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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PSD2
Full Name:
PH and SEC7 domain-containing protein 2
Alias:
DKFZp761B0514; Pleckstrin and Sec7 domain containing 2
Type:
Intracellular, Membrane, Integral membrane protein
Mass (Da):
84760
Number AA:
771
UniProt ID:
Q9BQI7
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
GO:0005622
Uniprot
OncoNet
Molecular Function:
GO:0005086
PhosphoSite+
KinaseNET
Biological Process:
GO:0032012
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S8
M
E
E
D
K
L
L
S
A
V
P
E
E
G
D
Site 2
T17
V
P
E
E
G
D
A
T
R
D
P
G
P
E
P
Site 3
S36
G
V
R
N
G
M
A
S
E
G
L
N
S
S
L
Site 4
S41
M
A
S
E
G
L
N
S
S
L
C
S
P
G
H
Site 5
S42
A
S
E
G
L
N
S
S
L
C
S
P
G
H
E
Site 6
S45
G
L
N
S
S
L
C
S
P
G
H
E
R
R
G
Site 7
T53
P
G
H
E
R
R
G
T
P
A
D
T
E
E
P
Site 8
T57
R
R
G
T
P
A
D
T
E
E
P
T
K
D
P
Site 9
S93
D
L
N
I
L
E
D
S
A
E
S
R
P
W
R
Site 10
S111
L
A
E
G
D
N
A
S
R
S
L
Y
P
D
A
Site 11
S113
E
G
D
N
A
S
R
S
L
Y
P
D
A
E
D
Site 12
Y115
D
N
A
S
R
S
L
Y
P
D
A
E
D
P
Q
Site 13
S138
P
D
V
R
D
G
F
S
A
T
F
E
K
I
L
Site 14
T140
V
R
D
G
F
S
A
T
F
E
K
I
L
E
S
Site 15
T153
E
S
E
L
L
R
G
T
Q
Y
S
S
L
D
S
Site 16
Y155
E
L
L
R
G
T
Q
Y
S
S
L
D
S
L
D
Site 17
S156
L
L
R
G
T
Q
Y
S
S
L
D
S
L
D
G
Site 18
S157
L
R
G
T
Q
Y
S
S
L
D
S
L
D
G
L
Site 19
S160
T
Q
Y
S
S
L
D
S
L
D
G
L
S
L
T
Site 20
S165
L
D
S
L
D
G
L
S
L
T
D
E
S
D
S
Site 21
T167
S
L
D
G
L
S
L
T
D
E
S
D
S
C
V
Site 22
S170
G
L
S
L
T
D
E
S
D
S
C
V
S
F
E
Site 23
S172
S
L
T
D
E
S
D
S
C
V
S
F
E
A
P
Site 24
S175
D
E
S
D
S
C
V
S
F
E
A
P
L
T
P
Site 25
S191
I
Q
Q
R
A
R
D
S
P
E
P
G
A
G
L
Site 26
S220
G
G
D
G
E
L
G
S
P
L
R
R
S
I
S
Site 27
S225
L
G
S
P
L
R
R
S
I
S
S
S
R
S
E
Site 28
S227
S
P
L
R
R
S
I
S
S
S
R
S
E
N
V
Site 29
S228
P
L
R
R
S
I
S
S
S
R
S
E
N
V
L
Site 30
S229
L
R
R
S
I
S
S
S
R
S
E
N
V
L
S
Site 31
S231
R
S
I
S
S
S
R
S
E
N
V
L
S
R
L
Site 32
S236
S
R
S
E
N
V
L
S
R
L
S
L
M
A
M
Site 33
T266
E
D
D
D
E
E
D
T
D
K
L
L
N
S
A
Site 34
S272
D
T
D
K
L
L
N
S
A
S
D
P
S
L
K
Site 35
S274
D
K
L
L
N
S
A
S
D
P
S
L
K
D
G
Site 36
S277
L
N
S
A
S
D
P
S
L
K
D
G
L
S
D
Site 37
S283
P
S
L
K
D
G
L
S
D
S
D
S
E
L
S
Site 38
S285
L
K
D
G
L
S
D
S
D
S
E
L
S
S
S
Site 39
S287
D
G
L
S
D
S
D
S
E
L
S
S
S
E
G
Site 40
S290
S
D
S
D
S
E
L
S
S
S
E
G
L
E
P
Site 41
S291
D
S
D
S
E
L
S
S
S
E
G
L
E
P
G
Site 42
S292
S
D
S
E
L
S
S
S
E
G
L
E
P
G
S
Site 43
S299
S
E
G
L
E
P
G
S
A
D
P
L
A
N
G
Site 44
Y322
H
R
L
A
R
R
L
Y
H
L
E
G
F
Q
R
Site 45
S343
L
G
K
N
N
E
F
S
R
L
V
A
G
E
Y
Site 46
T386
Q
E
R
E
R
V
L
T
H
F
S
R
R
Y
C
Site 47
Y392
L
T
H
F
S
R
R
Y
C
Q
C
N
P
D
D
Site 48
S400
C
Q
C
N
P
D
D
S
T
S
E
D
G
I
H
Site 49
T401
Q
C
N
P
D
D
S
T
S
E
D
G
I
H
T
Site 50
S402
C
N
P
D
D
S
T
S
E
D
G
I
H
T
L
Site 51
T454
F
A
K
D
L
L
K
T
L
Y
N
S
I
K
N
Site 52
Y456
K
D
L
L
K
T
L
Y
N
S
I
K
N
E
K
Site 53
S476
D
E
D
E
L
R
K
S
L
S
E
L
V
D
D
Site 54
S478
D
E
L
R
K
S
L
S
E
L
V
D
D
K
F
Site 55
S510
L
D
V
P
Q
A
L
S
A
T
T
Y
K
H
G
Site 56
Y514
Q
A
L
S
A
T
T
Y
K
H
G
V
L
T
R
Site 57
T523
H
G
V
L
T
R
K
T
H
A
D
M
D
G
K
Site 58
T532
A
D
M
D
G
K
R
T
P
R
G
R
R
G
W
Site 59
Y543
R
R
G
W
K
K
F
Y
A
V
L
K
G
T
I
Site 60
Y552
V
L
K
G
T
I
L
Y
L
Q
K
D
E
Y
R
Site 61
Y558
L
Y
L
Q
K
D
E
Y
R
P
D
K
A
L
S
Site 62
S584
H
A
L
A
T
R
A
S
D
Y
S
K
K
S
N
Site 63
Y586
L
A
T
R
A
S
D
Y
S
K
K
S
N
V
L
Site 64
S587
A
T
R
A
S
D
Y
S
K
K
S
N
V
L
K
Site 65
S590
A
S
D
Y
S
K
K
S
N
V
L
K
L
K
T
Site 66
S615
P
S
K
E
E
M
L
S
W
I
L
R
I
N
L
Site 67
S649
F
C
R
P
L
L
P
S
C
T
T
R
L
C
Q
Site 68
T651
R
P
L
L
P
S
C
T
T
R
L
C
Q
E
E
Site 69
T652
P
L
L
P
S
C
T
T
R
L
C
Q
E
E
Q
Site 70
S662
C
Q
E
E
Q
L
R
S
H
E
N
K
L
R
Q
Site 71
T671
E
N
K
L
R
Q
L
T
A
E
L
A
E
H
R
Site 72
S688
P
V
E
R
G
I
K
S
K
E
A
E
E
Y
R
Site 73
Y694
K
S
K
E
A
E
E
Y
R
L
K
E
H
Y
L
Site 74
Y700
E
Y
R
L
K
E
H
Y
L
T
F
E
K
S
R
Site 75
T702
R
L
K
E
H
Y
L
T
F
E
K
S
R
Y
E
Site 76
Y708
L
T
F
E
K
S
R
Y
E
T
Y
I
H
L
L
Site 77
T710
F
E
K
S
R
Y
E
T
Y
I
H
L
L
A
M
Site 78
T735
R
I
E
A
R
L
A
T
L
E
G
D
D
P
S
Site 79
S742
T
L
E
G
D
D
P
S
L
R
K
T
H
S
S
Site 80
T746
D
D
P
S
L
R
K
T
H
S
S
P
A
L
S
Site 81
S748
P
S
L
R
K
T
H
S
S
P
A
L
S
Q
G
Site 82
S749
S
L
R
K
T
H
S
S
P
A
L
S
Q
G
H
Site 83
S753
T
H
S
S
P
A
L
S
Q
G
H
V
T
G
S
Site 84
T758
A
L
S
Q
G
H
V
T
G
S
K
T
T
K
D
Site 85
S760
S
Q
G
H
V
T
G
S
K
T
T
K
D
A
T
Site 86
T762
G
H
V
T
G
S
K
T
T
K
D
A
T
G
P
Site 87
T767
S
K
T
T
K
D
A
T
G
P
D
T
_
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation