KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
NPAS2
Full Name:
Neuronal PAS domain-containing protein 2
Alias:
Basic-helix-loop-helix-PAS protein MOP4;Class E basic helix-loop-helix protein 9;Member of PAS protein 4;PAS domain-containing protein 4
Type:
Mass (Da):
91761
Number AA:
824
UniProt ID:
Q99743
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S13
K
D
R
A
K
R
A
S
R
N
K
S
E
K
K
Site 2
S17
K
R
A
S
R
N
K
S
E
K
K
R
R
D
Q
Site 3
T46
N
T
R
K
M
D
K
T
T
V
L
E
K
V
I
Site 4
T47
T
R
K
M
D
K
T
T
V
L
E
K
V
I
G
Site 5
S78
I
Q
Q
D
W
K
P
S
F
L
S
N
E
E
F
Site 6
S81
D
W
K
P
S
F
L
S
N
E
E
F
T
Q
L
Site 7
Y108
T
T
D
G
S
I
I
Y
V
S
D
S
I
T
P
Site 8
S122
P
L
L
G
H
L
P
S
D
V
M
D
Q
N
L
Site 9
S139
F
L
P
E
Q
E
H
S
E
V
Y
K
I
L
S
Site 10
Y142
E
Q
E
H
S
E
V
Y
K
I
L
S
S
H
M
Site 11
T152
L
S
S
H
M
L
V
T
D
S
P
S
P
E
Y
Site 12
S154
S
H
M
L
V
T
D
S
P
S
P
E
Y
L
K
Site 13
S156
M
L
V
T
D
S
P
S
P
E
Y
L
K
S
D
Site 14
Y159
T
D
S
P
S
P
E
Y
L
K
S
D
S
D
L
Site 15
S162
P
S
P
E
Y
L
K
S
D
S
D
L
E
F
Y
Site 16
S164
P
E
Y
L
K
S
D
S
D
L
E
F
Y
C
H
Site 17
Y169
S
D
S
D
L
E
F
Y
C
H
L
L
R
G
S
Site 18
S176
Y
C
H
L
L
R
G
S
L
N
P
K
E
F
P
Site 19
Y185
N
P
K
E
F
P
T
Y
E
Y
I
K
F
V
G
Site 20
Y187
K
E
F
P
T
Y
E
Y
I
K
F
V
G
N
F
Site 21
S196
K
F
V
G
N
F
R
S
Y
N
N
V
P
S
P
Site 22
Y197
F
V
G
N
F
R
S
Y
N
N
V
P
S
P
S
Site 23
S202
R
S
Y
N
N
V
P
S
P
S
C
N
G
F
D
Site 24
T211
S
C
N
G
F
D
N
T
L
S
R
P
C
R
V
Site 25
T252
D
E
P
L
E
E
F
T
S
R
H
S
L
E
W
Site 26
S253
E
P
L
E
E
F
T
S
R
H
S
L
E
W
K
Site 27
S256
E
E
F
T
S
R
H
S
L
E
W
K
F
L
F
Site 28
T282
L
P
F
E
V
L
G
T
S
G
Y
D
Y
Y
H
Site 29
Y285
E
V
L
G
T
S
G
Y
D
Y
Y
H
I
D
D
Site 30
Y287
L
G
T
S
G
Y
D
Y
Y
H
I
D
D
L
E
Site 31
Y288
G
T
S
G
Y
D
Y
Y
H
I
D
D
L
E
L
Site 32
Y353
C
T
H
S
V
V
S
Y
A
D
V
R
V
E
R
Site 33
S371
L
A
L
E
D
P
P
S
E
A
L
H
S
S
A
Site 34
S376
P
P
S
E
A
L
H
S
S
A
L
K
D
K
G
Site 35
S377
P
S
E
A
L
H
S
S
A
L
K
D
K
G
S
Site 36
S384
S
A
L
K
D
K
G
S
S
L
E
P
R
Q
H
Site 37
S385
A
L
K
D
K
G
S
S
L
E
P
R
Q
H
F
Site 38
S400
N
A
L
D
V
G
A
S
G
L
N
T
S
H
S
Site 39
T404
V
G
A
S
G
L
N
T
S
H
S
P
S
A
S
Site 40
S405
G
A
S
G
L
N
T
S
H
S
P
S
A
S
S
Site 41
S407
S
G
L
N
T
S
H
S
P
S
A
S
S
R
S
Site 42
S409
L
N
T
S
H
S
P
S
A
S
S
R
S
S
H
Site 43
S411
T
S
H
S
P
S
A
S
S
R
S
S
H
K
S
Site 44
S412
S
H
S
P
S
A
S
S
R
S
S
H
K
S
S
Site 45
S414
S
P
S
A
S
S
R
S
S
H
K
S
S
H
T
Site 46
S415
P
S
A
S
S
R
S
S
H
K
S
S
H
T
A
Site 47
S418
S
S
R
S
S
H
K
S
S
H
T
A
M
S
E
Site 48
S419
S
R
S
S
H
K
S
S
H
T
A
M
S
E
P
Site 49
T421
S
S
H
K
S
S
H
T
A
M
S
E
P
T
S
Site 50
S424
K
S
S
H
T
A
M
S
E
P
T
S
T
P
T
Site 51
S428
T
A
M
S
E
P
T
S
T
P
T
K
L
M
A
Site 52
T429
A
M
S
E
P
T
S
T
P
T
K
L
M
A
E
Site 53
S438
T
K
L
M
A
E
A
S
T
P
A
L
P
R
S
Site 54
T439
K
L
M
A
E
A
S
T
P
A
L
P
R
S
A
Site 55
S445
S
T
P
A
L
P
R
S
A
T
L
P
Q
E
L
Site 56
T447
P
A
L
P
R
S
A
T
L
P
Q
E
L
P
V
Site 57
S469
T
M
P
A
P
L
P
S
P
S
S
C
D
L
T
Site 58
S471
P
A
P
L
P
S
P
S
S
C
D
L
T
Q
Q
Site 59
S472
A
P
L
P
S
P
S
S
C
D
L
T
Q
Q
L
Site 60
T476
S
P
S
S
C
D
L
T
Q
Q
L
L
P
Q
T
Site 61
T483
T
Q
Q
L
L
P
Q
T
V
L
Q
S
T
P
A
Site 62
T488
P
Q
T
V
L
Q
S
T
P
A
P
M
A
Q
F
Site 63
S500
A
Q
F
S
A
Q
F
S
M
F
Q
T
I
K
D
Site 64
T504
A
Q
F
S
M
F
Q
T
I
K
D
Q
L
E
Q
Site 65
S552
F
L
Q
Q
P
A
V
S
L
S
F
S
S
T
Q
Site 66
S554
Q
Q
P
A
V
S
L
S
F
S
S
T
Q
R
P
Site 67
S556
P
A
V
S
L
S
F
S
S
T
Q
R
P
E
A
Site 68
T558
V
S
L
S
F
S
S
T
Q
R
P
E
A
Q
Q
Site 69
T575
Q
Q
R
S
A
A
V
T
Q
P
Q
L
G
A
G
Site 70
S590
P
Q
L
P
G
Q
I
S
S
A
Q
V
T
S
Q
Site 71
S591
Q
L
P
G
Q
I
S
S
A
Q
V
T
S
Q
H
Site 72
S603
S
Q
H
L
L
R
E
S
S
V
I
S
T
Q
G
Site 73
S604
Q
H
L
L
R
E
S
S
V
I
S
T
Q
G
P
Site 74
S607
L
R
E
S
S
V
I
S
T
Q
G
P
K
P
M
Site 75
T608
R
E
S
S
V
I
S
T
Q
G
P
K
P
M
R
Site 76
S616
Q
G
P
K
P
M
R
S
S
Q
L
M
Q
S
S
Site 77
S617
G
P
K
P
M
R
S
S
Q
L
M
Q
S
S
G
Site 78
S622
R
S
S
Q
L
M
Q
S
S
G
R
S
G
S
S
Site 79
S623
S
S
Q
L
M
Q
S
S
G
R
S
G
S
S
L
Site 80
S626
L
M
Q
S
S
G
R
S
G
S
S
L
V
S
P
Site 81
S628
Q
S
S
G
R
S
G
S
S
L
V
S
P
F
S
Site 82
S629
S
S
G
R
S
G
S
S
L
V
S
P
F
S
S
Site 83
S632
R
S
G
S
S
L
V
S
P
F
S
S
A
T
A
Site 84
T648
L
P
P
S
L
N
L
T
T
P
A
S
T
S
Q
Site 85
T649
P
P
S
L
N
L
T
T
P
A
S
T
S
Q
D
Site 86
S652
L
N
L
T
T
P
A
S
T
S
Q
D
A
S
Q
Site 87
S654
L
T
T
P
A
S
T
S
Q
D
A
S
Q
C
Q
Site 88
S658
A
S
T
S
Q
D
A
S
Q
C
Q
P
S
P
D
Site 89
S663
D
A
S
Q
C
Q
P
S
P
D
F
S
H
D
R
Site 90
S667
C
Q
P
S
P
D
F
S
H
D
R
Q
L
R
L
Site 91
S677
R
Q
L
R
L
L
L
S
Q
P
I
Q
P
M
M
Site 92
S687
I
Q
P
M
M
P
G
S
C
D
A
R
Q
P
S
Site 93
S694
S
C
D
A
R
Q
P
S
E
V
S
R
T
G
R
Site 94
T699
Q
P
S
E
V
S
R
T
G
R
Q
V
K
Y
A
Site 95
Y705
R
T
G
R
Q
V
K
Y
A
Q
S
Q
T
V
F
Site 96
S708
R
Q
V
K
Y
A
Q
S
Q
T
V
F
Q
N
P
Site 97
S722
P
D
A
H
P
A
N
S
S
S
A
P
M
P
V
Site 98
S740
G
Q
A
V
L
H
P
S
F
P
A
S
Q
P
S
Site 99
S744
L
H
P
S
F
P
A
S
Q
P
S
P
L
Q
P
Site 100
S747
S
F
P
A
S
Q
P
S
P
L
Q
P
A
Q
A
Site 101
Y762
R
Q
Q
P
P
Q
H
Y
L
Q
V
Q
A
P
T
Site 102
S770
L
Q
V
Q
A
P
T
S
L
H
S
E
Q
Q
D
Site 103
S778
L
H
S
E
Q
Q
D
S
L
L
L
S
T
Y
S
Site 104
S782
Q
Q
D
S
L
L
L
S
T
Y
S
Q
Q
P
G
Site 105
Y784
D
S
L
L
L
S
T
Y
S
Q
Q
P
G
T
L
Site 106
S785
S
L
L
L
S
T
Y
S
Q
Q
P
G
T
L
G
Site 107
Y793
Q
Q
P
G
T
L
G
Y
P
Q
P
P
P
A
Q
Site 108
S811
L
R
P
P
R
R
V
S
S
L
S
E
S
S
G
Site 109
S812
R
P
P
R
R
V
S
S
L
S
E
S
S
G
L
Site 110
S814
P
R
R
V
S
S
L
S
E
S
S
G
L
Q
Q
Site 111
S816
R
V
S
S
L
S
E
S
S
G
L
Q
Q
P
P
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation