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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TSG101
Full Name:
Tumor susceptibility gene 101 protein
Alias:
TS101; TSG10; Tumor susceptibility gene 101; VPS23
Type:
Cell cycle regulation; Nuclear receptor co-regulator
Mass (Da):
43944
Number AA:
390
UniProt ID:
Q99816
International Prot ID:
IPI00018434
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005730
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0003676
GO:0003677
GO:0003712
PhosphoSite+
KinaseNET
Biological Process:
GO:0001558
GO:0006464
GO:0006508
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
A
V
S
E
S
Q
L
K
K
M
V
S
Site 2
S13
S
Q
L
K
K
M
V
S
K
Y
K
Y
R
D
L
Site 3
Y15
L
K
K
M
V
S
K
Y
K
Y
R
D
L
T
V
Site 4
Y17
K
M
V
S
K
Y
K
Y
R
D
L
T
V
R
E
Site 5
T21
K
Y
K
Y
R
D
L
T
V
R
E
T
V
N
V
Site 6
Y32
T
V
N
V
I
T
L
Y
K
D
L
K
P
V
L
Site 7
S41
D
L
K
P
V
L
D
S
Y
V
F
N
D
G
S
Site 8
Y42
L
K
P
V
L
D
S
Y
V
F
N
D
G
S
S
Site 9
S48
S
Y
V
F
N
D
G
S
S
R
E
L
M
N
L
Site 10
Y63
T
G
T
I
P
V
P
Y
R
G
N
T
Y
N
I
Site 11
T67
P
V
P
Y
R
G
N
T
Y
N
I
P
I
C
L
Site 12
Y68
V
P
Y
R
G
N
T
Y
N
I
P
I
C
L
W
Site 13
S94
C
F
V
K
P
T
S
S
M
T
I
K
T
G
K
Site 14
Y110
V
D
A
N
G
K
I
Y
L
P
Y
L
H
E
W
Site 15
Y113
N
G
K
I
Y
L
P
Y
L
H
E
W
K
H
P
Site 16
S122
H
E
W
K
H
P
Q
S
D
L
L
G
L
I
Q
Site 17
S143
G
D
E
P
P
V
F
S
R
P
I
S
A
S
Y
Site 18
S147
P
V
F
S
R
P
I
S
A
S
Y
P
P
Y
Q
Site 19
S149
F
S
R
P
I
S
A
S
Y
P
P
Y
Q
A
T
Site 20
Y150
S
R
P
I
S
A
S
Y
P
P
Y
Q
A
T
G
Site 21
Y153
I
S
A
S
Y
P
P
Y
Q
A
T
G
P
P
N
Site 22
T156
S
Y
P
P
Y
Q
A
T
G
P
P
N
T
S
Y
Site 23
S162
A
T
G
P
P
N
T
S
Y
M
P
G
M
P
G
Site 24
Y163
T
G
P
P
N
T
S
Y
M
P
G
M
P
G
G
Site 25
S172
P
G
M
P
G
G
I
S
P
Y
P
S
G
Y
P
Site 26
Y174
M
P
G
G
I
S
P
Y
P
S
G
Y
P
P
N
Site 27
S176
G
G
I
S
P
Y
P
S
G
Y
P
P
N
P
S
Site 28
Y178
I
S
P
Y
P
S
G
Y
P
P
N
P
S
G
Y
Site 29
S183
S
G
Y
P
P
N
P
S
G
Y
P
G
C
P
Y
Site 30
Y185
Y
P
P
N
P
S
G
Y
P
G
C
P
Y
P
P
Site 31
Y190
S
G
Y
P
G
C
P
Y
P
P
G
G
P
Y
P
Site 32
Y196
P
Y
P
P
G
G
P
Y
P
A
T
T
S
S
Q
Site 33
T199
P
G
G
P
Y
P
A
T
T
S
S
Q
Y
P
S
Site 34
T200
G
G
P
Y
P
A
T
T
S
S
Q
Y
P
S
Q
Site 35
S202
P
Y
P
A
T
T
S
S
Q
Y
P
S
Q
P
P
Site 36
Y204
P
A
T
T
S
S
Q
Y
P
S
Q
P
P
V
T
Site 37
S206
T
T
S
S
Q
Y
P
S
Q
P
P
V
T
T
V
Site 38
T211
Y
P
S
Q
P
P
V
T
T
V
G
P
S
R
D
Site 39
T212
P
S
Q
P
P
V
T
T
V
G
P
S
R
D
G
Site 40
T220
V
G
P
S
R
D
G
T
I
S
E
D
T
I
R
Site 41
S222
P
S
R
D
G
T
I
S
E
D
T
I
R
A
S
Site 42
T225
D
G
T
I
S
E
D
T
I
R
A
S
L
I
S
Site 43
S229
S
E
D
T
I
R
A
S
L
I
S
A
V
S
D
Site 44
S235
A
S
L
I
S
A
V
S
D
K
L
R
W
R
M
Site 45
T275
Q
K
L
E
E
M
V
T
R
L
D
Q
E
V
A
Site 46
S299
K
K
K
D
E
E
L
S
S
A
L
E
K
M
E
Site 47
S300
K
K
D
E
E
L
S
S
A
L
E
K
M
E
N
Site 48
T341
E
E
N
A
I
E
D
T
I
F
Y
L
G
E
A
Site 49
S367
L
K
H
V
R
L
L
S
R
K
Q
F
Q
L
R
Site 50
T383
L
M
Q
K
A
R
K
T
A
G
L
S
D
L
Y
Site 51
Y390
T
A
G
L
S
D
L
Y
_
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation