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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SFRS2IP
Full Name:
SRSF2-interacting protein
Alias:
CASP11; SFRIP; SIP1; Splicing factor Sip1; Splicing factor, arginine/serine-rich 2, interacting protein; SRrp129
Type:
RNA binding protein
Mass (Da):
164652
Number AA:
1463
UniProt ID:
Q99590
International Prot ID:
IPI00181359
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0000245
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T5
_
_
_
M
K
K
K
T
V
C
T
L
N
M
G
Site 2
T8
M
K
K
K
T
V
C
T
L
N
M
G
D
K
K
Site 3
Y16
L
N
M
G
D
K
K
Y
E
D
M
E
G
E
E
Site 4
T28
G
E
E
N
G
D
N
T
I
S
T
G
L
L
Y
Site 5
S77
L
L
K
K
K
L
R
S
S
V
A
A
P
E
K
Site 6
Y97
K
F
S
A
L
E
G
Y
V
K
V
Q
V
K
K
Site 7
T109
V
K
K
Q
L
R
E
T
K
D
K
K
N
E
N
Site 8
S117
K
D
K
K
N
E
N
S
F
E
K
Q
V
S
C
Site 9
S123
N
S
F
E
K
Q
V
S
C
H
E
N
S
K
S
Site 10
S128
Q
V
S
C
H
E
N
S
K
S
C
I
R
R
K
Site 11
S130
S
C
H
E
N
S
K
S
C
I
R
R
K
A
I
Site 12
S157
L
K
W
I
H
R
N
S
L
Y
S
E
T
G
G
Site 13
Y159
W
I
H
R
N
S
L
Y
S
E
T
G
G
K
K
Site 14
S160
E
R
V
G
S
S
S
S
E
S
C
A
Q
D
L
Site 15
S195
N
F
F
S
N
M
F
S
S
V
S
H
S
G
E
Site 16
S196
F
F
S
N
M
F
S
S
V
S
H
S
G
E
S
Site 17
S198
S
N
M
F
S
S
V
S
H
S
G
E
S
S
F
Site 18
S200
M
F
S
S
V
S
H
S
G
E
S
S
F
T
Y
Site 19
S204
V
S
H
S
G
E
S
S
F
T
Y
R
A
Y
C
Site 20
T206
H
S
G
E
S
S
F
T
Y
R
A
Y
C
T
E
Site 21
Y207
S
G
E
S
S
F
T
Y
R
A
Y
C
T
E
F
Site 22
Y210
S
S
F
T
Y
R
A
Y
C
T
E
F
I
E
A
Site 23
S218
Q
D
Q
I
S
G
L
S
Q
S
E
V
K
T
D
Site 24
S234
K
R
H
E
L
E
L
S
W
F
P
D
T
L
P
Site 25
T272
L
P
R
T
I
F
P
T
S
T
I
S
F
E
H
Site 26
S273
P
R
T
I
F
P
T
S
T
I
S
F
E
H
F
Site 27
T274
R
T
I
F
P
T
S
T
I
S
F
E
H
F
G
Site 28
Y287
F
G
T
S
C
K
G
Y
A
L
A
H
T
Q
E
Site 29
T292
K
G
Y
A
L
A
H
T
Q
E
G
E
E
K
K
Site 30
T301
E
G
E
E
K
K
Q
T
S
G
T
S
N
T
R
Site 31
S302
G
E
E
K
K
Q
T
S
G
T
S
N
T
R
G
Site 32
S305
K
K
Q
T
S
G
T
S
N
T
R
G
S
R
R
Site 33
S310
G
T
S
N
T
R
G
S
R
R
K
P
A
M
T
Site 34
T317
S
R
R
K
P
A
M
T
T
P
T
R
R
S
T
Site 35
T318
R
R
K
P
A
M
T
T
P
T
R
R
S
T
R
Site 36
T320
K
P
A
M
T
T
P
T
R
R
S
T
R
N
T
Site 37
S323
M
T
T
P
T
R
R
S
T
R
N
T
R
A
E
Site 38
T324
T
T
P
T
R
R
S
T
R
N
T
R
A
E
T
Site 39
T327
T
R
R
S
T
R
N
T
R
A
E
T
A
S
Q
Site 40
T331
T
R
N
T
R
A
E
T
A
S
Q
S
Q
R
S
Site 41
S333
N
T
R
A
E
T
A
S
Q
S
Q
R
S
P
I
Site 42
S335
R
A
E
T
A
S
Q
S
Q
R
S
P
I
S
D
Site 43
S338
T
A
S
Q
S
Q
R
S
P
I
S
D
N
S
G
Site 44
S341
Q
S
Q
R
S
P
I
S
D
N
S
G
C
D
A
Site 45
S344
R
S
P
I
S
D
N
S
G
C
D
A
P
G
N
Site 46
S352
G
C
D
A
P
G
N
S
N
P
S
L
S
V
P
Site 47
S355
A
P
G
N
S
N
P
S
L
S
V
P
S
S
A
Site 48
S357
G
N
S
N
P
S
L
S
V
P
S
S
A
E
S
Site 49
S361
P
S
L
S
V
P
S
S
A
E
S
E
K
Q
T
Site 50
S364
S
V
P
S
S
A
E
S
E
K
Q
T
R
Q
A
Site 51
S376
R
Q
A
P
K
R
K
S
V
R
R
G
R
K
P
Site 52
S393
L
K
K
K
L
R
S
S
V
A
A
P
E
K
S
Site 53
S400
S
V
A
A
P
E
K
S
S
S
N
D
S
V
D
Site 54
S401
V
A
A
P
E
K
S
S
S
N
D
S
V
D
E
Site 55
S402
A
A
P
E
K
S
S
S
N
D
S
V
D
E
E
Site 56
S405
E
K
S
S
S
N
D
S
V
D
E
E
T
A
E
Site 57
T410
N
D
S
V
D
E
E
T
A
E
S
D
T
S
P
Site 58
S413
V
D
E
E
T
A
E
S
D
T
S
P
V
L
E
Site 59
S416
F
C
S
D
Q
N
E
S
E
V
E
P
S
V
N
Site 60
S429
E
H
Q
P
D
V
D
S
S
N
I
C
T
V
Q
Site 61
T434
V
D
S
S
N
I
C
T
V
Q
T
H
V
E
N
Site 62
S449
Q
S
A
N
C
L
K
S
C
N
E
Q
I
E
E
Site 63
S472
D
T
E
E
R
V
G
S
S
S
S
E
S
C
A
Site 64
S473
T
E
E
R
V
G
S
S
S
S
E
S
C
A
Q
Site 65
S474
E
E
R
V
G
S
S
S
S
E
S
C
A
Q
D
Site 66
S475
E
R
V
G
S
S
S
S
E
S
C
A
Q
D
L
Site 67
S477
V
G
S
S
S
S
E
S
C
A
Q
D
L
P
V
Site 68
S512
R
R
E
T
G
K
E
S
R
K
S
Q
S
P
S
Site 69
S530
L
E
K
Q
D
Q
I
S
G
L
S
Q
S
E
V
Site 70
S533
Q
D
Q
I
S
G
L
S
Q
S
E
V
K
T
D
Site 71
S535
Q
I
S
G
L
S
Q
S
E
V
K
T
D
V
C
Site 72
T539
L
S
Q
S
E
V
K
T
D
V
C
T
V
H
L
Site 73
T543
E
V
K
T
D
V
C
T
V
H
L
P
N
D
F
Site 74
T552
H
L
P
N
D
F
P
T
C
L
T
S
E
S
K
Site 75
S556
D
F
P
T
C
L
T
S
E
S
K
V
Y
Q
P
Site 76
Y561
L
T
S
E
S
K
V
Y
Q
P
V
S
C
P
L
Site 77
S565
R
E
S
R
R
S
E
S
L
S
P
R
R
E
T
Site 78
S569
Q
P
V
S
C
P
L
S
D
L
S
E
N
V
E
Site 79
S577
D
L
S
E
N
V
E
S
V
V
N
E
E
K
I
Site 80
T585
V
V
N
E
E
K
I
T
E
S
S
L
V
E
I
Site 81
S587
N
E
E
K
I
T
E
S
S
L
V
E
I
T
E
Site 82
S588
E
E
K
I
T
E
S
S
L
V
E
I
T
E
H
Site 83
T599
I
T
E
H
K
D
F
T
L
K
T
E
E
L
I
Site 84
T602
H
K
D
F
T
L
K
T
E
E
L
I
E
S
P
Site 85
S608
K
T
E
E
L
I
E
S
P
K
L
E
S
S
E
Site 86
S613
I
E
S
P
K
L
E
S
S
E
G
E
I
I
Q
Site 87
S614
E
S
P
K
L
E
S
S
E
G
E
I
I
Q
T
Site 88
T621
S
E
G
E
I
I
Q
T
V
D
R
Q
S
V
K
Site 89
S626
I
Q
T
V
D
R
Q
S
V
K
S
P
E
V
Q
Site 90
S629
V
D
R
Q
S
V
K
S
P
E
V
Q
L
L
G
Site 91
T648
E
D
V
E
I
I
A
T
C
D
T
F
G
N
E
Site 92
S663
D
F
N
N
I
Q
D
S
E
N
N
L
L
K
N
Site 93
T675
L
K
N
N
L
L
N
T
K
L
E
K
S
L
E
Site 94
S680
L
N
T
K
L
E
K
S
L
E
E
K
N
E
S
Site 95
S687
S
L
E
E
K
N
E
S
L
T
E
H
P
R
S
Site 96
T689
E
E
K
N
E
S
L
T
E
H
P
R
S
T
E
Site 97
S694
S
L
T
E
H
P
R
S
T
E
L
P
K
T
H
Site 98
T695
L
T
E
H
P
R
S
T
E
L
P
K
T
H
I
Site 99
T700
R
S
T
E
L
P
K
T
H
I
E
Q
I
Q
K
Site 100
S723
M
I
P
M
E
C
D
S
F
C
S
D
Q
N
E
Site 101
S726
M
E
C
D
S
F
C
S
D
Q
N
E
S
E
V
Site 102
S731
F
C
S
D
Q
N
E
S
E
V
E
P
S
V
N
Site 103
S736
N
E
S
E
V
E
P
S
V
N
A
D
L
K
Q
Site 104
S753
E
N
S
V
T
H
C
S
E
N
N
M
P
S
S
Site 105
S760
S
E
N
N
M
P
S
S
D
L
A
D
E
K
V
Site 106
T769
L
A
D
E
K
V
E
T
V
S
Q
P
S
E
S
Site 107
S771
D
E
K
V
E
T
V
S
Q
P
S
E
S
P
K
Site 108
S774
V
E
T
V
S
Q
P
S
E
S
P
K
D
T
I
Site 109
S776
T
V
S
Q
P
S
E
S
P
K
D
T
I
D
K
Site 110
T780
P
S
E
S
P
K
D
T
I
D
K
T
K
K
P
Site 111
T784
P
K
D
T
I
D
K
T
K
K
P
R
T
R
R
Site 112
T789
D
K
T
K
K
P
R
T
R
R
S
R
F
H
S
Site 113
S792
K
K
P
R
T
R
R
S
R
F
H
S
P
S
T
Site 114
S796
T
R
R
S
R
F
H
S
P
S
T
T
W
S
P
Site 115
S798
R
S
R
F
H
S
P
S
T
T
W
S
P
N
K
Site 116
T799
S
R
F
H
S
P
S
T
T
W
S
P
N
K
D
Site 117
T800
R
F
H
S
P
S
T
T
W
S
P
N
K
D
T
Site 118
S802
H
S
P
S
T
T
W
S
P
N
K
D
T
P
Q
Site 119
T807
T
W
S
P
N
K
D
T
P
Q
E
K
K
R
P
Site 120
S816
Q
E
K
K
R
P
Q
S
P
S
P
R
R
E
T
Site 121
S818
K
K
R
P
Q
S
P
S
P
R
R
E
T
G
K
Site 122
T823
S
P
S
P
R
R
E
T
G
K
E
S
R
K
S
Site 123
S827
R
R
E
T
G
K
E
S
R
K
S
Q
S
P
S
Site 124
S830
T
G
K
E
S
R
K
S
Q
S
P
S
P
K
N
Site 125
S832
K
E
S
R
K
S
Q
S
P
S
P
K
N
E
S
Site 126
S834
S
R
K
S
Q
S
P
S
P
K
N
E
S
A
R
Site 127
S839
S
P
S
P
K
N
E
S
A
R
G
R
K
K
S
Site 128
S846
S
A
R
G
R
K
K
S
R
S
Q
S
P
K
K
Site 129
S848
R
G
R
K
K
S
R
S
Q
S
P
K
K
D
I
Site 130
S850
R
K
K
S
R
S
Q
S
P
K
K
D
I
A
R
Site 131
S862
I
A
R
E
R
R
Q
S
Q
S
R
S
P
K
R
Site 132
S864
R
E
R
R
Q
S
Q
S
R
S
P
K
R
D
T
Site 133
S866
R
R
Q
S
Q
S
R
S
P
K
R
D
T
T
R
Site 134
T871
S
R
S
P
K
R
D
T
T
R
E
S
R
R
S
Site 135
T872
R
S
P
K
R
D
T
T
R
E
S
R
R
S
E
Site 136
S875
K
R
D
T
T
R
E
S
R
R
S
E
S
L
S
Site 137
S878
T
T
R
E
S
R
R
S
E
S
L
S
P
R
R
Site 138
S880
R
E
S
R
R
S
E
S
L
S
P
R
R
E
T
Site 139
S882
S
R
R
S
E
S
L
S
P
R
R
E
T
S
R
Site 140
T887
S
L
S
P
R
R
E
T
S
R
E
N
K
R
S
Site 141
S888
L
S
P
R
R
E
T
S
R
E
N
K
R
S
Q
Site 142
S894
T
S
R
E
N
K
R
S
Q
P
R
V
K
D
S
Site 143
S901
S
Q
P
R
V
K
D
S
S
P
G
E
K
S
R
Site 144
S902
Q
P
R
V
K
D
S
S
P
G
E
K
S
R
S
Site 145
S907
D
S
S
P
G
E
K
S
R
S
Q
S
R
E
R
Site 146
S909
S
P
G
E
K
S
R
S
Q
S
R
E
R
E
S
Site 147
S911
G
E
K
S
R
S
Q
S
R
E
R
E
S
D
R
Site 148
S916
S
Q
S
R
E
R
E
S
D
R
D
G
Q
R
R
Site 149
T929
R
R
E
R
E
R
R
T
R
K
W
S
R
S
R
Site 150
S933
E
R
R
T
R
K
W
S
R
S
R
S
H
S
R
Site 151
S935
R
T
R
K
W
S
R
S
R
S
H
S
R
S
P
Site 152
S937
R
K
W
S
R
S
R
S
H
S
R
S
P
S
R
Site 153
S939
W
S
R
S
R
S
H
S
R
S
P
S
R
C
R
Site 154
S941
R
S
R
S
H
S
R
S
P
S
R
C
R
T
K
Site 155
S943
R
S
H
S
R
S
P
S
R
C
R
T
K
S
K
Site 156
T947
R
S
P
S
R
C
R
T
K
S
K
S
S
S
F
Site 157
S949
P
S
R
C
R
T
K
S
K
S
S
S
F
G
R
Site 158
S951
R
C
R
T
K
S
K
S
S
S
F
G
R
I
D
Site 159
S953
R
T
K
S
K
S
S
S
F
G
R
I
D
R
D
Site 160
S961
F
G
R
I
D
R
D
S
Y
S
P
R
W
K
G
Site 161
Y962
G
R
I
D
R
D
S
Y
S
P
R
W
K
G
R
Site 162
S963
R
I
D
R
D
S
Y
S
P
R
W
K
G
R
W
Site 163
Y984
C
P
R
G
N
D
R
Y
R
K
N
D
P
E
K
Site 164
S1012
L
D
A
D
D
P
N
S
A
D
K
H
R
N
D
Site 165
S1030
W
I
T
E
K
I
N
S
G
P
D
P
R
T
R
Site 166
T1036
N
S
G
P
D
P
R
T
R
N
P
E
K
L
K
Site 167
S1069
N
F
G
S
G
W
V
S
N
R
G
R
G
R
G
Site 168
T1082
R
G
N
R
G
R
G
T
Y
R
S
S
F
A
Y
Site 169
Y1083
G
N
R
G
R
G
T
Y
R
S
S
F
A
Y
K
Site 170
S1085
R
G
R
G
T
Y
R
S
S
F
A
Y
K
D
Q
Site 171
S1086
G
R
G
T
Y
R
S
S
F
A
Y
K
D
Q
N
Site 172
Y1089
T
Y
R
S
S
F
A
Y
K
D
Q
N
E
N
R
Site 173
S1104
W
Q
N
R
K
P
L
S
G
N
S
N
S
S
G
Site 174
S1107
R
K
P
L
S
G
N
S
N
S
S
G
S
E
S
Site 175
S1109
P
L
S
G
N
S
N
S
S
G
S
E
S
F
K
Site 176
S1110
L
S
G
N
S
N
S
S
G
S
E
S
F
K
F
Site 177
S1112
G
N
S
N
S
S
G
S
E
S
F
K
F
V
E
Site 178
S1114
S
N
S
S
G
S
E
S
F
K
F
V
E
Q
Q
Site 179
S1122
F
K
F
V
E
Q
Q
S
Y
K
R
K
S
E
Q
Site 180
Y1123
K
F
V
E
Q
Q
S
Y
K
R
K
S
E
Q
E
Site 181
S1127
Q
Q
S
Y
K
R
K
S
E
Q
E
F
S
F
D
Site 182
S1132
R
K
S
E
Q
E
F
S
F
D
T
P
A
D
R
Site 183
T1135
E
Q
E
F
S
F
D
T
P
A
D
R
S
G
W
Site 184
S1140
F
D
T
P
A
D
R
S
G
W
T
S
A
S
S
Site 185
S1144
A
D
R
S
G
W
T
S
A
S
S
W
A
V
R
Site 186
S1147
S
G
W
T
S
A
S
S
W
A
V
R
K
T
L
Site 187
T1153
S
S
W
A
V
R
K
T
L
P
A
D
V
Q
N
Site 188
Y1161
L
P
A
D
V
Q
N
Y
Y
S
R
R
G
R
N
Site 189
Y1162
P
A
D
V
Q
N
Y
Y
S
R
R
G
R
N
S
Site 190
S1163
A
D
V
Q
N
Y
Y
S
R
R
G
R
N
S
S
Site 191
S1169
Y
S
R
R
G
R
N
S
S
G
P
Q
S
G
W
Site 192
S1170
S
R
R
G
R
N
S
S
G
P
Q
S
G
W
M
Site 193
S1174
R
N
S
S
G
P
Q
S
G
W
M
K
Q
E
E
Site 194
S1184
M
K
Q
E
E
E
T
S
G
Q
D
S
S
L
K
Site 195
S1188
E
E
T
S
G
Q
D
S
S
L
K
D
Q
T
N
Site 196
S1189
E
T
S
G
Q
D
S
S
L
K
D
Q
T
N
Q
Site 197
S1271
M
Q
V
A
T
P
T
S
V
S
Q
G
L
P
P
Site 198
S1273
V
A
T
P
T
S
V
S
Q
G
L
P
P
P
P
Site 199
S1286
P
P
P
P
P
P
P
S
Q
Q
V
N
Y
I
A
Site 200
Y1291
P
P
S
Q
Q
V
N
Y
I
A
S
Q
P
D
G
Site 201
S1294
Q
Q
V
N
Y
I
A
S
Q
P
D
G
K
Q
L
Site 202
S1306
K
Q
L
Q
G
I
P
S
S
S
H
V
S
N
N
Site 203
S1307
Q
L
Q
G
I
P
S
S
S
H
V
S
N
N
M
Site 204
S1308
L
Q
G
I
P
S
S
S
H
V
S
N
N
M
S
Site 205
S1311
I
P
S
S
S
H
V
S
N
N
M
S
T
P
V
Site 206
S1315
S
H
V
S
N
N
M
S
T
P
V
L
P
A
P
Site 207
T1316
H
V
S
N
N
M
S
T
P
V
L
P
A
P
T
Site 208
S1336
T
G
M
V
Q
G
P
S
S
G
N
T
S
S
S
Site 209
S1337
G
M
V
Q
G
P
S
S
G
N
T
S
S
S
S
Site 210
T1340
Q
G
P
S
S
G
N
T
S
S
S
S
H
S
K
Site 211
S1341
G
P
S
S
G
N
T
S
S
S
S
H
S
K
A
Site 212
S1342
P
S
S
G
N
T
S
S
S
S
H
S
K
A
S
Site 213
S1343
S
S
G
N
T
S
S
S
S
H
S
K
A
S
N
Site 214
S1344
S
G
N
T
S
S
S
S
H
S
K
A
S
N
A
Site 215
S1346
N
T
S
S
S
S
H
S
K
A
S
N
A
A
V
Site 216
S1367
V
S
V
A
V
E
A
S
A
D
S
S
K
T
D
Site 217
S1371
V
E
A
S
A
D
S
S
K
T
D
K
K
L
Q
Site 218
Y1395
K
L
A
I
K
P
F
Y
Q
N
K
D
I
T
K
Site 219
S1419
A
V
D
K
V
C
H
S
K
S
G
E
V
N
S
Site 220
S1421
D
K
V
C
H
S
K
S
G
E
V
N
S
T
K
Site 221
S1426
S
K
S
G
E
V
N
S
T
K
V
A
N
L
V
Site 222
T1427
K
S
G
E
V
N
S
T
K
V
A
N
L
V
K
Site 223
Y1436
V
A
N
L
V
K
A
Y
V
D
K
Y
K
Y
S
Site 224
Y1440
V
K
A
Y
V
D
K
Y
K
Y
S
R
K
G
S
Site 225
Y1442
A
Y
V
D
K
Y
K
Y
S
R
K
G
S
Q
K
Site 226
S1443
Y
V
D
K
Y
K
Y
S
R
K
G
S
Q
K
K
Site 227
S1447
Y
K
Y
S
R
K
G
S
Q
K
K
T
L
E
E
Site 228
T1451
R
K
G
S
Q
K
K
T
L
E
E
P
V
S
T
Site 229
S1457
K
T
L
E
E
P
V
S
T
E
K
N
I
G
_
Site 230
T1458
T
L
E
E
P
V
S
T
E
K
N
I
G
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation