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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
JPH2
Full Name:
Junctophilin-2
Alias:
JP2; JP-2; Junctophilin type 2
Type:
Anchoring protein, junctional membrane complexes
Mass (Da):
74222
Number AA:
696
UniProt ID:
Q9BR39
International Prot ID:
IPI00176532
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0019898
GO:0016021
GO:0014701
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0060402
GO:0060314
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
Y14
D
F
D
D
G
G
A
Y
C
G
G
W
E
G
G
Site 2
S39
P
K
G
Q
G
E
Y
S
G
S
W
N
F
G
F
Site 3
S41
G
Q
G
E
Y
S
G
S
W
N
F
G
F
E
V
Site 4
Y52
G
F
E
V
A
G
V
Y
T
W
P
S
G
N
T
Site 5
Y63
S
G
N
T
F
E
G
Y
W
S
Q
G
K
R
H
Site 6
T76
R
H
G
L
G
I
E
T
K
G
R
W
L
Y
K
Site 7
Y82
E
T
K
G
R
W
L
Y
K
G
E
W
T
H
G
Site 8
Y94
T
H
G
F
K
G
R
Y
G
I
R
Q
S
S
S
Site 9
S99
G
R
Y
G
I
R
Q
S
S
S
S
G
A
K
Y
Site 10
S100
R
Y
G
I
R
Q
S
S
S
S
G
A
K
Y
E
Site 11
S101
Y
G
I
R
Q
S
S
S
S
G
A
K
Y
E
G
Site 12
S102
G
I
R
Q
S
S
S
S
G
A
K
Y
E
G
T
Site 13
Y106
S
S
S
S
G
A
K
Y
E
G
T
W
N
N
G
Site 14
T109
S
G
A
K
Y
E
G
T
W
N
N
G
L
Q
D
Site 15
Y118
N
N
G
L
Q
D
G
Y
G
T
E
T
Y
A
D
Site 16
T122
Q
D
G
Y
G
T
E
T
Y
A
D
G
G
T
Y
Site 17
Y123
D
G
Y
G
T
E
T
Y
A
D
G
G
T
Y
Q
Site 18
Y129
T
Y
A
D
G
G
T
Y
Q
G
Q
F
T
N
G
Site 19
Y141
T
N
G
M
R
H
G
Y
G
V
R
Q
S
V
P
Site 20
S146
H
G
Y
G
V
R
Q
S
V
P
Y
G
M
A
V
Site 21
S157
G
M
A
V
V
V
R
S
P
L
R
T
S
L
S
Site 22
T161
V
V
R
S
P
L
R
T
S
L
S
S
L
R
S
Site 23
S162
V
R
S
P
L
R
T
S
L
S
S
L
R
S
E
Site 24
S164
S
P
L
R
T
S
L
S
S
L
R
S
E
H
S
Site 25
S165
P
L
R
T
S
L
S
S
L
R
S
E
H
S
N
Site 26
S168
T
S
L
S
S
L
R
S
E
H
S
N
G
T
V
Site 27
S171
S
S
L
R
S
E
H
S
N
G
T
V
A
P
D
Site 28
T174
R
S
E
H
S
N
G
T
V
A
P
D
S
P
A
Site 29
S179
N
G
T
V
A
P
D
S
P
A
S
P
A
S
D
Site 30
S182
V
A
P
D
S
P
A
S
P
A
S
D
G
P
A
Site 31
S185
D
S
P
A
S
P
A
S
D
G
P
A
L
P
S
Site 32
S192
S
D
G
P
A
L
P
S
P
A
I
P
R
G
G
Site 33
S235
G
K
L
R
R
A
E
S
R
T
S
V
G
S
Q
Site 34
T237
L
R
R
A
E
S
R
T
S
V
G
S
Q
R
S
Site 35
S238
R
R
A
E
S
R
T
S
V
G
S
Q
R
S
R
Site 36
S241
E
S
R
T
S
V
G
S
Q
R
S
R
V
S
F
Site 37
S244
T
S
V
G
S
Q
R
S
R
V
S
F
L
K
S
Site 38
S247
G
S
Q
R
S
R
V
S
F
L
K
S
D
L
S
Site 39
S251
S
R
V
S
F
L
K
S
D
L
S
S
G
A
S
Site 40
S254
S
F
L
K
S
D
L
S
S
G
A
S
D
A
A
Site 41
S255
F
L
K
S
D
L
S
S
G
A
S
D
A
A
S
Site 42
S258
S
D
L
S
S
G
A
S
D
A
A
S
T
A
S
Site 43
S262
S
G
A
S
D
A
A
S
T
A
S
L
G
E
A
Site 44
S265
S
D
A
A
S
T
A
S
L
G
E
A
A
E
G
Site 45
S301
E
W
K
N
D
K
R
S
G
F
G
V
S
E
R
Site 46
S306
K
R
S
G
F
G
V
S
E
R
S
S
G
L
R
Site 47
S310
F
G
V
S
E
R
S
S
G
L
R
Y
E
G
E
Site 48
Y314
E
R
S
S
G
L
R
Y
E
G
E
W
L
D
N
Site 49
Y326
L
D
N
L
R
H
G
Y
G
C
T
T
L
P
D
Site 50
T329
L
R
H
G
Y
G
C
T
T
L
P
D
G
H
R
Site 51
T330
R
H
G
Y
G
C
T
T
L
P
D
G
H
R
E
Site 52
Y341
G
H
R
E
E
G
K
Y
R
H
N
V
L
V
K
Site 53
T350
H
N
V
L
V
K
D
T
K
R
R
M
L
Q
L
Site 54
S359
R
R
M
L
Q
L
K
S
N
K
V
R
Q
K
V
Site 55
S392
E
I
A
A
S
R
T
S
H
A
K
A
K
A
E
Site 56
T417
Q
E
S
N
I
A
R
T
L
A
R
E
L
A
P
Site 57
Y427
R
E
L
A
P
D
F
Y
Q
P
G
P
E
Y
Q
Site 58
Y433
F
Y
Q
P
G
P
E
Y
Q
K
R
R
L
L
Q
Site 59
S448
E
I
L
E
N
S
E
S
L
L
E
P
P
D
R
Site 60
S469
L
P
Q
P
P
R
E
S
P
Q
L
H
E
R
E
Site 61
T477
P
Q
L
H
E
R
E
T
P
R
P
E
G
G
S
Site 62
S484
T
P
R
P
E
G
G
S
P
S
P
A
G
T
P
Site 63
S486
R
P
E
G
G
S
P
S
P
A
G
T
P
P
Q
Site 64
T490
G
S
P
S
P
A
G
T
P
P
Q
P
K
R
P
Site 65
S502
K
R
P
R
P
G
V
S
K
D
G
L
L
S
P
Site 66
S508
V
S
K
D
G
L
L
S
P
G
A
W
N
G
E
Site 67
S517
G
A
W
N
G
E
P
S
G
E
G
S
R
S
V
Site 68
S521
G
E
P
S
G
E
G
S
R
S
V
T
P
S
E
Site 69
S523
P
S
G
E
G
S
R
S
V
T
P
S
E
G
A
Site 70
T525
G
E
G
S
R
S
V
T
P
S
E
G
A
G
R
Site 71
S527
G
S
R
S
V
T
P
S
E
G
A
G
R
R
S
Site 72
S534
S
E
G
A
G
R
R
S
P
A
R
P
A
T
E
Site 73
T540
R
S
P
A
R
P
A
T
E
R
M
A
I
E
A
Site 74
S555
L
Q
A
P
P
A
P
S
R
E
P
E
V
A
L
Site 75
Y563
R
E
P
E
V
A
L
Y
Q
G
Y
H
S
Y
A
Site 76
S568
A
L
Y
Q
G
Y
H
S
Y
A
V
R
T
T
P
Site 77
Y569
L
Y
Q
G
Y
H
S
Y
A
V
R
T
T
P
P
Site 78
T573
Y
H
S
Y
A
V
R
T
T
P
P
E
P
P
P
Site 79
T574
H
S
Y
A
V
R
T
T
P
P
E
P
P
P
F
Site 80
S590
D
Q
P
E
P
E
V
S
G
S
E
S
A
P
S
Site 81
S592
P
E
P
E
V
S
G
S
E
S
A
P
S
S
P
Site 82
S594
P
E
V
S
G
S
E
S
A
P
S
S
P
A
T
Site 83
S597
S
G
S
E
S
A
P
S
S
P
A
T
A
P
L
Site 84
S598
G
S
E
S
A
P
S
S
P
A
T
A
P
L
Q
Site 85
T601
S
A
P
S
S
P
A
T
A
P
L
Q
A
P
T
Site 86
T608
T
A
P
L
Q
A
P
T
L
R
G
P
E
P
A
Site 87
T618
G
P
E
P
A
R
E
T
P
A
K
L
E
P
K
Site 88
T640
P
R
A
K
A
R
K
T
E
A
R
G
L
T
K
Site 89
T646
K
T
E
A
R
G
L
T
K
A
G
A
K
K
K
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation