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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
LZTS2
Full Name:
Leucine zipper putative tumor suppressor 2
Alias:
KIAA1813; LAPSER1; Leucine zipper tumor suppressor 2; Leucine zipper, putative tumor suppressor 2; Protein LAPSER1
Type:
Mass (Da):
72759
Number AA:
669
UniProt ID:
Q9BRK4
International Prot ID:
IPI00101927
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005813
GO:0016020
GO:0005874
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
GO:0016055
GO:0051301
GO:0007067
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S34
G
S
V
S
S
L
I
S
G
R
P
C
P
G
G
Site 2
T54
H
H
G
P
P
G
P
T
F
F
R
Q
Q
D
G
Site 3
Y67
D
G
L
L
R
G
G
Y
E
A
Q
E
P
L
C
Site 4
S87
R
K
A
V
P
V
T
S
F
T
Y
I
N
E
D
Site 5
Y90
V
P
V
T
S
F
T
Y
I
N
E
D
F
R
T
Site 6
T97
Y
I
N
E
D
F
R
T
E
S
P
P
S
P
S
Site 7
S99
N
E
D
F
R
T
E
S
P
P
S
P
S
S
D
Site 8
S102
F
R
T
E
S
P
P
S
P
S
S
D
V
E
D
Site 9
S104
T
E
S
P
P
S
P
S
S
D
V
E
D
A
R
Site 10
S105
E
S
P
P
S
P
S
S
D
V
E
D
A
R
E
Site 11
S131
P
P
K
L
I
P
V
S
G
K
L
E
K
N
M
Site 12
S160
P
K
P
R
G
A
P
S
L
P
S
F
M
G
P
Site 13
S163
R
G
A
P
S
L
P
S
F
M
G
P
R
A
T
Site 14
T170
S
F
M
G
P
R
A
T
G
L
S
G
S
Q
G
Site 15
S173
G
P
R
A
T
G
L
S
G
S
Q
G
S
L
T
Site 16
S175
R
A
T
G
L
S
G
S
Q
G
S
L
T
Q
L
Site 17
S178
G
L
S
G
S
Q
G
S
L
T
Q
L
F
G
G
Site 18
T180
S
G
S
Q
G
S
L
T
Q
L
F
G
G
P
A
Site 19
S188
Q
L
F
G
G
P
A
S
S
S
S
S
S
S
S
Site 20
S189
L
F
G
G
P
A
S
S
S
S
S
S
S
S
S
Site 21
S190
F
G
G
P
A
S
S
S
S
S
S
S
S
S
S
Site 22
S191
G
G
P
A
S
S
S
S
S
S
S
S
S
S
A
Site 23
S192
G
P
A
S
S
S
S
S
S
S
S
S
S
A
A
Site 24
S193
P
A
S
S
S
S
S
S
S
S
S
S
A
A
D
Site 25
S194
A
S
S
S
S
S
S
S
S
S
S
A
A
D
K
Site 26
S195
S
S
S
S
S
S
S
S
S
S
A
A
D
K
P
Site 27
S196
S
S
S
S
S
S
S
S
S
A
A
D
K
P
L
Site 28
S197
S
S
S
S
S
S
S
S
A
A
D
K
P
L
A
Site 29
S206
A
D
K
P
L
A
F
S
G
W
A
S
G
C
P
Site 30
S214
G
W
A
S
G
C
P
S
G
T
L
S
D
S
G
Site 31
T216
A
S
G
C
P
S
G
T
L
S
D
S
G
R
N
Site 32
S218
G
C
P
S
G
T
L
S
D
S
G
R
N
S
L
Site 33
S220
P
S
G
T
L
S
D
S
G
R
N
S
L
S
S
Site 34
S224
L
S
D
S
G
R
N
S
L
S
S
L
P
T
Y
Site 35
S226
D
S
G
R
N
S
L
S
S
L
P
T
Y
S
T
Site 36
S227
S
G
R
N
S
L
S
S
L
P
T
Y
S
T
G
Site 37
T230
N
S
L
S
S
L
P
T
Y
S
T
G
G
A
E
Site 38
Y231
S
L
S
S
L
P
T
Y
S
T
G
G
A
E
P
Site 39
S232
L
S
S
L
P
T
Y
S
T
G
G
A
E
P
T
Site 40
T233
S
S
L
P
T
Y
S
T
G
G
A
E
P
T
T
Site 41
T239
S
T
G
G
A
E
P
T
T
S
S
P
G
G
H
Site 42
T240
T
G
G
A
E
P
T
T
S
S
P
G
G
H
L
Site 43
S241
G
G
A
E
P
T
T
S
S
P
G
G
H
L
P
Site 44
S242
G
A
E
P
T
T
S
S
P
G
G
H
L
P
S
Site 45
S249
S
P
G
G
H
L
P
S
H
G
S
G
R
G
A
Site 46
S252
G
H
L
P
S
H
G
S
G
R
G
A
L
P
G
Site 47
S269
R
G
V
P
T
G
P
S
H
S
D
S
G
R
S
Site 48
S271
V
P
T
G
P
S
H
S
D
S
G
R
S
S
S
Site 49
S273
T
G
P
S
H
S
D
S
G
R
S
S
S
S
K
Site 50
S276
S
H
S
D
S
G
R
S
S
S
S
K
S
T
G
Site 51
S277
H
S
D
S
G
R
S
S
S
S
K
S
T
G
S
Site 52
S278
S
D
S
G
R
S
S
S
S
K
S
T
G
S
L
Site 53
S279
D
S
G
R
S
S
S
S
K
S
T
G
S
L
G
Site 54
S281
G
R
S
S
S
S
K
S
T
G
S
L
G
G
R
Site 55
T282
R
S
S
S
S
K
S
T
G
S
L
G
G
R
V
Site 56
S284
S
S
S
K
S
T
G
S
L
G
G
R
V
A
G
Site 57
S296
V
A
G
G
L
L
G
S
G
T
R
A
S
P
D
Site 58
T298
G
G
L
L
G
S
G
T
R
A
S
P
D
S
S
Site 59
S301
L
G
S
G
T
R
A
S
P
D
S
S
S
C
G
Site 60
S304
G
T
R
A
S
P
D
S
S
S
C
G
E
R
S
Site 61
S305
T
R
A
S
P
D
S
S
S
C
G
E
R
S
P
Site 62
S306
R
A
S
P
D
S
S
S
C
G
E
R
S
P
P
Site 63
S311
S
S
S
C
G
E
R
S
P
P
P
P
P
P
P
Site 64
S320
P
P
P
P
P
P
P
S
D
E
A
L
L
H
C
Site 65
S346
E
L
Q
Q
L
R
D
S
L
D
E
N
E
A
T
Site 66
T353
S
L
D
E
N
E
A
T
M
C
Q
A
Y
E
E
Site 67
Y358
E
A
T
M
C
Q
A
Y
E
E
R
Q
R
H
W
Site 68
T424
Q
L
E
R
R
C
A
T
L
E
R
E
Q
R
E
Site 69
S447
K
W
E
V
C
Q
K
S
G
E
I
S
L
L
K
Site 70
S451
C
Q
K
S
G
E
I
S
L
L
K
Q
Q
L
K
Site 71
S460
L
K
Q
Q
L
K
E
S
Q
A
E
L
V
Q
K
Site 72
T484
A
L
R
E
A
R
A
T
L
R
V
S
E
G
R
Site 73
S488
A
R
A
T
L
R
V
S
E
G
R
A
R
G
L
Site 74
S510
E
L
E
L
E
A
C
S
Q
E
L
Q
R
H
R
Site 75
T546
E
P
P
V
P
P
A
T
A
D
P
F
L
L
A
Site 76
S555
D
P
F
L
L
A
E
S
D
E
A
K
V
Q
R
Site 77
S570
A
A
A
G
V
G
G
S
L
R
A
Q
V
E
R
Site 78
S595
R
G
E
E
Q
R
D
S
F
E
G
E
R
L
A
Site 79
Y613
E
K
E
Q
V
I
R
Y
Q
K
Q
L
Q
H
N
Site 80
Y625
Q
H
N
Y
I
Q
M
Y
R
R
N
R
Q
L
E
Site 81
S639
E
Q
E
L
Q
Q
L
S
L
E
L
E
A
R
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation