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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
RNF2
Full Name:
E3 ubiquitin-protein ligase RING2
Alias:
Bap1; Bap-1; Ding; Hipi3; Ring finger 2; Ring finger protein 2; RING finger protein 2; Ring1b; Ring2
Type:
EC 6.3.2.-; Ligase; Ubiquitin conjugating system
Mass (Da):
37655
Number AA:
336
UniProt ID:
Q99496
International Prot ID:
IPI00026993
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005694
GO:0043226
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0005488
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0006139
GO:0006350
GO:0006355
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S2
_
_
_
_
_
_
M
S
Q
A
V
Q
T
N
G
Site 2
S14
T
N
G
T
Q
P
L
S
K
T
W
E
L
S
L
Site 3
T16
G
T
Q
P
L
S
K
T
W
E
L
S
L
Y
E
Site 4
S20
L
S
K
T
W
E
L
S
L
Y
E
L
Q
R
T
Site 5
Y22
K
T
W
E
L
S
L
Y
E
L
Q
R
T
P
Q
Site 6
T27
S
L
Y
E
L
Q
R
T
P
Q
E
A
I
T
D
Site 7
S41
D
G
L
E
I
V
V
S
P
R
S
L
H
S
E
Site 8
T63
D
M
L
K
N
T
M
T
T
K
E
C
L
H
R
Site 9
S82
C
I
I
T
A
L
R
S
G
N
K
E
C
P
T
Site 10
T89
S
G
N
K
E
C
P
T
C
R
K
K
L
V
S
Site 11
S96
T
C
R
K
K
L
V
S
K
R
S
L
R
P
D
Site 12
S99
K
K
L
V
S
K
R
S
L
R
P
D
P
N
F
Site 13
Y114
D
A
L
I
S
K
I
Y
P
S
R
D
E
Y
E
Site 14
S116
L
I
S
K
I
Y
P
S
R
D
E
Y
E
A
H
Site 15
Y120
I
Y
P
S
R
D
E
Y
E
A
H
Q
E
R
V
Site 16
S141
H
N
N
Q
Q
A
L
S
H
S
I
E
E
G
L
Site 17
S143
N
Q
Q
A
L
S
H
S
I
E
E
G
L
K
I
Site 18
S168
K
Q
Q
I
E
N
G
S
G
A
E
D
N
G
D
Site 19
S176
G
A
E
D
N
G
D
S
S
H
C
S
N
A
S
Site 20
S177
A
E
D
N
G
D
S
S
H
C
S
N
A
S
T
Site 21
S180
N
G
D
S
S
H
C
S
N
A
S
T
H
S
N
Site 22
S183
S
S
H
C
S
N
A
S
T
H
S
N
Q
E
A
Site 23
T184
S
H
C
S
N
A
S
T
H
S
N
Q
E
A
G
Site 24
S193
S
N
Q
E
A
G
P
S
N
K
R
T
K
T
S
Site 25
T197
A
G
P
S
N
K
R
T
K
T
S
D
D
S
G
Site 26
T199
P
S
N
K
R
T
K
T
S
D
D
S
G
L
E
Site 27
S200
S
N
K
R
T
K
T
S
D
D
S
G
L
E
L
Site 28
S203
R
T
K
T
S
D
D
S
G
L
E
L
D
N
N
Site 29
S242
T
L
M
E
K
D
D
S
A
Q
T
R
Y
I
K
Site 30
Y247
D
D
S
A
Q
T
R
Y
I
K
T
S
G
N
A
Site 31
S251
Q
T
R
Y
I
K
T
S
G
N
A
T
V
D
H
Site 32
T255
I
K
T
S
G
N
A
T
V
D
H
L
S
K
Y
Site 33
S274
L
A
L
E
E
L
R
S
K
G
E
S
N
Q
M
Site 34
S278
E
L
R
S
K
G
E
S
N
Q
M
N
L
D
T
Site 35
T285
S
N
Q
M
N
L
D
T
A
S
E
K
Q
Y
T
Site 36
T292
T
A
S
E
K
Q
Y
T
I
Y
I
A
T
A
S
Site 37
Y294
S
E
K
Q
Y
T
I
Y
I
A
T
A
S
G
Q
Site 38
Y318
L
E
L
V
S
E
K
Y
W
K
V
N
K
P
M
Site 39
Y328
V
N
K
P
M
E
L
Y
Y
A
P
T
K
E
H
Site 40
Y329
N
K
P
M
E
L
Y
Y
A
P
T
K
E
H
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation