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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
HRI
Full Name:
Eukaryotic translation initiation factor 2-alpha kinase 1
Alias:
E2AK1; EC 2.7.11.1; EIF2AK1; HCR; Heme-controlled repressor;heme-regulated inhibitor; Hemin-sensitive initiation factor-2 alpha kinase
Type:
Protein-serine kinase, Other group, PEK family
Mass (Da):
71106
Number AA:
629
UniProt ID:
Q9BQI3
International Prot ID:
IPI00328149
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0004694
GO:0020037
PhosphoSite+
KinaseNET
Biological Process:
GO:0046986
GO:0045993
GO:0046777
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S6
_
_
M
Q
G
G
N
S
G
V
R
K
R
E
E
Site 2
Y38
A
E
G
P
D
P
E
Y
D
E
S
D
V
P
A
Site 3
S41
P
D
P
E
Y
D
E
S
D
V
P
A
E
I
Q
Site 4
T58
K
E
P
L
Q
Q
P
T
F
P
F
A
V
A
N
Site 5
S77
V
S
L
L
E
H
L
S
H
V
H
E
P
N
P
Site 6
S110
L
L
S
S
F
T
C
S
D
E
F
S
S
L
R
Site 7
S114
F
T
C
S
D
E
F
S
S
L
R
L
H
H
N
Site 8
S115
T
C
S
D
E
F
S
S
L
R
L
H
H
N
R
Site 9
T125
L
H
H
N
R
A
I
T
H
L
M
R
S
A
K
Site 10
S151
S
R
I
Q
K
I
R
S
R
E
V
A
L
E
A
Site 11
S161
V
A
L
E
A
Q
T
S
R
Y
L
N
E
F
E
Site 12
Y163
L
E
A
Q
T
S
R
Y
L
N
E
F
E
E
L
Site 13
Y178
A
I
L
G
K
G
G
Y
G
R
V
Y
K
V
R
Site 14
Y182
K
G
G
Y
G
R
V
Y
K
V
R
N
K
L
D
Site 15
Y192
R
N
K
L
D
G
Q
Y
Y
A
I
K
K
I
L
Site 16
Y193
N
K
L
D
G
Q
Y
Y
A
I
K
K
I
L
I
Site 17
S253
R
A
A
I
E
L
P
S
L
E
V
L
S
D
Q
Site 18
S258
L
P
S
L
E
V
L
S
D
Q
E
E
D
R
E
Site 19
S274
C
G
V
K
N
D
E
S
S
S
S
S
I
I
F
Site 20
S275
G
V
K
N
D
E
S
S
S
S
S
I
I
F
A
Site 21
S276
V
K
N
D
E
S
S
S
S
S
I
I
F
A
E
Site 22
S277
K
N
D
E
S
S
S
S
S
I
I
F
A
E
P
Site 23
S278
N
D
E
S
S
S
S
S
I
I
F
A
E
P
T
Site 24
T285
S
I
I
F
A
E
P
T
P
E
K
E
K
R
F
Site 25
S295
K
E
K
R
F
G
E
S
D
T
E
N
Q
N
N
Site 26
T297
K
R
F
G
E
S
D
T
E
N
Q
N
N
K
S
Site 27
S304
T
E
N
Q
N
N
K
S
V
K
Y
T
T
N
L
Site 28
S316
T
N
L
V
I
R
E
S
G
E
L
E
S
T
L
Site 29
T322
E
S
G
E
L
E
S
T
L
E
L
Q
E
N
G
Site 30
S334
E
N
G
L
A
G
L
S
A
S
S
I
V
E
Q
Site 31
S349
Q
L
P
L
R
R
N
S
H
L
E
E
S
F
T
Site 32
S354
R
N
S
H
L
E
E
S
F
T
S
T
E
E
S
Site 33
T356
S
H
L
E
E
S
F
T
S
T
E
E
S
S
E
Site 34
S357
H
L
E
E
S
F
T
S
T
E
E
S
S
E
E
Site 35
T358
L
E
E
S
F
T
S
T
E
E
S
S
E
E
N
Site 36
S361
S
F
T
S
T
E
E
S
S
E
E
N
V
N
F
Site 37
Y376
L
G
Q
T
E
A
Q
Y
H
L
M
L
H
I
Q
Site 38
Y405
R
N
K
R
G
R
E
Y
V
D
E
S
A
C
P
Site 39
T477
L
Q
K
N
T
D
W
T
N
R
N
G
K
R
T
Site 40
T484
T
N
R
N
G
K
R
T
P
T
H
T
S
R
V
Site 41
T486
R
N
G
K
R
T
P
T
H
T
S
R
V
G
T
Site 42
T488
G
K
R
T
P
T
H
T
S
R
V
G
T
C
L
Site 43
S489
K
R
T
P
T
H
T
S
R
V
G
T
C
L
Y
Site 44
T493
T
H
T
S
R
V
G
T
C
L
Y
A
S
P
E
Site 45
Y496
S
R
V
G
T
C
L
Y
A
S
P
E
Q
L
E
Site 46
S498
V
G
T
C
L
Y
A
S
P
E
Q
L
E
G
S
Site 47
S505
S
P
E
Q
L
E
G
S
E
Y
D
A
K
S
D
Site 48
Y507
E
Q
L
E
G
S
E
Y
D
A
K
S
D
M
Y
Site 49
S511
G
S
E
Y
D
A
K
S
D
M
Y
S
L
G
V
Site 50
T538
M
E
R
A
E
V
L
T
G
L
R
T
G
Q
L
Site 51
S548
R
T
G
Q
L
P
E
S
L
R
K
R
C
P
V
Site 52
Y559
R
C
P
V
Q
A
K
Y
I
Q
H
L
T
R
R
Site 53
T564
A
K
Y
I
Q
H
L
T
R
R
N
S
S
Q
R
Site 54
S568
Q
H
L
T
R
R
N
S
S
Q
R
P
S
A
I
Site 55
S569
H
L
T
R
R
N
S
S
Q
R
P
S
A
I
Q
Site 56
S573
R
N
S
S
Q
R
P
S
A
I
Q
L
L
Q
S
Site 57
T592
N
S
G
N
V
N
L
T
L
Q
M
K
I
I
E
Site 58
S615
K
K
Q
L
N
L
L
S
Q
D
K
G
V
R
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation