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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MTR
Full Name:
Methionine synthase
Alias:
5-methyltetrahydrofolate-homocysteine methyltransferase; 5-methyltetrahydrofolate--homocysteine methyltransferase; CblG; METH; Vitamin-B12 dependent methionine synthase
Type:
Amino Acid Metabolism - cysteine and methionine; EC 2.1.1.13; Methyltransferase; Cofactor and Vitamin Metabolism - one carbon pool by folate
Mass (Da):
140527
Number AA:
1265
UniProt ID:
Q99707
International Prot ID:
IPI00743284
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005622
GO:0005737
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0003824
GO:0004156
GO:0005488
PhosphoSite+
KinaseNET
Biological Process:
GO:0000096
GO:0000097
GO:0006082
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S9
S
P
A
L
Q
D
L
S
Q
P
E
G
L
K
K
Site 2
T17
Q
P
E
G
L
K
K
T
L
R
D
E
I
N
A
Site 3
S71
K
G
N
N
D
I
L
S
I
T
Q
P
D
V
I
Site 4
Y79
I
T
Q
P
D
V
I
Y
Q
I
H
K
E
Y
L
Site 5
T95
A
G
A
D
I
I
E
T
N
T
F
S
S
T
S
Site 6
Y108
T
S
I
A
Q
A
D
Y
G
L
E
H
L
A
Y
Site 7
Y115
Y
G
L
E
H
L
A
Y
R
M
N
M
C
S
A
Site 8
S154
G
P
T
N
K
T
L
S
V
S
P
S
V
E
R
Site 9
S156
T
N
K
T
L
S
V
S
P
S
V
E
R
P
D
Site 10
S158
K
T
L
S
V
S
P
S
V
E
R
P
D
Y
R
Site 11
Y164
P
S
V
E
R
P
D
Y
R
N
I
T
F
D
E
Site 12
T168
R
P
D
Y
R
N
I
T
F
D
E
L
V
E
A
Site 13
Y217
Q
N
L
F
E
E
K
Y
A
P
R
P
I
F
I
Site 14
T227
R
P
I
F
I
S
G
T
I
V
D
K
S
G
R
Site 15
S232
S
G
T
I
V
D
K
S
G
R
T
L
S
G
Q
Site 16
S237
D
K
S
G
R
T
L
S
G
Q
T
G
E
G
F
Site 17
T293
P
N
A
G
L
P
N
T
F
G
D
Y
D
E
T
Site 18
Y297
L
P
N
T
F
G
D
Y
D
E
T
P
S
M
M
Site 19
T300
T
F
G
D
Y
D
E
T
P
S
M
M
A
K
H
Site 20
S302
G
D
Y
D
E
T
P
S
M
M
A
K
H
L
K
Site 21
T327
V
G
G
C
C
G
S
T
P
D
H
I
R
E
I
Site 22
T349
K
P
R
V
P
P
A
T
A
F
E
G
H
M
L
Site 23
T369
P
F
R
I
G
P
Y
T
N
F
V
N
I
G
E
Site 24
Y395
K
L
I
M
A
G
N
Y
E
E
A
L
C
V
A
Site 25
S471
Q
G
K
C
I
V
N
S
I
S
L
K
E
G
E
Site 26
S473
K
C
I
V
N
S
I
S
L
K
E
G
E
D
D
Site 27
Y491
K
A
R
K
I
K
K
Y
G
A
A
M
V
V
M
Site 28
T507
F
D
E
E
G
Q
A
T
E
T
D
T
K
I
R
Site 29
T511
G
Q
A
T
E
T
D
T
K
I
R
V
C
T
R
Site 30
Y520
I
R
V
C
T
R
A
Y
H
L
L
V
K
K
L
Site 31
Y553
G
M
E
E
H
N
L
Y
A
I
N
F
I
H
A
Site 32
S578
A
R
I
S
G
G
L
S
N
L
S
F
S
F
R
Site 33
S581
S
G
G
L
S
N
L
S
F
S
F
R
G
M
E
Site 34
Y620
N
A
G
N
L
P
V
Y
D
D
I
H
K
E
L
Site 35
Y649
A
T
E
K
L
L
R
Y
A
Q
T
Q
G
T
G
Site 36
T663
G
G
K
K
V
I
Q
T
D
E
W
R
N
G
P
Site 37
Y677
P
V
E
E
R
L
E
Y
A
L
V
K
G
I
E
Site 38
T691
E
K
H
I
I
E
D
T
E
E
A
R
L
N
Q
Site 39
Y701
A
R
L
N
Q
K
K
Y
P
R
P
L
N
I
I
Site 40
T758
M
E
K
E
R
E
E
T
R
V
L
N
G
T
V
Site 41
T764
E
T
R
V
L
N
G
T
V
E
E
E
D
P
Y
Site 42
Y771
T
V
E
E
E
D
P
Y
Q
G
T
I
V
L
A
Site 43
T774
E
E
D
P
Y
Q
G
T
I
V
L
A
T
V
K
Site 44
S864
L
I
G
G
A
T
T
S
K
T
H
T
A
V
K
Site 45
T866
G
G
A
T
T
S
K
T
H
T
A
V
K
I
A
Site 46
T868
A
T
T
S
K
T
H
T
A
V
K
I
A
P
R
Site 47
Y905
D
E
N
L
K
D
E
Y
F
E
E
I
M
E
E
Site 48
Y913
F
E
E
I
M
E
E
Y
E
D
I
R
Q
D
H
Site 49
Y921
E
D
I
R
Q
D
H
Y
E
S
L
K
E
R
R
Site 50
S923
I
R
Q
D
H
Y
E
S
L
K
E
R
R
Y
L
Site 51
Y929
E
S
L
K
E
R
R
Y
L
P
L
S
Q
A
R
Site 52
S933
E
R
R
Y
L
P
L
S
Q
A
R
K
S
G
F
Site 53
S938
P
L
S
Q
A
R
K
S
G
F
Q
M
D
W
L
Site 54
T954
E
P
H
P
V
K
P
T
F
I
G
T
Q
V
F
Site 55
Y964
G
T
Q
V
F
E
D
Y
D
L
Q
K
L
V
D
Site 56
Y972
D
L
Q
K
L
V
D
Y
I
D
W
K
P
F
F
Site 57
Y988
V
W
Q
L
R
G
K
Y
P
N
R
G
F
P
K
Site 58
T1001
P
K
I
F
N
D
K
T
V
G
G
E
A
R
K
Site 59
Y1010
G
G
E
A
R
K
V
Y
D
D
A
H
N
M
L
Site 60
S1022
N
M
L
N
T
L
I
S
Q
K
K
L
R
A
R
Site 61
Y1047
I
Q
D
D
I
H
L
Y
A
E
A
A
V
P
Q
Site 62
T1061
Q
A
A
E
P
I
A
T
F
Y
G
L
R
Q
Q
Site 63
S1073
R
Q
Q
A
E
K
D
S
A
S
T
E
P
Y
Y
Site 64
S1075
Q
A
E
K
D
S
A
S
T
E
P
Y
Y
C
L
Site 65
Y1079
D
S
A
S
T
E
P
Y
Y
C
L
S
D
F
I
Site 66
Y1080
S
A
S
T
E
P
Y
Y
C
L
S
D
F
I
A
Site 67
S1111
C
F
G
V
E
E
L
S
K
A
Y
E
D
D
G
Site 68
Y1114
V
E
E
L
S
K
A
Y
E
D
D
G
D
D
Y
Site 69
Y1121
Y
E
D
D
G
D
D
Y
S
S
I
M
V
K
A
Site 70
S1122
E
D
D
G
D
D
Y
S
S
I
M
V
K
A
L
Site 71
S1123
D
D
G
D
D
Y
S
S
I
M
V
K
A
L
G
Site 72
Y1152
V
R
R
E
L
W
A
Y
C
G
S
E
Q
L
D
Site 73
S1155
E
L
W
A
Y
C
G
S
E
Q
L
D
V
A
D
Site 74
Y1168
A
D
L
R
R
L
R
Y
K
G
I
R
P
A
P
Site 75
Y1177
G
I
R
P
A
P
G
Y
P
S
Q
P
D
H
T
Site 76
S1179
R
P
A
P
G
Y
P
S
Q
P
D
H
T
E
K
Site 77
T1184
Y
P
S
Q
P
D
H
T
E
K
L
T
M
W
R
Site 78
T1204
Q
S
T
G
I
R
L
T
E
S
L
A
M
A
P
Site 79
S1206
T
G
I
R
L
T
E
S
L
A
M
A
P
A
S
Site 80
Y1219
A
S
A
V
S
G
L
Y
F
S
N
L
K
S
K
Site 81
S1221
A
V
S
G
L
Y
F
S
N
L
K
S
K
Y
F
Site 82
S1225
L
Y
F
S
N
L
K
S
K
Y
F
A
V
G
K
Site 83
Y1227
F
S
N
L
K
S
K
Y
F
A
V
G
K
I
S
Site 84
Y1241
S
K
D
Q
V
E
D
Y
A
L
R
K
N
I
S
Site 85
S1248
Y
A
L
R
K
N
I
S
V
A
E
V
E
K
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation