PhosphoNET

           
Protein Info 
   
Short Name:  VRK1
Full Name:  Serine/threonine-protein kinase VRK1
Alias:  EC 2.7.11.1; Serine/threonine protein kinase VRK1; vaccinia related kinase 1; Vaccinia-related kinase 1
Type:  EC 2.7.11.1; Protein kinase, Ser/Thr (non-receptor); CK1 group; TTBK family
Mass (Da):  45476
Number AA:  396
UniProt ID:  Q99986
International Prot ID:  IPI00019640
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:  GO:0005737  GO:0005730  GO:0043226 Uniprot OncoNet
Molecular Function:  GO:0005524  GO:0005515  GO:0004674 PhosphoSite+ KinaseNET
Biological Process:  GO:0006468  GO:0006468  GO:0006793 Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1S13AAQAGRQSSAKRHLA
Site 2S14AQAGRQSSAKRHLAE
Site 3S58IYLADMNSSESVGSD
Site 4S59YLADMNSSESVGSDA
Site 5S61ADMNSSESVGSDAPC
Site 6S64NSSESVGSDAPCVVK
Site 7Y87LFTELKFYQRAAKPE
Site 8Y107IRTRKLKYLGVPKYW
Site 9Y113KYLGVPKYWGSGLHD
Site 10S116GVPKYWGSGLHDKNG
Site 11S136MIMDRFGSDLQKIYE
Site 12Y142GSDLQKIYEANAKRF
Site 13S150EANAKRFSRKTVLQL
Site 14T153AKRFSRKTVLQLSLR
Site 15S158RKTVLQLSLRILDIL
Site 16Y167RILDILEYIHEHEYV
Site 17Y173EYIHEHEYVHGDIKA
Site 18Y187ASNLLLNYKNPDQVY
Site 19Y194YKNPDQVYLVDYGLA
Site 20Y198DQVYLVDYGLAYRYC
Site 21Y204DYGLAYRYCPEGVHK
Site 22T224PKRCHDGTIEFTSID
Site 23S229DGTIEFTSIDAHNGV
Site 24S239AHNGVAPSRRGDLEI
Site 25Y270DNLKDPKYVRDSKIR
Site 26S274DPKYVRDSKIRYREN
Site 27Y278VRDSKIRYRENIASL
Site 28S284RYRENIASLMDKCFP
Site 29Y302KPGEIAKYMETVKLL
Site 30T305EIAKYMETVKLLDYT
Site 31Y311ETVKLLDYTEKPLYE
Site 32T312TVKLLDYTEKPLYEN
Site 33Y317DYTEKPLYENLRDIL
Site 34S333QGLKAIGSKDDGKLD
Site 35S342DDGKLDLSVVENGGL
Site 36T353NGGLKAKTITKKRKK
Site 37T355GLKAKTITKKRKKEI
Site 38S365RKKEIEESKEPGVED
Site 39S376GVEDTEWSNTQTEEA
Site 40T378EDTEWSNTQTEEAIQ
Site 41T380TEWSNTQTEEAIQTR
Site 42T386QTEEAIQTRSRTRKR
Site 43S388EEAIQTRSRTRKRVQ
Site 44T390AIQTRSRTRKRVQK_
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


2019 Kinexus Bioinformatics Corporation