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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
Cytohesin 2
Full Name:
Cytohesin-2
Alias:
ARF exchange factor;ARF nucleotide-binding site opener;PH, SEC7 and coiled-coil domain-containing protein 2
Type:
Guanine nucleotide exchange factor for G protein
Mass (Da):
46546
Number AA:
400
UniProt ID:
Q99418
International Prot ID:
IPI00015228
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005624
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005086
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0030036
GO:0006897
GO:0032012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y6
_
_
M
E
D
G
V
Y
E
P
P
D
L
T
P
Site 2
T12
V
Y
E
P
P
D
L
T
P
E
E
R
M
E
L
Site 3
S41
Q
R
L
R
E
E
L
S
E
A
M
S
E
V
E
Site 4
S45
E
E
L
S
E
A
M
S
E
V
E
G
L
E
A
Site 5
S56
G
L
E
A
N
E
G
S
K
T
L
Q
R
N
R
Site 6
T58
E
A
N
E
G
S
K
T
L
Q
R
N
R
K
M
Site 7
T92
E
N
E
L
L
Q
N
T
P
E
E
I
A
R
F
Site 8
Y101
E
E
I
A
R
F
L
Y
K
G
E
G
L
N
K
Site 9
T109
K
G
E
G
L
N
K
T
A
I
G
D
Y
L
G
Site 10
Y114
N
K
T
A
I
G
D
Y
L
G
E
R
E
E
L
Site 11
S150
A
L
R
Q
F
L
W
S
F
R
L
P
G
E
A
Site 12
Y235
E
E
L
L
R
N
L
Y
D
S
I
R
N
E
P
Site 13
S237
L
L
R
N
L
Y
D
S
I
R
N
E
P
F
K
Site 14
T254
E
D
D
G
N
D
L
T
H
T
F
F
N
P
D
Site 15
T256
D
G
N
D
L
T
H
T
F
F
N
P
D
R
E
Site 16
T276
L
G
G
G
R
V
K
T
W
K
R
R
W
F
I
Site 17
Y290
I
L
T
D
N
C
L
Y
Y
F
E
Y
T
T
D
Site 18
Y291
L
T
D
N
C
L
Y
Y
F
E
Y
T
T
D
K
Site 19
Y294
N
C
L
Y
Y
F
E
Y
T
T
D
K
E
P
R
Site 20
S310
I
I
P
L
E
N
L
S
I
R
E
V
D
D
P
Site 21
Y326
K
P
N
C
F
E
L
Y
I
P
N
N
K
G
Q
Site 22
Y354
V
E
G
N
H
M
V
Y
R
I
S
A
P
T
Q
Site 23
S357
N
H
M
V
Y
R
I
S
A
P
T
Q
E
E
K
Site 24
T360
V
Y
R
I
S
A
P
T
Q
E
E
K
D
E
W
Site 25
S370
E
K
D
E
W
I
K
S
I
Q
A
A
V
S
V
Site 26
Y381
A
V
S
V
D
P
F
Y
E
M
L
A
A
R
K
Site 27
S392
A
A
R
K
K
R
I
S
V
K
K
K
Q
E
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation