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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PIK3R4
Full Name:
Phosphoinositide 3-kinase regulatory subunit 4
Alias:
EC 2.7.11.1; Kinase kinase PIK3R4; P150; Phosphoinositide-3-kinase, regulatory subunit 4; PI3R4; VPS15
Type:
Kinase, lipid; Protein kinase, Ser/Thr (non-receptor); EC 2.7.11.1; Other group; VPS15 family
Mass (Da):
153103
Number AA:
1358
UniProt ID:
Q99570
International Prot ID:
IPI00024006
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004674
GO:0004713
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S18
S
Q
I
L
S
V
E
S
Y
F
S
D
I
H
D
Site 2
Y19
Q
I
L
S
V
E
S
Y
F
S
D
I
H
D
F
Site 3
S21
L
S
V
E
S
Y
F
S
D
I
H
D
F
E
Y
Site 4
Y28
S
D
I
H
D
F
E
Y
D
K
S
L
G
S
T
Site 5
S31
H
D
F
E
Y
D
K
S
L
G
S
T
R
F
F
Site 6
S34
E
Y
D
K
S
L
G
S
T
R
F
F
K
V
A
Site 7
T61
V
F
A
I
Q
D
P
T
L
P
L
T
S
Y
K
Site 8
T65
Q
D
P
T
L
P
L
T
S
Y
K
Q
E
L
E
Site 9
Y67
P
T
L
P
L
T
S
Y
K
Q
E
L
E
E
L
Site 10
S80
E
L
K
I
R
L
N
S
A
Q
N
C
L
P
F
Site 11
S95
Q
K
A
S
E
K
A
S
E
K
A
A
M
L
F
Site 12
Y105
A
A
M
L
F
R
Q
Y
V
R
D
N
L
Y
D
Site 13
Y111
Q
Y
V
R
D
N
L
Y
D
R
I
S
T
R
P
Site 14
S115
D
N
L
Y
D
R
I
S
T
R
P
F
L
N
N
Site 15
T116
N
L
Y
D
R
I
S
T
R
P
F
L
N
N
I
Site 16
S142
A
V
D
Q
A
H
K
S
G
V
R
H
G
D
I
Site 17
T151
V
R
H
G
D
I
K
T
E
N
V
M
V
T
S
Site 18
T173
D
F
A
S
F
K
P
T
Y
L
P
E
D
N
P
Site 19
Y174
F
A
S
F
K
P
T
Y
L
P
E
D
N
P
A
Site 20
Y185
D
N
P
A
D
F
N
Y
F
F
D
T
S
R
R
Site 21
T194
F
D
T
S
R
R
R
T
C
Y
I
A
P
E
R
Site 22
Y196
T
S
R
R
R
T
C
Y
I
A
P
E
R
F
V
Site 23
Y214
M
F
A
T
E
L
E
Y
M
R
D
P
S
T
P
Site 24
S219
L
E
Y
M
R
D
P
S
T
P
L
V
D
L
N
Site 25
T220
E
Y
M
R
D
P
S
T
P
L
V
D
L
N
S
Site 26
S227
T
P
L
V
D
L
N
S
N
Q
R
T
R
G
E
Site 27
S285
L
N
K
I
E
D
H
S
I
R
E
L
V
T
Q
Site 28
Y307
K
R
L
E
A
E
D
Y
L
K
Q
Q
R
G
N
Site 29
Y327
F
Y
T
F
L
Q
P
Y
M
A
Q
F
A
K
E
Site 30
Y391
S
C
L
Q
T
L
K
Y
C
D
S
K
L
A
A
Site 31
S394
Q
T
L
K
Y
C
D
S
K
L
A
A
L
E
L
Site 32
T419
E
I
L
L
D
R
I
T
P
Y
L
L
H
F
S
Site 33
Y421
L
L
D
R
I
T
P
Y
L
L
H
F
S
N
D
Site 34
S426
T
P
Y
L
L
H
F
S
N
D
S
V
P
R
V
Site 35
S429
L
L
H
F
S
N
D
S
V
P
R
V
R
A
E
Site 36
Y459
P
R
N
D
I
N
I
Y
P
E
Y
I
L
P
G
Site 37
T520
N
E
E
I
D
E
V
T
H
P
N
G
N
Y
D
Site 38
T528
H
P
N
G
N
Y
D
T
E
L
Q
A
L
H
E
Site 39
S546
Q
K
V
V
T
L
L
S
D
P
E
N
I
V
K
Site 40
S614
Y
V
G
W
Q
S
S
S
I
L
K
P
L
L
Q
Site 41
Y673
H
P
N
L
W
I
R
Y
G
A
V
G
F
I
T
Site 42
T680
Y
G
A
V
G
F
I
T
V
V
A
R
Q
I
S
Site 43
T704
P
Y
L
D
P
Y
I
T
Q
P
I
I
Q
I
E
Site 44
S725
S
V
L
K
E
P
V
S
R
S
I
F
D
Y
A
Site 45
Y731
V
S
R
S
I
F
D
Y
A
L
R
S
K
D
I
Site 46
T739
A
L
R
S
K
D
I
T
S
L
F
R
H
L
H
Site 47
S740
L
R
S
K
D
I
T
S
L
F
R
H
L
H
M
Site 48
S755
R
Q
K
K
R
N
G
S
L
P
D
C
P
P
P
Site 49
S776
Q
L
L
K
K
L
L
S
Q
G
M
T
E
E
E
Site 50
T780
K
L
L
S
Q
G
M
T
E
E
E
E
D
K
L
Site 51
S808
K
A
N
I
V
D
Q
S
H
L
H
D
S
S
Q
Site 52
S813
D
Q
S
H
L
H
D
S
S
Q
K
G
V
I
D
Site 53
S814
Q
S
H
L
H
D
S
S
Q
K
G
V
I
D
L
Site 54
S853
R
K
H
V
K
Q
D
S
N
V
N
E
E
W
K
Site 55
S861
N
V
N
E
E
W
K
S
M
F
G
S
L
D
P
Site 56
S865
E
W
K
S
M
F
G
S
L
D
P
P
N
M
P
Site 57
T886
S
D
Q
E
V
I
Q
T
G
K
P
P
R
S
E
Site 58
S892
Q
T
G
K
P
P
R
S
E
S
S
A
G
I
C
Site 59
S894
G
K
P
P
R
S
E
S
S
A
G
I
C
V
P
Site 60
S925
P
V
I
P
V
L
S
S
T
I
L
P
S
T
Y
Site 61
T927
V
I
P
V
L
S
S
T
I
L
P
S
T
Y
Q
Site 62
T932
S
S
T
I
L
P
S
T
Y
Q
I
R
I
T
T
Site 63
T938
S
T
Y
Q
I
R
I
T
T
C
K
T
E
L
Q
Site 64
T939
T
Y
Q
I
R
I
T
T
C
K
T
E
L
Q
Q
Site 65
T942
I
R
I
T
T
C
K
T
E
L
Q
Q
L
I
Q
Site 66
S994
A
H
L
H
E
H
K
S
A
V
N
R
I
R
V
Site 67
S1002
A
V
N
R
I
R
V
S
D
E
H
S
L
F
A
Site 68
S1006
I
R
V
S
D
E
H
S
L
F
A
T
C
S
N
Site 69
T1010
D
E
H
S
L
F
A
T
C
S
N
D
G
T
V
Site 70
S1012
H
S
L
F
A
T
C
S
N
D
G
T
V
K
I
Site 71
T1029
S
Q
K
M
E
G
K
T
T
T
T
R
S
I
L
Site 72
T1030
Q
K
M
E
G
K
T
T
T
T
R
S
I
L
T
Site 73
T1031
K
M
E
G
K
T
T
T
T
R
S
I
L
T
Y
Site 74
S1034
G
K
T
T
T
T
R
S
I
L
T
Y
S
R
I
Site 75
T1037
T
T
T
R
S
I
L
T
Y
S
R
I
G
G
R
Site 76
Y1038
T
T
R
S
I
L
T
Y
S
R
I
G
G
R
V
Site 77
T1047
R
I
G
G
R
V
K
T
L
T
F
C
Q
G
S
Site 78
T1049
G
G
R
V
K
T
L
T
F
C
Q
G
S
H
Y
Site 79
Y1056
T
F
C
Q
G
S
H
Y
L
A
I
A
S
D
N
Site 80
S1074
Q
L
L
G
I
E
A
S
K
L
P
K
S
P
K
Site 81
S1079
E
A
S
K
L
P
K
S
P
K
I
H
P
L
Q
Site 82
S1106
V
D
M
H
H
F
N
S
G
A
Q
S
V
L
A
Site 83
S1128
L
V
G
W
D
L
R
S
S
S
N
A
W
T
L
Site 84
S1129
V
G
W
D
L
R
S
S
S
N
A
W
T
L
K
Site 85
S1130
G
W
D
L
R
S
S
S
N
A
W
T
L
K
H
Site 86
T1134
R
S
S
S
N
A
W
T
L
K
H
D
L
K
S
Site 87
S1177
M
R
F
Q
L
P
I
S
S
H
C
H
P
S
R
Site 88
S1178
R
F
Q
L
P
I
S
S
H
C
H
P
S
R
A
Site 89
S1183
I
S
S
H
C
H
P
S
R
A
R
I
R
R
L
Site 90
S1191
R
A
R
I
R
R
L
S
M
H
P
L
Y
Q
S
Site 91
T1217
V
S
M
W
D
M
E
T
G
D
R
R
F
T
L
Site 92
T1223
E
T
G
D
R
R
F
T
L
W
A
S
S
A
P
Site 93
S1227
R
R
F
T
L
W
A
S
S
A
P
P
L
S
E
Site 94
S1228
R
F
T
L
W
A
S
S
A
P
P
L
S
E
L
Site 95
S1233
A
S
S
A
P
P
L
S
E
L
Q
P
S
P
H
Site 96
S1238
P
L
S
E
L
Q
P
S
P
H
S
V
H
G
I
Site 97
S1241
E
L
Q
P
S
P
H
S
V
H
G
I
Y
C
S
Site 98
Y1246
P
H
S
V
H
G
I
Y
C
S
P
A
D
G
N
Site 99
S1248
S
V
H
G
I
Y
C
S
P
A
D
G
N
P
I
Site 100
S1261
P
I
L
L
T
A
G
S
D
M
K
I
R
F
W
Site 101
Y1272
I
R
F
W
D
L
A
Y
P
E
R
S
Y
V
V
Site 102
Y1277
L
A
Y
P
E
R
S
Y
V
V
A
G
S
T
S
Site 103
S1282
R
S
Y
V
V
A
G
S
T
S
S
P
S
V
S
Site 104
T1283
S
Y
V
V
A
G
S
T
S
S
P
S
V
S
Y
Site 105
S1284
Y
V
V
A
G
S
T
S
S
P
S
V
S
Y
Y
Site 106
S1285
V
V
A
G
S
T
S
S
P
S
V
S
Y
Y
R
Site 107
S1287
A
G
S
T
S
S
P
S
V
S
Y
Y
R
K
I
Site 108
S1289
S
T
S
S
P
S
V
S
Y
Y
R
K
I
I
E
Site 109
Y1290
T
S
S
P
S
V
S
Y
Y
R
K
I
I
E
G
Site 110
Y1291
S
S
P
S
V
S
Y
Y
R
K
I
I
E
G
T
Site 111
T1316
K
V
G
P
S
D
D
T
P
R
R
G
P
E
S
Site 112
S1323
T
P
R
R
G
P
E
S
L
P
V
G
H
H
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation