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Updated November 2019
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Protein Info
Short Name:
MUC4
Full Name:
Mucin-4
Alias:
Ascites sialoglycoprotein;Pancreatic adenocarcinoma mucin;Testis mucin;Tracheobronchial mucin;Ascites sialoglycoprotein 1;Ascites sialoglycoprotein 2
Type:
Mass (Da):
231584
Number AA:
2169
UniProt ID:
Q99102
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T33
V
P
G
T
T
E
D
T
L
I
T
G
S
K
T
Site 2
S38
E
D
T
L
I
T
G
S
K
T
P
A
P
V
T
Site 3
T40
T
L
I
T
G
S
K
T
P
A
P
V
T
S
T
Site 4
T45
S
K
T
P
A
P
V
T
S
T
G
S
T
T
A
Site 5
S46
K
T
P
A
P
V
T
S
T
G
S
T
T
A
T
Site 6
S49
A
P
V
T
S
T
G
S
T
T
A
T
L
E
G
Site 7
T50
P
V
T
S
T
G
S
T
T
A
T
L
E
G
Q
Site 8
T53
S
T
G
S
T
T
A
T
L
E
G
Q
S
T
A
Site 9
S58
T
A
T
L
E
G
Q
S
T
A
A
S
S
R
T
Site 10
T59
A
T
L
E
G
Q
S
T
A
A
S
S
R
T
S
Site 11
S62
E
G
Q
S
T
A
A
S
S
R
T
S
N
Q
D
Site 12
S66
T
A
A
S
S
R
T
S
N
Q
D
I
S
A
S
Site 13
S71
R
T
S
N
Q
D
I
S
A
S
S
Q
N
H
Q
Site 14
S74
N
Q
D
I
S
A
S
S
Q
N
H
Q
T
K
S
Site 15
S81
S
Q
N
H
Q
T
K
S
T
E
T
T
S
K
A
Site 16
T90
E
T
T
S
K
A
Q
T
D
T
L
T
Q
M
M
Site 17
T92
T
S
K
A
Q
T
D
T
L
T
Q
M
M
T
S
Site 18
T94
K
A
Q
T
D
T
L
T
Q
M
M
T
S
T
L
Site 19
T98
D
T
L
T
Q
M
M
T
S
T
L
F
S
S
P
Site 20
S99
T
L
T
Q
M
M
T
S
T
L
F
S
S
P
S
Site 21
S106
S
T
L
F
S
S
P
S
V
H
N
V
M
E
T
Site 22
T113
S
V
H
N
V
M
E
T
V
T
Q
E
T
A
P
Site 23
T125
T
A
P
P
D
E
M
T
T
S
F
P
S
S
V
Site 24
T126
A
P
P
D
E
M
T
T
S
F
P
S
S
V
T
Site 25
S127
P
P
D
E
M
T
T
S
F
P
S
S
V
T
N
Site 26
T135
F
P
S
S
V
T
N
T
L
M
M
T
S
K
T
Site 27
T144
M
M
T
S
K
T
I
T
M
T
T
S
T
D
S
Site 28
T147
S
K
T
I
T
M
T
T
S
T
D
S
T
L
G
Site 29
S151
T
M
T
T
S
T
D
S
T
L
G
N
T
E
E
Site 30
T152
M
T
T
S
T
D
S
T
L
G
N
T
E
E
T
Site 31
S160
L
G
N
T
E
E
T
S
T
A
G
T
E
S
S
Site 32
T161
G
N
T
E
E
T
S
T
A
G
T
E
S
S
T
Site 33
T164
E
E
T
S
T
A
G
T
E
S
S
T
P
V
T
Site 34
S166
T
S
T
A
G
T
E
S
S
T
P
V
T
S
A
Site 35
S167
S
T
A
G
T
E
S
S
T
P
V
T
S
A
V
Site 36
T168
T
A
G
T
E
S
S
T
P
V
T
S
A
V
S
Site 37
T187
Q
E
G
Q
S
R
T
T
S
W
R
T
S
I
Q
Site 38
S188
E
G
Q
S
R
T
T
S
W
R
T
S
I
Q
D
Site 39
S192
R
T
T
S
W
R
T
S
I
Q
D
T
S
A
S
Site 40
T196
W
R
T
S
I
Q
D
T
S
A
S
S
Q
N
H
Site 41
S197
R
T
S
I
Q
D
T
S
A
S
S
Q
N
H
W
Site 42
S199
S
I
Q
D
T
S
A
S
S
Q
N
H
W
T
R
Site 43
S200
I
Q
D
T
S
A
S
S
Q
N
H
W
T
R
S
Site 44
S207
S
Q
N
H
W
T
R
S
T
Q
T
T
R
E
S
Site 45
T208
Q
N
H
W
T
R
S
T
Q
T
T
R
E
S
Q
Site 46
T210
H
W
T
R
S
T
Q
T
T
R
E
S
Q
T
S
Site 47
T211
W
T
R
S
T
Q
T
T
R
E
S
Q
T
S
T
Site 48
S214
S
T
Q
T
T
R
E
S
Q
T
S
T
L
T
H
Site 49
S217
T
T
R
E
S
Q
T
S
T
L
T
H
R
T
T
Site 50
T218
T
R
E
S
Q
T
S
T
L
T
H
R
T
T
S
Site 51
T220
E
S
Q
T
S
T
L
T
H
R
T
T
S
T
P
Site 52
T224
S
T
L
T
H
R
T
T
S
T
P
S
F
S
P
Site 53
S225
T
L
T
H
R
T
T
S
T
P
S
F
S
P
S
Site 54
T226
L
T
H
R
T
T
S
T
P
S
F
S
P
S
V
Site 55
S228
H
R
T
T
S
T
P
S
F
S
P
S
V
H
N
Site 56
S230
T
T
S
T
P
S
F
S
P
S
V
H
N
V
T
Site 57
S232
S
T
P
S
F
S
P
S
V
H
N
V
T
G
T
Site 58
T237
S
P
S
V
H
N
V
T
G
T
V
S
Q
K
T
Site 59
T239
S
V
H
N
V
T
G
T
V
S
Q
K
T
S
P
Site 60
S241
H
N
V
T
G
T
V
S
Q
K
T
S
P
S
G
Site 61
S245
G
T
V
S
Q
K
T
S
P
S
G
E
T
A
T
Site 62
S247
V
S
Q
K
T
S
P
S
G
E
T
A
T
S
S
Site 63
S253
P
S
G
E
T
A
T
S
S
L
C
S
V
T
N
Site 64
S254
S
G
E
T
A
T
S
S
L
C
S
V
T
N
T
Site 65
T261
S
L
C
S
V
T
N
T
S
M
M
T
S
E
K
Site 66
S266
T
N
T
S
M
M
T
S
E
K
I
T
V
T
T
Site 67
T270
M
M
T
S
E
K
I
T
V
T
T
S
T
G
S
Site 68
T272
T
S
E
K
I
T
V
T
T
S
T
G
S
T
L
Site 69
S277
T
V
T
T
S
T
G
S
T
L
G
N
P
G
E
Site 70
T278
V
T
T
S
T
G
S
T
L
G
N
P
G
E
T
Site 71
S286
L
G
N
P
G
E
T
S
S
V
P
V
T
G
S
Site 72
S287
G
N
P
G
E
T
S
S
V
P
V
T
G
S
L
Site 73
T298
T
G
S
L
M
P
V
T
S
A
A
L
V
T
V
Site 74
S299
G
S
L
M
P
V
T
S
A
A
L
V
T
V
D
Site 75
S311
T
V
D
P
E
G
Q
S
P
A
T
F
S
R
T
Site 76
T314
P
E
G
Q
S
P
A
T
F
S
R
T
S
T
Q
Site 77
S316
G
Q
S
P
A
T
F
S
R
T
S
T
Q
D
T
Site 78
S319
P
A
T
F
S
R
T
S
T
Q
D
T
T
A
F
Site 79
T320
A
T
F
S
R
T
S
T
Q
D
T
T
A
F
S
Site 80
T323
S
R
T
S
T
Q
D
T
T
A
F
S
K
N
H
Site 81
T324
R
T
S
T
Q
D
T
T
A
F
S
K
N
H
Q
Site 82
T332
A
F
S
K
N
H
Q
T
Q
S
V
E
T
T
R
Site 83
S334
S
K
N
H
Q
T
Q
S
V
E
T
T
R
V
S
Site 84
T337
H
Q
T
Q
S
V
E
T
T
R
V
S
Q
I
N
Site 85
T338
Q
T
Q
S
V
E
T
T
R
V
S
Q
I
N
T
Site 86
S341
S
V
E
T
T
R
V
S
Q
I
N
T
L
N
T
Site 87
T345
T
R
V
S
Q
I
N
T
L
N
T
L
T
P
V
Site 88
T348
S
Q
I
N
T
L
N
T
L
T
P
V
T
T
S
Site 89
S359
V
T
T
S
T
V
L
S
S
P
S
G
F
N
P
Site 90
S360
T
T
S
T
V
L
S
S
P
S
G
F
N
P
S
Site 91
S362
S
T
V
L
S
S
P
S
G
F
N
P
S
G
T
Site 92
S367
S
P
S
G
F
N
P
S
G
T
V
S
Q
E
T
Site 93
T369
S
G
F
N
P
S
G
T
V
S
Q
E
T
F
P
Site 94
S371
F
N
P
S
G
T
V
S
Q
E
T
F
P
S
G
Site 95
T374
S
G
T
V
S
Q
E
T
F
P
S
G
E
T
T
Site 96
S377
V
S
Q
E
T
F
P
S
G
E
T
T
I
S
S
Site 97
T380
E
T
F
P
S
G
E
T
T
I
S
S
P
S
S
Site 98
T381
T
F
P
S
G
E
T
T
I
S
S
P
S
S
V
Site 99
S383
P
S
G
E
T
T
I
S
S
P
S
S
V
S
N
Site 100
S384
S
G
E
T
T
I
S
S
P
S
S
V
S
N
T
Site 101
S386
E
T
T
I
S
S
P
S
S
V
S
N
T
F
L
Site 102
S404
K
V
F
R
M
P
I
S
R
D
S
T
L
G
N
Site 103
S407
R
M
P
I
S
R
D
S
T
L
G
N
T
E
E
Site 104
T408
M
P
I
S
R
D
S
T
L
G
N
T
E
E
T
Site 105
T412
R
D
S
T
L
G
N
T
E
E
T
S
L
S
V
Site 106
S416
L
G
N
T
E
E
T
S
L
S
V
S
G
T
I
Site 107
S418
N
T
E
E
T
S
L
S
V
S
G
T
I
S
A
Site 108
T438
S
T
I
W
W
S
D
T
L
S
T
A
L
S
P
Site 109
S440
I
W
W
S
D
T
L
S
T
A
L
S
P
S
S
Site 110
S444
D
T
L
S
T
A
L
S
P
S
S
L
P
P
K
Site 111
S446
L
S
T
A
L
S
P
S
S
L
P
P
K
I
S
Site 112
S447
S
T
A
L
S
P
S
S
L
P
P
K
I
S
T
Site 113
S453
S
S
L
P
P
K
I
S
T
A
F
H
T
Q
Q
Site 114
T466
Q
Q
S
E
G
A
E
T
T
G
R
P
H
E
R
Site 115
S474
T
G
R
P
H
E
R
S
S
F
S
P
G
V
S
Site 116
S475
G
R
P
H
E
R
S
S
F
S
P
G
V
S
Q
Site 117
S477
P
H
E
R
S
S
F
S
P
G
V
S
Q
E
I
Site 118
S481
S
S
F
S
P
G
V
S
Q
E
I
F
T
L
H
Site 119
T490
E
I
F
T
L
H
E
T
T
T
W
P
S
S
F
Site 120
T491
I
F
T
L
H
E
T
T
T
W
P
S
S
F
S
Site 121
T492
F
T
L
H
E
T
T
T
W
P
S
S
F
S
S
Site 122
S496
E
T
T
T
W
P
S
S
F
S
S
K
G
H
T
Site 123
S499
T
W
P
S
S
F
S
S
K
G
H
T
T
W
S
Site 124
T503
S
F
S
S
K
G
H
T
T
W
S
Q
T
E
L
Site 125
S506
S
K
G
H
T
T
W
S
Q
T
E
L
P
S
T
Site 126
T508
G
H
T
T
W
S
Q
T
E
L
P
S
T
S
T
Site 127
T513
S
Q
T
E
L
P
S
T
S
T
G
A
A
T
R
Site 128
T523
G
A
A
T
R
L
V
T
G
N
P
S
T
R
A
Site 129
S527
R
L
V
T
G
N
P
S
T
R
A
A
G
T
I
Site 130
T533
P
S
T
R
A
A
G
T
I
P
R
V
P
S
K
Site 131
S539
G
T
I
P
R
V
P
S
K
V
S
A
I
G
E
Site 132
T551
I
G
E
P
G
E
P
T
T
Y
S
S
H
S
T
Site 133
T552
G
E
P
G
E
P
T
T
Y
S
S
H
S
T
T
Site 134
Y553
E
P
G
E
P
T
T
Y
S
S
H
S
T
T
L
Site 135
S554
P
G
E
P
T
T
Y
S
S
H
S
T
T
L
P
Site 136
S555
G
E
P
T
T
Y
S
S
H
S
T
T
L
P
K
Site 137
T558
T
T
Y
S
S
H
S
T
T
L
P
K
T
T
G
Site 138
T559
T
Y
S
S
H
S
T
T
L
P
K
T
T
G
A
Site 139
T573
A
G
A
Q
T
Q
W
T
Q
E
T
G
T
T
G
Site 140
T597
S
V
I
Q
M
I
K
T
A
T
S
P
S
S
S
Site 141
T599
I
Q
M
I
K
T
A
T
S
P
S
S
S
P
M
Site 142
S600
Q
M
I
K
T
A
T
S
P
S
S
S
P
M
L
Site 143
S602
I
K
T
A
T
S
P
S
S
S
P
M
L
D
R
Site 144
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W
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L
G
S
N
T
Y
Q
A
I
L
S
T
D
Site 298
S1232
N
T
Y
Q
A
I
L
S
T
D
G
S
R
S
Y
Site 299
S1238
L
S
T
D
G
S
R
S
Y
A
L
F
L
Y
Q
Site 300
Y1239
S
T
D
G
S
R
S
Y
A
L
F
L
Y
Q
S
Site 301
Y1244
R
S
Y
A
L
F
L
Y
Q
S
G
G
M
Q
W
Site 302
S1257
Q
W
D
V
A
Q
R
S
G
N
P
V
L
M
G
Site 303
S1267
P
V
L
M
G
F
S
S
G
D
G
Y
F
E
N
Site 304
Y1271
G
F
S
S
G
D
G
Y
F
E
N
S
P
L
M
Site 305
S1275
G
D
G
Y
F
E
N
S
P
L
M
S
Q
P
V
Site 306
S1279
F
E
N
S
P
L
M
S
Q
P
V
W
E
R
Y
Site 307
S1294
R
P
D
R
F
L
N
S
N
S
G
L
Q
G
L
Site 308
S1296
D
R
F
L
N
S
N
S
G
L
Q
G
L
Q
F
Site 309
Y1314
H
R
E
E
R
P
N
Y
R
L
E
C
L
Q
W
Site 310
S1355
D
L
R
F
Q
P
V
S
I
G
R
W
G
L
G
Site 311
S1363
I
G
R
W
G
L
G
S
R
Q
L
C
S
F
T
Site 312
S1368
L
G
S
R
Q
L
C
S
F
T
S
W
R
G
G
Site 313
T1370
S
R
Q
L
C
S
F
T
S
W
R
G
G
V
C
Site 314
Y1380
R
G
G
V
C
C
S
Y
G
P
W
G
E
F
R
Site 315
Y1416
C
R
W
N
D
K
P
Y
L
C
A
L
Y
Q
Q
Site 316
Y1421
K
P
Y
L
C
A
L
Y
Q
Q
R
R
P
H
V
Site 317
T1432
R
P
H
V
G
C
A
T
Y
R
P
P
Q
P
A
Site 318
Y1433
P
H
V
G
C
A
T
Y
R
P
P
Q
P
A
W
Site 319
T1449
F
G
D
P
H
I
T
T
L
D
G
V
S
Y
T
Site 320
Y1455
T
T
L
D
G
V
S
Y
T
F
N
G
L
G
D
Site 321
S1473
V
G
A
Q
D
G
N
S
S
F
L
L
Q
G
R
Site 322
S1474
G
A
Q
D
G
N
S
S
F
L
L
Q
G
R
T
Site 323
S1501
A
F
A
A
Q
Y
R
S
S
S
L
G
P
V
T
Site 324
S1503
A
A
Q
Y
R
S
S
S
L
G
P
V
T
V
Q
Site 325
T1527
R
V
L
L
D
N
Q
T
V
T
F
Q
P
D
H
Site 326
T1529
L
L
D
N
Q
T
V
T
F
Q
P
D
H
E
D
Site 327
T1542
E
D
G
G
G
Q
E
T
F
N
A
T
G
V
L
Site 328
S1551
N
A
T
G
V
L
L
S
R
N
G
S
E
V
S
Site 329
S1555
V
L
L
S
R
N
G
S
E
V
S
A
S
F
D
Site 330
S1558
S
R
N
G
S
E
V
S
A
S
F
D
G
W
A
Site 331
S1560
N
G
S
E
V
S
A
S
F
D
G
W
A
T
V
Site 332
S1579
L
S
N
I
L
H
A
S
A
S
L
P
P
E
Y
Site 333
S1581
N
I
L
H
A
S
A
S
L
P
P
E
Y
Q
N
Site 334
Y1586
S
A
S
L
P
P
E
Y
Q
N
R
T
E
G
L
Site 335
S1611
D
F
R
M
P
N
G
S
T
I
P
P
G
S
P
Site 336
T1612
F
R
M
P
N
G
S
T
I
P
P
G
S
P
E
Site 337
S1617
G
S
T
I
P
P
G
S
P
E
E
M
L
F
H
Site 338
T1649
D
Q
L
P
S
N
F
T
P
V
F
Y
S
Q
L
Site 339
S1654
N
F
T
P
V
F
Y
S
Q
L
Q
K
N
S
S
Site 340
S1661
S
Q
L
Q
K
N
S
S
W
A
E
H
L
I
S
Site 341
S1668
S
W
A
E
H
L
I
S
N
C
D
G
D
S
S
Site 342
S1675
S
N
C
D
G
D
S
S
C
I
Y
D
T
L
A
Site 343
Y1678
D
G
D
S
S
C
I
Y
D
T
L
A
L
R
N
Site 344
T1680
D
S
S
C
I
Y
D
T
L
A
L
R
N
A
S
Site 345
S1687
T
L
A
L
R
N
A
S
I
G
L
H
T
R
E
Site 346
T1692
N
A
S
I
G
L
H
T
R
E
V
S
K
N
Y
Site 347
S1696
G
L
H
T
R
E
V
S
K
N
Y
E
Q
A
N
Site 348
Y1709
A
N
A
T
L
N
Q
Y
P
P
S
I
N
G
G
Site 349
S1712
T
L
N
Q
Y
P
P
S
I
N
G
G
R
V
I
Site 350
Y1722
G
G
R
V
I
E
A
Y
K
G
Q
T
T
L
I
Site 351
T1741
N
A
E
D
A
N
F
T
L
R
D
S
C
T
D
Site 352
S1745
A
N
F
T
L
R
D
S
C
T
D
L
E
L
F
Site 353
T1747
F
T
L
R
D
S
C
T
D
L
E
L
F
E
N
Site 354
T1756
L
E
L
F
E
N
G
T
L
L
W
T
P
K
S
Site 355
T1760
E
N
G
T
L
L
W
T
P
K
S
L
E
P
F
Site 356
S1763
T
L
L
W
T
P
K
S
L
E
P
F
T
L
E
Site 357
T1768
P
K
S
L
E
P
F
T
L
E
I
L
A
R
S
Site 358
Y1801
N
A
E
S
Q
C
L
Y
N
Q
T
S
R
V
G
Site 359
S1805
Q
C
L
Y
N
Q
T
S
R
V
G
N
S
S
L
Site 360
S1811
T
S
R
V
G
N
S
S
L
E
V
A
G
C
K
Site 361
Y1827
D
G
G
T
F
G
R
Y
C
E
G
S
E
D
A
Site 362
S1831
F
G
R
Y
C
E
G
S
E
D
A
C
E
E
P
Site 363
S1871
H
C
A
A
L
G
S
S
F
L
C
Q
N
Q
S
Site 364
T1923
A
G
N
N
F
S
P
T
V
N
L
E
L
P
L
Site 365
S1938
R
V
I
Q
L
L
L
S
E
E
E
N
A
S
M
Site 366
S1944
L
S
E
E
E
N
A
S
M
A
E
V
N
A
S
Site 367
S1968
M
R
A
F
L
R
N
S
Q
V
E
R
I
D
S
Site 368
S1975
S
Q
V
E
R
I
D
S
A
A
P
A
S
G
S
Site 369
S1980
I
D
S
A
A
P
A
S
G
S
P
I
Q
H
W
Site 370
S1982
S
A
A
P
A
S
G
S
P
I
Q
H
W
M
V
Site 371
Y1995
M
V
I
S
E
F
Q
Y
R
P
R
G
P
V
I
Site 372
Y2019
A
V
V
E
A
F
L
Y
H
V
P
R
R
S
E
Site 373
S2025
L
Y
H
V
P
R
R
S
E
E
P
R
N
D
V
Site 374
S2038
D
V
V
F
Q
P
I
S
G
E
D
V
R
D
V
Site 375
T2046
G
E
D
V
R
D
V
T
A
L
N
V
S
T
L
Site 376
Y2056
N
V
S
T
L
K
A
Y
F
R
C
D
G
Y
K
Site 377
Y2062
A
Y
F
R
C
D
G
Y
K
G
Y
D
L
V
Y
Site 378
Y2065
R
C
D
G
Y
K
G
Y
D
L
V
Y
S
P
Q
Site 379
Y2069
Y
K
G
Y
D
L
V
Y
S
P
Q
S
G
F
T
Site 380
S2070
K
G
Y
D
L
V
Y
S
P
Q
S
G
F
T
C
Site 381
S2073
D
L
V
Y
S
P
Q
S
G
F
T
C
V
S
P
Site 382
Y2085
V
S
P
C
S
R
G
Y
C
D
H
G
G
Q
C
Site 383
S2159
G
C
S
G
A
R
F
S
Y
F
L
N
S
A
E
Site 384
Y2160
C
S
G
A
R
F
S
Y
F
L
N
S
A
E
A
Site 385
S2164
R
F
S
Y
F
L
N
S
A
E
A
L
P
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation