
A
C
L
Q
L
T
A
R
N
A
K
T
S
Site 34
T317
L
T
A
R
N
A
K
T
S
P
L
S
S
D
K
Site 35
S318
T
A
R
N
A
K
T
S
P
L
S
S
D
K
I
Site 36
S321
N
A
K
T
S
P
L
S
S
D
K
I
T
T
G
Site 37
S322
A
K
T
S
P
L
S
S
D
K
I
T
T
G
Y
Site 38
T326
P
L
S
S
D
K
I
T
T
G
Y
K
Y
K
R
Site 39
Y329
S
D
K
I
T
T
G
Y
K
Y
K
R
L
Q
R
Site 40
Y331
K
I
T
T
G
Y
K
Y
K
R
L
Q
R
Q
I
Site 41
T374
V
R
L
Q
V
F
K
T
E
Q
K
G
W
G
V
Site 42
S402
I
Y
S
G
R
L
L
S
R
A
N
T
E
K
S
Site 43
T406
R
L
L
S
R
A
N
T
E
K
S
Y
G
I
D
Site 44
T421
E
N
G
R
D
E
N
T
M
K
N
I
F
S
K
Site 45
S427
N
T
M
K
N
I
F
S
K
K
R
K
L
E
V
Site 46
S465
E
K
C
P
P
K
F
S
N
N
P
K
E
L
T
Site 47
T472
S
N
N
P
K
E
L
T
V
E
T
K
Y
D
N
Site 48
T475
P
K
E
L
T
V
E
T
K
Y
D
N
I
S
R
Site 49
Y477
E
L
T
V
E
T
K
Y
D
N
I
S
R
I
Q
Site 50
Y485
D
N
I
S
R
I
Q
Y
H
S
V
I
R
D
P
Site 51
S487
I
S
R
I
Q
Y
H
S
V
I
R
D
P
E
S
Site 52
S494
S
V
I
R
D
P
E
S
K
T
A
I
F
Q
H
Site 53
S510
G
K
K
M
E
F
V
S
S
E
S
V
T
P
E
Site 54
S511
K
K
M
E
F
V
S
S
E
S
V
T
P
E
D
Site 55
S513
M
E
F
V
S
S
E
S
V
T
P
E
D
N
D
Site 56
T515
F
V
S
S
E
S
V
T
P
E
D
N
D
G
F
Site 57
S531
P
P
R
E
H
L
N
S
K
T
K
G
A
Q
K
Site 58
S541
K
G
A
Q
K
D
S
S
S
N
H
V
D
E
F
Site 59
S542
G
A
Q
K
D
S
S
S
N
H
V
D
E
F
E
Site 60
S556
E
D
N
L
L
I
E
S
D
V
I
D
I
T
K
Site 61
T562
E
S
D
V
I
D
I
T
K
Y
R
E
E
T
P
Site 62
Y564
D
V
I
D
I
T
K
Y
R
E
E
T
P
P
R
Site 63
T568
I
T
K
Y
R
E
E
T
P
P
R
S
R
C
N
Site 64
S572
R
E
E
T
P
P
R
S
R
C
N
Q
A
T
T
Site 65
T578
R
S
R
C
N
Q
A
T
T
L
D
N
Q
N
I
Site 66
T602
K
P
Q
E
G
R
S
T
A
C
Q
R
Q
Q
V
Site 67
S617
F
C
D
E
E
L
L
S
E
T
K
N
T
S
S
Site 68
T622
L
L
S
E
T
K
N
T
S
S
D
S
L
T
K
Site 69
S623
L
S
E
T
K
N
T
S
S
D
S
L
T
K
F
Site 70
S624
S
E
T
K
N
T
S
S
D
S
L
T
K
F
N
Site 71
S626
T
K
N
T
S
S
D
S
L
T
K
F
N
K
G
Site 72
T628
N
T
S
S
D
S
L
T
K
F
N
K
G
N
V
Site 73
T641
N
V
F
L
L
D
A
T
K
E
G
N
V
G
R
Site 74
Y682
V
A
F
F
T
N
R
Y
V
K
A
R
T
E
L
Site 75
Y693
R
T
E
L
T
W
D
Y
G
Y
E
A
G
T
V
Site 76
Y695
E
L
T
W
D
Y
G
Y
E
A
G
T
V
P
E
Site 77
T699
D
Y
G
Y
E
A
G
T
V
P
E
K
E
I
F
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation