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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PRRX2
Full Name:
Paired mesoderm homeobox protein 2
Alias:
Paired-related homeobox protein 2
Type:
Mass (Da):
27079
Number AA:
253
UniProt ID:
Q99811
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
A
Q
A
R
K
N
F
S
V
S
H
L
L
D
L
Site 2
S74
E
G
A
A
R
E
P
S
G
G
S
S
G
S
E
Site 3
S78
R
E
P
S
G
G
S
S
G
S
E
A
A
P
Q
Site 4
S80
P
S
G
G
S
S
G
S
E
A
A
P
Q
D
G
Site 5
S91
P
Q
D
G
E
C
P
S
P
G
R
G
S
A
A
Site 6
S96
C
P
S
P
G
R
G
S
A
A
K
R
K
K
K
Site 7
T109
K
K
Q
R
R
N
R
T
T
F
N
S
S
Q
L
Site 8
T110
K
Q
R
R
N
R
T
T
F
N
S
S
Q
L
Q
Site 9
S113
R
N
R
T
T
F
N
S
S
Q
L
Q
A
L
E
Site 10
S114
N
R
T
T
F
N
S
S
Q
L
Q
A
L
E
R
Site 11
T126
L
E
R
V
F
E
R
T
H
Y
P
D
A
F
V
Site 12
Y128
R
V
F
E
R
T
H
Y
P
D
A
F
V
R
E
Site 13
S144
L
A
R
R
V
N
L
S
E
A
R
V
Q
V
W
Site 14
S169
N
E
R
A
M
L
A
S
R
S
A
S
L
L
K
Site 15
S171
R
A
M
L
A
S
R
S
A
S
L
L
K
S
Y
Site 16
S173
M
L
A
S
R
S
A
S
L
L
K
S
Y
S
Q
Site 17
S177
R
S
A
S
L
L
K
S
Y
S
Q
E
A
A
I
Site 18
S179
A
S
L
L
K
S
Y
S
Q
E
A
A
I
E
Q
Site 19
T193
Q
P
V
A
P
R
P
T
A
L
S
P
D
Y
L
Site 20
S196
A
P
R
P
T
A
L
S
P
D
Y
L
S
W
T
Site 21
Y199
P
T
A
L
S
P
D
Y
L
S
W
T
A
S
S
Site 22
S201
A
L
S
P
D
Y
L
S
W
T
A
S
S
P
Y
Site 23
T203
S
P
D
Y
L
S
W
T
A
S
S
P
Y
S
T
Site 24
S205
D
Y
L
S
W
T
A
S
S
P
Y
S
T
V
P
Site 25
S206
Y
L
S
W
T
A
S
S
P
Y
S
T
V
P
P
Site 26
Y208
S
W
T
A
S
S
P
Y
S
T
V
P
P
Y
S
Site 27
S209
W
T
A
S
S
P
Y
S
T
V
P
P
Y
S
P
Site 28
T210
T
A
S
S
P
Y
S
T
V
P
P
Y
S
P
G
Site 29
Y214
P
Y
S
T
V
P
P
Y
S
P
G
S
S
G
P
Site 30
S215
Y
S
T
V
P
P
Y
S
P
G
S
S
G
P
A
Site 31
S218
V
P
P
Y
S
P
G
S
S
G
P
A
T
P
G
Site 32
S219
P
P
Y
S
P
G
S
S
G
P
A
T
P
G
V
Site 33
T223
P
G
S
S
G
P
A
T
P
G
V
N
M
A
N
Site 34
S234
N
M
A
N
S
I
A
S
L
R
L
K
A
K
E
Site 35
S243
R
L
K
A
K
E
F
S
L
H
H
S
Q
V
P
Site 36
S247
K
E
F
S
L
H
H
S
Q
V
P
T
V
N
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation