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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
SGIP1
Full Name:
SH3-containing GRB2-like protein 3-interacting protein 1
Alias:
DKFZp686A16142; DKFZp761D221; Endophilin-3-interacting protein; SH3-domain GRB2-like (endophilin) interacting protein 1
Type:
Mass (Da):
89109
Number AA:
828
UniProt ID:
Q9BQI5
International Prot ID:
IPI00031087
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
I
R
K
K
E
K
D
T
D
S
T
G
S
P
D
Site 2
S24
K
K
E
K
D
T
D
S
T
G
S
P
D
R
D
Site 3
T25
K
E
K
D
T
D
S
T
G
S
P
D
R
D
G
Site 4
S27
K
D
T
D
S
T
G
S
P
D
R
D
G
I
Q
Site 5
S36
D
R
D
G
I
Q
P
S
P
H
E
P
P
Y
N
Site 6
Y42
P
S
P
H
E
P
P
Y
N
S
K
A
E
C
A
Site 7
S57
R
E
G
G
K
K
V
S
K
K
S
N
G
A
P
Site 8
S60
G
K
K
V
S
K
K
S
N
G
A
P
N
G
F
Site 9
Y68
N
G
A
P
N
G
F
Y
A
E
I
D
W
E
R
Site 10
Y76
A
E
I
D
W
E
R
Y
N
S
P
E
L
D
E
Site 11
S78
I
D
W
E
R
Y
N
S
P
E
L
D
E
E
G
Site 12
Y86
P
E
L
D
E
E
G
Y
S
I
R
P
E
E
P
Site 13
S87
E
L
D
E
E
G
Y
S
I
R
P
E
E
P
G
Site 14
S95
I
R
P
E
E
P
G
S
T
K
G
K
H
F
Y
Site 15
T96
R
P
E
E
P
G
S
T
K
G
K
H
F
Y
S
Site 16
Y102
S
T
K
G
K
H
F
Y
S
S
S
E
S
E
E
Site 17
S103
T
K
G
K
H
F
Y
S
S
S
E
S
E
E
E
Site 18
S104
K
G
K
H
F
Y
S
S
S
E
S
E
E
E
E
Site 19
S105
G
K
H
F
Y
S
S
S
E
S
E
E
E
E
E
Site 20
S107
H
F
Y
S
S
S
E
S
E
E
E
E
E
S
H
Site 21
S113
E
S
E
E
E
E
E
S
H
K
K
F
N
I
K
Site 22
T135
D
I
L
K
N
A
A
T
V
D
E
L
K
A
S
Site 23
S149
S
I
G
N
I
A
L
S
P
S
P
V
R
K
S
Site 24
S151
G
N
I
A
L
S
P
S
P
V
R
K
S
P
R
Site 25
S156
S
P
S
P
V
R
K
S
P
R
R
S
P
G
A
Site 26
S160
V
R
K
S
P
R
R
S
P
G
A
I
K
R
N
Site 27
S169
G
A
I
K
R
N
L
S
S
E
E
V
A
R
P
Site 28
S170
A
I
K
R
N
L
S
S
E
E
V
A
R
P
R
Site 29
S179
E
V
A
R
P
R
R
S
T
P
T
P
E
L
I
Site 30
T180
V
A
R
P
R
R
S
T
P
T
P
E
L
I
S
Site 31
T182
R
P
R
R
S
T
P
T
P
E
L
I
S
K
K
Site 32
T194
S
K
K
P
P
D
D
T
T
A
L
A
P
L
F
Site 33
T195
K
K
P
P
D
D
T
T
A
L
A
P
L
F
G
Site 34
S226
D
Q
P
E
I
W
G
S
G
Q
P
I
N
P
S
Site 35
S233
S
G
Q
P
I
N
P
S
M
E
S
P
K
L
T
Site 36
S236
P
I
N
P
S
M
E
S
P
K
L
T
R
P
F
Site 37
T240
S
M
E
S
P
K
L
T
R
P
F
P
T
G
T
Site 38
T245
K
L
T
R
P
F
P
T
G
T
P
P
P
L
P
Site 39
T247
T
R
P
F
P
T
G
T
P
P
P
L
P
P
K
Site 40
T259
P
P
K
N
V
P
A
T
P
P
R
T
G
S
P
Site 41
T263
V
P
A
T
P
P
R
T
G
S
P
L
T
I
G
Site 42
S265
A
T
P
P
R
T
G
S
P
L
T
I
G
P
G
Site 43
T268
P
R
T
G
S
P
L
T
I
G
P
G
N
D
Q
Site 44
S276
I
G
P
G
N
D
Q
S
A
T
E
V
K
I
E
Site 45
S287
V
K
I
E
K
L
P
S
I
N
D
L
D
S
I
Site 46
S293
P
S
I
N
D
L
D
S
I
F
G
P
V
L
S
Site 47
S300
S
I
F
G
P
V
L
S
P
K
S
V
A
V
N
Site 48
S303
G
P
V
L
S
P
K
S
V
A
V
N
A
E
E
Site 49
S316
E
E
K
W
V
H
F
S
D
T
S
P
E
H
V
Site 50
T318
K
W
V
H
F
S
D
T
S
P
E
H
V
T
P
Site 51
S319
W
V
H
F
S
D
T
S
P
E
H
V
T
P
E
Site 52
T324
D
T
S
P
E
H
V
T
P
E
L
T
P
R
E
Site 53
T328
E
H
V
T
P
E
L
T
P
R
E
K
V
V
S
Site 54
S335
T
P
R
E
K
V
V
S
P
P
A
T
P
D
N
Site 55
T339
K
V
V
S
P
P
A
T
P
D
N
P
A
D
S
Site 56
S346
T
P
D
N
P
A
D
S
P
A
P
G
P
L
G
Site 57
T358
P
L
G
P
P
G
P
T
G
P
P
G
P
P
G
Site 58
S372
G
P
P
R
N
V
L
S
P
L
N
L
E
E
V
Site 59
T387
Q
K
K
V
A
E
Q
T
F
I
K
D
D
Y
L
Site 60
Y393
Q
T
F
I
K
D
D
Y
L
E
T
I
S
S
P
Site 61
S399
D
Y
L
E
T
I
S
S
P
K
D
F
G
L
G
Site 62
T410
F
G
L
G
Q
R
A
T
P
P
P
P
P
P
P
Site 63
T418
P
P
P
P
P
P
P
T
Y
R
T
V
V
S
S
Site 64
Y419
P
P
P
P
P
P
T
Y
R
T
V
V
S
S
P
Site 65
T421
P
P
P
P
T
Y
R
T
V
V
S
S
P
G
P
Site 66
S424
P
T
Y
R
T
V
V
S
S
P
G
P
G
S
G
Site 67
S425
T
Y
R
T
V
V
S
S
P
G
P
G
S
G
P
Site 68
S430
V
S
S
P
G
P
G
S
G
P
G
P
G
T
T
Site 69
T436
G
S
G
P
G
P
G
T
T
S
G
A
S
S
P
Site 70
T437
S
G
P
G
P
G
T
T
S
G
A
S
S
P
A
Site 71
S438
G
P
G
P
G
T
T
S
G
A
S
S
P
A
R
Site 72
S441
P
G
T
T
S
G
A
S
S
P
A
R
P
A
T
Site 73
S442
G
T
T
S
G
A
S
S
P
A
R
P
A
T
P
Site 74
T448
S
S
P
A
R
P
A
T
P
L
V
P
C
R
S
Site 75
S455
T
P
L
V
P
C
R
S
T
T
P
P
P
P
P
Site 76
T456
P
L
V
P
C
R
S
T
T
P
P
P
P
P
P
Site 77
T457
L
V
P
C
R
S
T
T
P
P
P
P
P
P
R
Site 78
S467
P
P
P
P
R
P
P
S
R
P
K
L
P
P
G
Site 79
S482
K
P
G
V
G
D
V
S
R
P
F
S
P
P
I
Site 80
S486
G
D
V
S
R
P
F
S
P
P
I
H
S
S
S
Site 81
S491
P
F
S
P
P
I
H
S
S
S
P
P
P
I
A
Site 82
S492
F
S
P
P
I
H
S
S
S
P
P
P
I
A
P
Site 83
S493
S
P
P
I
H
S
S
S
P
P
P
I
A
P
L
Site 84
S505
A
P
L
A
R
A
E
S
T
S
S
I
S
S
T
Site 85
T506
P
L
A
R
A
E
S
T
S
S
I
S
S
T
N
Site 86
S507
L
A
R
A
E
S
T
S
S
I
S
S
T
N
S
Site 87
S508
A
R
A
E
S
T
S
S
I
S
S
T
N
S
L
Site 88
S510
A
E
S
T
S
S
I
S
S
T
N
S
L
S
A
Site 89
S511
E
S
T
S
S
I
S
S
T
N
S
L
S
A
A
Site 90
T512
S
T
S
S
I
S
S
T
N
S
L
S
A
A
T
Site 91
S514
S
S
I
S
S
T
N
S
L
S
A
A
T
T
P
Site 92
T520
N
S
L
S
A
A
T
T
P
T
V
E
N
E
Q
Site 93
S529
T
V
E
N
E
Q
P
S
L
V
W
F
D
R
G
Site 94
Y539
W
F
D
R
G
K
F
Y
L
T
F
E
G
S
S
Site 95
T541
D
R
G
K
F
Y
L
T
F
E
G
S
S
R
G
Site 96
S545
F
Y
L
T
F
E
G
S
S
R
G
P
S
P
L
Site 97
S546
Y
L
T
F
E
G
S
S
R
G
P
S
P
L
T
Site 98
S550
E
G
S
S
R
G
P
S
P
L
T
M
G
A
Q
Site 99
T553
S
R
G
P
S
P
L
T
M
G
A
Q
D
T
L
Site 100
Y573
F
T
E
T
V
N
A
Y
F
K
G
A
D
P
S
Site 101
S607
R
H
F
A
N
N
P
S
P
A
A
L
T
F
R
Site 102
Y668
E
Q
K
P
Q
A
T
Y
Y
N
V
D
M
L
K
Site 103
Y669
Q
K
P
Q
A
T
Y
Y
N
V
D
M
L
K
Y
Site 104
Y676
Y
N
V
D
M
L
K
Y
Q
V
S
A
Q
G
I
Site 105
S679
D
M
L
K
Y
Q
V
S
A
Q
G
I
Q
S
T
Site 106
T686
S
A
Q
G
I
Q
S
T
P
L
N
L
A
V
N
Site 107
S699
V
N
W
R
C
E
P
S
S
T
D
L
R
I
D
Site 108
T701
W
R
C
E
P
S
S
T
D
L
R
I
D
Y
K
Site 109
Y707
S
T
D
L
R
I
D
Y
K
Y
N
T
D
A
M
Site 110
Y709
D
L
R
I
D
Y
K
Y
N
T
D
A
M
T
T
Site 111
T711
R
I
D
Y
K
Y
N
T
D
A
M
T
T
A
V
Site 112
T715
K
Y
N
T
D
A
M
T
T
A
V
A
L
N
N
Site 113
S760
L
W
K
I
P
D
I
S
Q
K
S
E
N
G
G
Site 114
S763
I
P
D
I
S
Q
K
S
E
N
G
G
V
G
S
Site 115
S778
L
L
A
R
F
Q
L
S
E
G
P
S
K
P
S
Site 116
S782
F
Q
L
S
E
G
P
S
K
P
S
P
L
V
V
Site 117
S785
S
E
G
P
S
K
P
S
P
L
V
V
Q
F
T
Site 118
T797
Q
F
T
S
E
G
S
T
L
S
G
C
D
I
E
Site 119
Y824
K
R
F
A
A
G
K
Y
L
A
D
N
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation