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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MPHOSPH8
Full Name:
M-phase phosphoprotein 8
Alias:
HSMPP8; MPP8; Two hybrid-associated protein 3 with RanBPM
Type:
Cell cycle regulation
Mass (Da):
97182
Number AA:
860
UniProt ID:
Q99549
International Prot ID:
IPI00030408
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0000785
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0003682
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0007049
GO:0006333
GO:0006996
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S16
R
V
T
A
V
P
V
S
A
A
D
S
T
E
E
Site 2
S20
V
P
V
S
A
A
D
S
T
E
E
L
A
E
V
Site 3
T21
P
V
S
A
A
D
S
T
E
E
L
A
E
V
E
Site 4
S51
G
A
E
A
F
G
D
S
E
E
D
G
E
D
V
Site 5
T69
E
K
I
L
D
M
K
T
E
G
G
K
V
L
Y
Site 6
Y76
T
E
G
G
K
V
L
Y
K
V
R
W
K
G
Y
Site 7
Y83
Y
K
V
R
W
K
G
Y
T
S
D
D
D
T
W
Site 8
T84
K
V
R
W
K
G
Y
T
S
D
D
D
T
W
E
Site 9
S85
V
R
W
K
G
Y
T
S
D
D
D
T
W
E
P
Site 10
T89
G
Y
T
S
D
D
D
T
W
E
P
E
I
H
L
Site 11
S126
R
K
D
I
Q
R
L
S
L
N
N
D
I
F
E
Site 12
S136
N
D
I
F
E
A
N
S
D
S
D
Q
Q
S
E
Site 13
S138
I
F
E
A
N
S
D
S
D
Q
Q
S
E
T
K
Site 14
S142
N
S
D
S
D
Q
Q
S
E
T
K
E
D
T
S
Site 15
T144
D
S
D
Q
Q
S
E
T
K
E
D
T
S
P
K
Site 16
S149
S
E
T
K
E
D
T
S
P
K
K
K
K
K
K
Site 17
S164
L
R
Q
R
E
E
K
S
P
D
D
L
K
K
K
Site 18
S182
A
G
K
L
K
D
K
S
K
P
D
L
E
S
S
Site 19
S188
K
S
K
P
D
L
E
S
S
L
E
S
L
V
F
Site 20
S189
S
K
P
D
L
E
S
S
L
E
S
L
V
F
D
Site 21
S192
D
L
E
S
S
L
E
S
L
V
F
D
L
R
T
Site 22
T199
S
L
V
F
D
L
R
T
K
K
R
I
S
E
A
Site 23
S204
L
R
T
K
K
R
I
S
E
A
K
E
E
L
K
Site 24
S213
A
K
E
E
L
K
E
S
K
K
P
K
K
D
E
Site 25
T224
K
K
D
E
V
K
E
T
K
E
L
K
K
V
K
Site 26
T240
G
E
I
R
D
L
K
T
K
T
R
E
D
P
K
Site 27
T252
D
P
K
E
N
R
K
T
K
K
E
K
F
V
E
Site 28
S260
K
K
E
K
F
V
E
S
Q
V
E
S
E
S
S
Site 29
S264
F
V
E
S
Q
V
E
S
E
S
S
V
L
N
D
Site 30
S267
S
Q
V
E
S
E
S
S
V
L
N
D
S
P
F
Site 31
S272
E
S
S
V
L
N
D
S
P
F
P
E
D
D
S
Site 32
S279
S
P
F
P
E
D
D
S
E
G
L
H
S
D
S
Site 33
S284
D
D
S
E
G
L
H
S
D
S
R
E
E
K
Q
Site 34
S286
S
E
G
L
H
S
D
S
R
E
E
K
Q
N
T
Site 35
T293
S
R
E
E
K
Q
N
T
K
S
A
R
E
R
A
Site 36
S295
E
E
K
Q
N
T
K
S
A
R
E
R
A
G
Q
Site 37
S316
G
F
E
K
P
L
D
S
A
M
S
A
E
E
D
Site 38
S319
K
P
L
D
S
A
M
S
A
E
E
D
T
D
V
Site 39
T324
A
M
S
A
E
E
D
T
D
V
R
G
R
R
K
Site 40
T334
R
G
R
R
K
K
K
T
P
R
K
A
E
D
T
Site 41
T341
T
P
R
K
A
E
D
T
R
E
N
R
K
L
E
Site 42
T358
N
A
F
L
E
K
K
T
V
P
K
K
Q
R
N
Site 43
S369
K
Q
R
N
Q
D
R
S
K
S
A
A
E
L
E
Site 44
S371
R
N
Q
D
R
S
K
S
A
A
E
L
E
K
L
Site 45
S382
L
E
K
L
M
P
V
S
A
Q
T
P
K
G
R
Site 46
T385
L
M
P
V
S
A
Q
T
P
K
G
R
R
L
S
Site 47
S392
T
P
K
G
R
R
L
S
G
E
E
R
G
L
W
Site 48
S400
G
E
E
R
G
L
W
S
T
D
S
A
E
E
D
Site 49
T401
E
E
R
G
L
W
S
T
D
S
A
E
E
D
K
Site 50
S403
R
G
L
W
S
T
D
S
A
E
E
D
K
E
T
Site 51
T410
S
A
E
E
D
K
E
T
K
R
N
E
S
K
E
Site 52
S415
K
E
T
K
R
N
E
S
K
E
K
Y
Q
K
R
Site 53
Y419
R
N
E
S
K
E
K
Y
Q
K
R
H
D
S
D
Site 54
S425
K
Y
Q
K
R
H
D
S
D
K
E
E
K
G
R
Site 55
T440
K
E
P
K
G
L
K
T
L
K
E
I
R
N
A
Site 56
T454
A
F
D
L
F
K
L
T
P
E
E
K
N
D
V
Site 57
S462
P
E
E
K
N
D
V
S
E
N
N
R
K
R
E
Site 58
T477
E
I
P
L
D
F
K
T
I
D
D
H
K
T
K
Site 59
T483
K
T
I
D
D
H
K
T
K
E
N
K
Q
S
L
Site 60
S489
K
T
K
E
N
K
Q
S
L
K
E
R
R
N
T
Site 61
T496
S
L
K
E
R
R
N
T
R
D
E
T
D
T
W
Site 62
T500
R
R
N
T
R
D
E
T
D
T
W
A
Y
I
A
Site 63
T502
N
T
R
D
E
T
D
T
W
A
Y
I
A
A
E
Site 64
Y505
D
E
T
D
T
W
A
Y
I
A
A
E
G
D
Q
Site 65
S517
G
D
Q
E
V
L
D
S
V
C
Q
A
D
E
N
Site 66
S525
V
C
Q
A
D
E
N
S
D
G
R
Q
Q
I
L
Site 67
S533
D
G
R
Q
Q
I
L
S
L
G
M
D
L
Q
L
Site 68
S567
A
A
T
D
A
I
P
S
N
V
L
R
D
A
V
Site 69
T581
V
K
N
G
D
Y
I
T
V
K
V
A
L
N
S
Site 70
Y592
A
L
N
S
N
E
E
Y
N
L
D
Q
E
D
S
Site 71
S599
Y
N
L
D
Q
E
D
S
S
G
M
T
L
V
M
Site 72
T635
N
G
R
Q
K
N
G
T
T
A
L
I
H
A
A
Site 73
S680
K
A
C
K
R
G
N
S
D
I
V
R
L
V
I
Site 74
S697
G
A
D
C
N
I
L
S
K
H
Q
N
S
A
L
Site 75
Y716
Q
S
N
N
V
L
V
Y
D
L
L
K
N
H
L
Site 76
T733
L
S
R
V
A
E
E
T
I
K
D
Y
F
E
A
Site 77
Y737
A
E
E
T
I
K
D
Y
F
E
A
R
L
A
L
Site 78
S763
L
C
E
G
P
D
F
S
T
D
F
N
Y
K
P
Site 79
Y768
D
F
S
T
D
F
N
Y
K
P
P
Q
N
I
P
Site 80
S828
S
H
F
V
Y
S
F
S
P
V
A
G
P
N
K
Site 81
T841
N
K
L
F
I
R
L
T
E
A
P
S
A
K
V
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation