PhosphoNET

           
Protein Info 
   
Short Name:  GDF15
Full Name:  Growth/differentiation factor 15
Alias:  Macrophage inhibitory cytokine 1;NSAID-activated gene 1 protein;NSAID-regulated gene 1 protein;Placental TGF-beta;Placental bone morphogenetic protein;Prostate differentiation factor
Type: 
Mass (Da):  34154
Number AA:  308
UniProt ID:  Q99988
International Prot ID: 
Sequence:  Retrieve full protein sequence
   
GO Terms  External Links Internal Links  
   
Cellular Component:      Uniprot OncoNet
Molecular Function:      PhosphoSite+ KinaseNET
Biological Process:      Phosida TranscriptoNet
    STRING Kinexus Products
   
Info Box  A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites 
-7-6-5-4-3-2-101234567Expt. conf.EffectKinasePPaseKinexus ProductsRef.Evol.Kinase Pred.P-site Match
Site 1T8MPGQELRTVNGSQML
Site 2S39LAEASRASFPGPSEL
Site 3T48PGPSELHTEDSRFRE
Site 4S51SELHTEDSRFRELRK
Site 5Y60FRELRKRYEDLLTRL
Site 6T65KRYEDLLTRLRANQS
Site 7S72TRLRANQSWEDSNTD
Site 8S76ANQSWEDSNTDLVPA
Site 9T78QSWEDSNTDLVPAPA
Site 10S97TPEVRLGSGGHLHLR
Site 11S106GHLHLRISRAALPEG
Site 12S128HRALFRLSPTASRSW
Site 13T130ALFRLSPTASRSWDV
Site 14S132FRLSPTASRSWDVTR
Site 15S134LSPTASRSWDVTRPL
Site 16T138ASRSWDVTRPLRRQL
Site 17S146RPLRRQLSLARPQAP
Site 18S160PALHLRLSPPPSQSD
Site 19S164LRLSPPPSQSDQLLA
Site 20S166LSPPPSQSDQLLAES
Site 21S173SDQLLAESSSARPQL
Site 22S174DQLLAESSSARPQLE
Site 23S175QLLAESSSARPQLEL
Site 24T215GRCCRLHTVRASLED
Site 25S219RLHTVRASLEDLGWA
Site 26S231GWADWVLSPREVQVT
Site 27S260MHAQIKTSLHRLKPD
Site 28Y297TGVSLQTYDDLLAKD
 
Legend 
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available  
Products available
 


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