KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
LYST
Full Name:
Lysosomal-trafficking regulator
Alias:
Beige; Beige homolog; Chediak-Higashi syndrome 1; CHS; CHS1; Lysosomal trafficking regulator
Type:
Unknown function
Mass (Da):
429139
Number AA:
3801
UniProt ID:
Q99698
International Prot ID:
IPI00017094
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0015630
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0042742
GO:0042832
GO:0051607
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
S
T
D
S
N
S
L
A
R
E
F
L
T
Site 2
T14
S
L
A
R
E
F
L
T
D
V
N
R
L
C
N
Site 3
T37
R
E
E
E
E
E
E
T
H
M
A
T
L
G
Q
Site 4
T94
P
V
Q
E
E
K
A
T
D
F
N
L
P
L
S
Site 5
T107
L
S
A
D
I
I
L
T
K
E
K
N
S
S
S
Site 6
S112
I
L
T
K
E
K
N
S
S
S
Q
R
S
T
Q
Site 7
S113
L
T
K
E
K
N
S
S
S
Q
R
S
T
Q
E
Site 8
S114
T
K
E
K
N
S
S
S
Q
R
S
T
Q
E
K
Site 9
S117
K
N
S
S
S
Q
R
S
T
Q
E
K
L
H
L
Site 10
T118
N
S
S
S
Q
R
S
T
Q
E
K
L
H
L
E
Site 11
S127
E
K
L
H
L
E
G
S
A
L
S
S
Q
V
S
Site 12
S130
H
L
E
G
S
A
L
S
S
Q
V
S
A
K
V
Site 13
S131
L
E
G
S
A
L
S
S
Q
V
S
A
K
V
N
Site 14
S143
K
V
N
V
F
R
K
S
R
R
Q
R
K
I
T
Site 15
T150
S
R
R
Q
R
K
I
T
H
R
Y
S
V
R
D
Site 16
S154
R
K
I
T
H
R
Y
S
V
R
D
A
R
K
T
Site 17
T161
S
V
R
D
A
R
K
T
Q
L
S
T
S
D
S
Site 18
S164
D
A
R
K
T
Q
L
S
T
S
D
S
E
A
N
Site 19
S166
R
K
T
Q
L
S
T
S
D
S
E
A
N
S
D
Site 20
S168
T
Q
L
S
T
S
D
S
E
A
N
S
D
E
K
Site 21
S172
T
S
D
S
E
A
N
S
D
E
K
G
I
A
M
Site 22
T193
H
L
L
H
H
F
L
T
S
F
P
K
Q
D
H
Site 23
S194
L
L
H
H
F
L
T
S
F
P
K
Q
D
H
P
Site 24
T210
A
K
L
D
R
L
A
T
K
E
Q
T
P
P
D
Site 25
T214
R
L
A
T
K
E
Q
T
P
P
D
A
M
A
L
Site 26
S233
E
I
I
P
R
Q
G
S
N
T
D
I
L
S
E
Site 27
T235
I
P
R
Q
G
S
N
T
D
I
L
S
E
P
A
Site 28
T274
K
V
C
K
F
D
V
T
L
N
H
N
S
P
L
Site 29
S301
A
G
F
G
D
C
C
S
L
S
D
N
L
E
S
Site 30
S303
F
G
D
C
C
S
L
S
D
N
L
E
S
R
V
Site 31
S308
S
L
S
D
N
L
E
S
R
V
V
S
A
G
W
Site 32
S312
N
L
E
S
R
V
V
S
A
G
W
T
E
E
P
Site 33
T316
R
V
V
S
A
G
W
T
E
E
P
V
A
L
I
Site 34
T381
F
A
P
R
Q
K
K
T
L
Q
E
V
Q
E
D
Site 35
Y394
E
D
F
V
F
S
K
Y
R
H
R
A
L
L
L
Site 36
Y425
S
A
A
S
N
P
F
Y
F
S
Q
A
M
D
L
Site 37
S427
A
S
N
P
F
Y
F
S
Q
A
M
D
L
V
Q
Site 38
S481
N
S
V
M
K
I
M
S
T
V
K
K
V
K
S
Site 39
S488
S
T
V
K
K
V
K
S
E
Q
L
H
H
S
M
Site 40
S529
S
A
F
K
N
Q
V
S
K
N
P
F
E
E
T
Site 41
Y542
E
T
A
D
G
D
V
Y
Y
P
E
R
C
C
C
Site 42
Y543
T
A
D
G
D
V
Y
Y
P
E
R
C
C
C
I
Site 43
S629
Q
L
G
G
A
E
I
S
P
K
I
K
K
A
A
Site 44
S664
N
L
C
D
A
E
L
S
S
S
L
S
S
P
S
Site 45
S665
L
C
D
A
E
L
S
S
S
L
S
S
P
S
Y
Site 46
S666
C
D
A
E
L
S
S
S
L
S
S
P
S
Y
R
Site 47
S668
A
E
L
S
S
S
L
S
S
P
S
Y
R
F
Q
Site 48
S669
E
L
S
S
S
L
S
S
P
S
Y
R
F
Q
G
Site 49
S671
S
S
S
L
S
S
P
S
Y
R
F
Q
G
I
L
Site 50
Y672
S
S
L
S
S
P
S
Y
R
F
Q
G
I
L
P
Site 51
S680
R
F
Q
G
I
L
P
S
S
G
S
E
D
L
L
Site 52
S681
F
Q
G
I
L
P
S
S
G
S
E
D
L
L
W
Site 53
S683
G
I
L
P
S
S
G
S
E
D
L
L
W
K
W
Site 54
S708
F
E
E
D
R
L
H
S
I
Q
I
A
N
H
I
Site 55
S759
L
S
V
T
S
A
Q
S
H
V
C
S
H
H
N
Site 56
S814
N
C
L
N
G
I
R
S
H
S
L
K
A
F
E
Site 57
S816
L
N
G
I
R
S
H
S
L
K
A
F
E
T
L
Site 58
S835
G
E
Q
Q
K
D
A
S
V
P
D
I
D
G
I
Site 59
S851
I
E
Q
K
E
L
S
S
V
H
V
G
T
S
F
Site 60
Y864
S
F
H
H
Q
Q
A
Y
S
D
S
P
Q
S
L
Site 61
S865
F
H
H
Q
Q
A
Y
S
D
S
P
Q
S
L
S
Site 62
S867
H
Q
Q
A
Y
S
D
S
P
Q
S
L
S
K
F
Site 63
S870
A
Y
S
D
S
P
Q
S
L
S
K
F
Y
A
G
Site 64
S872
S
D
S
P
Q
S
L
S
K
F
Y
A
G
L
K
Site 65
T888
A
Y
P
K
R
R
K
T
V
N
Q
D
V
H
I
Site 66
S915
C
V
S
K
E
A
E
S
D
R
E
S
A
N
D
Site 67
S919
E
A
E
S
D
R
E
S
A
N
D
S
E
D
T
Site 68
S923
D
R
E
S
A
N
D
S
E
D
T
S
G
Y
D
Site 69
S927
A
N
D
S
E
D
T
S
G
Y
D
S
T
A
S
Site 70
Y929
D
S
E
D
T
S
G
Y
D
S
T
A
S
E
P
Site 71
S931
E
D
T
S
G
Y
D
S
T
A
S
E
P
L
S
Site 72
T932
D
T
S
G
Y
D
S
T
A
S
E
P
L
S
H
Site 73
S934
S
G
Y
D
S
T
A
S
E
P
L
S
H
M
L
Site 74
S953
L
E
S
L
V
L
P
S
P
E
H
M
H
Q
A
Site 75
Y982
S
V
F
Q
K
Q
F
Y
R
L
G
G
F
R
V
Site 76
T1016
Q
G
K
K
E
G
D
T
S
V
N
E
N
Q
D
Site 77
S1017
G
K
K
E
G
D
T
S
V
N
E
N
Q
D
L
Site 78
S1028
N
Q
D
L
N
R
I
S
Q
P
K
R
T
M
K
Site 79
S1040
T
M
K
E
D
L
L
S
L
A
I
K
S
D
P
Site 80
S1050
I
K
S
D
P
I
P
S
E
L
G
S
L
K
K
Site 81
S1054
P
I
P
S
E
L
G
S
L
K
K
S
A
D
S
Site 82
S1058
E
L
G
S
L
K
K
S
A
D
S
L
G
K
L
Site 83
S1061
S
L
K
K
S
A
D
S
L
G
K
L
E
L
Q
Site 84
S1072
L
E
L
Q
H
I
S
S
I
N
V
E
E
V
S
Site 85
S1093
E
E
A
K
L
F
T
S
Q
E
S
E
T
S
L
Site 86
S1096
K
L
F
T
S
Q
E
S
E
T
S
L
Q
S
I
Site 87
S1099
T
S
Q
E
S
E
T
S
L
Q
S
I
R
L
L
Site 88
S1102
E
S
E
T
S
L
Q
S
I
R
L
L
E
A
L
Site 89
T1119
I
C
L
H
G
A
R
T
S
Q
Q
K
M
E
L
Site 90
S1120
C
L
H
G
A
R
T
S
Q
Q
K
M
E
L
E
Site 91
S1134
E
L
P
N
Q
N
L
S
V
E
S
I
L
F
E
Site 92
S1147
F
E
M
R
D
H
L
S
Q
S
K
V
I
E
T
Site 93
S1149
M
R
D
H
L
S
Q
S
K
V
I
E
T
Q
L
Site 94
Y1172
L
R
V
A
L
G
N
Y
S
A
D
F
E
H
N
Site 95
S1173
R
V
A
L
G
N
Y
S
A
D
F
E
H
N
D
Site 96
S1189
M
T
E
K
S
H
Q
S
A
E
E
L
S
S
Q
Site 97
S1194
H
Q
S
A
E
E
L
S
S
Q
P
G
D
F
S
Site 98
S1195
Q
S
A
E
E
L
S
S
Q
P
G
D
F
S
E
Site 99
S1201
S
S
Q
P
G
D
F
S
E
E
A
E
D
S
Q
Site 100
S1207
F
S
E
E
A
E
D
S
Q
C
C
S
F
K
L
Site 101
S1211
A
E
D
S
Q
C
C
S
F
K
L
L
V
E
E
Site 102
Y1221
L
L
V
E
E
E
G
Y
E
A
D
S
E
S
N
Site 103
S1225
E
E
G
Y
E
A
D
S
E
S
N
P
E
D
G
Site 104
S1227
G
Y
E
A
D
S
E
S
N
P
E
D
G
E
T
Site 105
T1234
S
N
P
E
D
G
E
T
Q
D
D
G
V
D
L
Site 106
S1243
D
D
G
V
D
L
K
S
E
T
E
G
F
S
A
Site 107
T1245
G
V
D
L
K
S
E
T
E
G
F
S
A
S
S
Site 108
S1249
K
S
E
T
E
G
F
S
A
S
S
S
P
N
D
Site 109
S1251
E
T
E
G
F
S
A
S
S
S
P
N
D
L
L
Site 110
S1253
E
G
F
S
A
S
S
S
P
N
D
L
L
E
N
Site 111
T1328
G
G
F
L
S
I
L
T
Q
D
D
S
D
F
Q
Site 112
S1332
S
I
L
T
Q
D
D
S
D
F
Q
A
C
Q
R
Site 113
S1350
D
L
L
V
S
L
M
S
S
R
T
C
S
E
E
Site 114
S1385
G
I
L
K
I
I
E
S
D
T
T
M
S
P
S
Site 115
T1387
L
K
I
I
E
S
D
T
T
M
S
P
S
Q
Y
Site 116
T1388
K
I
I
E
S
D
T
T
M
S
P
S
Q
Y
L
Site 117
S1390
I
E
S
D
T
T
M
S
P
S
Q
Y
L
T
F
Site 118
S1392
S
D
T
T
M
S
P
S
Q
Y
L
T
F
P
L
Site 119
Y1394
T
T
M
S
P
S
Q
Y
L
T
F
P
L
L
H
Site 120
S1406
L
L
H
A
P
N
L
S
N
G
V
S
S
Q
K
Site 121
S1410
P
N
L
S
N
G
V
S
S
Q
K
Y
P
G
I
Site 122
S1411
N
L
S
N
G
V
S
S
Q
K
Y
P
G
I
L
Site 123
Y1414
N
G
V
S
S
Q
K
Y
P
G
I
L
N
S
K
Site 124
S1420
K
Y
P
G
I
L
N
S
K
A
M
G
L
L
R
Site 125
S1432
L
L
R
R
A
R
V
S
R
S
K
K
E
A
D
Site 126
S1442
K
K
E
A
D
R
E
S
F
P
H
R
L
L
S
Site 127
S1470
Q
N
C
W
P
H
L
S
E
G
F
S
V
S
L
Site 128
S1476
L
S
E
G
F
S
V
S
L
W
F
N
V
E
C
Site 129
T1490
C
I
H
E
A
E
S
T
T
E
K
G
K
K
I
Site 130
T1491
I
H
E
A
E
S
T
T
E
K
G
K
K
I
K
Site 131
S1503
K
I
K
K
R
N
K
S
L
I
L
P
D
S
S
Site 132
S1509
K
S
L
I
L
P
D
S
S
F
D
G
T
E
S
Site 133
S1510
S
L
I
L
P
D
S
S
F
D
G
T
E
S
D
Site 134
T1514
P
D
S
S
F
D
G
T
E
S
D
R
P
E
G
Site 135
S1516
S
S
F
D
G
T
E
S
D
R
P
E
G
A
E
Site 136
Y1524
D
R
P
E
G
A
E
Y
I
N
P
G
E
R
L
Site 137
T1598
K
W
Q
H
L
V
L
T
Y
L
Q
Q
P
Q
G
Site 138
S1614
R
R
I
H
G
K
I
S
I
W
V
S
G
Q
R
Site 139
S1618
G
K
I
S
I
W
V
S
G
Q
R
K
P
D
V
Site 140
T1626
G
Q
R
K
P
D
V
T
L
D
F
M
L
P
R
Site 141
T1635
D
F
M
L
P
R
K
T
S
L
S
S
D
S
N
Site 142
S1636
F
M
L
P
R
K
T
S
L
S
S
D
S
N
K
Site 143
S1638
L
P
R
K
T
S
L
S
S
D
S
N
K
T
F
Site 144
S1639
P
R
K
T
S
L
S
S
D
S
N
K
T
F
C
Site 145
S1641
K
T
S
L
S
S
D
S
N
K
T
F
C
M
I
Site 146
T1644
L
S
S
D
S
N
K
T
F
C
M
I
G
H
C
Site 147
S1680
F
N
G
A
K
V
G
S
Q
E
A
F
Y
L
Y
Site 148
Y1685
V
G
S
Q
E
A
F
Y
L
Y
A
C
G
P
N
Site 149
Y1687
S
Q
E
A
F
Y
L
Y
A
C
G
P
N
H
T
Site 150
Y1701
T
S
V
M
P
C
K
Y
G
K
P
V
N
D
Y
Site 151
Y1708
Y
G
K
P
V
N
D
Y
S
K
Y
I
N
K
E
Site 152
Y1711
P
V
N
D
Y
S
K
Y
I
N
K
E
I
L
R
Site 153
T1728
Q
I
R
E
L
F
M
T
K
K
D
V
D
I
G
Site 154
T1746
E
S
L
S
V
V
Y
T
T
Y
C
P
A
Q
Y
Site 155
Y1756
C
P
A
Q
Y
T
I
Y
E
P
V
I
R
L
K
Site 156
T1768
R
L
K
G
Q
M
K
T
Q
L
S
Q
R
P
F
Site 157
S1771
G
Q
M
K
T
Q
L
S
Q
R
P
F
S
S
K
Site 158
S1776
Q
L
S
Q
R
P
F
S
S
K
E
V
Q
S
I
Site 159
S1777
L
S
Q
R
P
F
S
S
K
E
V
Q
S
I
L
Site 160
Y1798
K
N
L
Q
P
T
E
Y
K
T
I
Q
G
I
L
Site 161
T1800
L
Q
P
T
E
Y
K
T
I
Q
G
I
L
H
E
Site 162
S1825
F
A
R
V
V
E
L
S
S
C
E
E
T
Q
A
Site 163
S1826
A
R
V
V
E
L
S
S
C
E
E
T
Q
A
L
Site 164
T1830
E
L
S
S
C
E
E
T
Q
A
L
A
L
R
V
Site 165
Y1844
V
I
L
S
L
I
K
Y
N
Q
Q
R
V
H
E
Site 166
S1859
L
E
N
C
N
G
L
S
M
I
H
Q
V
L
I
Site 167
Y1891
C
C
G
E
D
I
I
Y
M
N
E
N
G
E
F
Site 168
S1904
E
F
K
L
D
V
D
S
N
A
I
I
Q
D
V
Site 169
T1982
E
Y
K
E
G
Q
L
T
P
M
P
R
E
V
C
Site 170
Y2026
V
H
P
P
T
N
T
Y
V
C
H
N
P
T
N
Site 171
Y2035
C
H
N
P
T
N
F
Y
F
S
L
H
I
D
G
Site 172
Y2054
E
K
V
R
S
I
M
Y
L
R
H
S
S
S
G
Site 173
S2058
S
I
M
Y
L
R
H
S
S
S
G
G
R
S
L
Site 174
S2059
I
M
Y
L
R
H
S
S
S
G
G
R
S
L
M
Site 175
S2060
M
Y
L
R
H
S
S
S
G
G
R
S
L
M
S
Site 176
S2064
H
S
S
S
G
G
R
S
L
M
S
P
G
F
M
Site 177
S2081
S
P
S
G
F
T
A
S
P
Y
E
G
E
N
S
Site 178
Y2083
S
G
F
T
A
S
P
Y
E
G
E
N
S
S
N
Site 179
S2088
S
P
Y
E
G
E
N
S
S
N
I
I
P
Q
Q
Site 180
S2089
P
Y
E
G
E
N
S
S
N
I
I
P
Q
Q
M
Site 181
S2103
M
A
A
H
M
L
R
S
R
S
L
P
A
F
P
Site 182
S2105
A
H
M
L
R
S
R
S
L
P
A
F
P
T
S
Site 183
T2111
R
S
L
P
A
F
P
T
S
S
L
L
T
Q
S
Site 184
S2112
S
L
P
A
F
P
T
S
S
L
L
T
Q
S
Q
Site 185
S2113
L
P
A
F
P
T
S
S
L
L
T
Q
S
Q
K
Site 186
T2116
F
P
T
S
S
L
L
T
Q
S
Q
K
L
T
G
Site 187
S2118
T
S
S
L
L
T
Q
S
Q
K
L
T
G
S
L
Site 188
T2122
L
T
Q
S
Q
K
L
T
G
S
L
G
C
S
I
Site 189
S2124
Q
S
Q
K
L
T
G
S
L
G
C
S
I
D
R
Site 190
T2138
R
L
Q
N
I
A
D
T
Y
V
A
T
Q
S
K
Site 191
Y2139
L
Q
N
I
A
D
T
Y
V
A
T
Q
S
K
K
Site 192
S2144
D
T
Y
V
A
T
Q
S
K
K
Q
N
S
L
G
Site 193
S2149
T
Q
S
K
K
Q
N
S
L
G
S
S
D
T
L
Site 194
S2153
K
Q
N
S
L
G
S
S
D
T
L
K
K
G
K
Site 195
T2155
N
S
L
G
S
S
D
T
L
K
K
G
K
E
D
Site 196
S2166
G
K
E
D
A
F
I
S
S
C
E
S
A
K
T
Site 197
S2167
K
E
D
A
F
I
S
S
C
E
S
A
K
T
V
Site 198
S2170
A
F
I
S
S
C
E
S
A
K
T
V
C
E
M
Site 199
T2173
S
S
C
E
S
A
K
T
V
C
E
M
E
A
V
Site 200
S2213
Q
L
G
A
E
P
R
S
E
D
D
S
P
G
D
Site 201
S2217
E
P
R
S
E
D
D
S
P
G
D
E
S
C
P
Site 202
S2222
D
D
S
P
G
D
E
S
C
P
R
R
P
D
Y
Site 203
Y2229
S
C
P
R
R
P
D
Y
L
K
G
L
A
S
F
Site 204
S2235
D
Y
L
K
G
L
A
S
F
Q
R
S
H
S
T
Site 205
S2239
G
L
A
S
F
Q
R
S
H
S
T
I
A
S
L
Site 206
S2241
A
S
F
Q
R
S
H
S
T
I
A
S
L
G
L
Site 207
T2242
S
F
Q
R
S
H
S
T
I
A
S
L
G
L
A
Site 208
S2256
A
F
P
S
Q
N
G
S
A
A
V
G
R
W
P
Site 209
S2264
A
A
V
G
R
W
P
S
L
V
D
R
N
T
D
Site 210
T2270
P
S
L
V
D
R
N
T
D
D
W
E
N
F
A
Site 211
Y2278
D
D
W
E
N
F
A
Y
S
L
G
Y
E
P
N
Site 212
Y2286
S
L
G
Y
E
P
N
Y
N
R
T
A
S
A
H
Site 213
S2291
P
N
Y
N
R
T
A
S
A
H
S
V
T
E
D
Site 214
S2363
D
A
Y
F
A
R
A
S
K
E
Q
K
D
K
F
Site 215
S2377
F
L
K
N
R
G
F
S
L
L
A
N
Q
L
Y
Site 216
Y2384
S
L
L
A
N
Q
L
Y
L
H
R
G
T
Q
E
Site 217
T2389
Q
L
Y
L
H
R
G
T
Q
E
L
L
E
C
F
Site 218
S2491
L
E
K
N
I
P
M
S
E
Y
K
L
L
A
C
Site 219
S2515
T
I
H
A
C
S
S
S
G
S
Q
Y
F
R
V
Site 220
S2517
H
A
C
S
S
S
G
S
Q
Y
F
R
V
I
E
Site 221
Y2519
C
S
S
S
G
S
Q
Y
F
R
V
I
E
D
L
Site 222
Y2532
D
L
I
V
M
L
G
Y
L
Q
N
S
K
N
K
Site 223
S2536
M
L
G
Y
L
Q
N
S
K
N
K
R
T
Q
N
Site 224
T2562
A
A
M
E
F
I
R
T
T
A
N
H
D
S
E
Site 225
T2563
A
M
E
F
I
R
T
T
A
N
H
D
S
E
N
Site 226
S2568
R
T
T
A
N
H
D
S
E
N
L
T
D
S
L
Site 227
T2572
N
H
D
S
E
N
L
T
D
S
L
Q
S
P
S
Site 228
S2574
D
S
E
N
L
T
D
S
L
Q
S
P
S
A
P
Site 229
S2577
N
L
T
D
S
L
Q
S
P
S
A
P
H
H
A
Site 230
S2591
A
V
V
Q
K
R
K
S
I
A
G
P
R
K
F
Site 231
S2605
F
P
L
A
Q
T
E
S
L
L
M
K
M
R
S
Site 232
S2612
S
L
L
M
K
M
R
S
V
A
N
D
E
L
H
Site 233
S2627
V
M
M
Q
R
R
M
S
Q
E
N
P
S
Q
A
Site 234
S2632
R
M
S
Q
E
N
P
S
Q
A
T
E
T
E
L
Site 235
T2669
D
I
I
D
I
L
R
T
P
E
N
V
T
Q
S
Site 236
S2676
T
P
E
N
V
T
Q
S
K
T
S
V
F
Q
T
Site 237
T2683
S
K
T
S
V
F
Q
T
E
I
S
E
E
N
I
Site 238
T2707
P
F
Q
K
E
I
F
T
Y
L
V
E
G
F
K
Site 239
Y2708
F
Q
K
E
I
F
T
Y
L
V
E
G
F
K
V
Site 240
S2719
G
F
K
V
S
I
G
S
S
K
A
S
G
S
K
Site 241
S2720
F
K
V
S
I
G
S
S
K
A
S
G
S
K
Q
Site 242
S2723
S
I
G
S
S
K
A
S
G
S
K
Q
Q
W
T
Site 243
S2782
E
I
L
R
D
C
L
S
P
S
L
Q
H
G
A
Site 244
S2784
L
R
D
C
L
S
P
S
L
Q
H
G
A
K
L
Site 245
S2832
G
H
K
C
I
P
P
S
A
S
T
K
A
D
L
Site 246
Y2850
I
K
E
E
Q
K
K
Y
E
T
E
E
G
V
N
Site 247
S2871
T
V
N
N
N
Q
Q
S
L
F
Q
R
L
D
S
Site 248
S2878
S
L
F
Q
R
L
D
S
K
S
K
D
I
S
K
Site 249
S2880
F
Q
R
L
D
S
K
S
K
D
I
S
K
I
A
Site 250
S2884
D
S
K
S
K
D
I
S
K
I
A
A
D
I
T
Site 251
S2897
I
T
Q
A
V
S
L
S
Q
G
N
E
R
K
K
Site 252
Y2913
I
Q
H
I
R
G
M
Y
K
V
D
L
S
A
S
Site 253
S2918
G
M
Y
K
V
D
L
S
A
S
R
H
W
Q
E
Site 254
Y2938
T
H
D
R
A
V
W
Y
D
P
I
Y
Y
P
T
Site 255
Y2942
A
V
W
Y
D
P
I
Y
Y
P
T
S
W
Q
L
Site 256
T2952
T
S
W
Q
L
D
P
T
E
G
P
N
R
E
R
Site 257
Y2966
R
R
R
L
Q
R
C
Y
L
T
I
P
N
K
Y
Site 258
Y2973
Y
L
T
I
P
N
K
Y
L
L
R
D
R
Q
K
Site 259
S2981
L
L
R
D
R
Q
K
S
E
D
V
V
K
P
P
Site 260
S2990
D
V
V
K
P
P
L
S
Y
L
F
E
D
K
T
Site 261
T2997
S
Y
L
F
E
D
K
T
H
S
S
F
S
S
T
Site 262
S2999
L
F
E
D
K
T
H
S
S
F
S
S
T
V
K
Site 263
S3000
F
E
D
K
T
H
S
S
F
S
S
T
V
K
D
Site 264
S3003
K
T
H
S
S
F
S
S
T
V
K
D
K
A
A
Site 265
T3004
T
H
S
S
F
S
S
T
V
K
D
K
A
A
S
Site 266
S3013
K
D
K
A
A
S
E
S
I
R
V
N
R
R
C
Site 267
S3022
R
V
N
R
R
C
I
S
V
A
P
S
R
E
T
Site 268
S3026
R
C
I
S
V
A
P
S
R
E
T
A
G
E
L
Site 269
S3048
Y
F
V
E
D
N
A
S
D
T
V
E
S
S
S
Site 270
T3050
V
E
D
N
A
S
D
T
V
E
S
S
S
L
Q
Site 271
S3055
S
D
T
V
E
S
S
S
L
Q
G
E
L
E
P
Site 272
S3064
Q
G
E
L
E
P
A
S
F
S
W
T
Y
E
E
Site 273
S3066
E
L
E
P
A
S
F
S
W
T
Y
E
E
I
K
Site 274
T3068
E
P
A
S
F
S
W
T
Y
E
E
I
K
E
V
Site 275
Y3069
P
A
S
F
S
W
T
Y
E
E
I
K
E
V
H
Site 276
Y3111
T
K
V
R
D
D
V
Y
H
N
I
L
T
N
N
Site 277
Y3145
G
Q
I
T
N
F
E
Y
L
T
H
L
N
K
H
Site 278
Y3186
D
L
N
D
L
L
I
Y
R
N
L
S
K
P
I
Site 279
Y3197
S
K
P
I
A
V
Q
Y
K
E
K
E
D
R
Y
Site 280
Y3204
Y
K
E
K
E
D
R
Y
V
D
T
Y
K
Y
L
Site 281
Y3208
E
D
R
Y
V
D
T
Y
K
Y
L
E
E
E
Y
Site 282
Y3210
R
Y
V
D
T
Y
K
Y
L
E
E
E
Y
R
K
Site 283
Y3231
P
M
P
P
V
Q
P
Y
H
Y
G
S
H
Y
S
Site 284
Y3233
P
P
V
Q
P
Y
H
Y
G
S
H
Y
S
N
S
Site 285
Y3237
P
Y
H
Y
G
S
H
Y
S
N
S
G
T
V
L
Site 286
S3240
Y
G
S
H
Y
S
N
S
G
T
V
L
H
F
L
Site 287
T3242
S
H
Y
S
N
S
G
T
V
L
H
F
L
V
R
Site 288
Y3260
F
T
K
M
F
L
A
Y
Q
D
Q
S
F
D
I
Site 289
S3264
F
L
A
Y
Q
D
Q
S
F
D
I
P
D
R
T
Site 290
T3271
S
F
D
I
P
D
R
T
F
H
S
T
N
T
T
Site 291
T3275
P
D
R
T
F
H
S
T
N
T
T
W
R
L
S
Site 292
T3277
R
T
F
H
S
T
N
T
T
W
R
L
S
S
F
Site 293
T3278
T
F
H
S
T
N
T
T
W
R
L
S
S
F
E
Site 294
S3282
T
N
T
T
W
R
L
S
S
F
E
S
M
T
D
Site 295
S3283
N
T
T
W
R
L
S
S
F
E
S
M
T
D
V
Site 296
S3286
W
R
L
S
S
F
E
S
M
T
D
V
K
E
L
Site 297
T3288
L
S
S
F
E
S
M
T
D
V
K
E
L
I
P
Site 298
S3347
I
H
R
Q
A
L
E
S
D
Y
V
S
Q
N
I
Site 299
Y3349
R
Q
A
L
E
S
D
Y
V
S
Q
N
I
C
Q
Site 300
S3371
Y
K
Q
K
G
K
A
S
V
Q
A
I
N
V
F
Site 301
S3389
T
Y
F
G
M
D
V
S
A
V
E
D
P
V
Q
Site 302
T3402
V
Q
R
R
A
L
E
T
M
I
K
T
Y
G
Q
Site 303
T3406
A
L
E
T
M
I
K
T
Y
G
Q
T
P
R
Q
Site 304
S3421
L
F
H
M
A
H
V
S
R
P
G
A
K
L
N
Site 305
T3448
V
Q
F
A
F
R
E
T
R
E
Q
V
K
E
I
Site 306
T3456
R
E
Q
V
K
E
I
T
Y
P
S
P
L
S
W
Site 307
Y3457
E
Q
V
K
E
I
T
Y
P
S
P
L
S
W
I
Site 308
S3459
V
K
E
I
T
Y
P
S
P
L
S
W
I
K
G
Site 309
S3462
I
T
Y
P
S
P
L
S
W
I
K
G
L
K
W
Site 310
Y3472
K
G
L
K
W
G
E
Y
V
G
S
P
S
A
P
Site 311
S3475
K
W
G
E
Y
V
G
S
P
S
A
P
V
P
V
Site 312
S3486
P
V
P
V
V
C
F
S
Q
P
H
G
E
R
F
Site 313
S3495
P
H
G
E
R
F
G
S
L
Q
A
L
P
T
R
Site 314
S3518
F
C
L
L
M
T
Y
S
K
E
Q
G
V
R
S
Site 315
S3525
S
K
E
Q
G
V
R
S
M
N
S
T
D
I
Q
Site 316
T3529
G
V
R
S
M
N
S
T
D
I
Q
W
S
A
I
Site 317
S3550
D
N
I
L
R
L
K
S
K
Q
S
E
P
P
V
Site 318
S3553
L
R
L
K
S
K
Q
S
E
P
P
V
N
F
I
Site 319
S3563
P
V
N
F
I
Q
S
S
Q
Q
Y
Q
V
T
S
Site 320
Y3566
F
I
Q
S
S
Q
Q
Y
Q
V
T
S
C
A
W
Site 321
Y3592
K
C
G
V
I
T
A
Y
T
N
R
F
T
S
S
Site 322
T3593
C
G
V
I
T
A
Y
T
N
R
F
T
S
S
T
Site 323
T3597
T
A
Y
T
N
R
F
T
S
S
T
P
S
E
I
Site 324
S3598
A
Y
T
N
R
F
T
S
S
T
P
S
E
I
E
Site 325
T3600
T
N
R
F
T
S
S
T
P
S
E
I
E
M
E
Site 326
S3602
R
F
T
S
S
T
P
S
E
I
E
M
E
T
Q
Site 327
Y3613
M
E
T
Q
I
H
L
Y
G
H
T
E
E
I
T
Site 328
S3633
K
P
Y
S
I
L
I
S
V
S
R
D
G
T
C
Site 329
Y3650
W
D
L
N
R
L
C
Y
V
Q
S
L
A
G
H
Site 330
S3653
N
R
L
C
Y
V
Q
S
L
A
G
H
K
S
P
Site 331
S3659
Q
S
L
A
G
H
K
S
P
V
T
A
V
S
A
Site 332
T3662
A
G
H
K
S
P
V
T
A
V
S
A
S
E
T
Site 333
S3665
K
S
P
V
T
A
V
S
A
S
E
T
S
G
D
Site 334
T3675
E
T
S
G
D
I
A
T
V
C
D
S
A
G
G
Site 335
T3690
G
S
D
L
R
L
W
T
V
N
G
D
L
V
G
Site 336
S3718
S
N
Q
P
E
G
V
S
I
N
V
I
A
G
G
Site 337
T3736
G
I
V
R
L
W
S
T
W
D
L
K
P
V
R
Site 338
T3746
L
K
P
V
R
E
I
T
F
P
K
S
N
K
P
Site 339
S3750
R
E
I
T
F
P
K
S
N
K
P
I
I
S
L
Site 340
S3756
K
S
N
K
P
I
I
S
L
T
F
S
C
D
G
Site 341
T3758
N
K
P
I
I
S
L
T
F
S
C
D
G
H
H
Site 342
Y3767
S
C
D
G
H
H
L
Y
T
A
N
S
D
G
T
Site 343
Y3792
R
L
K
Q
P
M
F
Y
S
F
L
S
S
Y
A
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation