KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
Fez1
Full Name:
Fasciculation and elongation protein zeta-1
Alias:
Zygin I;Zygin-1
Type:
Mass (Da):
45119
Number AA:
392
UniProt ID:
Q99689
International Prot ID:
IPI00017070
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0043015
PhosphoSite+
KinaseNET
Biological Process:
GO:0007411
GO:0007155
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
A
P
L
V
S
L
D
E
E
F
E
D
Site 2
S18
E
F
E
D
L
R
P
S
C
S
E
D
P
E
E
Site 3
S20
E
D
L
R
P
S
C
S
E
D
P
E
E
K
P
Site 4
Y31
E
E
K
P
Q
C
F
Y
G
S
S
P
H
H
L
Site 5
S33
K
P
Q
C
F
Y
G
S
S
P
H
H
L
E
D
Site 6
S34
P
Q
C
F
Y
G
S
S
P
H
H
L
E
D
P
Site 7
S42
P
H
H
L
E
D
P
S
L
S
E
L
E
N
F
Site 8
S44
H
L
E
D
P
S
L
S
E
L
E
N
F
S
S
Site 9
S51
S
E
L
E
N
F
S
S
E
I
I
S
F
K
S
Site 10
S55
N
F
S
S
E
I
I
S
F
K
S
M
E
D
L
Site 11
S58
S
E
I
I
S
F
K
S
M
E
D
L
V
N
E
Site 12
Y77
L
N
V
C
F
R
N
Y
N
A
K
T
E
N
L
Site 13
T99
Q
I
Q
E
E
E
E
T
L
Q
D
E
E
V
W
Site 14
T110
E
E
V
W
D
A
L
T
D
N
Y
I
P
S
L
Site 15
Y113
W
D
A
L
T
D
N
Y
I
P
S
L
S
E
D
Site 16
S116
L
T
D
N
Y
I
P
S
L
S
E
D
W
R
D
Site 17
S118
D
N
Y
I
P
S
L
S
E
D
W
R
D
P
N
Site 18
S134
E
A
L
N
G
N
C
S
D
T
E
I
H
E
K
Site 19
T136
L
N
G
N
C
S
D
T
E
I
H
E
K
E
E
Site 20
S150
E
E
E
F
N
E
K
S
E
N
D
S
G
I
N
Site 21
S154
N
E
K
S
E
N
D
S
G
I
N
E
E
P
L
Site 22
T163
I
N
E
E
P
L
L
T
A
D
Q
V
I
E
E
Site 23
S178
I
E
E
M
M
Q
N
S
P
D
P
E
E
E
E
Site 24
S198
E
D
G
G
E
T
S
S
Q
A
D
S
V
L
L
Site 25
S202
E
T
S
S
Q
A
D
S
V
L
L
Q
E
M
Q
Site 26
S228
Y
E
G
L
R
H
M
S
G
S
E
L
T
E
L
Site 27
S230
G
L
R
H
M
S
G
S
E
L
T
E
L
L
D
Site 28
S247
E
G
A
I
R
D
F
S
E
E
L
V
Q
Q
L
Site 29
S298
R
R
K
E
K
G
L
S
L
Q
S
S
R
I
E
Site 30
S301
E
K
G
L
S
L
Q
S
S
R
I
E
K
G
N
Site 31
S302
K
G
L
S
L
Q
S
S
R
I
E
K
G
N
Q
Site 32
S316
Q
M
P
L
K
R
F
S
M
E
G
I
S
N
I
Site 33
S326
G
I
S
N
I
L
Q
S
G
I
R
Q
T
F
G
Site 34
T331
L
Q
S
G
I
R
Q
T
F
G
S
S
G
T
D
Site 35
S334
G
I
R
Q
T
F
G
S
S
G
T
D
K
Q
Y
Site 36
Y341
S
S
G
T
D
K
Q
Y
L
N
T
V
I
P
Y
Site 37
T344
T
D
K
Q
Y
L
N
T
V
I
P
Y
E
K
K
Site 38
Y348
Y
L
N
T
V
I
P
Y
E
K
K
A
S
P
P
Site 39
S353
I
P
Y
E
K
K
A
S
P
P
S
V
E
D
L
Site 40
S356
E
K
K
A
S
P
P
S
V
E
D
L
Q
M
L
Site 41
T379
E
D
N
E
K
V
P
T
L
L
T
D
Y
I
L
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation