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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ACO2
Full Name:
Aconitate hydratase, mitochondrial
Alias:
ACON; Aconitase; Aconitase 2; Aconitase 2, mitochondrial; Aconitate hydratase; Aconitate hydratase, mitochondrial; ACONM; Citrate hydro-lyase; EC 4.2.1.3
Type:
Carbohydrate Metabolism - citrate (TCA) cycle; Carbohydrate Metabolism - glyoxylate and dicarboxylate; Lyase; EC 4.2.1.3; Mitochondrial
Mass (Da):
85425
Number AA:
780
UniProt ID:
Q99798
International Prot ID:
IPI00017855
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005759
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0051539
GO:0003994
GO:0005506
PhosphoSite+
KinaseNET
Biological Process:
GO:0006101
GO:0006099
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y42
S
H
F
E
P
N
E
Y
I
H
Y
D
L
L
E
Site 2
Y45
E
P
N
E
Y
I
H
Y
D
L
L
E
K
N
I
Site 3
T64
K
R
L
N
R
P
L
T
L
S
E
K
I
V
Y
Site 4
S66
L
N
R
P
L
T
L
S
E
K
I
V
Y
G
H
Site 5
Y71
T
L
S
E
K
I
V
Y
G
H
L
D
D
P
A
Site 6
S79
G
H
L
D
D
P
A
S
Q
E
I
E
R
G
K
Site 7
S87
Q
E
I
E
R
G
K
S
Y
L
R
L
R
P
D
Site 8
Y88
E
I
E
R
G
K
S
Y
L
R
L
R
P
D
R
Site 9
Y151
K
D
I
N
Q
E
V
Y
N
F
L
A
T
A
G
Site 10
T191
P
G
V
L
L
I
G
T
D
S
H
T
P
N
G
Site 11
S193
V
L
L
I
G
T
D
S
H
T
P
N
G
G
G
Site 12
T195
L
I
G
T
D
S
H
T
P
N
G
G
G
L
G
Site 13
S237
I
G
V
K
L
T
G
S
L
S
G
W
S
S
P
Site 14
S239
V
K
L
T
G
S
L
S
G
W
S
S
P
K
D
Site 15
S243
G
S
L
S
G
W
S
S
P
K
D
V
I
L
K
Site 16
Y267
G
T
G
A
I
V
E
Y
H
G
P
G
V
D
S
Site 17
S274
Y
H
G
P
G
V
D
S
I
S
C
T
G
M
A
Site 18
S295
A
E
I
G
A
T
T
S
V
F
P
Y
N
H
R
Site 19
Y299
A
T
T
S
V
F
P
Y
N
H
R
M
K
K
Y
Site 20
Y306
Y
N
H
R
M
K
K
Y
L
S
K
T
G
R
E
Site 21
S308
H
R
M
K
K
Y
L
S
K
T
G
R
E
D
I
Site 22
T310
M
K
K
Y
L
S
K
T
G
R
E
D
I
A
N
Site 23
Y334
V
P
D
P
G
C
H
Y
D
Q
L
I
E
I
N
Site 24
S343
Q
L
I
E
I
N
L
S
E
L
K
P
H
I
N
Site 25
T354
P
H
I
N
G
P
F
T
P
D
L
A
H
P
V
Site 26
S384
I
R
V
G
L
I
G
S
C
T
N
S
S
Y
E
Site 27
T386
V
G
L
I
G
S
C
T
N
S
S
Y
E
D
M
Site 28
S388
L
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
Site 29
S389
I
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
Site 30
Y390
G
S
C
T
N
S
S
Y
E
D
M
G
R
S
A
Site 31
S412
A
H
G
L
K
C
K
S
Q
F
T
I
T
P
G
Site 32
T415
L
K
C
K
S
Q
F
T
I
T
P
G
S
E
Q
Site 33
T417
C
K
S
Q
F
T
I
T
P
G
S
E
Q
I
R
Site 34
S420
Q
F
T
I
T
P
G
S
E
Q
I
R
A
T
I
Site 35
T426
G
S
E
Q
I
R
A
T
I
E
R
D
G
Y
A
Site 36
Y432
A
T
I
E
R
D
G
Y
A
Q
I
L
R
D
L
Site 37
Y472
K
N
T
I
V
T
S
Y
N
R
N
F
T
G
R
Site 38
T477
T
S
Y
N
R
N
F
T
G
R
N
D
A
N
P
Site 39
T486
R
N
D
A
N
P
E
T
H
A
F
V
T
S
P
Site 40
Y513
K
F
N
P
E
T
D
Y
L
T
G
T
D
G
K
Site 41
T515
N
P
E
T
D
Y
L
T
G
T
D
G
K
K
F
Site 42
T543
E
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
Site 43
Y544
F
D
P
G
Q
D
T
Y
Q
H
P
P
K
D
S
Site 44
S551
Y
Q
H
P
P
K
D
S
S
G
Q
H
V
D
V
Site 45
S559
S
G
Q
H
V
D
V
S
P
T
S
Q
R
L
Q
Site 46
T561
Q
H
V
D
V
S
P
T
S
Q
R
L
Q
L
L
Site 47
S562
H
V
D
V
S
P
T
S
Q
R
L
Q
L
L
E
Site 48
T593
I
K
V
K
G
K
C
T
T
D
H
I
S
A
A
Site 49
T594
K
V
K
G
K
C
T
T
D
H
I
S
A
A
G
Site 50
S614
R
G
H
L
D
N
I
S
N
N
L
L
I
G
A
Site 51
S631
I
E
N
G
K
A
N
S
V
R
N
A
V
T
Q
Site 52
T646
E
F
G
P
V
P
D
T
A
R
Y
Y
K
K
H
Site 53
Y649
P
V
P
D
T
A
R
Y
Y
K
K
H
G
I
R
Site 54
Y650
V
P
D
T
A
R
Y
Y
K
K
H
G
I
R
W
Site 55
Y665
V
V
I
G
D
E
N
Y
G
E
G
S
S
R
E
Site 56
S669
D
E
N
Y
G
E
G
S
S
R
E
H
A
A
L
Site 57
S670
E
N
Y
G
E
G
S
S
R
E
H
A
A
L
E
Site 58
S690
G
R
A
I
I
T
K
S
F
A
R
I
H
E
T
Site 59
T708
K
Q
G
L
L
P
L
T
F
A
D
P
A
D
Y
Site 60
Y715
T
F
A
D
P
A
D
Y
N
K
I
H
P
V
D
Site 61
T725
I
H
P
V
D
K
L
T
I
Q
G
L
K
D
F
Site 62
T733
I
Q
G
L
K
D
F
T
P
G
K
P
L
K
C
Site 63
T757
E
T
I
L
L
N
H
T
F
N
E
T
Q
I
E
Site 64
S770
I
E
W
F
R
A
G
S
A
L
N
R
M
K
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation