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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
AKAP9
Full Name:
A-kinase anchor protein 9
Alias:
AKAP 120-like protein; AKAP 350; AKAP 450; AKAP120-like protein; AKAP350; AKAP450; AKAP9-BRAF fusion protein; A-kinase (PRKA) anchor protein (yotiao) 9; A-kinase anchor protein 350 kDa; A-kinase anchor protein 450 kDa; A-kinase anchor protein, 350kDa; A-kinase anchoring protein 450; Centrosome- and Golgi-localized PKN-associated protein; Centrosome- and golgi-localized protein; CG-NAP; HgAKAP 350; HYPERION; Hyperion protein; KIAA0803; Kinase N-associated protein; MU-RMS-40.16A; PRKA9; Protein kinase A anchoring protein 9; YOTIAO; Yotiao protein
Type:
Adapter/scaffold protein
Mass (Da):
453667
Number AA:
3911
UniProt ID:
Q99996
International Prot ID:
IPI00019223
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005794
GO:0005813
GO:0005829
Uniprot
OncoNet
Molecular Function:
GO:0005102
PhosphoSite+
KinaseNET
Biological Process:
GO:0007165
GO:0007268
GO:0006810
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S39
F
R
Q
R
K
A
Q
S
D
G
Q
S
P
S
K
Site 2
S43
K
A
Q
S
D
G
Q
S
P
S
K
K
Q
K
K
Site 3
S45
Q
S
D
G
Q
S
P
S
K
K
Q
K
K
K
R
Site 4
T54
K
Q
K
K
K
R
K
T
S
S
S
K
H
D
V
Site 5
S55
Q
K
K
K
R
K
T
S
S
S
K
H
D
V
S
Site 6
S57
K
K
R
K
T
S
S
S
K
H
D
V
S
A
H
Site 7
S62
S
S
S
K
H
D
V
S
A
H
H
D
L
N
I
Site 8
Y78
Q
S
Q
C
N
E
M
Y
I
N
S
S
Q
R
V
Site 9
S82
N
E
M
Y
I
N
S
S
Q
R
V
E
S
T
V
Site 10
S87
N
S
S
Q
R
V
E
S
T
V
I
P
E
S
T
Site 11
T88
S
S
Q
R
V
E
S
T
V
I
P
E
S
T
I
Site 12
S93
E
S
T
V
I
P
E
S
T
I
M
R
T
L
H
Site 13
T94
S
T
V
I
P
E
S
T
I
M
R
T
L
H
S
Site 14
S101
T
I
M
R
T
L
H
S
G
E
I
T
S
H
E
Site 15
T105
T
L
H
S
G
E
I
T
S
H
E
Q
G
F
S
Site 16
S106
L
H
S
G
E
I
T
S
H
E
Q
G
F
S
V
Site 17
S112
T
S
H
E
Q
G
F
S
V
E
L
E
S
E
I
Site 18
S120
V
E
L
E
S
E
I
S
T
T
A
D
D
C
S
Site 19
T121
E
L
E
S
E
I
S
T
T
A
D
D
C
S
S
Site 20
T122
L
E
S
E
I
S
T
T
A
D
D
C
S
S
E
Site 21
S127
S
T
T
A
D
D
C
S
S
E
V
N
G
C
S
Site 22
S128
T
T
A
D
D
C
S
S
E
V
N
G
C
S
F
Site 23
S134
S
S
E
V
N
G
C
S
F
V
M
R
T
G
K
Site 24
S156
E
E
F
G
V
D
D
S
Y
S
E
Q
G
A
Q
Site 25
Y157
E
F
G
V
D
D
S
Y
S
E
Q
G
A
Q
D
Site 26
S158
F
G
V
D
D
S
Y
S
E
Q
G
A
Q
D
S
Site 27
S165
S
E
Q
G
A
Q
D
S
P
T
H
L
E
M
M
Site 28
T167
Q
G
A
Q
D
S
P
T
H
L
E
M
M
E
S
Site 29
S174
T
H
L
E
M
M
E
S
E
L
A
G
K
Q
H
Site 30
T196
E
L
E
E
M
R
V
T
Y
G
T
E
G
L
Q
Site 31
Y197
L
E
E
M
R
V
T
Y
G
T
E
G
L
Q
Q
Site 32
T199
E
M
R
V
T
Y
G
T
E
G
L
Q
Q
L
Q
Site 33
T220
K
Q
R
D
G
I
I
T
Q
L
T
A
N
L
Q
Site 34
T223
D
G
I
I
T
Q
L
T
A
N
L
Q
Q
A
R
Site 35
T236
A
R
R
E
K
D
E
T
M
R
E
F
L
E
L
Site 36
T262
Q
Q
L
Q
A
S
E
T
L
R
N
S
T
H
S
Site 37
S266
A
S
E
T
L
R
N
S
T
H
S
S
T
A
A
Site 38
T267
S
E
T
L
R
N
S
T
H
S
S
T
A
A
D
Site 39
S269
T
L
R
N
S
T
H
S
S
T
A
A
D
L
L
Site 40
S270
L
R
N
S
T
H
S
S
T
A
A
D
L
L
Q
Site 41
Y299
Q
D
H
L
L
E
D
Y
Q
K
K
K
E
D
F
Site 42
T307
Q
K
K
K
E
D
F
T
M
Q
I
S
F
L
Q
Site 43
S311
E
D
F
T
M
Q
I
S
F
L
Q
E
K
I
K
Site 44
Y320
L
Q
E
K
I
K
V
Y
E
M
E
Q
D
K
K
Site 45
T348
T
I
I
E
E
L
N
T
K
I
I
E
E
E
K
Site 46
T357
I
I
E
E
E
K
K
T
L
E
L
K
D
K
L
Site 47
T365
L
E
L
K
D
K
L
T
T
A
D
K
L
L
G
Site 48
T393
K
N
M
K
L
E
L
T
N
S
K
Q
K
E
R
Site 49
S395
M
K
L
E
L
T
N
S
K
Q
K
E
R
Q
S
Site 50
S402
S
K
Q
K
E
R
Q
S
S
E
E
I
K
Q
L
Site 51
S403
K
Q
K
E
R
Q
S
S
E
E
I
K
Q
L
M
Site 52
T412
E
I
K
Q
L
M
G
T
V
E
E
L
Q
K
R
Site 53
S424
Q
K
R
N
H
K
D
S
Q
F
E
T
D
I
V
Site 54
T428
H
K
D
S
Q
F
E
T
D
I
V
Q
R
M
E
Site 55
T438
V
Q
R
M
E
Q
E
T
Q
R
K
L
E
Q
L
Site 56
Y453
R
A
E
L
D
E
M
Y
G
Q
Q
I
V
Q
M
Site 57
T477
A
Q
M
E
E
M
K
T
R
H
K
G
E
M
E
Site 58
S489
E
M
E
N
A
L
R
S
Y
S
N
I
T
V
N
Site 59
Y490
M
E
N
A
L
R
S
Y
S
N
I
T
V
N
E
Site 60
S491
E
N
A
L
R
S
Y
S
N
I
T
V
N
E
D
Site 61
T494
L
R
S
Y
S
N
I
T
V
N
E
D
Q
I
K
Site 62
T517
L
N
I
K
L
Q
D
T
N
S
Q
K
E
K
L
Site 63
S519
I
K
L
Q
D
T
N
S
Q
K
E
K
L
K
E
Site 64
S550
E
D
L
V
E
E
L
S
F
S
R
E
Q
I
Q
Site 65
S552
L
V
E
E
L
S
F
S
R
E
Q
I
Q
R
A
Site 66
T562
Q
I
Q
R
A
R
Q
T
I
A
E
Q
E
S
K
Site 67
S576
K
L
N
E
A
H
K
S
L
S
T
V
E
D
L
Site 68
S589
D
L
K
A
E
I
V
S
A
S
E
S
R
K
E
Site 69
S591
K
A
E
I
V
S
A
S
E
S
R
K
E
L
E
Site 70
S593
E
I
V
S
A
S
E
S
R
K
E
L
E
L
K
Site 71
T606
L
K
H
E
A
E
V
T
N
Y
K
I
K
L
E
Site 72
Y608
H
E
A
E
V
T
N
Y
K
I
K
L
E
M
L
Site 73
S629
V
L
D
R
M
A
E
S
Q
E
A
E
L
E
R
Site 74
T639
A
E
L
E
R
L
R
T
Q
L
L
F
S
H
E
Site 75
S644
L
R
T
Q
L
L
F
S
H
E
E
E
L
S
K
Site 76
S650
F
S
H
E
E
E
L
S
K
L
K
E
D
L
E
Site 77
Y675
K
D
N
L
G
I
H
Y
K
Q
Q
I
D
G
L
Site 78
S687
D
G
L
Q
N
E
M
S
Q
K
I
E
T
M
Q
Site 79
S712
N
Q
L
I
L
E
I
S
K
L
K
D
L
Q
Q
Site 80
S720
K
L
K
D
L
Q
Q
S
L
V
N
S
K
S
E
Site 81
S724
L
Q
Q
S
L
V
N
S
K
S
E
E
M
T
L
Site 82
S726
Q
S
L
V
N
S
K
S
E
E
M
T
L
Q
I
Site 83
T730
N
S
K
S
E
E
M
T
L
Q
I
N
E
L
Q
Site 84
S790
A
Q
L
E
A
E
N
S
I
L
K
D
E
K
K
Site 85
T807
E
D
M
L
K
I
H
T
P
V
S
Q
E
E
R
Site 86
S810
L
K
I
H
T
P
V
S
Q
E
E
R
L
I
F
Site 87
S820
E
R
L
I
F
L
D
S
I
K
S
K
S
K
D
Site 88
S823
I
F
L
D
S
I
K
S
K
S
K
D
S
V
W
Site 89
S825
L
D
S
I
K
S
K
S
K
D
S
V
W
E
K
Site 90
S828
I
K
S
K
S
K
D
S
V
W
E
K
E
I
E
Site 91
T861
E
I
E
K
Q
R
N
T
F
S
F
A
E
K
N
Site 92
S863
E
K
Q
R
N
T
F
S
F
A
E
K
N
F
E
Site 93
Y873
E
K
N
F
E
V
N
Y
Q
E
L
Q
E
E
Y
Site 94
Y880
Y
Q
E
L
Q
E
E
Y
A
C
L
L
K
V
K
Site 95
S893
V
K
D
D
L
E
D
S
K
N
K
Q
E
L
E
Site 96
T921
L
Q
R
I
N
P
T
T
V
K
M
K
S
S
V
Site 97
S926
P
T
T
V
K
M
K
S
S
V
F
D
E
D
K
Site 98
T934
S
V
F
D
E
D
K
T
F
V
A
E
T
L
E
Site 99
T951
E
V
V
E
K
D
T
T
E
L
M
E
K
L
E
Site 100
T960
L
M
E
K
L
E
V
T
K
R
E
K
L
E
L
Site 101
S968
K
R
E
K
L
E
L
S
Q
R
L
S
D
L
S
Site 102
S972
L
E
L
S
Q
R
L
S
D
L
S
E
Q
L
K
Site 103
S975
S
Q
R
L
S
D
L
S
E
Q
L
K
Q
K
H
Site 104
S986
K
Q
K
H
G
E
I
S
F
L
N
E
E
V
K
Site 105
S994
F
L
N
E
E
V
K
S
L
K
Q
E
K
E
Q
Site 106
S1003
K
Q
E
K
E
Q
V
S
L
R
C
R
E
L
E
Site 107
T1026
E
N
V
Q
S
C
D
T
Q
V
S
S
L
L
D
Site 108
T1039
L
D
G
V
V
T
M
T
S
R
G
A
E
G
S
Site 109
S1040
D
G
V
V
T
M
T
S
R
G
A
E
G
S
V
Site 110
S1046
T
S
R
G
A
E
G
S
V
S
K
V
N
K
S
Site 111
S1048
R
G
A
E
G
S
V
S
K
V
N
K
S
F
G
Site 112
S1053
S
V
S
K
V
N
K
S
F
G
E
E
S
K
I
Site 113
T1072
K
V
S
F
E
N
M
T
V
G
E
E
S
K
Q
Site 114
T1091
L
D
H
L
P
S
V
T
K
E
S
S
L
R
A
Site 115
S1095
P
S
V
T
K
E
S
S
L
R
A
T
Q
P
S
Site 116
T1099
K
E
S
S
L
R
A
T
Q
P
S
E
N
D
K
Site 117
S1102
S
L
R
A
T
Q
P
S
E
N
D
K
L
Q
K
Site 118
S1116
K
E
L
N
V
L
K
S
E
Q
N
D
L
R
L
Site 119
Y1146
H
V
D
Q
V
R
E
Y
M
E
N
E
K
D
K
Site 120
S1157
E
K
D
K
A
L
C
S
L
K
E
E
L
I
F
Site 121
T1186
L
E
L
Q
T
M
K
T
Q
E
T
G
D
E
G
Site 122
S1208
G
K
L
Q
K
A
V
S
E
E
C
S
Y
F
L
Site 123
Y1225
L
C
S
V
L
G
E
Y
Y
T
P
A
L
K
C
Site 124
Y1226
C
S
V
L
G
E
Y
Y
T
P
A
L
K
C
E
Site 125
S1242
N
A
E
D
K
E
N
S
G
D
Y
I
S
E
N
Site 126
Y1245
D
K
E
N
S
G
D
Y
I
S
E
N
E
D
P
Site 127
S1247
E
N
S
G
D
Y
I
S
E
N
E
D
P
E
L
Site 128
Y1257
E
D
P
E
L
Q
D
Y
R
Y
E
V
Q
D
F
Site 129
Y1259
P
E
L
Q
D
Y
R
Y
E
V
Q
D
F
Q
E
Site 130
T1270
D
F
Q
E
N
M
H
T
L
L
N
K
V
T
E
Site 131
S1290
L
V
L
Q
T
R
L
S
K
I
W
G
Q
Q
T
Site 132
T1297
S
K
I
W
G
Q
Q
T
D
G
M
K
L
E
F
Site 133
T1314
E
N
L
P
K
E
E
T
E
F
L
S
I
H
S
Site 134
S1318
K
E
E
T
E
F
L
S
I
H
S
Q
M
T
N
Site 135
S1335
D
I
D
V
N
H
K
S
K
L
S
S
L
Q
D
Site 136
S1339
N
H
K
S
K
L
S
S
L
Q
D
L
E
K
T
Site 137
S1357
E
Q
V
Q
E
L
E
S
L
I
S
S
L
Q
Q
Site 138
S1360
Q
E
L
E
S
L
I
S
S
L
Q
Q
Q
L
K
Site 139
S1361
E
L
E
S
L
I
S
S
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S3160
E
L
Q
E
Q
L
S
S
E
K
M
V
V
A
E
Site 292
T3182
T
K
L
E
L
E
T
T
L
K
A
Q
H
K
H
Site 293
T3204
R
L
E
V
K
D
K
T
D
E
V
H
L
L
N
Site 294
T3213
E
V
H
L
L
N
D
T
L
A
S
E
Q
K
K
Site 295
S3221
L
A
S
E
Q
K
K
S
R
E
L
Q
W
A
L
Site 296
S3238
E
K
A
K
L
G
R
S
E
E
R
D
K
E
E
Site 297
S3277
Q
K
Q
L
L
N
E
S
Q
Q
K
I
E
S
Q
Site 298
S3283
E
S
Q
Q
K
I
E
S
Q
R
M
L
Y
D
A
Site 299
Y3288
I
E
S
Q
R
M
L
Y
D
A
Q
L
S
E
E
Site 300
S3317
K
V
R
I
R
E
M
S
S
T
L
D
R
E
R
Site 301
T3319
R
I
R
E
M
S
S
T
L
D
R
E
R
E
L
Site 302
T3336
Q
L
Q
S
S
D
G
T
G
Q
S
R
P
P
L
Site 303
S3339
S
S
D
G
T
G
Q
S
R
P
P
L
P
S
E
Site 304
S3345
Q
S
R
P
P
L
P
S
E
D
L
L
K
E
L
Site 305
S3361
K
Q
L
E
E
K
H
S
R
I
V
E
L
L
N
Site 306
Y3373
L
L
N
E
T
E
K
Y
K
L
D
S
L
Q
T
Site 307
S3377
T
E
K
Y
K
L
D
S
L
Q
T
R
Q
Q
M
Site 308
T3394
D
R
Q
V
H
R
K
T
L
Q
T
E
Q
E
A
Site 309
T3397
V
H
R
K
T
L
Q
T
E
Q
E
A
N
T
E
Site 310
S3460
E
R
E
E
K
R
E
S
R
R
I
L
Y
Q
N
Site 311
Y3465
R
E
S
R
R
I
L
Y
Q
N
L
N
E
P
T
Site 312
T3473
Q
N
L
N
E
P
T
T
W
S
L
T
S
D
R
Site 313
S3475
L
N
E
P
T
T
W
S
L
T
S
D
R
T
R
Site 314
T3477
E
P
T
T
W
S
L
T
S
D
R
T
R
N
W
Site 315
S3478
P
T
T
W
S
L
T
S
D
R
T
R
N
W
V
Site 316
S3497
I
E
G
E
T
K
E
S
N
Y
A
K
L
I
E
Site 317
Y3499
G
E
T
K
E
S
N
Y
A
K
L
I
E
M
N
Site 318
S3528
Q
K
L
Q
C
V
A
S
K
L
Q
V
L
P
Q
Site 319
S3538
Q
V
L
P
Q
K
A
S
E
R
L
Q
F
E
T
Site 320
T3545
S
E
R
L
Q
F
E
T
A
D
D
E
D
F
I
Site 321
S3577
G
Q
Q
G
E
E
P
S
L
V
S
P
S
T
S
Site 322
S3580
G
E
E
P
S
L
V
S
P
S
T
S
C
G
S
Site 323
S3582
E
P
S
L
V
S
P
S
T
S
C
G
S
L
T
Site 324
T3583
P
S
L
V
S
P
S
T
S
C
G
S
L
T
E
Site 325
S3584
S
L
V
S
P
S
T
S
C
G
S
L
T
E
R
Site 326
S3587
S
P
S
T
S
C
G
S
L
T
E
R
L
L
R
Site 327
T3589
S
T
S
C
G
S
L
T
E
R
L
L
R
Q
N
Site 328
T3600
L
R
Q
N
A
E
L
T
G
H
I
S
Q
L
T
Site 329
S3604
A
E
L
T
G
H
I
S
Q
L
T
E
E
K
N
Site 330
T3607
T
G
H
I
S
Q
L
T
E
E
K
N
D
L
R
Site 331
Y3627
L
E
E
Q
I
R
W
Y
R
Q
T
G
A
G
R
Site 332
T3630
Q
I
R
W
Y
R
Q
T
G
A
G
R
D
N
S
Site 333
S3637
T
G
A
G
R
D
N
S
S
R
F
S
L
N
G
Site 334
S3638
G
A
G
R
D
N
S
S
R
F
S
L
N
G
G
Site 335
S3641
R
D
N
S
S
R
F
S
L
N
G
G
A
N
I
Site 336
T3665
V
W
N
R
E
K
L
T
L
Q
K
S
L
K
R
Site 337
S3669
E
K
L
T
L
Q
K
S
L
K
R
A
E
A
E
Site 338
Y3678
K
R
A
E
A
E
V
Y
K
L
K
A
E
L
R
Site 339
S3688
K
A
E
L
R
N
D
S
L
L
Q
T
L
S
P
Site 340
T3692
R
N
D
S
L
L
Q
T
L
S
P
D
S
E
H
Site 341
S3694
D
S
L
L
Q
T
L
S
P
D
S
E
H
V
T
Site 342
S3697
L
Q
T
L
S
P
D
S
E
H
V
T
L
K
R
Site 343
T3701
S
P
D
S
E
H
V
T
L
K
R
I
Y
G
K
Site 344
Y3706
H
V
T
L
K
R
I
Y
G
K
Y
L
R
A
E
Site 345
Y3709
L
K
R
I
Y
G
K
Y
L
R
A
E
S
F
R
Site 346
S3714
G
K
Y
L
R
A
E
S
F
R
K
A
L
I
Y
Site 347
Y3721
S
F
R
K
A
L
I
Y
Q
K
K
Y
L
L
L
Site 348
T3760
F
T
D
L
E
V
I
T
N
R
P
K
G
F
T
Site 349
T3767
T
N
R
P
K
G
F
T
R
F
R
S
A
V
R
Site 350
S3771
K
G
F
T
R
F
R
S
A
V
R
V
S
I
A
Site 351
T3793
V
R
R
W
H
R
V
T
G
S
V
S
I
N
I
Site 352
S3795
R
W
H
R
V
T
G
S
V
S
I
N
I
N
R
Site 353
T3814
L
N
Q
G
A
E
K
T
D
S
F
Y
H
S
S
Site 354
S3816
Q
G
A
E
K
T
D
S
F
Y
H
S
S
G
G
Site 355
Y3818
A
E
K
T
D
S
F
Y
H
S
S
G
G
L
E
Site 356
S3820
K
T
D
S
F
Y
H
S
S
G
G
L
E
L
Y
Site 357
Y3827
S
S
G
G
L
E
L
Y
G
E
P
R
H
T
T
Site 358
T3833
L
Y
G
E
P
R
H
T
T
Y
R
S
R
S
D
Site 359
T3834
Y
G
E
P
R
H
T
T
Y
R
S
R
S
D
L
Site 360
Y3835
G
E
P
R
H
T
T
Y
R
S
R
S
D
L
D
Site 361
S3837
P
R
H
T
T
Y
R
S
R
S
D
L
D
Y
I
Site 362
S3839
H
T
T
Y
R
S
R
S
D
L
D
Y
I
R
S
Site 363
Y3843
R
S
R
S
D
L
D
Y
I
R
S
P
L
P
F
Site 364
S3846
S
D
L
D
Y
I
R
S
P
L
P
F
Q
N
R
Site 365
Y3854
P
L
P
F
Q
N
R
Y
P
G
T
P
A
D
F
Site 366
T3857
F
Q
N
R
Y
P
G
T
P
A
D
F
N
P
G
Site 367
S3865
P
A
D
F
N
P
G
S
L
A
C
S
Q
L
Q
Site 368
S3869
N
P
G
S
L
A
C
S
Q
L
Q
N
Y
D
P
Site 369
Y3874
A
C
S
Q
L
Q
N
Y
D
P
D
R
A
L
T
Site 370
T3881
Y
D
P
D
R
A
L
T
D
Y
I
T
R
L
E
Site 371
Y3883
P
D
R
A
L
T
D
Y
I
T
R
L
E
A
L
Site 372
T3885
R
A
L
T
D
Y
I
T
R
L
E
A
L
Q
R
Site 373
T3896
A
L
Q
R
R
L
G
T
I
Q
S
G
S
T
T
Site 374
S3899
R
R
L
G
T
I
Q
S
G
S
T
T
Q
F
H
Site 375
S3901
L
G
T
I
Q
S
G
S
T
T
Q
F
H
A
G
Site 376
T3903
T
I
Q
S
G
S
T
T
Q
F
H
A
G
M
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation