KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
SCN2A
Full Name:
Sodium channel protein type 2 subunit alpha
Alias:
CIN2; HBSC II; HBSCI; HBSCII; NAC2; Nav1.2; SCN2A1; SCN2A2; Sodium channel protein brain II subunit alpha; Sodium channel protein type II subunit alpha; Sodium channel protein, brain II alpha subunit; Sodium channel type II alpha subunit; Sodium channel, voltage-gated, type II, alpha subunit; Voltage-gated sodium channel subunit alpha Nav1.2
Type:
Channel, sodium
Mass (Da):
227975
Number AA:
2005
UniProt ID:
Q99250
International Prot ID:
IPI00220666
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0001518
Uniprot
OncoNet
Molecular Function:
GO:0031402
GO:0005248
PhosphoSite+
KinaseNET
Biological Process:
GO:0006814
GO:0055085
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
L
V
P
P
G
P
D
S
F
R
F
F
T
R
E
Site 2
T18
P
D
S
F
R
F
F
T
R
E
S
L
A
A
I
Site 3
S21
F
R
F
F
T
R
E
S
L
A
A
I
E
Q
R
Site 4
S54
E
N
G
P
K
P
N
S
D
L
E
A
G
K
S
Site 5
S61
S
D
L
E
A
G
K
S
L
P
F
I
Y
G
D
Site 6
Y66
G
K
S
L
P
F
I
Y
G
D
I
P
P
E
M
Site 7
Y84
P
L
E
D
L
D
P
Y
Y
I
N
K
K
T
F
Site 8
Y85
L
E
D
L
D
P
Y
Y
I
N
K
K
T
F
I
Site 9
T90
P
Y
Y
I
N
K
K
T
F
I
V
L
N
K
G
Site 10
Y160
D
W
T
K
N
V
E
Y
T
F
T
G
I
Y
T
Site 11
T163
K
N
V
E
Y
T
F
T
G
I
Y
T
F
E
S
Site 12
S287
Q
W
P
P
D
N
S
S
F
E
I
N
I
T
S
Site 13
T293
S
S
F
E
I
N
I
T
S
F
F
N
N
S
L
Site 14
S294
S
F
E
I
N
I
T
S
F
F
N
N
S
L
D
Site 15
S299
I
T
S
F
F
N
N
S
L
D
G
N
G
T
T
Site 16
T306
S
L
D
G
N
G
T
T
F
N
R
T
V
S
I
Site 17
Y319
S
I
F
N
W
D
E
Y
I
E
D
K
S
H
F
Site 18
Y327
I
E
D
K
S
H
F
Y
F
L
E
G
Q
N
D
Site 19
S341
D
A
L
L
C
G
N
S
S
D
A
G
Q
C
P
Site 20
S342
A
L
L
C
G
N
S
S
D
A
G
Q
C
P
E
Site 21
Y351
A
G
Q
C
P
E
G
Y
I
C
V
K
A
G
R
Site 22
Y362
K
A
G
R
N
P
N
Y
G
Y
T
S
F
D
T
Site 23
Y364
G
R
N
P
N
Y
G
Y
T
S
F
D
T
F
S
Site 24
S471
A
A
A
A
S
A
E
S
R
D
F
S
G
A
G
Site 25
S475
S
A
E
S
R
D
F
S
G
A
G
G
I
G
V
Site 26
S488
G
V
F
S
E
S
S
S
V
A
S
K
L
S
S
Site 27
S491
S
E
S
S
S
V
A
S
K
L
S
S
K
S
E
Site 28
S494
S
S
V
A
S
K
L
S
S
K
S
E
K
E
L
Site 29
S495
S
V
A
S
K
L
S
S
K
S
E
K
E
L
K
Site 30
S497
A
S
K
L
S
S
K
S
E
K
E
L
K
N
R
Site 31
S514
K
K
K
Q
K
E
Q
S
G
E
E
E
K
N
D
Site 32
S526
K
N
D
R
V
R
K
S
E
S
E
D
S
I
R
Site 33
S528
D
R
V
R
K
S
E
S
E
D
S
I
R
R
K
Site 34
S531
R
K
S
E
S
E
D
S
I
R
R
K
G
F
R
Site 35
S540
R
R
K
G
F
R
F
S
L
E
G
S
R
L
T
Site 36
S544
F
R
F
S
L
E
G
S
R
L
T
Y
E
K
R
Site 37
T547
S
L
E
G
S
R
L
T
Y
E
K
R
F
S
S
Site 38
Y548
L
E
G
S
R
L
T
Y
E
K
R
F
S
S
P
Site 39
S553
L
T
Y
E
K
R
F
S
S
P
H
Q
S
L
L
Site 40
S554
T
Y
E
K
R
F
S
S
P
H
Q
S
L
L
S
Site 41
S558
R
F
S
S
P
H
Q
S
L
L
S
I
R
G
S
Site 42
S561
S
P
H
Q
S
L
L
S
I
R
G
S
L
F
S
Site 43
S565
S
L
L
S
I
R
G
S
L
F
S
P
R
R
N
Site 44
S568
S
I
R
G
S
L
F
S
P
R
R
N
S
R
A
Site 45
S573
L
F
S
P
R
R
N
S
R
A
S
L
F
S
F
Site 46
S576
P
R
R
N
S
R
A
S
L
F
S
F
R
G
R
Site 47
S579
N
S
R
A
S
L
F
S
F
R
G
R
A
K
D
Site 48
S589
G
R
A
K
D
I
G
S
E
N
D
F
A
D
D
Site 49
T600
F
A
D
D
E
H
S
T
F
E
D
N
D
S
R
Site 50
S606
S
T
F
E
D
N
D
S
R
R
D
S
L
F
V
Site 51
S610
D
N
D
S
R
R
D
S
L
F
V
P
H
R
H
Site 52
S623
R
H
G
E
R
R
H
S
N
V
S
Q
A
S
R
Site 53
S626
E
R
R
H
S
N
V
S
Q
A
S
R
A
S
R
Site 54
S629
H
S
N
V
S
Q
A
S
R
A
S
R
V
L
P
Site 55
S632
V
S
Q
A
S
R
A
S
R
V
L
P
I
L
P
Site 56
S665
G
G
P
S
T
L
T
S
A
G
Q
L
L
P
E
Site 57
T676
L
L
P
E
G
T
T
T
E
T
E
I
R
K
R
Site 58
S685
T
E
I
R
K
R
R
S
S
S
Y
H
V
S
M
Site 59
S686
E
I
R
K
R
R
S
S
S
Y
H
V
S
M
D
Site 60
S687
I
R
K
R
R
S
S
S
Y
H
V
S
M
D
L
Site 61
Y688
R
K
R
R
S
S
S
Y
H
V
S
M
D
L
L
Site 62
S691
R
S
S
S
Y
H
V
S
M
D
L
L
E
D
P
Site 63
T699
M
D
L
L
E
D
P
T
S
R
Q
R
A
M
S
Site 64
S700
D
L
L
E
D
P
T
S
R
Q
R
A
M
S
I
Site 65
S706
T
S
R
Q
R
A
M
S
I
A
S
I
L
T
N
Site 66
S721
T
M
E
E
L
E
E
S
R
Q
K
C
P
P
C
Site 67
Y730
Q
K
C
P
P
C
W
Y
K
F
A
N
M
C
L
Site 68
Y781
L
F
M
A
M
E
H
Y
P
M
T
E
Q
F
S
Site 69
T784
A
M
E
H
Y
P
M
T
E
Q
F
S
S
V
L
Site 70
Y816
K
I
I
A
M
D
P
Y
Y
Y
F
Q
E
G
W
Site 71
T1058
S
C
I
S
N
H
T
T
I
E
I
G
K
D
L
Site 72
Y1067
E
I
G
K
D
L
N
Y
L
K
D
G
N
G
T
Site 73
S1076
K
D
G
N
G
T
T
S
G
I
G
S
S
V
E
Site 74
S1081
T
T
S
G
I
G
S
S
V
E
K
Y
V
V
D
Site 75
Y1085
I
G
S
S
V
E
K
Y
V
V
D
E
S
D
Y
Site 76
Y1092
Y
V
V
D
E
S
D
Y
M
S
F
I
N
N
P
Site 77
S1094
V
D
E
S
D
Y
M
S
F
I
N
N
P
S
L
Site 78
S1112
V
P
I
A
V
G
E
S
D
F
E
N
L
N
T
Site 79
T1119
S
D
F
E
N
L
N
T
E
E
F
S
S
E
S
Site 80
S1124
L
N
T
E
E
F
S
S
E
S
D
M
E
E
S
Site 81
S1126
T
E
E
F
S
S
E
S
D
M
E
E
S
K
E
Site 82
T1138
S
K
E
K
L
N
A
T
S
S
S
E
G
S
T
Site 83
S1139
K
E
K
L
N
A
T
S
S
S
E
G
S
T
V
Site 84
S1140
E
K
L
N
A
T
S
S
S
E
G
S
T
V
D
Site 85
S1141
K
L
N
A
T
S
S
S
E
G
S
T
V
D
I
Site 86
S1144
A
T
S
S
S
E
G
S
T
V
D
I
G
A
P
Site 87
T1145
T
S
S
S
E
G
S
T
V
D
I
G
A
P
A
Site 88
S1164
P
E
V
E
P
E
E
S
L
E
P
E
A
C
F
Site 89
T1172
L
E
P
E
A
C
F
T
E
D
C
V
R
K
F
Site 90
S1185
K
F
K
C
C
Q
I
S
I
E
E
G
K
G
K
Site 91
Y1231
A
L
A
F
E
D
I
Y
I
E
Q
R
K
T
I
Site 92
T1237
I
Y
I
E
Q
R
K
T
I
K
T
M
L
E
Y
Site 93
T1240
E
Q
R
K
T
I
K
T
M
L
E
Y
A
D
K
Site 94
S1318
L
R
P
L
R
A
L
S
R
F
E
G
M
R
V
Site 95
S1378
T
G
E
M
F
D
V
S
V
V
N
N
Y
S
E
Site 96
T1395
A
L
I
E
S
N
Q
T
A
R
W
K
N
V
K
Site 97
Y1429
K
G
W
M
D
I
M
Y
A
A
V
D
S
R
N
Site 98
S1434
I
M
Y
A
A
V
D
S
R
N
V
E
L
Q
P
Site 99
Y1443
N
V
E
L
Q
P
K
Y
E
D
N
L
Y
M
Y
Site 100
Y1448
P
K
Y
E
D
N
L
Y
M
Y
L
Y
F
V
I
Site 101
T1491
G
G
Q
D
I
F
M
T
E
E
Q
K
K
Y
Y
Site 102
Y1497
M
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
Site 103
Y1498
T
E
E
Q
K
K
Y
Y
N
A
M
K
K
L
G
Site 104
S1556
M
V
E
T
D
D
Q
S
Q
E
M
T
N
I
L
Site 105
Y1588
K
L
I
S
L
R
Y
Y
Y
F
T
I
G
W
N
Site 106
S1740
P
D
K
D
H
P
G
S
S
V
K
G
D
C
G
Site 107
S1786
F
S
V
A
T
E
E
S
A
E
P
L
S
E
D
Site 108
S1791
E
E
S
A
E
P
L
S
E
D
D
F
E
M
F
Site 109
Y1799
E
D
D
F
E
M
F
Y
E
V
W
E
K
F
D
Site 110
T1810
E
K
F
D
P
D
A
T
Q
F
I
E
F
A
K
Site 111
S1869
T
K
R
V
L
G
E
S
G
E
M
D
A
L
R
Site 112
S1886
M
E
E
R
F
M
A
S
N
P
S
K
V
S
Y
Site 113
S1889
R
F
M
A
S
N
P
S
K
V
S
Y
E
P
I
Site 114
S1892
A
S
N
P
S
K
V
S
Y
E
P
I
T
T
T
Site 115
Y1893
S
N
P
S
K
V
S
Y
E
P
I
T
T
T
L
Site 116
T1898
V
S
Y
E
P
I
T
T
T
L
K
R
K
Q
E
Site 117
T1899
S
Y
E
P
I
T
T
T
L
K
R
K
Q
E
E
Site 118
Y1916
A
I
I
I
Q
R
A
Y
R
R
Y
L
L
K
Q
Site 119
Y1919
I
Q
R
A
Y
R
R
Y
L
L
K
Q
K
V
K
Site 120
S1930
Q
K
V
K
K
V
S
S
I
Y
K
K
D
K
G
Site 121
T1943
K
G
K
E
C
D
G
T
P
I
K
E
D
T
L
Site 122
T1949
G
T
P
I
K
E
D
T
L
I
D
K
L
N
E
Site 123
T1959
D
K
L
N
E
N
S
T
P
E
K
T
D
M
T
Site 124
T1966
T
P
E
K
T
D
M
T
P
S
T
T
S
P
P
Site 125
S1968
E
K
T
D
M
T
P
S
T
T
S
P
P
S
Y
Site 126
T1969
K
T
D
M
T
P
S
T
T
S
P
P
S
Y
D
Site 127
T1970
T
D
M
T
P
S
T
T
S
P
P
S
Y
D
S
Site 128
S1971
D
M
T
P
S
T
T
S
P
P
S
Y
D
S
V
Site 129
S1974
P
S
T
T
S
P
P
S
Y
D
S
V
T
K
P
Site 130
Y1975
S
T
T
S
P
P
S
Y
D
S
V
T
K
P
E
Site 131
S1977
T
S
P
P
S
Y
D
S
V
T
K
P
E
K
E
Site 132
T1979
P
P
S
Y
D
S
V
T
K
P
E
K
E
K
F
Site 133
S1991
E
K
F
E
K
D
K
S
E
K
E
D
K
G
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation