KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
EIF3C
Full Name:
Eukaryotic translation initiation factor 3 subunit C
Alias:
EIF3 p110; EIF3c; EIF3-p110; EIF3S8; Eukaryotic translation initiation factor 3 subunit 8; Eukaryotic translation initiation factor 3, subunit C; IF38
Type:
Translation protein, initiation complex
Mass (Da):
105344
Number AA:
913
UniProt ID:
Q99613
International Prot ID:
IPI00016910
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005829
GO:0005852
GO:0032991
Uniprot
OncoNet
Molecular Function:
GO:0005515
GO:0003743
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0006413
GO:0006413
GO:0006417
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T6
_
_
M
S
R
F
F
T
T
G
S
D
S
E
S
Site 2
T7
_
M
S
R
F
F
T
T
G
S
D
S
E
S
E
Site 3
S9
S
R
F
F
T
T
G
S
D
S
E
S
E
S
S
Site 4
S11
F
F
T
T
G
S
D
S
E
S
E
S
S
L
S
Site 5
S13
T
T
G
S
D
S
E
S
E
S
S
L
S
G
E
Site 6
S15
G
S
D
S
E
S
E
S
S
L
S
G
E
E
L
Site 7
S16
S
D
S
E
S
E
S
S
L
S
G
E
E
L
V
Site 8
S18
S
E
S
E
S
S
L
S
G
E
E
L
V
T
K
Site 9
T24
L
S
G
E
E
L
V
T
K
P
V
G
G
N
Y
Site 10
S39
G
K
Q
P
L
L
L
S
E
D
E
E
D
T
K
Site 11
T45
L
S
E
D
E
E
D
T
K
R
V
V
R
S
A
Site 12
T61
D
K
R
F
E
E
L
T
N
L
I
R
T
I
R
Site 13
T77
A
M
K
I
R
D
V
T
K
C
L
E
E
F
E
Site 14
S95
K
A
Y
G
K
A
K
S
I
V
D
K
E
G
V
Site 15
Y116
I
L
A
D
L
E
D
Y
L
N
E
L
W
E
D
Site 16
T140
N
N
A
K
A
L
S
T
L
R
Q
K
I
R
K
Site 17
Y148
L
R
Q
K
I
R
K
Y
N
R
D
F
E
S
H
Site 18
T157
R
D
F
E
S
H
I
T
S
Y
K
Q
N
P
E
Site 19
S158
D
F
E
S
H
I
T
S
Y
K
Q
N
P
E
Q
Site 20
S166
Y
K
Q
N
P
E
Q
S
A
D
E
D
A
E
K
Site 21
S178
A
E
K
N
E
E
D
S
E
G
S
S
D
E
D
Site 22
S181
N
E
E
D
S
E
G
S
S
D
E
D
E
D
E
Site 23
S182
E
E
D
S
E
G
S
S
D
E
D
E
D
E
D
Site 24
S192
D
E
D
E
D
G
V
S
A
A
T
F
L
K
K
Site 25
T195
E
D
G
V
S
A
A
T
F
L
K
K
K
S
E
Site 26
S201
A
T
F
L
K
K
K
S
E
A
P
S
G
E
S
Site 27
S205
K
K
K
S
E
A
P
S
G
E
S
R
K
F
L
Site 28
S222
M
D
D
E
D
E
D
S
E
D
S
E
D
D
E
Site 29
S225
E
D
E
D
S
E
D
S
E
D
D
E
D
W
D
Site 30
T233
E
D
D
E
D
W
D
T
G
S
T
S
S
D
S
Site 31
S235
D
E
D
W
D
T
G
S
T
S
S
D
S
D
S
Site 32
S237
D
W
D
T
G
S
T
S
S
D
S
D
S
E
E
Site 33
S238
W
D
T
G
S
T
S
S
D
S
D
S
E
E
E
Site 34
S240
T
G
S
T
S
S
D
S
D
S
E
E
E
E
G
Site 35
S242
S
T
S
S
D
S
D
S
E
E
E
E
G
K
Q
Site 36
T250
E
E
E
E
G
K
Q
T
A
L
A
S
R
F
L
Site 37
T262
R
F
L
K
K
A
P
T
T
D
E
D
K
K
A
Site 38
T263
F
L
K
K
A
P
T
T
D
E
D
K
K
A
A
Site 39
S286
K
K
K
H
D
R
K
S
K
R
L
D
E
E
E
Site 40
T345
Q
A
R
G
K
K
G
T
D
R
A
A
Q
I
E
Site 41
Y392
Y
N
P
N
L
A
T
Y
M
K
P
E
M
W
G
Site 42
T446
R
V
R
G
C
I
L
T
L
V
E
R
M
D
E
Site 43
T462
F
T
K
I
M
Q
N
T
D
P
H
S
Q
E
Y
Site 44
S466
M
Q
N
T
D
P
H
S
Q
E
Y
V
E
H
L
Site 45
Y469
T
D
P
H
S
Q
E
Y
V
E
H
L
K
D
E
Site 46
Y489
I
I
E
R
V
Q
R
Y
L
E
E
K
G
T
T
Site 47
T495
R
Y
L
E
E
K
G
T
T
E
E
V
C
R
I
Site 48
T496
Y
L
E
E
K
G
T
T
E
E
V
C
R
I
Y
Site 49
T510
Y
L
L
R
I
L
H
T
Y
Y
K
F
D
Y
K
Site 50
Y511
L
L
R
I
L
H
T
Y
Y
K
F
D
Y
K
A
Site 51
Y512
L
R
I
L
H
T
Y
Y
K
F
D
Y
K
A
H
Site 52
Y516
H
T
Y
Y
K
F
D
Y
K
A
H
Q
R
Q
L
Site 53
T524
K
A
H
Q
R
Q
L
T
P
P
E
G
S
S
K
Site 54
S532
P
P
E
G
S
S
K
S
E
Q
D
Q
A
E
N
Site 55
S544
A
E
N
E
G
E
D
S
A
V
L
M
E
R
L
Site 56
Y554
L
M
E
R
L
C
K
Y
I
Y
A
K
D
R
T
Site 57
Y556
E
R
L
C
K
Y
I
Y
A
K
D
R
T
D
R
Site 58
T561
Y
I
Y
A
K
D
R
T
D
R
I
R
T
C
A
Site 59
T566
D
R
T
D
R
I
R
T
C
A
I
L
C
H
I
Site 60
Y583
H
A
L
H
S
R
W
Y
Q
A
R
D
L
M
L
Site 61
Y609
D
P
P
V
Q
I
L
Y
N
R
T
M
V
Q
L
Site 62
T612
V
Q
I
L
Y
N
R
T
M
V
Q
L
G
I
C
Site 63
S638
N
A
L
L
D
I
Q
S
S
G
R
A
K
E
L
Site 64
S654
G
Q
G
L
L
L
R
S
L
Q
E
R
N
Q
E
Site 65
S703
P
Y
M
A
A
H
E
S
D
A
R
R
R
M
I
Site 66
S711
D
A
R
R
R
M
I
S
K
Q
F
H
H
Q
L
Site 67
S732
P
L
L
G
P
P
E
S
M
R
E
H
V
V
A
Site 68
S787
V
R
K
I
Q
E
E
S
L
R
T
Y
L
F
T
Site 69
T790
I
Q
E
E
S
L
R
T
Y
L
F
T
Y
S
S
Site 70
Y791
Q
E
E
S
L
R
T
Y
L
F
T
Y
S
S
V
Site 71
T794
S
L
R
T
Y
L
F
T
Y
S
S
V
Y
D
S
Site 72
S796
R
T
Y
L
F
T
Y
S
S
V
Y
D
S
I
S
Site 73
Y799
L
F
T
Y
S
S
V
Y
D
S
I
S
M
E
T
Site 74
S801
T
Y
S
S
V
Y
D
S
I
S
M
E
T
L
S
Site 75
S803
S
S
V
Y
D
S
I
S
M
E
T
L
S
D
M
Site 76
S834
I
N
E
E
L
M
A
S
L
D
Q
P
T
Q
T
Site 77
T839
M
A
S
L
D
Q
P
T
Q
T
V
V
M
H
R
Site 78
T841
S
L
D
Q
P
T
Q
T
V
V
M
H
R
T
E
Site 79
S865
Q
L
A
E
K
L
G
S
L
V
E
N
N
E
R
Site 80
T880
V
F
D
H
K
Q
G
T
Y
G
G
Y
F
R
D
Site 81
Y881
F
D
H
K
Q
G
T
Y
G
G
Y
F
R
D
Q
Site 82
Y884
K
Q
G
T
Y
G
G
Y
F
R
D
Q
K
D
G
Site 83
Y892
F
R
D
Q
K
D
G
Y
R
K
N
E
G
Y
M
Site 84
Y898
G
Y
R
K
N
E
G
Y
M
R
R
G
G
Y
R
Site 85
Y904
G
Y
M
R
R
G
G
Y
R
Q
Q
Q
S
Q
T
Site 86
S909
G
G
Y
R
Q
Q
Q
S
Q
T
A
Y
_
_
_
Site 87
Y913
Q
Q
Q
S
Q
T
A
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation