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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HIF2A
Full Name:
Endothelial PAS domain-containing protein 1
Alias:
Basic-helix-loop-helix-PAS protein MOP2; BHLHe73; Endothelial PAS domain protein 1; EPAS1; EPAS-1; HIF-1 alpha-like factor; HIF2 alpha; HIF-2 alpha; HLF; Hypoxia-inducible factor 2 alpha; Member of PAS protein 2; MOP2; PAS1; PASD2
Type:
Transcription protein
Mass (Da):
96459
Number AA:
870
UniProt ID:
Q99814
International Prot ID:
IPI00294084
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005667
Uniprot
OncoNet
Molecular Function:
GO:0003705
GO:0035035
GO:0046982
PhosphoSite+
KinaseNET
Biological Process:
GO:0001525
GO:0045944
GO:0001666
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S11
D
K
E
K
K
R
S
S
S
E
R
R
K
E
K
Site 2
S12
K
E
K
K
R
S
S
S
E
R
R
K
E
K
S
Site 3
S19
S
E
R
R
K
E
K
S
R
D
A
A
R
C
R
Site 4
S28
D
A
A
R
C
R
R
S
K
E
T
E
V
F
Y
Site 5
T31
R
C
R
R
S
K
E
T
E
V
F
Y
E
L
A
Site 6
S46
H
E
L
P
L
P
H
S
V
S
S
H
L
D
K
Site 7
S48
L
P
L
P
H
S
V
S
S
H
L
D
K
A
S
Site 8
S49
P
L
P
H
S
V
S
S
H
L
D
K
A
S
I
Site 9
S71
L
R
T
H
K
L
L
S
S
V
C
S
E
N
E
Site 10
S72
R
T
H
K
L
L
S
S
V
C
S
E
N
E
S
Site 11
S75
K
L
L
S
S
V
C
S
E
N
E
S
E
A
E
Site 12
S79
S
V
C
S
E
N
E
S
E
A
E
A
D
Q
Q
Site 13
Y91
D
Q
Q
M
D
N
L
Y
L
K
A
L
E
G
F
Site 14
S130
Q
V
E
L
T
G
H
S
I
F
D
F
T
H
P
Site 15
S148
E
E
I
R
E
N
L
S
L
K
N
G
S
G
F
Site 16
S159
G
S
G
F
G
K
K
S
K
D
M
S
T
E
R
Site 17
S163
G
K
K
S
K
D
M
S
T
E
R
D
F
F
M
Site 18
T164
K
K
S
K
D
M
S
T
E
R
D
F
F
M
R
Site 19
T177
M
R
M
K
C
T
V
T
N
R
G
R
T
V
N
Site 20
T182
T
V
T
N
R
G
R
T
V
N
L
K
S
A
T
Site 21
S187
G
R
T
V
N
L
K
S
A
T
W
K
V
L
H
Site 22
Y214
P
H
N
S
L
C
G
Y
K
E
P
L
L
S
C
Site 23
S241
H
M
D
I
P
L
D
S
K
T
F
L
S
R
H
Site 24
T243
D
I
P
L
D
S
K
T
F
L
S
R
H
S
M
Site 25
S246
L
D
S
K
T
F
L
S
R
H
S
M
D
M
K
Site 26
Y256
S
M
D
M
K
F
T
Y
C
D
D
R
I
T
E
Site 27
Y267
R
I
T
E
L
I
G
Y
H
P
E
E
L
L
G
Site 28
S276
P
E
E
L
L
G
R
S
A
Y
E
F
Y
H
A
Site 29
Y278
E
L
L
G
R
S
A
Y
E
F
Y
H
A
L
D
Site 30
T290
A
L
D
S
E
N
M
T
K
S
H
Q
N
L
C
Site 31
Y307
G
Q
V
V
S
G
Q
Y
R
M
L
A
K
H
G
Site 32
Y316
M
L
A
K
H
G
G
Y
V
W
L
E
T
Q
G
Site 33
T324
V
W
L
E
T
Q
G
T
V
I
Y
N
P
R
N
Site 34
Y327
E
T
Q
G
T
V
I
Y
N
P
R
N
L
Q
P
Site 35
T359
V
V
F
S
M
D
Q
T
E
S
L
F
K
P
H
Site 36
S361
F
S
M
D
Q
T
E
S
L
F
K
P
H
L
M
Site 37
S372
P
H
L
M
A
M
N
S
I
F
D
S
S
G
K
Site 38
S376
A
M
N
S
I
F
D
S
S
G
K
G
A
V
S
Site 39
S383
S
S
G
K
G
A
V
S
E
K
S
N
F
L
F
Site 40
S386
K
G
A
V
S
E
K
S
N
F
L
F
T
K
L
Site 41
S413
T
P
G
D
A
I
I
S
L
D
F
G
N
Q
N
Site 42
Y427
N
F
E
E
S
S
A
Y
G
K
A
I
L
P
P
Site 43
S435
G
K
A
I
L
P
P
S
Q
P
W
A
T
E
L
Site 44
T440
P
P
S
Q
P
W
A
T
E
L
R
S
H
S
T
Site 45
S444
P
W
A
T
E
L
R
S
H
S
T
Q
S
E
A
Site 46
S446
A
T
E
L
R
S
H
S
T
Q
S
E
A
G
S
Site 47
T447
T
E
L
R
S
H
S
T
Q
S
E
A
G
S
L
Site 48
S449
L
R
S
H
S
T
Q
S
E
A
G
S
L
P
A
Site 49
S453
S
T
Q
S
E
A
G
S
L
P
A
F
T
V
P
Site 50
S467
P
Q
A
A
A
P
G
S
T
T
P
S
A
T
S
Site 51
T469
A
A
A
P
G
S
T
T
P
S
A
T
S
S
S
Site 52
S471
A
P
G
S
T
T
P
S
A
T
S
S
S
S
S
Site 53
T473
G
S
T
T
P
S
A
T
S
S
S
S
S
C
S
Site 54
S474
S
T
T
P
S
A
T
S
S
S
S
S
C
S
T
Site 55
S475
T
T
P
S
A
T
S
S
S
S
S
C
S
T
P
Site 56
S476
T
P
S
A
T
S
S
S
S
S
C
S
T
P
N
Site 57
S477
P
S
A
T
S
S
S
S
S
C
S
T
P
N
S
Site 58
S478
S
A
T
S
S
S
S
S
C
S
T
P
N
S
P
Site 59
S480
T
S
S
S
S
S
C
S
T
P
N
S
P
E
D
Site 60
T481
S
S
S
S
S
C
S
T
P
N
S
P
E
D
Y
Site 61
S484
S
S
C
S
T
P
N
S
P
E
D
Y
Y
T
S
Site 62
Y488
T
P
N
S
P
E
D
Y
Y
T
S
L
D
N
D
Site 63
Y489
P
N
S
P
E
D
Y
Y
T
S
L
D
N
D
L
Site 64
T490
N
S
P
E
D
Y
Y
T
S
L
D
N
D
L
K
Site 65
S491
S
P
E
D
Y
Y
T
S
L
D
N
D
L
K
I
Site 66
T509
E
K
L
F
A
M
D
T
E
A
K
D
Q
C
S
Site 67
Y532
D
L
E
T
L
A
P
Y
I
P
M
D
G
E
D
Site 68
S543
D
G
E
D
F
Q
L
S
P
I
C
P
E
E
R
Site 69
S558
L
L
A
E
N
P
Q
S
T
P
Q
H
C
F
S
Site 70
T559
L
A
E
N
P
Q
S
T
P
Q
H
C
F
S
A
Site 71
T597
Q
Q
L
E
S
K
K
T
E
P
E
H
R
P
M
Site 72
S605
E
P
E
H
R
P
M
S
S
I
F
F
D
A
G
Site 73
S616
F
D
A
G
S
K
A
S
L
P
P
C
C
G
Q
Site 74
S625
P
P
C
C
G
Q
A
S
T
P
L
S
S
M
G
Site 75
T626
P
C
C
G
Q
A
S
T
P
L
S
S
M
G
G
Site 76
S629
G
Q
A
S
T
P
L
S
S
M
G
G
R
S
N
Site 77
S630
Q
A
S
T
P
L
S
S
M
G
G
R
S
N
T
Site 78
S635
L
S
S
M
G
G
R
S
N
T
Q
W
P
P
D
Site 79
T637
S
M
G
G
R
S
N
T
Q
W
P
P
D
P
P
Site 80
S677
P
V
S
P
P
H
V
S
T
F
K
T
R
S
A
Site 81
T678
V
S
P
P
H
V
S
T
F
K
T
R
S
A
K
Site 82
T681
P
H
V
S
T
F
K
T
R
S
A
K
G
F
G
Site 83
S683
V
S
T
F
K
T
R
S
A
K
G
F
G
A
R
Site 84
S703
S
P
A
M
V
A
L
S
N
K
L
K
L
K
R
Site 85
S723
E
Q
A
F
Q
D
L
S
G
G
D
P
P
G
G
Site 86
S731
G
G
D
P
P
G
G
S
T
S
H
L
M
W
K
Site 87
S733
D
P
P
G
G
S
T
S
H
L
M
W
K
R
M
Site 88
S747
M
K
N
L
R
G
G
S
C
P
L
M
P
D
K
Site 89
S757
L
M
P
D
K
P
L
S
A
N
V
P
N
D
K
Site 90
T766
N
V
P
N
D
K
F
T
Q
N
P
M
R
G
L
Site 91
S787
L
P
L
P
Q
P
P
S
A
I
S
P
G
E
N
Site 92
S790
P
Q
P
P
S
A
I
S
P
G
E
N
S
K
S
Site 93
S795
A
I
S
P
G
E
N
S
K
S
R
F
P
P
Q
Site 94
S797
S
P
G
E
N
S
K
S
R
F
P
P
Q
C
Y
Site 95
Y804
S
R
F
P
P
Q
C
Y
A
T
Q
Y
Q
D
Y
Site 96
Y808
P
Q
C
Y
A
T
Q
Y
Q
D
Y
S
L
S
S
Site 97
Y811
Y
A
T
Q
Y
Q
D
Y
S
L
S
S
A
H
K
Site 98
S812
A
T
Q
Y
Q
D
Y
S
L
S
S
A
H
K
V
Site 99
S814
Q
Y
Q
D
Y
S
L
S
S
A
H
K
V
S
G
Site 100
S824
H
K
V
S
G
M
A
S
R
L
L
G
P
S
F
Site 101
S830
A
S
R
L
L
G
P
S
F
E
S
Y
L
L
P
Site 102
Y834
L
G
P
S
F
E
S
Y
L
L
P
E
L
T
R
Site 103
T840
S
Y
L
L
P
E
L
T
R
Y
D
C
E
V
N
Site 104
Y842
L
L
P
E
L
T
R
Y
D
C
E
V
N
V
P
Site 105
S853
V
N
V
P
V
L
G
S
S
T
L
L
Q
G
G
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation