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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DPH2
Full Name:
Diphthamide biosynthesis protein 2
Alias:
Diphthamide biosynthesis 2; Diphthamide biosynthesis 2 homologue-like 2; DPH2 homologue; DPH2L2; DPH2-like 2
Type:
Mass (Da):
52083
Number AA:
489
UniProt ID:
Q9BQC3
International Prot ID:
IPI00106549
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S7
_
M
E
S
M
F
S
S
P
A
E
A
A
L
Q
Site 2
T17
E
A
A
L
Q
R
E
T
G
V
P
G
L
L
T
Site 3
Y33
L
P
D
L
D
G
V
Y
E
L
E
R
V
A
G
Site 4
S75
R
L
E
E
T
T
G
S
K
M
F
I
L
G
D
Site 5
S112
H
F
G
P
A
C
L
S
P
P
A
R
P
L
P
Site 6
S178
R
Y
L
D
L
L
V
S
S
P
A
F
P
Q
P
Site 7
S188
A
F
P
Q
P
V
G
S
L
S
P
E
P
M
P
Site 8
S190
P
Q
P
V
G
S
L
S
P
E
P
M
P
L
E
Site 9
Y214
P
G
R
R
L
E
E
Y
G
A
F
Y
V
G
G
Site 10
Y218
L
E
E
Y
G
A
F
Y
V
G
G
S
K
A
S
Site 11
S225
Y
V
G
G
S
K
A
S
P
D
P
D
L
D
P
Site 12
S235
P
D
L
D
P
D
L
S
R
L
L
L
G
W
A
Site 13
S249
A
P
G
Q
P
F
S
S
C
C
P
D
T
G
K
Site 14
T254
F
S
S
C
C
P
D
T
G
K
T
Q
D
E
G
Site 15
Y273
R
L
R
A
R
R
R
Y
L
V
E
R
A
R
D
Site 16
T307
L
A
H
L
R
N
L
T
Q
A
A
G
K
R
S
Site 17
S314
T
Q
A
A
G
K
R
S
Y
V
L
A
L
G
R
Site 18
Y315
Q
A
A
G
K
R
S
Y
V
L
A
L
G
R
P
Site 19
S402
V
A
L
P
P
P
E
S
E
L
W
E
T
P
D
Site 20
T407
P
E
S
E
L
W
E
T
P
D
V
S
L
I
T
Site 21
S411
L
W
E
T
P
D
V
S
L
I
T
G
D
L
R
Site 22
S425
R
P
P
P
A
W
K
S
S
N
D
H
G
S
L
Site 23
S426
P
P
P
A
W
K
S
S
N
D
H
G
S
L
A
Site 24
S431
K
S
S
N
D
H
G
S
L
A
L
T
P
R
P
Site 25
T435
D
H
G
S
L
A
L
T
P
R
P
Q
L
E
L
Site 26
S445
P
Q
L
E
L
A
E
S
S
P
A
A
S
F
L
Site 27
S446
Q
L
E
L
A
E
S
S
P
A
A
S
F
L
S
Site 28
S450
A
E
S
S
P
A
A
S
F
L
S
S
R
S
W
Site 29
S453
S
P
A
A
S
F
L
S
S
R
S
W
Q
G
L
Site 30
S454
P
A
A
S
F
L
S
S
R
S
W
Q
G
L
E
Site 31
S456
A
S
F
L
S
S
R
S
W
Q
G
L
E
P
R
Site 32
T467
L
E
P
R
L
G
Q
T
P
V
T
E
A
V
S
Site 33
T470
R
L
G
Q
T
P
V
T
E
A
V
S
G
R
R
Site 34
Y483
R
R
G
I
A
I
A
Y
E
D
E
G
S
G
_
Site 35
S488
I
A
Y
E
D
E
G
S
G
_
_
_
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation