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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ELAC2
Full Name:
Zinc phosphodiesterase ELAC protein 2
Alias:
ElaC (E. coli) homolog 2; ElaC 2; ElaC homolog 2; ElaC homolog 2 (E. coli); ElaC homolog protein 2; ELC2; FLJ10530; Hereditary prostate cancer; Heredity prostate cancer 2; Heredity prostate cancer protein 2; HPC2; Prostate cancer susceptibility protein; Ribonuclease Z 2; RNase Z 2; RNZ2; TRNA 3 endonuclease 2; TRNase Z (long form); TRNase Z 2; Zinc phosphodiesterase ELAC 2; Zinc phosphodiesterase ELAC protein 2: Ribonuclease Z 2: tRNase Z 2: tRNA 3 endonuclease 2: ElaC homolog protein 2: Heredity prostate cancer protein 2: Putative prostate cancer susceptibility protein HPC2/ELAC2: Zinc phosphodiesterase ELAC protein 2: Ribonuclease Z 2: tRNase Z 2: tRNA 3 endonuclease 2: ElaC homolog protein 2: Heredity prostate cancer protein 2
Type:
EC 3.1.26.11; Phosphodiesterase; Ribonuclease; RNA processing
Mass (Da):
92219
Number AA:
826
UniProt ID:
Q9BQ52
International Prot ID:
IPI00396627
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0004519
GO:0005515
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
GO:0008033
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S17
S
A
A
G
R
T
M
S
Q
G
R
T
I
S
Q
Site 2
T21
R
T
M
S
Q
G
R
T
I
S
Q
A
P
A
R
Site 3
S23
M
S
Q
G
R
T
I
S
Q
A
P
A
R
R
E
Site 4
T42
D
P
L
R
H
L
R
T
R
E
K
R
G
P
S
Site 5
S49
T
R
E
K
R
G
P
S
G
C
S
G
G
P
N
Site 6
Y75
R
D
S
G
A
A
L
Y
V
F
S
E
F
N
R
Site 7
Y83
V
F
S
E
F
N
R
Y
L
F
N
C
G
E
G
Site 8
S139
G
L
P
K
C
V
L
S
G
P
P
Q
L
E
K
Site 9
Y147
G
P
P
Q
L
E
K
Y
L
E
A
I
K
I
F
Site 10
S169
E
L
A
V
R
P
H
S
A
P
E
Y
E
D
E
Site 11
Y173
R
P
H
S
A
P
E
Y
E
D
E
T
M
T
V
Site 12
T177
A
P
E
Y
E
D
E
T
M
T
V
Y
Q
I
P
Site 13
Y181
E
D
E
T
M
T
V
Y
Q
I
P
I
H
S
E
Site 14
S199
G
K
H
Q
P
W
Q
S
P
E
R
P
L
S
R
Site 15
S205
Q
S
P
E
R
P
L
S
R
L
S
P
E
R
S
Site 16
S208
E
R
P
L
S
R
L
S
P
E
R
S
S
D
S
Site 17
S212
S
R
L
S
P
E
R
S
S
D
S
E
S
N
E
Site 18
S213
R
L
S
P
E
R
S
S
D
S
E
S
N
E
N
Site 19
S215
S
P
E
R
S
S
D
S
E
S
N
E
N
E
P
Site 20
S217
E
R
S
S
D
S
E
S
N
E
N
E
P
H
L
Site 21
S229
P
H
L
P
H
G
V
S
Q
R
R
G
V
R
D
Site 22
S283
A
A
V
K
D
G
K
S
I
T
H
E
G
R
E
Site 23
Y354
S
V
L
V
D
S
R
Y
Q
Q
W
M
E
R
F
Site 24
T365
M
E
R
F
G
P
D
T
Q
H
L
V
L
N
E
Site 25
S376
V
L
N
E
N
C
A
S
V
H
N
L
R
S
H
Site 26
S402
D
I
F
P
L
L
T
S
F
R
C
K
K
E
G
Site 27
S413
K
K
E
G
P
T
L
S
V
P
M
V
Q
G
E
Site 28
Y425
Q
G
E
C
L
L
K
Y
Q
L
R
P
R
R
E
Site 29
Y463
F
Q
Q
S
V
Q
E
Y
R
R
S
A
Q
D
G
Site 30
S466
S
V
Q
E
Y
R
R
S
A
Q
D
G
P
A
P
Site 31
S478
P
A
P
A
E
K
R
S
Q
Y
P
E
I
I
F
Site 32
Y480
P
A
E
K
R
S
Q
Y
P
E
I
I
F
L
G
Site 33
T502
K
I
R
N
V
S
A
T
L
V
N
I
S
P
D
Site 34
T520
L
L
D
C
G
E
G
T
F
G
Q
L
C
R
H
Site 35
Y528
F
G
Q
L
C
R
H
Y
G
D
Q
V
D
R
V
Site 36
S568
Q
R
E
R
A
L
A
S
L
G
K
P
L
H
P
Site 37
Y591
L
K
A
W
L
Q
Q
Y
H
N
Q
C
Q
E
V
Site 38
S617
L
Q
E
G
A
E
I
S
S
P
A
V
E
R
L
Site 39
S618
Q
E
G
A
E
I
S
S
P
A
V
E
R
L
I
Site 40
T631
L
I
S
S
L
L
R
T
C
D
L
E
E
F
Q
Site 41
T688
T
L
L
I
H
E
A
T
L
E
D
G
L
E
E
Site 42
T701
E
E
E
A
V
E
K
T
H
S
T
T
S
Q
A
Site 43
S703
E
A
V
E
K
T
H
S
T
T
S
Q
A
I
S
Site 44
S706
E
K
T
H
S
T
T
S
Q
A
I
S
V
G
M
Site 45
S710
S
T
T
S
Q
A
I
S
V
G
M
R
M
N
A
Site 46
S736
Y
A
K
V
P
L
F
S
P
N
F
S
E
K
V
Site 47
S740
P
L
F
S
P
N
F
S
E
K
V
G
V
A
F
Site 48
T815
P
Q
Q
K
R
A
H
T
E
E
P
Q
A
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation