KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
APBA2
Full Name:
Amyloid beta A4 precursor protein-binding family A member 2
Alias:
Adapter protein X11beta; Amyloid beta (A4) precursor protein-binding, family A, member 2; Amyloid beta A4 precursor protein-binding family A member 2; D15S1518E; HsT16821; LIN-10; MGC14091; MINT2; Mint-2; Neuronal Munc18-1-interacting protein 2; Neuron-specific X11L protein; X11L
Type:
Adapter/scaffold protein
Mass (Da):
82512
Number AA:
749
UniProt ID:
Q99767
International Prot ID:
IPI00017817
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007399
GO:0015031
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
A
H
R
K
L
E
S
V
G
S
G
M
L
D
Site 2
S11
R
K
L
E
S
V
G
S
G
M
L
D
H
R
V
Site 3
S26
R
P
G
P
V
P
H
S
Q
E
P
E
S
E
D
Site 4
S31
P
H
S
Q
E
P
E
S
E
D
M
E
L
P
L
Site 5
S55
L
A
A
L
R
P
E
S
P
A
P
E
E
Q
E
Site 6
S67
E
Q
E
C
H
N
H
S
P
D
G
D
S
S
S
Site 7
S72
N
H
S
P
D
G
D
S
S
S
D
Y
V
N
N
Site 8
S73
H
S
P
D
G
D
S
S
S
D
Y
V
N
N
T
Site 9
S74
S
P
D
G
D
S
S
S
D
Y
V
N
N
T
S
Site 10
Y76
D
G
D
S
S
S
D
Y
V
N
N
T
S
E
E
Site 11
Y86
N
T
S
E
E
E
D
Y
D
E
G
L
P
E
E
Site 12
T98
P
E
E
E
E
G
I
T
Y
Y
I
R
Y
C
P
Site 13
Y99
E
E
E
E
G
I
T
Y
Y
I
R
Y
C
P
E
Site 14
Y100
E
E
E
G
I
T
Y
Y
I
R
Y
C
P
E
D
Site 15
Y103
G
I
T
Y
Y
I
R
Y
C
P
E
D
D
S
Y
Site 16
Y110
Y
C
P
E
D
D
S
Y
L
E
G
M
D
C
N
Site 17
Y121
M
D
C
N
G
E
E
Y
L
A
H
S
A
H
P
Site 18
S144
A
V
E
E
W
T
D
S
A
G
P
H
P
H
G
Site 19
S157
H
G
H
E
A
E
G
S
Q
D
Y
P
D
G
Q
Site 20
Y160
E
A
E
G
S
Q
D
Y
P
D
G
Q
L
P
I
Site 21
S173
P
I
P
E
D
E
P
S
V
L
E
A
H
D
Q
Site 22
Y186
D
Q
E
E
D
G
H
Y
C
A
S
K
E
G
Y
Site 23
Y193
Y
C
A
S
K
E
G
Y
Q
D
Y
Y
P
E
E
Site 24
Y196
S
K
E
G
Y
Q
D
Y
Y
P
E
E
A
N
G
Site 25
Y197
K
E
G
Y
Q
D
Y
Y
P
E
E
A
N
G
N
Site 26
S208
A
N
G
N
T
G
A
S
P
Y
R
L
R
R
G
Site 27
S236
I
V
A
E
I
K
M
S
L
S
M
T
S
I
T
Site 28
S238
A
E
I
K
M
S
L
S
M
T
S
I
T
S
A
Site 29
S241
K
M
S
L
S
M
T
S
I
T
S
A
S
E
A
Site 30
S244
L
S
M
T
S
I
T
S
A
S
E
A
S
P
E
Site 31
S246
M
T
S
I
T
S
A
S
E
A
S
P
E
H
G
Site 32
S249
I
T
S
A
S
E
A
S
P
E
H
G
P
E
P
Site 33
S261
P
E
P
G
P
E
D
S
V
E
A
C
P
P
I
Site 34
S271
A
C
P
P
I
K
A
S
C
S
P
S
R
H
E
Site 35
S273
P
P
I
K
A
S
C
S
P
S
R
H
E
A
R
Site 36
S275
I
K
A
S
C
S
P
S
R
H
E
A
R
P
K
Site 37
S283
R
H
E
A
R
P
K
S
L
N
L
L
P
E
A
Site 38
T304
Q
R
G
F
K
P
K
T
R
T
P
E
E
R
L
Site 39
T306
G
F
K
P
K
T
R
T
P
E
E
R
L
K
W
Site 40
S331
Q
P
R
K
Q
Q
R
S
D
L
N
G
P
V
D
Site 41
S384
L
G
S
T
Q
L
L
S
E
R
N
P
S
K
N
Site 42
S389
L
L
S
E
R
N
P
S
K
N
I
R
M
M
Q
Site 43
T427
E
G
D
A
Q
T
L
T
E
V
D
L
F
I
S
Site 44
S458
D
H
A
L
R
T
I
S
Y
I
A
D
I
G
N
Site 45
S478
A
R
R
R
M
P
R
S
A
S
Q
D
C
I
E
Site 46
S480
R
R
M
P
R
S
A
S
Q
D
C
I
E
T
T
Site 47
T487
S
Q
D
C
I
E
T
T
P
G
A
Q
E
G
K
Site 48
S539
G
I
N
P
E
D
L
S
Q
K
E
Y
S
D
I
Site 49
Y543
E
D
L
S
Q
K
E
Y
S
D
I
I
N
T
Q
Site 50
Y553
I
I
N
T
Q
E
M
Y
N
D
D
L
I
H
F
Site 51
S563
D
L
I
H
F
S
N
S
E
N
C
K
E
L
Q
Site 52
S609
N
G
G
P
A
A
R
S
G
K
L
S
I
G
D
Site 53
S613
A
A
R
S
G
K
L
S
I
G
D
Q
I
M
S
Site 54
Y669
I
K
R
P
D
L
K
Y
Q
L
G
F
S
V
Q
Site 55
T711
N
G
Q
S
V
V
A
T
A
H
E
K
I
V
Q
Site 56
S721
E
K
I
V
Q
A
L
S
N
S
V
G
E
I
H
Site 57
T745
R
L
L
T
G
Q
E
T
P
L
Y
I
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation