PhosphoNET

           
Protein Info 
   
Short Name:  Smad5
Full Name:  Mothers against decapentaplegic homolog 5
Alias:  Dwarfin-C; Dwfc; Dwf-C; JV5-1; MADH5; Mothers against decapentaplegic homolog 5: SMAD 5: hSmad5: JV5-1; Mothers against DPP homolog 5; MSMAD5; SMAD 5; SMAD family member 5
Type:  Transcription, coactivator/corepressor
Mass (Da):  52258
Number AA:  465
UniProt ID:  Q99717
International Prot ID:  IPI00017730
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005829  GO:0016021  GO:0005667 Uniprot OncoNet
Molecular Function:  GO:0005515  GO:0016563  GO:0003700 PhosphoSite+ KinaseNET
Biological Process:  GO:0030509  GO:0009880  GO:0006350 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T11MASLFSFTSPAVKRL
Site 2S57EELEKALSSPGQPSK
Site 3S58ELEKALSSPGQPSKC
Site 4S63LSSPGQPSKCVTIPR
Site 5T67GQPSKCVTIPRSLDG
Site 6S71KCVTIPRSLDGRLQV
Site 7S79LDGRLQVSHRKGLPH
Site 8Y89KGLPHVIYCRVWRWP
Site 9Y128VCINPYHYKRVESPV
Site 10S133YHYKRVESPVLPPVL
Site 11S161LVQFRNLSHNEPHMP
Site 12T183SFHQPNNTPFPLSPN
Site 13S188NNTPFPLSPNSPYPP
Site 14S191PFPLSPNSPYPPSPA
Site 15Y193PLSPNSPYPPSPASS
Site 16S196PNSPYPPSPASSTYP
Site 17S199PYPPSPASSTYPNSP
Site 18S200YPPSPASSTYPNSPA
Site 19T201PPSPASSTYPNSPAS
Site 20Y202PSPASSTYPNSPASS
Site 21S205ASSTYPNSPASSGPG
Site 22S208TYPNSPASSGPGSPF
Site 23S209YPNSPASSGPGSPFQ
Site 24S213PASSGPGSPFQLPAD
Site 25T221PFQLPADTPPPAYMP
Site 26Y226ADTPPPAYMPPDDQM
Site 27S238DQMGQDNSQPMDTSN
Site 28S254MIPQIMPSISSRDVQ
Site 29S256PQIMPSISSRDVQPV
Site 30S257QIMPSISSRDVQPVA
Site 31Y265RDVQPVAYEEPKHWC
Site 32T300SVLVDGFTDPSNNKS
Site 33S303VDGFTDPSNNKSRFC
Site 34S307TDPSNNKSRFCLGLL
Site 35S315RFCLGLLSNVNRNST
Site 36S321LSNVNRNSTIENTRR
Site 37T322SNVNRNSTIENTRRH
Site 38T326RNSTIENTRRHIGKG
Site 39S351YAECLSDSSIFVQSR
Site 40S352AECLSDSSIFVQSRN
Site 41T370HHGFHPTTVCKIPSS
Site 42Y404NHGFEAVYELTKMCT
Site 43Y424VKGWGAEYHRQDVTS
Site 44T430EYHRQDVTSTPCWIE
Site 45S431YHRQDVTSTPCWIEI
Site 46T452QWLDKVLTQMGSPLN
Site 47S456KVLTQMGSPLNPISS
Site 48S462GSPLNPISSVS____
Site 49S463 SPLNPISSVS_____
Site 50S465 LNPISSVS_______
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation