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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
YME1L1
Full Name:
ATP-dependent zinc metalloprotease YME1L1
Alias:
ATP-dependent metalloprotease FtsH1; EC 3.4.24.-; FTSH; FTSH1; MEG4; Meg-4; PAMP; Presenilin-associated metalloprotease; YME1-like 1; YME1-like protein 1; YMEL1
Type:
Protease; Mitochondrial; EC 3.4.24.-
Mass (Da):
86455
Number AA:
773
UniProt ID:
Q96TA2
International Prot ID:
IPI00045946
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005739
GO:0016020
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003824
GO:0004175
PhosphoSite+
KinaseNET
Biological Process:
GO:0006508
GO:0008152
GO:0009056
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T7
_
M
F
S
L
S
S
T
V
Q
P
Q
V
T
V
Site 2
T25
H
L
I
N
A
F
H
T
P
K
N
T
S
V
S
Site 3
S30
F
H
T
P
K
N
T
S
V
S
L
S
G
V
S
Site 4
S32
T
P
K
N
T
S
V
S
L
S
G
V
S
V
S
Site 5
S34
K
N
T
S
V
S
L
S
G
V
S
V
S
Q
N
Site 6
S37
S
V
S
L
S
G
V
S
V
S
Q
N
Q
H
R
Site 7
S39
S
L
S
G
V
S
V
S
Q
N
Q
H
R
D
V
Site 8
S55
P
E
H
E
A
P
S
S
E
C
M
F
S
D
F
Site 9
S60
P
S
S
E
C
M
F
S
D
F
L
T
K
L
N
Site 10
Y80
K
G
K
I
F
E
G
Y
R
S
M
F
M
E
P
Site 11
S82
K
I
F
E
G
Y
R
S
M
F
M
E
P
A
K
Site 12
S94
P
A
K
R
M
K
K
S
L
D
T
T
D
N
W
Site 13
S109
H
I
R
P
E
P
F
S
L
S
I
P
P
S
L
Site 14
S111
R
P
E
P
F
S
L
S
I
P
P
S
L
N
L
Site 15
S124
N
L
R
D
L
G
L
S
E
L
K
I
G
Q
I
Site 16
T154
N
I
S
S
H
W
H
T
S
H
V
S
A
Q
S
Site 17
S161
T
S
H
V
S
A
Q
S
F
F
E
N
K
Y
G
Site 18
Y167
Q
S
F
F
E
N
K
Y
G
N
L
D
I
F
S
Site 19
S178
D
I
F
S
T
L
R
S
S
C
L
Y
R
H
H
Site 20
S179
I
F
S
T
L
R
S
S
C
L
Y
R
H
H
S
Site 21
Y182
T
L
R
S
S
C
L
Y
R
H
H
S
R
A
L
Site 22
S186
S
C
L
Y
R
H
H
S
R
A
L
Q
S
I
C
Site 23
S191
H
H
S
R
A
L
Q
S
I
C
S
D
L
Q
Y
Site 24
S194
R
A
L
Q
S
I
C
S
D
L
Q
Y
W
P
V
Site 25
Y198
S
I
C
S
D
L
Q
Y
W
P
V
F
I
Q
S
Site 26
T210
I
Q
S
R
G
F
K
T
L
K
S
R
T
R
R
Site 27
S213
R
G
F
K
T
L
K
S
R
T
R
R
L
Q
S
Site 28
T215
F
K
T
L
K
S
R
T
R
R
L
Q
S
T
S
Site 29
S220
S
R
T
R
R
L
Q
S
T
S
E
R
L
A
E
Site 30
T221
R
T
R
R
L
Q
S
T
S
E
R
L
A
E
T
Site 31
S222
T
R
R
L
Q
S
T
S
E
R
L
A
E
T
Q
Site 32
S246
F
L
L
R
D
R
G
S
D
V
E
S
L
D
K
Site 33
S250
D
R
G
S
D
V
E
S
L
D
K
L
M
K
T
Site 34
T257
S
L
D
K
L
M
K
T
K
N
I
P
E
A
H
Site 35
T270
A
H
Q
D
A
F
K
T
G
F
A
E
G
F
L
Site 36
S289
L
T
Q
K
T
N
D
S
L
R
R
T
R
L
I
Site 37
Y306
V
L
L
L
F
G
I
Y
G
L
L
K
N
P
F
Site 38
S315
L
L
K
N
P
F
L
S
V
R
F
R
T
T
T
Site 39
T322
S
V
R
F
R
T
T
T
G
L
D
S
A
V
D
Site 40
S326
R
T
T
T
G
L
D
S
A
V
D
P
V
Q
M
Site 41
T337
P
V
Q
M
K
N
V
T
F
E
H
V
K
G
V
Site 42
Y401
G
E
A
D
V
P
F
Y
Y
A
S
G
S
E
F
Site 43
Y402
E
A
D
V
P
F
Y
Y
A
S
G
S
E
F
D
Site 44
S404
D
V
P
F
Y
Y
A
S
G
S
E
F
D
E
M
Site 45
S406
P
F
Y
Y
A
S
G
S
E
F
D
E
M
F
V
Site 46
S442
I
F
I
D
E
L
D
S
V
G
G
K
R
I
E
Site 47
S450
V
G
G
K
R
I
E
S
P
M
H
P
Y
S
R
Site 48
Y455
I
E
S
P
M
H
P
Y
S
R
Q
T
I
N
Q
Site 49
S456
E
S
P
M
H
P
Y
S
R
Q
T
I
N
Q
L
Site 50
T459
M
H
P
Y
S
R
Q
T
I
N
Q
L
L
A
E
Site 51
T503
G
R
F
D
M
Q
V
T
V
P
R
P
D
V
K
Site 52
Y519
R
T
E
I
L
K
W
Y
L
N
K
I
K
F
D
Site 53
S528
N
K
I
K
F
D
Q
S
V
D
P
E
I
I
A
Site 54
S573
T
M
K
E
L
E
F
S
K
D
K
I
L
M
G
Site 55
S585
L
M
G
P
E
R
R
S
V
E
I
D
N
K
N
Site 56
T594
E
I
D
N
K
N
K
T
I
T
A
Y
H
E
S
Site 57
Y598
K
N
K
T
I
T
A
Y
H
E
S
G
H
A
I
Site 58
Y608
S
G
H
A
I
I
A
Y
Y
T
K
D
A
M
P
Site 59
T620
A
M
P
I
N
K
A
T
I
M
P
R
G
P
T
Site 60
S632
G
P
T
L
G
H
V
S
L
L
P
E
N
D
R
Site 61
T671
I
F
G
T
D
H
I
T
T
G
A
S
S
D
F
Site 62
T672
F
G
T
D
H
I
T
T
G
A
S
S
D
F
D
Site 63
T682
S
S
D
F
D
N
A
T
K
I
A
K
R
M
V
Site 64
T690
K
I
A
K
R
M
V
T
K
F
G
M
S
E
K
Site 65
T702
S
E
K
L
G
V
M
T
Y
S
D
T
G
K
L
Site 66
Y703
E
K
L
G
V
M
T
Y
S
D
T
G
K
L
S
Site 67
S704
K
L
G
V
M
T
Y
S
D
T
G
K
L
S
P
Site 68
T706
G
V
M
T
Y
S
D
T
G
K
L
S
P
E
T
Site 69
S710
Y
S
D
T
G
K
L
S
P
E
T
Q
S
A
I
Site 70
S715
K
L
S
P
E
T
Q
S
A
I
E
Q
E
I
R
Site 71
S728
I
R
I
L
L
R
D
S
Y
E
R
A
K
H
I
Site 72
Y729
R
I
L
L
R
D
S
Y
E
R
A
K
H
I
L
Site 73
T738
R
A
K
H
I
L
K
T
H
A
K
E
H
K
N
Site 74
T752
N
L
A
E
A
L
L
T
Y
E
T
L
D
A
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation