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Updated November 2019
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Protein Info
Short Name:
ATXN2
Full Name:
Ataxin-2
Alias:
Ataxin 2; ATX2; SCA2; Spinocerebellar ataxia type 2 protein; TNRC13; Trinucleotide repeat containing 13
Type:
RNA binding protein
Mass (Da):
140283
Number AA:
1313
UniProt ID:
Q99700
International Prot ID:
IPI00783008
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0048471
GO:0005844
GO:0010494
Uniprot
OncoNet
Molecular Function:
GO:0003723
GO:0008022
PhosphoSite+
KinaseNET
Biological Process:
GO:0016070
GO:0050658
GO:0008219
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S3
_
_
_
_
_
M
R
S
A
A
A
A
P
R
S
Site 2
S10
S
A
A
A
A
P
R
S
P
A
V
A
T
E
S
Site 3
S17
S
P
A
V
A
T
E
S
R
R
F
A
A
A
R
Site 4
S30
A
R
W
P
G
W
R
S
L
Q
R
P
A
R
R
Site 5
S38
L
Q
R
P
A
R
R
S
G
R
G
G
G
G
A
Site 6
Y50
G
G
A
A
P
G
P
Y
P
S
A
A
P
P
P
Site 7
S52
A
A
P
G
P
Y
P
S
A
A
P
P
P
P
G
Site 8
S65
P
G
P
G
P
P
P
S
R
Q
S
S
P
P
S
Site 9
S68
G
P
P
P
S
R
Q
S
S
P
P
S
A
S
D
Site 10
S69
P
P
P
S
R
Q
S
S
P
P
S
A
S
D
C
Site 11
S72
S
R
Q
S
S
P
P
S
A
S
D
C
F
G
S
Site 12
S74
Q
S
S
P
P
S
A
S
D
C
F
G
S
N
G
Site 13
S79
S
A
S
D
C
F
G
S
N
G
N
G
G
G
A
Site 14
S91
G
G
A
F
R
P
G
S
R
R
L
L
G
L
G
Site 15
S113
V
L
L
L
P
L
A
S
P
G
A
P
P
A
A
Site 16
S125
P
A
A
P
T
R
A
S
P
L
G
A
R
A
S
Site 17
S132
S
P
L
G
A
R
A
S
P
P
R
S
G
V
S
Site 18
S136
A
R
A
S
P
P
R
S
G
V
S
L
A
R
P
Site 19
S139
S
P
P
R
S
G
V
S
L
A
R
P
A
P
G
Site 20
T160
E
P
V
Y
G
P
L
T
M
S
L
K
P
Q
Q
Site 21
S162
V
Y
G
P
L
T
M
S
L
K
P
Q
Q
Q
Q
Site 22
S202
N
V
R
K
P
G
G
S
G
L
L
A
S
P
A
Site 23
S213
A
S
P
A
A
A
P
S
P
S
S
S
S
V
S
Site 24
S215
P
A
A
A
P
S
P
S
S
S
S
V
S
S
S
Site 25
S216
A
A
A
P
S
P
S
S
S
S
V
S
S
S
S
Site 26
S217
A
A
P
S
P
S
S
S
S
V
S
S
S
S
A
Site 27
S218
A
P
S
P
S
S
S
S
V
S
S
S
S
A
T
Site 28
S220
S
P
S
S
S
S
V
S
S
S
S
A
T
A
P
Site 29
S221
P
S
S
S
S
V
S
S
S
S
A
T
A
P
S
Site 30
S222
S
S
S
S
V
S
S
S
S
A
T
A
P
S
S
Site 31
S223
S
S
S
V
S
S
S
S
A
T
A
P
S
S
V
Site 32
S248
G
L
G
R
G
R
N
S
N
K
G
L
P
Q
S
Site 33
S255
S
N
K
G
L
P
Q
S
T
I
S
F
D
G
I
Site 34
S258
G
L
P
Q
S
T
I
S
F
D
G
I
Y
A
N
Site 35
Y263
T
I
S
F
D
G
I
Y
A
N
M
R
M
V
H
Site 36
Y290
Q
V
K
N
G
G
I
Y
E
G
V
F
K
T
Y
Site 37
T296
I
Y
E
G
V
F
K
T
Y
S
P
K
C
D
L
Site 38
Y297
Y
E
G
V
F
K
T
Y
S
P
K
C
D
L
V
Site 39
S312
L
D
A
A
H
E
K
S
T
E
S
S
S
G
P
Site 40
T313
D
A
A
H
E
K
S
T
E
S
S
S
G
P
K
Site 41
S316
H
E
K
S
T
E
S
S
S
G
P
K
R
E
E
Site 42
S317
E
K
S
T
E
S
S
S
G
P
K
R
E
E
I
Site 43
S327
K
R
E
E
I
M
E
S
I
L
F
K
C
S
D
Site 44
S345
V
Q
F
K
D
M
D
S
S
Y
A
K
R
D
A
Site 45
Y347
F
K
D
M
D
S
S
Y
A
K
R
D
A
F
T
Site 46
T354
Y
A
K
R
D
A
F
T
D
S
A
I
S
A
K
Site 47
S356
K
R
D
A
F
T
D
S
A
I
S
A
K
V
N
Site 48
S393
E
A
L
E
N
D
V
S
N
G
W
D
P
N
D
Site 49
Y404
D
P
N
D
M
F
R
Y
N
E
E
N
Y
G
V
Site 50
Y409
F
R
Y
N
E
E
N
Y
G
V
V
S
T
Y
D
Site 51
S413
E
E
N
Y
G
V
V
S
T
Y
D
S
S
L
S
Site 52
T414
E
N
Y
G
V
V
S
T
Y
D
S
S
L
S
S
Site 53
Y415
N
Y
G
V
V
S
T
Y
D
S
S
L
S
S
Y
Site 54
S417
G
V
V
S
T
Y
D
S
S
L
S
S
Y
T
V
Site 55
S418
V
V
S
T
Y
D
S
S
L
S
S
Y
T
V
P
Site 56
S420
S
T
Y
D
S
S
L
S
S
Y
T
V
P
L
E
Site 57
S421
T
Y
D
S
S
L
S
S
Y
T
V
P
L
E
R
Site 58
Y422
Y
D
S
S
L
S
S
Y
T
V
P
L
E
R
D
Site 59
S431
V
P
L
E
R
D
N
S
E
E
F
L
K
R
E
Site 60
S450
Q
L
A
E
E
I
E
S
S
A
Q
Y
K
A
R
Site 61
S451
L
A
E
E
I
E
S
S
A
Q
Y
K
A
R
V
Site 62
Y454
E
I
E
S
S
A
Q
Y
K
A
R
V
A
L
E
Site 63
S466
A
L
E
N
D
D
R
S
E
E
E
K
Y
T
A
Site 64
Y471
D
R
S
E
E
E
K
Y
T
A
V
Q
R
N
S
Site 65
T472
R
S
E
E
E
K
Y
T
A
V
Q
R
N
S
S
Site 66
S478
Y
T
A
V
Q
R
N
S
S
E
R
E
G
H
S
Site 67
S479
T
A
V
Q
R
N
S
S
E
R
E
G
H
S
I
Site 68
S485
S
S
E
R
E
G
H
S
I
N
T
R
E
N
K
Site 69
T488
R
E
G
H
S
I
N
T
R
E
N
K
Y
I
P
Site 70
Y493
I
N
T
R
E
N
K
Y
I
P
P
G
Q
R
N
Site 71
S508
R
E
V
I
S
W
G
S
G
R
Q
N
S
P
R
Site 72
S513
W
G
S
G
R
Q
N
S
P
R
M
G
Q
P
G
Site 73
S521
P
R
M
G
Q
P
G
S
G
S
M
P
S
R
S
Site 74
S523
M
G
Q
P
G
S
G
S
M
P
S
R
S
T
S
Site 75
S526
P
G
S
G
S
M
P
S
R
S
T
S
H
T
S
Site 76
S528
S
G
S
M
P
S
R
S
T
S
H
T
S
D
F
Site 77
T529
G
S
M
P
S
R
S
T
S
H
T
S
D
F
N
Site 78
S530
S
M
P
S
R
S
T
S
H
T
S
D
F
N
P
Site 79
T532
P
S
R
S
T
S
H
T
S
D
F
N
P
N
S
Site 80
S533
S
R
S
T
S
H
T
S
D
F
N
P
N
S
G
Site 81
S539
T
S
D
F
N
P
N
S
G
S
D
Q
R
V
V
Site 82
S541
D
F
N
P
N
S
G
S
D
Q
R
V
V
N
G
Site 83
S554
N
G
G
V
P
W
P
S
P
C
P
S
P
S
S
Site 84
S558
P
W
P
S
P
C
P
S
P
S
S
R
P
P
S
Site 85
S560
P
S
P
C
P
S
P
S
S
R
P
P
S
R
Y
Site 86
S561
S
P
C
P
S
P
S
S
R
P
P
S
R
Y
Q
Site 87
S565
S
P
S
S
R
P
P
S
R
Y
Q
S
G
P
N
Site 88
Y567
S
S
R
P
P
S
R
Y
Q
S
G
P
N
S
L
Site 89
S569
R
P
P
S
R
Y
Q
S
G
P
N
S
L
P
P
Site 90
S573
R
Y
Q
S
G
P
N
S
L
P
P
R
A
A
T
Site 91
T580
S
L
P
P
R
A
A
T
P
T
R
P
P
S
R
Site 92
T582
P
P
R
A
A
T
P
T
R
P
P
S
R
P
P
Site 93
S586
A
T
P
T
R
P
P
S
R
P
P
S
R
P
S
Site 94
S590
R
P
P
S
R
P
P
S
R
P
S
R
P
P
S
Site 95
S593
S
R
P
P
S
R
P
S
R
P
P
S
H
P
S
Site 96
S597
S
R
P
S
R
P
P
S
H
P
S
A
H
G
S
Site 97
S600
S
R
P
P
S
H
P
S
A
H
G
S
P
A
P
Site 98
S604
S
H
P
S
A
H
G
S
P
A
P
V
S
T
M
Site 99
S609
H
G
S
P
A
P
V
S
T
M
P
K
R
M
S
Site 100
T610
G
S
P
A
P
V
S
T
M
P
K
R
M
S
S
Site 101
S616
S
T
M
P
K
R
M
S
S
E
G
P
P
R
M
Site 102
S617
T
M
P
K
R
M
S
S
E
G
P
P
R
M
S
Site 103
S624
S
E
G
P
P
R
M
S
P
K
A
Q
R
H
P
Site 104
S637
H
P
R
N
H
R
V
S
A
G
R
G
S
I
S
Site 105
S642
R
V
S
A
G
R
G
S
I
S
S
G
L
E
F
Site 106
S645
A
G
R
G
S
I
S
S
G
L
E
F
V
S
H
Site 107
S651
S
S
G
L
E
F
V
S
H
N
P
P
S
E
A
Site 108
S656
F
V
S
H
N
P
P
S
E
A
A
T
P
P
V
Site 109
T660
N
P
P
S
E
A
A
T
P
P
V
A
R
T
S
Site 110
T666
A
T
P
P
V
A
R
T
S
P
S
G
G
T
W
Site 111
S667
T
P
P
V
A
R
T
S
P
S
G
G
T
W
S
Site 112
S669
P
V
A
R
T
S
P
S
G
G
T
W
S
S
V
Site 113
T672
R
T
S
P
S
G
G
T
W
S
S
V
V
S
G
Site 114
S674
S
P
S
G
G
T
W
S
S
V
V
S
G
V
P
Site 115
S675
P
S
G
G
T
W
S
S
V
V
S
G
V
P
R
Site 116
S678
G
T
W
S
S
V
V
S
G
V
P
R
L
S
P
Site 117
S684
V
S
G
V
P
R
L
S
P
K
T
H
R
P
R
Site 118
T687
V
P
R
L
S
P
K
T
H
R
P
R
S
P
R
Site 119
S692
P
K
T
H
R
P
R
S
P
R
Q
N
S
I
G
Site 120
S697
P
R
S
P
R
Q
N
S
I
G
N
T
P
S
G
Site 121
T701
R
Q
N
S
I
G
N
T
P
S
G
P
V
L
A
Site 122
S703
N
S
I
G
N
T
P
S
G
P
V
L
A
S
P
Site 123
S728
A
M
P
I
P
A
A
S
P
T
P
A
S
P
A
Site 124
T730
P
I
P
A
A
S
P
T
P
A
S
P
A
S
N
Site 125
S733
A
A
S
P
T
P
A
S
P
A
S
N
R
A
V
Site 126
S736
P
T
P
A
S
P
A
S
N
R
A
V
T
P
S
Site 127
T741
P
A
S
N
R
A
V
T
P
S
S
E
A
K
D
Site 128
S743
S
N
R
A
V
T
P
S
S
E
A
K
D
S
R
Site 129
S744
N
R
A
V
T
P
S
S
E
A
K
D
S
R
L
Site 130
S749
P
S
S
E
A
K
D
S
R
L
Q
D
Q
R
Q
Site 131
S758
L
Q
D
Q
R
Q
N
S
P
A
G
N
K
E
N
Site 132
T771
E
N
I
K
P
N
E
T
S
P
S
F
S
K
A
Site 133
S772
N
I
K
P
N
E
T
S
P
S
F
S
K
A
E
Site 134
S774
K
P
N
E
T
S
P
S
F
S
K
A
E
N
K
Site 135
S776
N
E
T
S
P
S
F
S
K
A
E
N
K
G
I
Site 136
S784
K
A
E
N
K
G
I
S
P
V
V
S
E
H
R
Site 137
S788
K
G
I
S
P
V
V
S
E
H
R
K
Q
I
D
Site 138
S809
N
D
F
R
L
Q
P
S
S
T
S
E
S
M
D
Site 139
S810
D
F
R
L
Q
P
S
S
T
S
E
S
M
D
Q
Site 140
T811
F
R
L
Q
P
S
S
T
S
E
S
M
D
Q
L
Site 141
S814
Q
P
S
S
T
S
E
S
M
D
Q
L
L
N
K
Site 142
S828
K
N
R
E
G
E
K
S
R
D
L
I
K
D
K
Site 143
S839
I
K
D
K
I
E
P
S
A
K
D
S
F
I
E
Site 144
S843
I
E
P
S
A
K
D
S
F
I
E
N
S
S
S
Site 145
S848
K
D
S
F
I
E
N
S
S
S
N
C
T
S
G
Site 146
S849
S
F
I
E
N
S
S
S
N
C
T
S
G
S
S
Site 147
S850
S
F
I
E
N
S
S
S
N
C
T
S
G
S
S
Site 148
T853
E
N
S
S
S
N
C
T
S
G
S
S
K
P
N
Site 149
S854
N
S
S
S
N
C
T
S
G
S
S
K
P
N
S
Site 150
S856
S
N
C
T
S
G
S
S
K
P
N
S
P
S
I
Site 151
S857
S
N
C
T
S
G
S
S
K
P
N
S
P
S
I
Site 152
S861
S
G
S
S
K
P
N
S
P
S
I
S
P
S
I
Site 153
S863
S
S
K
P
N
S
P
S
I
S
P
S
I
L
S
Site 154
S865
K
P
N
S
P
S
I
S
P
S
I
L
S
N
T
Site 155
S867
N
S
P
S
I
S
P
S
I
L
S
N
T
E
H
Site 156
S870
S
I
S
P
S
I
L
S
N
T
E
H
K
R
G
Site 157
T872
S
P
S
I
L
S
N
T
E
H
K
R
G
P
E
Site 158
T881
H
K
R
G
P
E
V
T
S
Q
G
V
Q
T
S
Site 159
S882
K
R
G
P
E
V
T
S
Q
G
V
Q
T
S
S
Site 160
S888
T
S
Q
G
V
Q
T
S
S
P
A
C
K
Q
E
Site 161
S889
S
Q
G
V
Q
T
S
S
P
A
C
K
Q
E
K
Site 162
S912
A
A
E
Q
V
R
K
S
T
L
N
P
N
A
K
Site 163
T913
A
E
Q
V
R
K
S
T
L
N
P
N
A
K
E
Site 164
S925
A
K
E
F
N
P
R
S
F
S
Q
P
K
P
S
Site 165
S927
E
F
N
P
R
S
F
S
Q
P
K
P
S
T
T
Site 166
S932
S
F
S
Q
P
K
P
S
T
T
P
T
S
P
R
Site 167
T933
F
S
Q
P
K
P
S
T
T
P
T
S
P
R
P
Site 168
T934
S
Q
P
K
P
S
T
T
P
T
S
P
R
P
Q
Site 169
T936
P
K
P
S
T
T
P
T
S
P
R
P
Q
A
Q
Site 170
S937
K
P
S
T
T
P
T
S
P
R
P
Q
A
Q
P
Site 171
S945
P
R
P
Q
A
Q
P
S
P
S
M
V
G
H
Q
Site 172
S947
P
Q
A
Q
P
S
P
S
M
V
G
H
Q
Q
P
Site 173
T955
M
V
G
H
Q
Q
P
T
P
V
Y
T
Q
P
V
Site 174
Y958
H
Q
Q
P
T
P
V
Y
T
Q
P
V
C
F
A
Site 175
T996
M
P
V
N
Q
A
K
T
Y
R
A
V
P
N
M
Site 176
T1030
A
G
P
P
I
A
A
T
P
P
A
Y
S
T
Q
Site 177
Y1038
P
P
A
Y
S
T
Q
Y
V
A
Y
S
P
Q
Q
Site 178
S1042
S
T
Q
Y
V
A
Y
S
P
Q
Q
F
P
N
Q
Site 179
Y1058
L
V
Q
H
V
P
H
Y
Q
S
Q
H
P
H
V
Site 180
S1067
S
Q
H
P
H
V
Y
S
P
V
I
Q
G
N
A
Site 181
T1081
A
R
M
M
A
P
P
T
H
A
Q
P
G
L
V
Site 182
S1091
Q
P
G
L
V
S
S
S
A
T
Q
Y
G
A
H
Site 183
T1093
G
L
V
S
S
S
A
T
Q
Y
G
A
H
E
Q
Site 184
Y1095
V
S
S
S
A
T
Q
Y
G
A
H
E
Q
T
H
Site 185
Y1105
H
E
Q
T
H
A
M
Y
A
C
P
K
L
P
Y
Site 186
S1117
L
P
Y
N
K
E
T
S
P
S
F
Y
F
A
I
Site 187
S1119
Y
N
K
E
T
S
P
S
F
Y
F
A
I
S
T
Site 188
Y1121
K
E
T
S
P
S
F
Y
F
A
I
S
T
G
S
Site 189
S1128
Y
F
A
I
S
T
G
S
L
A
Q
Q
Y
A
H
Site 190
Y1133
T
G
S
L
A
Q
Q
Y
A
H
P
N
A
T
L
Site 191
T1144
N
A
T
L
H
P
H
T
P
H
P
Q
P
S
A
Site 192
S1150
H
T
P
H
P
Q
P
S
A
T
P
T
G
Q
Q
Site 193
T1152
P
H
P
Q
P
S
A
T
P
T
G
Q
Q
Q
S
Site 194
T1154
P
Q
P
S
A
T
P
T
G
Q
Q
Q
S
Q
H
Site 195
S1159
T
P
T
G
Q
Q
Q
S
Q
H
G
G
S
H
P
Site 196
S1169
G
G
S
H
P
A
P
S
P
V
Q
H
H
Q
H
Site 197
S1186
A
Q
A
L
H
L
A
S
P
Q
Q
Q
S
A
I
Site 198
T1201
Y
H
A
G
L
A
P
T
P
P
S
M
T
P
A
Site 199
S1204
G
L
A
P
T
P
P
S
M
T
P
A
S
N
T
Site 200
T1206
A
P
T
P
P
S
M
T
P
A
S
N
T
Q
S
Site 201
S1209
P
P
S
M
T
P
A
S
N
T
Q
S
P
Q
N
Site 202
T1211
S
M
T
P
A
S
N
T
Q
S
P
Q
N
S
F
Site 203
S1213
T
P
A
S
N
T
Q
S
P
Q
N
S
F
P
A
Site 204
S1217
N
T
Q
S
P
Q
N
S
F
P
A
A
Q
Q
T
Site 205
T1224
S
F
P
A
A
Q
Q
T
V
F
T
I
H
P
S
Site 206
T1227
A
A
Q
Q
T
V
F
T
I
H
P
S
H
V
Q
Site 207
Y1237
P
S
H
V
Q
P
A
Y
T
N
P
P
H
M
A
Site 208
T1270
H
A
P
M
M
L
M
T
T
Q
P
P
G
G
P
Site 209
T1271
A
P
M
M
L
M
T
T
Q
P
P
G
G
P
Q
Site 210
Y1299
S
T
T
A
H
F
P
Y
M
T
H
P
S
V
Q
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation