PhosphoNET

           
Protein Info 
   
Short Name:  Neu1
Full Name:  Sialidase-1
Alias:  Acetylneuraminyl hydrolase;G9 sialidase;Lysosomal sialidase;N-acetyl-alpha-neuraminidase 1
Type:  Enzyme, hydrolase
Mass (Da):  45467
Number AA:  415
UniProt ID:  Q99519
International Prot ID:  IPI00029817
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0016023  GO:0043202  GO:0005886 Uniprot OncoNet
Molecular Function:  GO:0004308  GO:0005515   PhosphoSite+ KinaseNET
Biological Process:  GO:0008152     Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S7_MTGERPSTALPDRR
Site 2T8MTGERPSTALPDRRW
Site 3S43LLLSLAASWSKAEND
Site 4S45LSLAASWSKAENDFG
Site 5S73VSGRQIGSVDTFRIP
Site 6S100FAEARKMSSSDEGAK
Site 7S102EARKMSSSDEGAKFI
Site 8S114KFIALRRSMDQGSTW
Site 9S119RRSMDQGSTWSPTAF
Site 10S122MDQGSTWSPTAFIVN
Site 11S180WSKDDGVSWSTPRNL
Site 12S182KDDGVSWSTPRNLSL
Site 13T183DDGVSWSTPRNLSLD
Site 14S188WSTPRNLSLDIGTEV
Site 15S202VFAPGPGSGIQKQRE
Site 16S233DGVFCLLSDDHGASW
Site 17S239LSDDHGASWRYGSGV
Site 18Y242DHGASWRYGSGVSGI
Site 19S244GASWRYGSGVSGIPY
Site 20S247WRYGSGVSGIPYGQP
Site 21Y251SGVSGIPYGQPKQEN
Site 22Y268NPDECQPYELPDGSV
Site 23S274PYELPDGSVVINARN
Site 24Y296CRIVLRSYDACDTLR
Site 25T301RSYDACDTLRPRDVT
Site 26T308TLRPRDVTFDPELVD
Site 27S333SSGIVFFSNPAHPEF
Site 28T345PEFRVNLTLRWSFSN
Site 29S349VNLTLRWSFSNGTSW
Site 30S351LTLRWSFSNGTSWRK
Site 31T360GTSWRKETVQLWPGP
Site 32S368VQLWPGPSGYSSLAT
Site 33S372PGPSGYSSLATLEGS
Site 34T375SGYSSLATLEGSMDG
Site 35S379SLATLEGSMDGEEQA
Site 36Y390EEQAPQLYVLYEKGR
Site 37Y393APQLYVLYEKGRNHY
Site 38Y400YEKGRNHYTESISVA
Site 39T401EKGRNHYTESISVAK
Site 40S403GRNHYTESISVAKIS
Site 41S405NHYTESISVAKISVY
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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