KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
PRPF18
Full Name:
Pre-mRNA-splicing factor 18
Alias:
HPRP18; PRP18; PRP18 pre-mRNA processing factor 18
Type:
Mass (Da):
39860
Number AA:
UniProt ID:
Q99633
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016607
GO:0005681
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0008380
GO:0006397
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y27
L
L
V
E
N
K
K
Y
F
K
R
S
E
L
A
Site 2
Y41
A
K
K
E
E
E
A
Y
F
E
R
C
G
Y
K
Site 3
Y47
A
Y
F
E
R
C
G
Y
K
I
Q
P
K
E
E
Site 4
T60
E
E
D
Q
K
P
L
T
S
S
N
P
V
L
E
Site 5
T78
A
E
E
K
L
P
M
T
L
S
R
Q
E
V
I
Site 6
S80
E
K
L
P
M
T
L
S
R
Q
E
V
I
R
R
Site 7
T101
P
I
R
L
F
G
E
T
D
Y
D
A
F
Q
R
Site 8
Y103
R
L
F
G
E
T
D
Y
D
A
F
Q
R
L
R
Site 9
T116
L
R
K
I
E
I
L
T
P
E
V
N
K
G
L
Site 10
Y138
L
D
K
I
D
Q
Q
Y
L
N
E
I
V
G
G
Site 11
T165
K
V
H
E
E
N
T
T
I
E
E
L
E
A
L
Site 12
Y209
E
L
N
A
R
E
D
Y
V
K
R
S
V
Q
G
Site 13
S213
R
E
D
Y
V
K
R
S
V
Q
G
K
L
N
S
Site 14
S220
S
V
Q
G
K
L
N
S
A
T
Q
K
Q
T
E
Site 15
T222
Q
G
K
L
N
S
A
T
Q
K
Q
T
E
S
Y
Site 16
S228
A
T
Q
K
Q
T
E
S
Y
L
R
P
L
F
R
Site 17
Y229
T
Q
K
Q
T
E
S
Y
L
R
P
L
F
R
K
Site 18
Y262
K
F
M
L
Q
R
E
Y
V
K
A
N
D
A
Y
Site 19
Y269
Y
V
K
A
N
D
A
Y
L
Q
M
A
I
G
N
Site 20
S299
T
G
R
E
K
I
F
S
K
H
V
A
H
V
L
Site 21
T310
A
H
V
L
N
D
E
T
Q
R
K
Y
I
Q
G
Site 22
Y314
N
D
E
T
Q
R
K
Y
I
Q
G
L
K
R
L
Site 23
T323
Q
G
L
K
R
L
M
T
I
C
Q
K
H
F
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation