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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LGMN
Full Name:
Legumain
Alias:
Asparaginyl endopeptidase;Protease, cysteine 1
Type:
Mass (Da):
49411
Number AA:
433
UniProt ID:
Q99538
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y41
V
A
G
S
N
G
W
Y
N
Y
R
H
Q
A
D
Site 2
Y76
M
M
Y
D
D
I
A
Y
S
E
D
N
P
T
P
Site 3
T82
A
Y
S
E
D
N
P
T
P
G
I
V
I
N
R
Site 4
Y96
R
P
N
G
T
D
V
Y
Q
G
V
P
K
D
Y
Site 5
Y103
Y
Q
G
V
P
K
D
Y
T
G
E
D
V
T
P
Site 6
T104
Q
G
V
P
K
D
Y
T
G
E
D
V
T
P
Q
Site 7
T109
D
Y
T
G
E
D
V
T
P
Q
N
F
L
A
V
Site 8
S135
G
S
G
K
V
L
K
S
G
P
Q
D
H
V
F
Site 9
Y144
P
Q
D
H
V
F
I
Y
F
T
D
H
G
S
T
Site 10
Y172
D
L
N
E
T
I
H
Y
M
Y
K
H
K
M
Y
Site 11
Y185
M
Y
R
K
M
V
F
Y
I
E
A
C
E
S
G
Site 12
S215
T
A
A
N
P
R
E
S
S
Y
A
C
Y
Y
D
Site 13
S216
A
A
N
P
R
E
S
S
Y
A
C
Y
Y
D
E
Site 14
Y217
A
N
P
R
E
S
S
Y
A
C
Y
Y
D
E
K
Site 15
Y220
R
E
S
S
Y
A
C
Y
Y
D
E
K
R
S
T
Site 16
Y221
E
S
S
Y
A
C
Y
Y
D
E
K
R
S
T
Y
Site 17
Y228
Y
D
E
K
R
S
T
Y
L
G
D
W
Y
S
V
Site 18
Y233
S
T
Y
L
G
D
W
Y
S
V
N
W
M
E
D
Site 19
S241
S
V
N
W
M
E
D
S
D
V
E
D
L
T
K
Site 20
T247
D
S
D
V
E
D
L
T
K
E
T
L
H
K
Q
Site 21
Y255
K
E
T
L
H
K
Q
Y
H
L
V
K
S
H
T
Site 22
T264
L
V
K
S
H
T
N
T
S
H
V
M
Q
Y
G
Site 23
S291
Q
G
M
K
R
K
A
S
S
P
V
P
L
P
P
Site 24
S292
G
M
K
R
K
A
S
S
P
V
P
L
P
P
V
Site 25
T305
P
V
T
H
L
D
L
T
P
S
P
D
V
P
L
Site 26
T313
P
S
P
D
V
P
L
T
I
M
K
R
K
L
M
Site 27
T322
M
K
R
K
L
M
N
T
N
D
L
E
E
S
R
Site 28
T332
L
E
E
S
R
Q
L
T
E
E
I
Q
R
H
L
Site 29
S348
A
R
H
L
I
E
K
S
V
R
K
I
V
S
L
Site 30
S359
I
V
S
L
L
A
A
S
E
A
E
V
E
Q
L
Site 31
S368
A
E
V
E
Q
L
L
S
E
R
A
P
L
T
G
Site 32
T374
L
S
E
R
A
P
L
T
G
H
S
C
Y
P
E
Site 33
S377
R
A
P
L
T
G
H
S
C
Y
P
E
A
L
L
Site 34
Y398
F
N
W
H
S
P
T
Y
E
Y
A
L
R
H
L
Site 35
Y416
V
N
L
C
E
K
P
Y
P
L
H
R
I
K
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation