KinATLAS
TranscriptoNET
PhosphoNET
OncoNET
KinaseNET
DrugKiNET
DrugProNET
KiNET-AM
Kinetica Online
Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
Home
|
Kinexus
|
Contact
|
Credits
Protein Info
Short Name:
FYCO1
Full Name:
FYVE and coiled-coil domain-containing protein 1
Alias:
FLJ13335; FYVE and coiled-coil domain containing 1; MGC126517; MGC126519; RUFY3; ZFYVE7; Zinc finger FYVE domain-containing protein 7
Type:
Mass (Da):
166955
Number AA:
1478
UniProt ID:
Q9BQS8
International Prot ID:
IPI00001580
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
Uniprot
OncoNet
Molecular Function:
GO:0008270
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T22
R
D
L
Q
D
A
V
T
E
L
S
K
E
F
Q
Site 2
S25
Q
D
A
V
T
E
L
S
K
E
F
Q
E
A
G
Site 3
T36
Q
E
A
G
E
P
I
T
D
D
S
T
S
L
H
Site 4
S39
G
E
P
I
T
D
D
S
T
S
L
H
K
F
S
Site 5
T40
E
P
I
T
D
D
S
T
S
L
H
K
F
S
Y
Site 6
S41
P
I
T
D
D
S
T
S
L
H
K
F
S
Y
K
Site 7
Y51
K
F
S
Y
K
L
E
Y
L
L
Q
F
D
Q
K
Site 8
Y70
L
L
G
N
K
K
D
Y
W
D
Y
F
C
A
C
Site 9
Y73
N
K
K
D
Y
W
D
Y
F
C
A
C
L
A
K
Site 10
S93
D
G
I
R
F
V
K
S
I
S
E
L
R
T
S
Site 11
T99
K
S
I
S
E
L
R
T
S
L
G
K
G
R
A
Site 12
S100
S
I
S
E
L
R
T
S
L
G
K
G
R
A
F
Site 13
Y110
K
G
R
A
F
I
R
Y
S
L
V
H
Q
R
L
Site 14
S111
G
R
A
F
I
R
Y
S
L
V
H
Q
R
L
A
Site 15
Y135
T
K
V
T
S
D
W
Y
Y
A
R
S
P
F
L
Site 16
Y136
K
V
T
S
D
W
Y
Y
A
R
S
P
F
L
Q
Site 17
S139
S
D
W
Y
Y
A
R
S
P
F
L
Q
P
K
L
Site 18
T177
D
L
D
A
A
W
P
T
F
A
R
R
T
L
T
Site 19
T182
W
P
T
F
A
R
R
T
L
T
T
G
S
S
A
Site 20
T184
T
F
A
R
R
T
L
T
T
G
S
S
A
Y
L
Site 21
T185
F
A
R
R
T
L
T
T
G
S
S
A
Y
L
W
Site 22
S187
R
R
T
L
T
T
G
S
S
A
Y
L
W
K
P
Site 23
Y190
L
T
T
G
S
S
A
Y
L
W
K
P
P
S
R
Site 24
S196
A
Y
L
W
K
P
P
S
R
S
S
S
M
S
S
Site 25
S198
L
W
K
P
P
S
R
S
S
S
M
S
S
L
V
Site 26
S199
W
K
P
P
S
R
S
S
S
M
S
S
L
V
S
Site 27
S200
K
P
P
S
R
S
S
S
M
S
S
L
V
S
S
Site 28
S202
P
S
R
S
S
S
M
S
S
L
V
S
S
Y
L
Site 29
S203
S
R
S
S
S
M
S
S
L
V
S
S
Y
L
Q
Site 30
S206
S
S
M
S
S
L
V
S
S
Y
L
Q
T
Q
E
Site 31
S207
S
M
S
S
L
V
S
S
Y
L
Q
T
Q
E
M
Site 32
T211
L
V
S
S
Y
L
Q
T
Q
E
M
V
S
N
F
Site 33
S222
V
S
N
F
D
L
N
S
P
L
N
N
E
A
L
Site 34
S268
Q
E
L
R
A
A
V
S
Q
Q
G
E
Q
L
Q
Site 35
T276
Q
Q
G
E
Q
L
Q
T
E
R
E
R
G
R
T
Site 36
T283
T
E
R
E
R
G
R
T
A
A
E
D
N
V
R
Site 37
Y333
A
A
E
K
E
E
D
Y
H
T
A
L
R
R
L
Site 38
T335
E
K
E
E
D
Y
H
T
A
L
R
R
L
E
S
Site 39
S342
T
A
L
R
R
L
E
S
M
L
Q
P
L
A
Q
Site 40
T354
L
A
Q
E
L
E
A
T
R
D
S
L
D
K
K
Site 41
S357
E
L
E
A
T
R
D
S
L
D
K
K
N
Q
H
Site 42
S367
K
K
N
Q
H
L
A
S
F
P
G
W
L
A
M
Site 43
T381
M
A
Q
Q
K
A
D
T
A
S
D
T
K
G
R
Site 44
S383
Q
Q
K
A
D
T
A
S
D
T
K
G
R
Q
E
Site 45
T385
K
A
D
T
A
S
D
T
K
G
R
Q
E
P
I
Site 46
S394
G
R
Q
E
P
I
P
S
D
A
A
Q
E
M
Q
Site 47
T415
Q
A
L
E
R
E
R
T
K
V
E
E
V
N
R
Site 48
S425
E
E
V
N
R
Q
Q
S
A
Q
L
E
Q
L
V
Site 49
S444
L
K
E
D
A
R
A
S
L
E
R
L
V
K
E
Site 50
S482
E
L
L
A
H
T
S
S
W
E
E
E
L
A
E
Site 51
S510
L
L
E
Q
E
V
R
S
L
T
R
Q
L
Q
F
Site 52
T512
E
Q
E
V
R
S
L
T
R
Q
L
Q
F
L
E
Site 53
S526
E
T
Q
L
A
Q
V
S
Q
H
V
S
D
L
E
Site 54
S530
A
Q
V
S
Q
H
V
S
D
L
E
E
Q
K
K
Site 55
S547
I
Q
D
K
D
H
L
S
Q
Q
V
G
M
L
E
Site 56
S579
E
A
L
V
P
V
N
S
S
L
Q
E
A
W
G
Site 57
T603
Q
E
A
Q
L
D
D
T
K
V
Q
E
G
S
Q
Site 58
S609
D
T
K
V
Q
E
G
S
Q
E
E
E
L
R
Q
Site 59
Y646
L
Q
A
L
Q
A
D
Y
Q
A
L
Q
Q
R
E
Site 60
S654
Q
A
L
Q
Q
R
E
S
A
I
Q
G
S
L
A
Site 61
S659
R
E
S
A
I
Q
G
S
L
A
S
L
E
A
E
Site 62
S662
A
I
Q
G
S
L
A
S
L
E
A
E
Q
A
S
Site 63
S669
S
L
E
A
E
Q
A
S
I
R
H
L
G
D
Q
Site 64
S704
E
K
E
A
I
L
Q
S
K
E
G
E
C
Q
Q
Site 65
S735
R
E
L
R
A
L
E
S
Q
C
Q
Q
Q
T
Q
Site 66
S814
D
K
V
Q
S
Q
L
S
M
A
E
A
V
L
R
Site 67
T825
A
V
L
R
E
H
K
T
L
V
Q
Q
L
K
E
Site 68
S849
V
Q
E
L
L
Q
C
S
E
R
E
G
A
L
Q
Site 69
S878
R
A
L
Q
E
E
L
S
Q
A
K
C
S
S
E
Site 70
T903
E
Q
L
H
R
A
N
T
D
T
A
E
L
G
I
Site 71
T905
L
H
R
A
N
T
D
T
A
E
L
G
I
Q
V
Site 72
S960
G
L
Q
Q
E
K
E
S
L
Q
E
K
L
K
A
Site 73
S991
Q
A
E
Q
R
A
Q
S
L
Q
E
A
A
H
Q
Site 74
S1008
N
T
L
K
F
Q
L
S
A
E
I
M
D
Y
Q
Site 75
Y1014
L
S
A
E
I
M
D
Y
Q
S
R
L
K
N
A
Site 76
S1027
N
A
G
E
E
C
K
S
L
R
G
Q
L
E
E
Site 77
S1061
A
D
M
G
E
K
L
S
C
T
S
N
H
L
A
Site 78
T1100
K
E
L
E
K
A
T
T
K
I
Q
E
Y
Y
N
Site 79
T1114
N
K
L
C
Q
E
V
T
N
R
E
R
N
D
Q
Site 80
Y1136
D
L
N
R
T
K
K
Y
L
E
E
R
L
I
E
Site 81
S1155
K
D
A
L
W
Q
K
S
D
A
L
E
F
Q
Q
Site 82
S1165
L
E
F
Q
Q
K
L
S
A
E
E
R
W
L
G
Site 83
S1231
R
A
C
F
Q
K
L
S
E
G
P
G
S
P
D
Site 84
S1236
K
L
S
E
G
P
G
S
P
D
S
S
G
S
G
Site 85
S1239
E
G
P
G
S
P
D
S
S
G
S
G
T
S
Q
Site 86
S1240
G
P
G
S
P
D
S
S
G
S
G
T
S
Q
G
Site 87
S1242
G
S
P
D
S
S
G
S
G
T
S
Q
G
E
P
Site 88
T1244
P
D
S
S
G
S
G
T
S
Q
G
E
P
S
P
Site 89
S1250
G
T
S
Q
G
E
P
S
P
A
L
S
P
A
S
Site 90
S1254
G
E
P
S
P
A
L
S
P
A
S
P
G
P
Q
Site 91
S1257
S
P
A
L
S
P
A
S
P
G
P
Q
A
T
G
Site 92
T1270
T
G
G
Q
G
A
N
T
D
Y
R
P
P
D
D
Site 93
Y1272
G
Q
G
A
N
T
D
Y
R
P
P
D
D
A
V
Site 94
S1294
E
L
C
Q
I
Q
E
S
G
S
S
L
P
E
T
Site 95
S1296
C
Q
I
Q
E
S
G
S
S
L
P
E
T
P
T
Site 96
S1297
Q
I
Q
E
S
G
S
S
L
P
E
T
P
T
E
Site 97
T1301
S
G
S
S
L
P
E
T
P
T
E
T
D
S
L
Site 98
T1303
S
S
L
P
E
T
P
T
E
T
D
S
L
D
P
Site 99
S1307
E
T
P
T
E
T
D
S
L
D
P
N
A
A
E
Site 100
T1317
P
N
A
A
E
Q
D
T
T
S
T
S
L
T
P
Site 101
T1318
N
A
A
E
Q
D
T
T
S
T
S
L
T
P
E
Site 102
S1319
A
A
E
Q
D
T
T
S
T
S
L
T
P
E
D
Site 103
S1321
E
Q
D
T
T
S
T
S
L
T
P
E
D
T
E
Site 104
T1323
D
T
T
S
T
S
L
T
P
E
D
T
E
D
M
Site 105
T1327
T
S
L
T
P
E
D
T
E
D
M
P
V
G
Q
Site 106
S1336
D
M
P
V
G
Q
D
S
E
I
C
L
L
K
S
Site 107
S1359
L
T
V
D
E
I
A
S
F
G
E
G
S
R
E
Site 108
S1371
S
R
E
L
F
V
R
S
S
T
Y
S
L
I
P
Site 109
S1394
T
I
S
W
V
F
S
S
D
P
K
S
I
S
F
Site 110
S1400
S
S
D
P
K
S
I
S
F
S
V
V
F
Q
E
Site 111
S1402
D
P
K
S
I
S
F
S
V
V
F
Q
E
A
E
Site 112
T1411
V
F
Q
E
A
E
D
T
P
L
D
Q
C
K
V
Site 113
T1422
Q
C
K
V
L
I
P
T
T
R
C
N
S
H
K
Site 114
T1423
C
K
V
L
I
P
T
T
R
C
N
S
H
K
E
Site 115
S1427
I
P
T
T
R
C
N
S
H
K
E
N
I
Q
G
Site 116
T1465
K
K
V
F
Y
H
L
T
V
D
R
P
V
I
Y
Site 117
Y1472
T
V
D
R
P
V
I
Y
D
G
S
D
F
L
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation