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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DOK1
Full Name:
Docking protein 1
Alias:
Docking protein 1, 62kDa; Downstream of tyrosine kinase 1; P62(dok); P62dok; Pp62
Type:
Adapter/scaffold protein
Mass (Da):
52392
Number AA:
481
UniProt ID:
Q99704
International Prot ID:
IPI00015287
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0048471
Uniprot
OncoNet
Molecular Function:
GO:0005158
PhosphoSite+
KinaseNET
Biological Process:
GO:0007169
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
E
G
P
L
F
L
Q
S
Q
R
F
G
T
K
R
Site 2
T19
L
Q
S
Q
R
F
G
T
K
R
W
R
K
T
W
Site 3
T25
G
T
K
R
W
R
K
T
W
A
V
L
Y
P
A
Site 4
Y30
R
K
T
W
A
V
L
Y
P
A
S
P
H
G
V
Site 5
S33
W
A
V
L
Y
P
A
S
P
H
G
V
A
R
L
Site 6
S48
E
F
F
D
H
K
G
S
S
S
G
G
G
R
G
Site 7
S50
F
D
H
K
G
S
S
S
G
G
G
R
G
S
S
Site 8
S56
S
S
G
G
G
R
G
S
S
R
R
L
D
C
K
Site 9
S57
S
G
G
G
R
G
S
S
R
R
L
D
C
K
V
Site 10
T80
V
A
P
V
T
V
E
T
P
P
E
P
G
A
T
Site 11
T93
A
T
A
F
R
L
D
T
A
Q
R
S
H
L
L
Site 12
T125
A
F
P
K
G
S
W
T
L
A
P
T
D
N
P
Site 13
T129
G
S
W
T
L
A
P
T
D
N
P
P
K
L
S
Site 14
S136
T
D
N
P
P
K
L
S
A
L
E
M
L
E
N
Site 15
S144
A
L
E
M
L
E
N
S
L
Y
S
P
T
W
E
Site 16
Y146
E
M
L
E
N
S
L
Y
S
P
T
W
E
G
S
Site 17
S147
M
L
E
N
S
L
Y
S
P
T
W
E
G
S
Q
Site 18
T149
E
N
S
L
Y
S
P
T
W
E
G
S
Q
F
W
Site 19
T158
E
G
S
Q
F
W
V
T
V
Q
R
T
E
A
A
Site 20
S173
E
R
C
G
L
H
G
S
Y
V
L
R
V
E
A
Site 21
Y174
R
C
G
L
H
G
S
Y
V
L
R
V
E
A
E
Site 22
Y203
E
P
L
L
S
W
P
Y
T
L
L
R
R
Y
G
Site 23
T204
P
L
L
S
W
P
Y
T
L
L
R
R
Y
G
R
Site 24
Y209
P
Y
T
L
L
R
R
Y
G
R
D
K
V
M
F
Site 25
S217
G
R
D
K
V
M
F
S
F
E
A
G
R
R
C
Site 26
S226
E
A
G
R
R
C
P
S
G
P
G
T
F
T
F
Site 27
T230
R
C
P
S
G
P
G
T
F
T
F
Q
T
A
Q
Site 28
T232
P
S
G
P
G
T
F
T
F
Q
T
A
Q
G
N
Site 29
T235
P
G
T
F
T
F
Q
T
A
Q
G
N
D
I
F
Site 30
S269
H
D
V
L
R
A
D
S
H
E
G
E
V
A
E
Site 31
S281
V
A
E
G
K
L
P
S
P
P
G
P
Q
E
L
Site 32
S291
G
P
Q
E
L
L
D
S
P
P
A
L
Y
A
E
Site 33
Y296
L
D
S
P
P
A
L
Y
A
E
P
L
D
S
L
Site 34
S310
L
R
I
A
P
C
P
S
Q
D
S
L
Y
S
D
Site 35
S313
A
P
C
P
S
Q
D
S
L
Y
S
D
P
L
D
Site 36
Y315
C
P
S
Q
D
S
L
Y
S
D
P
L
D
S
T
Site 37
S316
P
S
Q
D
S
L
Y
S
D
P
L
D
S
T
S
Site 38
S321
L
Y
S
D
P
L
D
S
T
S
A
Q
A
G
E
Site 39
T322
Y
S
D
P
L
D
S
T
S
A
Q
A
G
E
G
Site 40
S323
S
D
P
L
D
S
T
S
A
Q
A
G
E
G
V
Site 41
Y337
V
Q
R
K
K
P
L
Y
W
D
L
Y
E
H
A
Site 42
Y341
K
P
L
Y
W
D
L
Y
E
H
A
Q
Q
Q
L
Site 43
T354
Q
L
L
K
A
K
L
T
D
P
K
E
D
P
I
Site 44
Y362
D
P
K
E
D
P
I
Y
D
E
P
E
G
L
A
Site 45
Y377
P
V
P
P
Q
G
L
Y
D
L
P
R
E
P
K
Site 46
Y398
A
R
V
K
E
E
G
Y
E
L
P
Y
N
P
A
Site 47
Y402
E
E
G
Y
E
L
P
Y
N
P
A
T
D
D
Y
Site 48
T406
E
L
P
Y
N
P
A
T
D
D
Y
A
V
P
P
Site 49
Y409
Y
N
P
A
T
D
D
Y
A
V
P
P
P
R
S
Site 50
S416
Y
A
V
P
P
P
R
S
T
K
P
L
L
A
P
Site 51
T417
A
V
P
P
P
R
S
T
K
P
L
L
A
P
K
Site 52
T435
P
A
F
P
E
P
G
T
A
T
G
S
G
I
K
Site 53
S439
E
P
G
T
A
T
G
S
G
I
K
S
H
N
S
Site 54
S443
A
T
G
S
G
I
K
S
H
N
S
A
L
Y
S
Site 55
S446
S
G
I
K
S
H
N
S
A
L
Y
S
Q
V
Q
Site 56
Y449
K
S
H
N
S
A
L
Y
S
Q
V
Q
K
S
G
Site 57
S450
S
H
N
S
A
L
Y
S
Q
V
Q
K
S
G
A
Site 58
S455
L
Y
S
Q
V
Q
K
S
G
A
S
G
S
W
D
Site 59
S460
Q
K
S
G
A
S
G
S
W
D
C
G
L
S
R
Site 60
S466
G
S
W
D
C
G
L
S
R
V
G
T
D
K
T
Site 61
T470
C
G
L
S
R
V
G
T
D
K
T
G
V
K
S
Site 62
T473
S
R
V
G
T
D
K
T
G
V
K
S
E
G
S
Site 63
S477
T
D
K
T
G
V
K
S
E
G
S
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation