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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MYOC
Full Name:
Myocilin
Alias:
Trabecular meshwork-induced glucocorticoid response protein
Type:
Mass (Da):
56972
Number AA:
504
UniProt ID:
Q99972
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y49
D
Q
S
G
R
C
Q
Y
T
F
S
V
A
S
P
Site 2
T50
Q
S
G
R
C
Q
Y
T
F
S
V
A
S
P
N
Site 3
S52
G
R
C
Q
Y
T
F
S
V
A
S
P
N
E
S
Site 4
S55
Q
Y
T
F
S
V
A
S
P
N
E
S
S
C
P
Site 5
S59
S
V
A
S
P
N
E
S
S
C
P
E
Q
S
Q
Site 6
S60
V
A
S
P
N
E
S
S
C
P
E
Q
S
Q
A
Site 7
S65
E
S
S
C
P
E
Q
S
Q
A
M
S
V
I
H
Site 8
S69
P
E
Q
S
Q
A
M
S
V
I
H
N
L
Q
R
Site 9
S78
I
H
N
L
Q
R
D
S
S
T
Q
R
L
D
L
Site 10
S79
H
N
L
Q
R
D
S
S
T
Q
R
L
D
L
E
Site 11
T80
N
L
Q
R
D
S
S
T
Q
R
L
D
L
E
A
Site 12
T88
Q
R
L
D
L
E
A
T
K
A
R
L
S
S
L
Site 13
S93
E
A
T
K
A
R
L
S
S
L
E
S
L
L
H
Site 14
S94
A
T
K
A
R
L
S
S
L
E
S
L
L
H
Q
Site 15
T103
E
S
L
L
H
Q
L
T
L
D
Q
A
A
R
P
Site 16
T123
G
L
Q
R
E
L
G
T
L
R
R
E
R
D
Q
Site 17
T133
R
E
R
D
Q
L
E
T
Q
T
R
E
L
E
T
Site 18
S143
R
E
L
E
T
A
Y
S
N
L
L
R
D
K
S
Site 19
S150
S
N
L
L
R
D
K
S
V
L
E
E
E
K
K
Site 20
S172
N
L
A
R
R
L
E
S
S
S
Q
E
V
A
R
Site 21
S173
L
A
R
R
L
E
S
S
S
Q
E
V
A
R
L
Site 22
S174
A
R
R
L
E
S
S
S
Q
E
V
A
R
L
R
Site 23
T191
Q
C
P
Q
T
R
D
T
A
R
A
V
P
P
G
Site 24
S199
A
R
A
V
P
P
G
S
R
E
V
S
T
W
N
Site 25
S203
P
P
G
S
R
E
V
S
T
W
N
L
D
T
L
Site 26
T209
V
S
T
W
N
L
D
T
L
A
F
Q
E
L
K
Site 27
S217
L
A
F
Q
E
L
K
S
E
L
T
E
V
P
A
Site 28
T220
Q
E
L
K
S
E
L
T
E
V
P
A
S
R
I
Site 29
S225
E
L
T
E
V
P
A
S
R
I
L
K
E
S
P
Site 30
S231
A
S
R
I
L
K
E
S
P
S
G
Y
L
R
S
Site 31
S233
R
I
L
K
E
S
P
S
G
Y
L
R
S
G
E
Site 32
Y235
L
K
E
S
P
S
G
Y
L
R
S
G
E
G
D
Site 33
S238
S
P
S
G
Y
L
R
S
G
E
G
D
T
G
C
Site 34
T243
L
R
S
G
E
G
D
T
G
C
G
E
L
V
W
Site 35
Y278
M
R
D
P
K
P
T
Y
P
Y
T
Q
E
T
T
Site 36
T281
P
K
P
T
Y
P
Y
T
Q
E
T
T
W
R
I
Site 37
T290
E
T
T
W
R
I
D
T
V
G
T
D
V
R
Q
Site 38
Y301
D
V
R
Q
V
F
E
Y
D
L
I
S
Q
F
M
Site 39
Y335
V
V
Y
S
G
S
L
Y
F
Q
G
A
E
S
R
Site 40
Y347
E
S
R
T
V
I
R
Y
E
L
N
T
E
T
V
Site 41
T351
V
I
R
Y
E
L
N
T
E
T
V
K
A
E
K
Site 42
T353
R
Y
E
L
N
T
E
T
V
K
A
E
K
E
I
Site 43
Y365
K
E
I
P
G
A
G
Y
H
G
Q
F
P
Y
S
Site 44
Y371
G
Y
H
G
Q
F
P
Y
S
W
G
G
Y
T
D
Site 45
T416
E
N
L
E
L
E
Q
T
W
E
T
N
I
R
K
Site 46
S425
E
T
N
I
R
K
Q
S
V
A
N
A
F
I
I
Site 47
S441
G
T
L
Y
T
V
S
S
Y
T
S
A
D
A
T
Site 48
S444
Y
T
V
S
S
Y
T
S
A
D
A
T
V
N
F
Site 49
T448
S
Y
T
S
A
D
A
T
V
N
F
A
Y
D
T
Site 50
Y453
D
A
T
V
N
F
A
Y
D
T
G
T
G
I
S
Site 51
T462
T
G
T
G
I
S
K
T
L
T
I
P
F
K
N
Site 52
T464
T
G
I
S
K
T
L
T
I
P
F
K
N
R
Y
Site 53
Y471
T
I
P
F
K
N
R
Y
K
Y
S
S
M
I
D
Site 54
Y473
P
F
K
N
R
Y
K
Y
S
S
M
I
D
Y
N
Site 55
S475
K
N
R
Y
K
Y
S
S
M
I
D
Y
N
P
L
Site 56
Y479
K
Y
S
S
M
I
D
Y
N
P
L
E
K
K
L
Site 57
Y497
D
N
L
N
M
V
T
Y
D
I
K
L
S
K
M
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation