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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX50
Full Name:
ATP-dependent RNA helicase DDX50
Alias:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 50; DEAD box protein 50; GU2; GUB; MGC3199; RH-II/GuB
Type:
Helicase; EC 3.6.1.-
Mass (Da):
82565
Number AA:
737
UniProt ID:
Q9BQ39
International Prot ID:
IPI00031554
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005730
GO:0043226
GO:0043227
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0008026
GO:0003723
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S22
A
P
L
E
E
S
E
S
Q
K
K
E
R
Q
K
Site 2
S30
Q
K
K
E
R
Q
K
S
D
R
R
K
S
R
H
Site 3
S35
Q
K
S
D
R
R
K
S
R
H
H
Y
D
S
D
Site 4
Y39
R
R
K
S
R
H
H
Y
D
S
D
E
K
S
E
Site 5
S41
K
S
R
H
H
Y
D
S
D
E
K
S
E
T
R
Site 6
S45
H
Y
D
S
D
E
K
S
E
T
R
E
N
G
V
Site 7
T47
D
S
D
E
K
S
E
T
R
E
N
G
V
T
D
Site 8
T53
E
T
R
E
N
G
V
T
D
D
L
D
A
P
K
Site 9
S64
D
A
P
K
A
K
K
S
K
M
K
E
K
L
N
Site 10
T74
K
E
K
L
N
G
D
T
E
E
G
F
N
R
L
Site 11
S82
E
E
G
F
N
R
L
S
D
E
F
S
K
S
H
Site 12
S86
N
R
L
S
D
E
F
S
K
S
H
K
S
R
R
Site 13
S88
L
S
D
E
F
S
K
S
H
K
S
R
R
K
D
Site 14
S91
E
F
S
K
S
H
K
S
R
R
K
D
L
P
N
Site 15
Y104
P
N
G
D
I
D
E
Y
E
K
K
S
K
R
V
Site 16
S108
I
D
E
Y
E
K
K
S
K
R
V
S
S
L
D
Site 17
S112
E
K
K
S
K
R
V
S
S
L
D
T
S
T
H
Site 18
S113
K
K
S
K
R
V
S
S
L
D
T
S
T
H
K
Site 19
T116
K
R
V
S
S
L
D
T
S
T
H
K
S
S
D
Site 20
S117
R
V
S
S
L
D
T
S
T
H
K
S
S
D
N
Site 21
T118
V
S
S
L
D
T
S
T
H
K
S
S
D
N
K
Site 22
S121
L
D
T
S
T
H
K
S
S
D
N
K
L
E
E
Site 23
T129
S
D
N
K
L
E
E
T
L
T
R
E
Q
K
E
Site 24
T131
N
K
L
E
E
T
L
T
R
E
Q
K
E
G
A
Site 25
S140
E
Q
K
E
G
A
F
S
N
F
P
I
S
E
E
Site 26
T185
I
A
Q
A
R
T
G
T
G
K
T
F
S
F
A
Site 27
T188
A
R
T
G
T
G
K
T
F
S
F
A
I
P
L
Site 28
T205
R
L
Q
R
N
Q
E
T
I
K
K
S
R
S
P
Site 29
S209
N
Q
E
T
I
K
K
S
R
S
P
K
V
L
V
Site 30
S211
E
T
I
K
K
S
R
S
P
K
V
L
V
L
A
Site 31
T235
A
K
D
F
K
D
I
T
R
K
L
S
V
A
C
Site 32
S239
K
D
I
T
R
K
L
S
V
A
C
F
Y
G
G
Site 33
Y249
C
F
Y
G
G
T
S
Y
Q
S
Q
I
N
H
I
Site 34
T266
G
I
D
I
L
V
G
T
P
G
R
I
K
D
H
Site 35
S276
R
I
K
D
H
L
Q
S
G
R
L
D
L
S
K
Site 36
S282
Q
S
G
R
L
D
L
S
K
L
R
H
V
V
L
Site 37
S311
V
E
D
I
I
H
E
S
Y
K
T
D
S
E
D
Site 38
Y312
E
D
I
I
H
E
S
Y
K
T
D
S
E
D
N
Site 39
T314
I
I
H
E
S
Y
K
T
D
S
E
D
N
P
Q
Site 40
T322
D
S
E
D
N
P
Q
T
L
L
F
S
A
T
C
Site 41
Y340
V
Y
K
V
A
K
K
Y
M
K
S
R
Y
E
Q
Site 42
S343
V
A
K
K
Y
M
K
S
R
Y
E
Q
V
D
L
Site 43
Y345
K
K
Y
M
K
S
R
Y
E
Q
V
D
L
V
G
Site 44
Y385
I
G
D
V
L
Q
V
Y
S
G
S
E
G
R
A
Site 45
S425
L
H
G
D
I
A
Q
S
Q
R
E
I
T
L
K
Site 46
T430
A
Q
S
Q
R
E
I
T
L
K
G
F
R
E
G
Site 47
S464
V
D
L
V
I
Q
S
S
P
P
Q
D
V
E
S
Site 48
S471
S
P
P
Q
D
V
E
S
Y
I
H
R
S
G
R
Site 49
Y472
P
P
Q
D
V
E
S
Y
I
H
R
S
G
R
T
Site 50
S476
V
E
S
Y
I
H
R
S
G
R
T
G
R
A
G
Site 51
Y492
T
G
I
C
I
C
F
Y
Q
P
R
E
R
G
Q
Site 52
Y502
R
E
R
G
Q
L
R
Y
V
E
Q
K
A
G
I
Site 53
T510
V
E
Q
K
A
G
I
T
F
K
R
V
G
V
P
Site 54
S518
F
K
R
V
G
V
P
S
T
M
D
L
V
K
S
Site 55
T519
K
R
V
G
V
P
S
T
M
D
L
V
K
S
K
Site 56
S525
S
T
M
D
L
V
K
S
K
S
M
D
A
I
R
Site 57
S527
M
D
L
V
K
S
K
S
M
D
A
I
R
S
L
Site 58
S533
K
S
M
D
A
I
R
S
L
A
S
V
S
Y
A
Site 59
S548
A
V
D
F
F
R
P
S
A
Q
R
L
I
E
E
Site 60
S574
A
H
I
S
G
A
S
S
F
E
P
R
S
L
I
Site 61
S579
A
S
S
F
E
P
R
S
L
I
T
S
D
K
G
Site 62
T582
F
E
P
R
S
L
I
T
S
D
K
G
F
V
T
Site 63
S583
E
P
R
S
L
I
T
S
D
K
G
F
V
T
M
Site 64
T591
D
K
G
F
V
T
M
T
L
E
S
L
E
E
I
Site 65
S602
L
E
E
I
Q
D
V
S
C
A
W
K
E
L
N
Site 66
S613
K
E
L
N
R
K
L
S
S
N
A
V
S
Q
I
Site 67
S614
E
L
N
R
K
L
S
S
N
A
V
S
Q
I
T
Site 68
T638
G
V
C
F
D
V
P
T
T
E
S
E
R
L
Q
Site 69
T639
V
C
F
D
V
P
T
T
E
S
E
R
L
Q
A
Site 70
S641
F
D
V
P
T
T
E
S
E
R
L
Q
A
E
W
Site 71
S656
H
D
S
D
W
I
L
S
V
P
A
K
L
P
E
Site 72
Y667
K
L
P
E
I
E
E
Y
Y
D
G
N
T
S
S
Site 73
Y668
L
P
E
I
E
E
Y
Y
D
G
N
T
S
S
N
Site 74
T672
E
E
Y
Y
D
G
N
T
S
S
N
S
R
Q
R
Site 75
S674
Y
Y
D
G
N
T
S
S
N
S
R
Q
R
S
G
Site 76
S676
D
G
N
T
S
S
N
S
R
Q
R
S
G
W
S
Site 77
S680
S
S
N
S
R
Q
R
S
G
W
S
S
G
R
S
Site 78
S683
S
R
Q
R
S
G
W
S
S
G
R
S
G
R
S
Site 79
S684
R
Q
R
S
G
W
S
S
G
R
S
G
R
S
G
Site 80
S687
S
G
W
S
S
G
R
S
G
R
S
G
R
S
G
Site 81
S690
S
S
G
R
S
G
R
S
G
R
S
G
G
R
S
Site 82
S693
R
S
G
R
S
G
R
S
G
G
R
S
G
G
R
Site 83
S697
S
G
R
S
G
G
R
S
G
G
R
S
G
R
Q
Site 84
S701
G
G
R
S
G
G
R
S
G
R
Q
S
R
Q
G
Site 85
S705
G
G
R
S
G
R
Q
S
R
Q
G
S
R
S
G
Site 86
S709
G
R
Q
S
R
Q
G
S
R
S
G
S
R
Q
D
Site 87
S711
Q
S
R
Q
G
S
R
S
G
S
R
Q
D
G
R
Site 88
S713
R
Q
G
S
R
S
G
S
R
Q
D
G
R
R
R
Site 89
S721
R
Q
D
G
R
R
R
S
G
N
R
N
R
S
R
Site 90
S727
R
S
G
N
R
N
R
S
R
S
G
G
H
K
R
Site 91
S729
G
N
R
N
R
S
R
S
G
G
H
K
R
S
F
Site 92
S735
R
S
G
G
H
K
R
S
F
D
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation