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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DKFZp451F163
Full Name:
Transcription factor 12
Alias:
Transcription factor 12
Type:
Mass (Da):
72948
Number AA:
682
UniProt ID:
Q99081
International Prot ID:
IPI00384333
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0030528
GO:0003676
GO:0003677
PhosphoSite+
KinaseNET
Biological Process:
GO:0009889
GO:0010468
GO:0010556
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
I
G
T
D
K
E
L
S
D
L
L
D
F
S
A
Site 2
S28
L
D
F
S
A
M
F
S
P
P
V
N
S
G
K
Site 3
T39
N
S
G
K
T
R
P
T
T
L
G
S
S
Q
F
Site 4
T40
S
G
K
T
R
P
T
T
L
G
S
S
Q
F
S
Site 5
S43
T
R
P
T
T
L
G
S
S
Q
F
S
G
S
G
Site 6
S44
R
P
T
T
L
G
S
S
Q
F
S
G
S
G
I
Site 7
S47
T
L
G
S
S
Q
F
S
G
S
G
I
D
E
R
Site 8
S49
G
S
S
Q
F
S
G
S
G
I
D
E
R
G
G
Site 9
T57
G
I
D
E
R
G
G
T
T
S
W
G
T
S
G
Site 10
S59
D
E
R
G
G
T
T
S
W
G
T
S
G
Q
P
Site 11
S63
G
T
T
S
W
G
T
S
G
Q
P
S
P
S
Y
Site 12
S67
W
G
T
S
G
Q
P
S
P
S
Y
D
S
S
R
Site 13
S69
T
S
G
Q
P
S
P
S
Y
D
S
S
R
G
F
Site 14
Y70
S
G
Q
P
S
P
S
Y
D
S
S
R
G
F
T
Site 15
S72
Q
P
S
P
S
Y
D
S
S
R
G
F
T
D
S
Site 16
S73
P
S
P
S
Y
D
S
S
R
G
F
T
D
S
P
Site 17
T77
Y
D
S
S
R
G
F
T
D
S
P
H
Y
S
D
Site 18
S79
S
S
R
G
F
T
D
S
P
H
Y
S
D
H
L
Site 19
Y82
G
F
T
D
S
P
H
Y
S
D
H
L
N
D
S
Site 20
S83
F
T
D
S
P
H
Y
S
D
H
L
N
D
S
R
Site 21
S89
Y
S
D
H
L
N
D
S
R
L
G
A
H
E
G
Site 22
S98
L
G
A
H
E
G
L
S
P
T
P
F
M
N
S
Site 23
T100
A
H
E
G
L
S
P
T
P
F
M
N
S
N
L
Site 24
T111
N
S
N
L
M
G
K
T
S
E
R
G
S
F
S
Site 25
S112
S
N
L
M
G
K
T
S
E
R
G
S
F
S
L
Site 26
S116
G
K
T
S
E
R
G
S
F
S
L
Y
S
R
D
Site 27
S118
T
S
E
R
G
S
F
S
L
Y
S
R
D
T
G
Site 28
Y120
E
R
G
S
F
S
L
Y
S
R
D
T
G
L
P
Site 29
S121
R
G
S
F
S
L
Y
S
R
D
T
G
L
P
G
Site 30
T124
F
S
L
Y
S
R
D
T
G
L
P
G
C
Q
S
Site 31
S131
T
G
L
P
G
C
Q
S
S
L
L
R
Q
D
L
Site 32
S132
G
L
P
G
C
Q
S
S
L
L
R
Q
D
L
G
Site 33
S142
R
Q
D
L
G
L
G
S
P
A
Q
L
S
S
S
Site 34
S147
L
G
S
P
A
Q
L
S
S
S
G
K
P
G
T
Site 35
S148
G
S
P
A
Q
L
S
S
S
G
K
P
G
T
A
Site 36
S149
S
P
A
Q
L
S
S
S
G
K
P
G
T
A
Y
Site 37
T154
S
S
S
G
K
P
G
T
A
Y
Y
S
F
S
A
Site 38
Y156
S
G
K
P
G
T
A
Y
Y
S
F
S
A
T
S
Site 39
Y157
G
K
P
G
T
A
Y
Y
S
F
S
A
T
S
S
Site 40
S158
K
P
G
T
A
Y
Y
S
F
S
A
T
S
S
R
Site 41
S160
G
T
A
Y
Y
S
F
S
A
T
S
S
R
R
R
Site 42
T162
A
Y
Y
S
F
S
A
T
S
S
R
R
R
P
L
Site 43
S163
Y
Y
S
F
S
A
T
S
S
R
R
R
P
L
H
Site 44
S164
Y
S
F
S
A
T
S
S
R
R
R
P
L
H
D
Site 45
S172
R
R
R
P
L
H
D
S
A
A
L
D
P
L
Q
Site 46
S192
K
V
P
P
G
L
P
S
S
V
Y
A
P
S
P
Site 47
S193
V
P
P
G
L
P
S
S
V
Y
A
P
S
P
N
Site 48
Y195
P
G
L
P
S
S
V
Y
A
P
S
P
N
S
D
Site 49
S198
P
S
S
V
Y
A
P
S
P
N
S
D
D
F
N
Site 50
S201
V
Y
A
P
S
P
N
S
D
D
F
N
R
E
S
Site 51
S208
S
D
D
F
N
R
E
S
P
S
Y
P
S
P
K
Site 52
S210
D
F
N
R
E
S
P
S
Y
P
S
P
K
P
P
Site 53
Y211
F
N
R
E
S
P
S
Y
P
S
P
K
P
P
T
Site 54
S213
R
E
S
P
S
Y
P
S
P
K
P
P
T
S
M
Site 55
T218
Y
P
S
P
K
P
P
T
S
M
F
A
S
T
F
Site 56
S219
P
S
P
K
P
P
T
S
M
F
A
S
T
F
F
Site 57
S223
P
P
T
S
M
F
A
S
T
F
F
M
Q
D
G
Site 58
T224
P
T
S
M
F
A
S
T
F
F
M
Q
D
G
T
Site 59
S234
M
Q
D
G
T
H
N
S
S
D
L
W
S
S
S
Site 60
S235
Q
D
G
T
H
N
S
S
D
L
W
S
S
S
N
Site 61
S239
H
N
S
S
D
L
W
S
S
S
N
G
M
S
Q
Site 62
S240
N
S
S
D
L
W
S
S
S
N
G
M
S
Q
P
Site 63
S241
S
S
D
L
W
S
S
S
N
G
M
S
Q
P
G
Site 64
S245
W
S
S
S
N
G
M
S
Q
P
G
F
G
G
I
Site 65
S256
F
G
G
I
L
G
T
S
T
S
H
M
S
Q
S
Site 66
T257
G
G
I
L
G
T
S
T
S
H
M
S
Q
S
S
Site 67
S258
G
I
L
G
T
S
T
S
H
M
S
Q
S
S
S
Site 68
S261
G
T
S
T
S
H
M
S
Q
S
S
S
Y
G
N
Site 69
S263
S
T
S
H
M
S
Q
S
S
S
Y
G
N
L
H
Site 70
S264
T
S
H
M
S
Q
S
S
S
Y
G
N
L
H
S
Site 71
S265
S
H
M
S
Q
S
S
S
Y
G
N
L
H
S
H
Site 72
S271
S
S
Y
G
N
L
H
S
H
D
R
L
S
Y
P
Site 73
S276
L
H
S
H
D
R
L
S
Y
P
P
H
S
V
S
Site 74
Y277
H
S
H
D
R
L
S
Y
P
P
H
S
V
S
P
Site 75
S281
R
L
S
Y
P
P
H
S
V
S
P
T
D
I
N
Site 76
S283
S
Y
P
P
H
S
V
S
P
T
D
I
N
T
S
Site 77
T285
P
P
H
S
V
S
P
T
D
I
N
T
S
L
P
Site 78
T289
V
S
P
T
D
I
N
T
S
L
P
P
M
S
S
Site 79
S290
S
P
T
D
I
N
T
S
L
P
P
M
S
S
F
Site 80
S295
N
T
S
L
P
P
M
S
S
F
H
R
G
S
T
Site 81
S296
T
S
L
P
P
M
S
S
F
H
R
G
S
T
S
Site 82
S301
M
S
S
F
H
R
G
S
T
S
S
S
P
Y
V
Site 83
T302
S
S
F
H
R
G
S
T
S
S
S
P
Y
V
A
Site 84
S303
S
F
H
R
G
S
T
S
S
S
P
Y
V
A
A
Site 85
S304
F
H
R
G
S
T
S
S
S
P
Y
V
A
A
S
Site 86
S305
H
R
G
S
T
S
S
S
P
Y
V
A
A
S
H
Site 87
Y307
G
S
T
S
S
S
P
Y
V
A
A
S
H
T
P
Site 88
S311
S
S
P
Y
V
A
A
S
H
T
P
P
I
N
G
Site 89
T313
P
Y
V
A
A
S
H
T
P
P
I
N
G
S
D
Site 90
S319
H
T
P
P
I
N
G
S
D
S
I
L
G
T
R
Site 91
S321
P
P
I
N
G
S
D
S
I
L
G
T
R
G
N
Site 92
T325
G
S
D
S
I
L
G
T
R
G
N
A
A
G
S
Site 93
S333
R
G
N
A
A
G
S
S
Q
T
G
D
A
L
G
Site 94
S345
A
L
G
K
A
L
A
S
I
Y
S
P
D
H
T
Site 95
S348
K
A
L
A
S
I
Y
S
P
D
H
T
S
S
S
Site 96
T352
S
I
Y
S
P
D
H
T
S
S
S
F
P
S
N
Site 97
S353
I
Y
S
P
D
H
T
S
S
S
F
P
S
N
P
Site 98
S354
Y
S
P
D
H
T
S
S
S
F
P
S
N
P
S
Site 99
S355
S
P
D
H
T
S
S
S
F
P
S
N
P
S
T
Site 100
S358
H
T
S
S
S
F
P
S
N
P
S
T
P
V
G
Site 101
S361
S
S
F
P
S
N
P
S
T
P
V
G
S
P
S
Site 102
T362
S
F
P
S
N
P
S
T
P
V
G
S
P
S
P
Site 103
S366
N
P
S
T
P
V
G
S
P
S
P
L
T
G
T
Site 104
S368
S
T
P
V
G
S
P
S
P
L
T
G
T
S
Q
Site 105
T371
V
G
S
P
S
P
L
T
G
T
S
Q
W
P
R
Site 106
S374
P
S
P
L
T
G
T
S
Q
W
P
R
P
G
G
Site 107
S385
R
P
G
G
Q
A
P
S
S
P
S
Y
E
N
S
Site 108
S386
P
G
G
Q
A
P
S
S
P
S
Y
E
N
S
L
Site 109
S388
G
Q
A
P
S
S
P
S
Y
E
N
S
L
H
S
Site 110
Y389
Q
A
P
S
S
P
S
Y
E
N
S
L
H
S
L
Site 111
S392
S
S
P
S
Y
E
N
S
L
H
S
L
Q
S
R
Site 112
S395
S
Y
E
N
S
L
H
S
L
Q
S
R
M
E
D
Site 113
S398
N
S
L
H
S
L
Q
S
R
M
E
D
R
L
D
Site 114
T423
N
H
A
V
G
P
S
T
S
L
P
A
G
H
S
Site 115
S424
H
A
V
G
P
S
T
S
L
P
A
G
H
S
D
Site 116
S430
T
S
L
P
A
G
H
S
D
I
H
S
L
L
G
Site 117
S434
A
G
H
S
D
I
H
S
L
L
G
P
S
H
N
Site 118
S446
S
H
N
A
P
I
G
S
L
N
S
N
Y
G
G
Site 119
S449
A
P
I
G
S
L
N
S
N
Y
G
G
S
S
L
Site 120
S455
N
S
N
Y
G
G
S
S
L
V
A
S
S
R
S
Site 121
S464
V
A
S
S
R
S
A
S
M
V
G
T
H
R
E
Site 122
T468
R
S
A
S
M
V
G
T
H
R
E
D
S
V
S
Site 123
S473
V
G
T
H
R
E
D
S
V
S
L
N
G
N
H
Site 124
S475
T
H
R
E
D
S
V
S
L
N
G
N
H
S
V
Site 125
S484
N
G
N
H
S
V
L
S
S
T
V
T
T
S
S
Site 126
S485
G
N
H
S
V
L
S
S
T
V
T
T
S
S
T
Site 127
T486
N
H
S
V
L
S
S
T
V
T
T
S
S
T
D
Site 128
T488
S
V
L
S
S
T
V
T
T
S
S
T
D
L
N
Site 129
T489
V
L
S
S
T
V
T
T
S
S
T
D
L
N
H
Site 130
S490
L
S
S
T
V
T
T
S
S
T
D
L
N
H
K
Site 131
T498
S
T
D
L
N
H
K
T
Q
E
N
Y
R
G
G
Site 132
S508
N
Y
R
G
G
L
Q
S
Q
S
G
T
V
V
T
Site 133
S510
R
G
G
L
Q
S
Q
S
G
T
V
V
T
T
E
Site 134
T512
G
L
Q
S
Q
S
G
T
V
V
T
T
E
I
K
Site 135
S534
E
N
L
H
E
P
P
S
S
D
D
M
K
S
D
Site 136
S535
N
L
H
E
P
P
S
S
D
D
M
K
S
D
D
Site 137
S540
P
S
S
D
D
M
K
S
D
D
E
S
S
Q
K
Site 138
S544
D
M
K
S
D
D
E
S
S
Q
K
D
I
K
V
Site 139
S545
M
K
S
D
D
E
S
S
Q
K
D
I
K
V
S
Site 140
S552
S
Q
K
D
I
K
V
S
S
R
G
R
T
S
S
Site 141
S553
Q
K
D
I
K
V
S
S
R
G
R
T
S
S
T
Site 142
T557
K
V
S
S
R
G
R
T
S
S
T
N
E
D
E
Site 143
S558
E
N
L
H
E
P
P
S
S
D
D
M
K
S
D
Site 144
S559
S
S
R
G
R
T
S
S
T
N
E
D
E
D
L
Site 145
T560
S
R
G
R
T
S
S
T
N
E
D
E
D
L
N
Site 146
S610
M
C
Q
L
H
L
K
S
E
K
P
Q
T
K
L
Site 147
T615
L
K
S
E
K
P
Q
T
K
L
L
I
L
H
Q
Site 148
S655
R
R
E
E
E
K
V
S
A
V
S
A
E
P
P
Site 149
T663
A
V
S
A
E
P
P
T
T
L
P
G
T
H
P
Site 150
T664
V
S
A
E
P
P
T
T
L
P
G
T
H
P
G
Site 151
T668
P
P
T
T
L
P
G
T
H
P
G
L
S
E
T
Site 152
S673
P
G
T
H
P
G
L
S
E
T
T
N
P
M
G
Site 153
T675
T
H
P
G
L
S
E
T
T
N
P
M
G
H
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation