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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TTYH2
Full Name:
Protein tweety homolog 2
Alias:
C17orf29; TTY2; Tweety 2
Type:
Channel protein, chloride
Mass (Da):
58786
Number AA:
534
UniProt ID:
Q9BSA4
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0034707
GO:0005886
Uniprot
OncoNet
Molecular Function:
GO:0005509
GO:0005254
GO:0031404
PhosphoSite+
KinaseNET
Biological Process:
GO:0006811
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S32
L
R
L
Q
P
V
N
S
T
F
S
P
G
D
E
Site 2
T33
R
L
Q
P
V
N
S
T
F
S
P
G
D
E
S
Site 3
S35
Q
P
V
N
S
T
F
S
P
G
D
E
S
Y
Q
Site 4
S40
T
F
S
P
G
D
E
S
Y
Q
E
S
L
L
F
Site 5
Y41
F
S
P
G
D
E
S
Y
Q
E
S
L
L
F
L
Site 6
S112
G
V
G
F
Y
G
N
S
E
T
N
D
G
A
Y
Site 7
Y119
S
E
T
N
D
G
A
Y
Q
L
M
Y
S
L
D
Site 8
Y123
D
G
A
Y
Q
L
M
Y
S
L
D
D
A
N
H
Site 9
S124
G
A
Y
Q
L
M
Y
S
L
D
D
A
N
H
T
Site 10
T131
S
L
D
D
A
N
H
T
F
S
G
I
D
A
L
Site 11
S133
D
D
A
N
H
T
F
S
G
I
D
A
L
V
S
Site 12
S158
E
Q
H
L
A
R
L
S
E
I
F
A
A
R
G
Site 13
T199
R
E
V
T
M
E
L
T
K
L
S
D
Q
T
G
Site 14
T205
L
T
K
L
S
D
Q
T
G
Y
V
E
Y
Y
R
Site 15
Y207
K
L
S
D
Q
T
G
Y
V
E
Y
Y
R
W
L
Site 16
Y210
D
Q
T
G
Y
V
E
Y
Y
R
W
L
S
Y
L
Site 17
Y211
Q
T
G
Y
V
E
Y
Y
R
W
L
S
Y
L
L
Site 18
S290
N
V
T
E
G
Q
I
S
T
E
V
T
R
Y
Y
Site 19
Y296
I
S
T
E
V
T
R
Y
Y
L
Y
C
S
Q
S
Site 20
Y297
S
T
E
V
T
R
Y
Y
L
Y
C
S
Q
S
G
Site 21
Y299
E
V
T
R
Y
Y
L
Y
C
S
Q
S
G
S
S
Site 22
S301
T
R
Y
Y
L
Y
C
S
Q
S
G
S
S
P
F
Site 23
S303
Y
Y
L
Y
C
S
Q
S
G
S
S
P
F
Q
Q
Site 24
S305
L
Y
C
S
Q
S
G
S
S
P
F
Q
Q
T
L
Site 25
S306
Y
C
S
Q
S
G
S
S
P
F
Q
Q
T
L
T
Site 26
T314
P
F
Q
Q
T
L
T
T
F
Q
R
A
L
T
T
Site 27
S353
A
I
Q
L
L
L
N
S
S
E
S
S
L
H
Q
Site 28
S354
I
Q
L
L
L
N
S
S
E
S
S
L
H
Q
L
Site 29
S356
L
L
L
N
S
S
E
S
S
L
H
Q
L
T
A
Site 30
S357
L
L
N
S
S
E
S
S
L
H
Q
L
T
A
M
Site 31
Y424
F
T
T
R
N
R
D
Y
D
D
I
D
D
D
D
Site 32
S444
A
W
R
M
A
A
H
S
P
P
R
G
Q
L
H
Site 33
S452
P
P
R
G
Q
L
H
S
F
C
S
Y
S
S
G
Site 34
S455
G
Q
L
H
S
F
C
S
Y
S
S
G
L
G
S
Site 35
Y456
Q
L
H
S
F
C
S
Y
S
S
G
L
G
S
Q
Site 36
S457
L
H
S
F
C
S
Y
S
S
G
L
G
S
Q
T
Site 37
S458
H
S
F
C
S
Y
S
S
G
L
G
S
Q
T
S
Site 38
S462
S
Y
S
S
G
L
G
S
Q
T
S
L
Q
P
P
Site 39
S465
S
G
L
G
S
Q
T
S
L
Q
P
P
A
Q
T
Site 40
S474
Q
P
P
A
Q
T
I
S
N
A
P
V
S
E
Y
Site 41
Y481
S
N
A
P
V
S
E
Y
M
N
Q
A
M
L
F
Site 42
Y494
L
F
G
R
N
P
R
Y
E
N
V
P
L
I
G
Site 43
S504
V
P
L
I
G
R
A
S
P
P
P
T
Y
S
P
Site 44
T508
G
R
A
S
P
P
P
T
Y
S
P
S
M
R
A
Site 45
Y509
R
A
S
P
P
P
T
Y
S
P
S
M
R
A
T
Site 46
S510
A
S
P
P
P
T
Y
S
P
S
M
R
A
T
Y
Site 47
S512
P
P
P
T
Y
S
P
S
M
R
A
T
Y
L
S
Site 48
T516
Y
S
P
S
M
R
A
T
Y
L
S
V
A
D
E
Site 49
Y517
S
P
S
M
R
A
T
Y
L
S
V
A
D
E
H
Site 50
S519
S
M
R
A
T
Y
L
S
V
A
D
E
H
L
R
Site 51
Y528
A
D
E
H
L
R
H
Y
G
N
Q
F
P
A
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation