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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
P2X7
Full Name:
P2X purinoceptor 7
Alias:
ATP receptor; MGC20089; P2RX7; P2Z receptor; Purinergic receptor; Purinergic receptor P2X, ligand-gated ion channel, 7
Type:
Channel, ligand-gated; Receptor, misc.
Mass (Da):
68559
Number AA:
595
UniProt ID:
Q99572
International Prot ID:
IPI00293328
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0032059
GO:0005737
GO:0005887
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004931
GO:0001530
PhosphoSite+
KinaseNET
Biological Process:
GO:0032060
GO:0007166
GO:0043409
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y13
S
C
S
D
V
F
Q
Y
E
T
N
K
V
T
R
Site 2
Y288
K
T
T
N
V
S
L
Y
P
G
Y
N
F
R
Y
Site 3
Y291
N
V
S
L
Y
P
G
Y
N
F
R
Y
A
K
Y
Site 4
Y295
Y
P
G
Y
N
F
R
Y
A
K
Y
Y
K
E
N
Site 5
Y298
Y
N
F
R
Y
A
K
Y
Y
K
E
N
N
V
E
Site 6
Y299
N
F
R
Y
A
K
Y
Y
K
E
N
N
V
E
K
Site 7
Y343
Y
I
G
S
T
L
S
Y
F
G
L
A
A
V
F
Site 8
Y358
I
D
F
L
I
D
T
Y
S
S
N
C
C
R
S
Site 9
Y382
Q
P
C
V
V
N
E
Y
Y
Y
R
K
K
C
E
Site 10
Y383
P
C
V
V
N
E
Y
Y
Y
R
K
K
C
E
S
Site 11
S390
Y
Y
R
K
K
C
E
S
I
V
E
P
K
P
T
Site 12
Y400
E
P
K
P
T
L
K
Y
V
S
F
V
D
E
S
Site 13
S402
K
P
T
L
K
Y
V
S
F
V
D
E
S
H
I
Site 14
T437
P
R
P
A
M
D
F
T
D
L
S
R
L
P
L
Site 15
T449
L
P
L
A
L
H
D
T
P
P
I
P
G
Q
P
Site 16
T467
Q
L
L
R
K
E
A
T
P
R
S
R
D
S
P
Site 17
S470
R
K
E
A
T
P
R
S
R
D
S
P
V
W
C
Site 18
S473
A
T
P
R
S
R
D
S
P
V
W
C
Q
C
G
Site 19
S485
Q
C
G
S
C
L
P
S
Q
L
P
E
S
H
R
Site 20
S490
L
P
S
Q
L
P
E
S
H
R
C
L
E
E
L
Site 21
S540
L
L
A
L
D
V
D
S
T
N
S
R
L
R
H
Site 22
T541
L
A
L
D
V
D
S
T
N
S
R
L
R
H
C
Site 23
S543
L
D
V
D
S
T
N
S
R
L
R
H
C
A
Y
Site 24
Y550
S
R
L
R
H
C
A
Y
R
C
Y
A
T
W
R
Site 25
S584
I
R
K
E
F
P
K
S
E
G
Q
Y
S
G
F
Site 26
Y588
F
P
K
S
E
G
Q
Y
S
G
F
K
S
P
Y
Site 27
S589
P
K
S
E
G
Q
Y
S
G
F
K
S
P
Y
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation