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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
NOTCH4
Full Name:
Neurogenic locus notch homolog protein 4
Alias:
Type:
Mass (Da):
209622
Number AA:
2003
UniProt ID:
Q99466
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S378
I
D
R
V
G
S
F
S
C
L
C
P
P
G
R
Site 2
S1320
F
A
L
A
R
V
L
S
L
T
L
R
V
G
L
Site 3
T1488
L
W
L
P
P
G
F
T
R
R
P
R
T
Q
S
Site 4
T1493
G
F
T
R
R
P
R
T
Q
S
A
P
H
R
R
Site 5
S1495
T
R
R
P
R
T
Q
S
A
P
H
R
R
R
P
Site 6
S1529
E
D
G
V
V
M
C
S
G
P
E
E
G
E
E
Site 7
T1543
E
V
G
Q
A
E
E
T
G
P
P
S
T
C
Q
Site 8
S1547
A
E
E
T
G
P
P
S
T
C
Q
L
W
S
L
Site 9
T1548
E
E
T
G
P
P
S
T
C
Q
L
W
S
L
S
Site 10
T1568
L
P
Q
A
A
M
L
T
P
P
Q
E
S
E
M
Site 11
T1582
M
E
A
P
D
L
D
T
R
G
P
D
G
V
T
Site 12
T1604
C
G
E
V
Q
S
G
T
F
Q
G
A
W
L
G
Site 13
T1630
G
A
C
P
Q
A
H
T
V
G
T
G
E
T
P
Site 14
T1636
H
T
V
G
T
G
E
T
P
L
H
L
A
A
R
Site 15
S1645
L
H
L
A
A
R
F
S
R
P
T
A
A
R
R
Site 16
T1648
A
A
R
F
S
R
P
T
A
A
R
R
L
L
E
Site 17
T1669
Q
P
D
R
A
G
R
T
P
L
H
A
A
V
A
Site 18
T1692
L
L
L
R
S
R
Q
T
A
V
D
A
R
T
E
Site 19
T1702
D
A
R
T
E
D
G
T
T
P
L
M
L
A
A
Site 20
T1703
A
R
T
E
D
G
T
T
P
L
M
L
A
A
R
Site 21
T1769
A
Q
D
N
R
E
Q
T
P
L
F
L
A
A
R
Site 22
T1817
R
N
H
W
D
L
L
T
L
L
E
G
A
G
P
Site 23
T1832
P
E
A
R
H
K
A
T
P
G
R
E
A
G
P
Site 24
T1845
G
P
F
P
R
A
R
T
V
S
V
S
V
P
P
Site 25
S1847
F
P
R
A
R
T
V
S
V
S
V
P
P
H
G
Site 26
S1849
R
A
R
T
V
S
V
S
V
P
P
H
G
G
G
Site 27
T1863
G
A
L
P
R
C
R
T
L
S
A
G
A
G
P
Site 28
S1865
L
P
R
C
R
T
L
S
A
G
A
G
P
R
G
Site 29
S1883
C
L
Q
A
R
T
W
S
V
D
L
A
A
R
G
Site 30
Y1894
A
A
R
G
G
G
A
Y
S
H
C
R
S
L
S
Site 31
S1895
A
R
G
G
G
A
Y
S
H
C
R
S
L
S
G
Site 32
S1899
G
A
Y
S
H
C
R
S
L
S
G
V
G
A
G
Site 33
S1901
Y
S
H
C
R
S
L
S
G
V
G
A
G
G
G
Site 34
T1910
V
G
A
G
G
G
P
T
P
R
G
R
R
F
S
Site 35
S1917
T
P
R
G
R
R
F
S
A
G
M
R
G
P
R
Site 36
Y1934
P
A
I
M
R
G
R
Y
G
V
A
A
G
R
G
Site 37
S1945
A
G
R
G
G
R
V
S
T
D
D
W
P
C
D
Site 38
T1946
G
R
G
G
R
V
S
T
D
D
W
P
C
D
W
Site 39
T1973
P
I
P
P
P
C
L
T
P
S
P
E
R
G
S
Site 40
S1975
P
P
P
C
L
T
P
S
P
E
R
G
S
P
Q
Site 41
S1980
T
P
S
P
E
R
G
S
P
Q
L
D
C
G
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation