PhosphoNET

           
Protein Info 
   
Short Name:  PIP5K1A
Full Name:  Phosphatidylinositol-4-phosphate 5-kinase type-1 alpha
Alias:  68 kDa type I phosphatidylinositol-4-phosphate 5-kinase alpha; EC 2.7.1.68; P-5-kinase alpha; Phosphatidylinositol-4-phosphate 5-kinase, type I, alpha; PI51A; PIP5KIalpha; PtdIns
Type:  Kinase, lipid; EC 2.7.1.68; Carbohydrate Metabolism - inositol phosphate
Mass (Da):  62633
Number AA:  562
UniProt ID:  Q99755
International Prot ID:  IPI00022150
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005795  GO:0012505  GO:0005886 Uniprot OncoNet
Molecular Function:  GO:0016308  GO:0005524   PhosphoSite+ KinaseNET
Biological Process:  GO:0046488  GO:0016310  GO:0007165 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S5___MASASSGPSSSV
Site 2S6__MASASSGPSSSVG
Site 3S9ASASSGPSSSVGFSS
Site 4S10SASSGPSSSVGFSSF
Site 5S11ASSGPSSSVGFSSFD
Site 6S15PSSSVGFSSFDPAVP
Site 7S16SSSVGFSSFDPAVPS
Site 8S48VLEARQDSYISLVPY
Site 9Y49LEARQDSYISLVPYA
Site 10S51ARQDSYISLVPYASG
Site 11Y55SYISLVPYASGMPIK
Site 12S68IKKIGHRSVDSSGET
Site 13S71IGHRSVDSSGETTYK
Site 14S72GHRSVDSSGETTYKK
Site 15T75SVDSSGETTYKKTTS
Site 16T76VDSSGETTYKKTTSS
Site 17Y77DSSGETTYKKTTSSA
Site 18T80GETTYKKTTSSALKG
Site 19S99GITHTVGSLSTKPER
Site 20S101THTVGSLSTKPERDV
Site 21S123VESIFFPSEGSNLTP
Site 22T129PSEGSNLTPAHHYND
Site 23T141YNDFRFKTYAPVAFR
Site 24Y142NDFRFKTYAPVAFRY
Site 25Y161FGIRPDDYLYSLCSE
Site 26Y163IRPDDYLYSLCSEPL
Site 27S164RPDDYLYSLCSEPLI
Site 28S181CSSGASGSLFYVSSD
Site 29Y184GASGSLFYVSSDDEF
Site 30T195DDEFIIKTVQHKEAE
Site 31Y211LQKLLPGYYMNLNQN
Site 32Y212QKLLPGYYMNLNQNP
Site 33T221NLNQNPRTLLPKFYG
Site 34Y258SVKMHIKYDLKGSTY
Site 35Y265YDLKGSTYKRRASQK
Site 36S270STYKRRASQKEREKP
Site 37T280EREKPLPTFKDLDFL
Site 38S341HAQREPLSSETQYSV
Site 39S342AQREPLSSETQYSVD
Site 40T344REPLSSETQYSVDTR
Site 41Y346PLSSETQYSVDTRRP
Site 42S347LSSETQYSVDTRRPA
Site 43T350ETQYSVDTRRPAPQK
Site 44Y360PAPQKALYSTAMESI
Site 45S361APQKALYSTAMESIQ
Site 46S366LYSTAMESIQGEARR
Site 47T376GEARRGGTMETDDHM
Site 48S391GGIPARNSKGERLLL
Site 49T428ALVHDGDTVSVHRPG
Site 50Y437SVHRPGFYAERFQRF
Site 51S458KKIPLKPSPSKKFRS
Site 52S460IPLKPSPSKKFRSGS
Site 53S465SPSKKFRSGSSFSRR
Site 54S467SKKFRSGSSFSRRAG
Site 55S468KKFRSGSSFSRRAGS
Site 56S470FRSGSSFSRRAGSSG
Site 57S475SFSRRAGSSGNSCIT
Site 58S476FSRRAGSSGNSCITY
Site 59S479RAGSSGNSCITYQPS
Site 60T482SSGNSCITYQPSVSG
Site 61Y483SGNSCITYQPSVSGE
Site 62S486SCITYQPSVSGEHKA
Site 63T516RPDVLPQTPPLEEIS
Site 64S523TPPLEEISEGSPIPD
Site 65S526LEEISEGSPIPDPSF
Site 66S532GSPIPDPSFSPLVGE
Site 67S534PIPDPSFSPLVGETL
Site 68T540FSPLVGETLQMLTTS
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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