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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
ESYT1
Full Name:
Extended synaptotagmin-1
Alias:
Extended synaptotagmin-like protein 1; FAM62A; GLUT4 vesicle protein; KIAA0747; MBC2; Membrane bound C2 domain containing protein
Type:
Membrane protein, integral
Mass (Da):
122856
Number AA:
1104
UniProt ID:
Q9BSJ8
International Prot ID:
IPI00022143
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0016021
Uniprot
OncoNet
Molecular Function:
PhosphoSite+
KinaseNET
Biological Process:
Phosida
TranscriptoNet
STRING
Kinexus Products
Extended synaptotagmin-1 Y822 phosphosite-specific antibody AB-PN514#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN514#Extended synaptotagmin-1 (L819-L825, human) pY822 phosphopeptide - Powder PE-04AHJ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHJ99
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S10
R
S
P
G
E
G
P
S
P
S
P
M
D
Q
P
Site 2
S12
P
G
E
G
P
S
P
S
P
M
D
Q
P
S
A
Site 3
S18
P
S
P
M
D
Q
P
S
A
P
S
D
P
T
D
Site 4
T24
P
S
A
P
S
D
P
T
D
Q
P
P
A
A
H
Site 5
S38
H
A
K
P
D
P
G
S
G
G
Q
P
A
G
P
Site 6
S101
V
R
D
E
K
E
R
S
L
R
A
A
R
Q
L
Site 7
T116
L
D
D
E
E
Q
L
T
A
K
T
L
Y
M
S
Site 8
T119
E
E
Q
L
T
A
K
T
L
Y
M
S
H
R
E
Site 9
Y121
Q
L
T
A
K
T
L
Y
M
S
H
R
E
L
P
Site 10
S123
T
A
K
T
L
Y
M
S
H
R
E
L
P
A
W
Site 11
S132
R
E
L
P
A
W
V
S
F
P
D
V
E
K
A
Site 12
S172
V
A
P
A
V
R
G
S
N
P
H
L
Q
T
F
Site 13
T178
G
S
N
P
H
L
Q
T
F
T
F
T
R
V
E
Site 14
T180
N
P
H
L
Q
T
F
T
F
T
R
V
E
L
G
Site 15
Y228
I
D
V
E
V
K
K
Y
F
C
K
A
G
V
K
Site 16
T269
M
F
F
I
R
R
P
T
L
D
I
N
W
T
G
Site 17
T275
P
T
L
D
I
N
W
T
G
M
T
N
L
L
D
Site 18
S324
Q
D
V
A
Q
L
R
S
P
L
P
R
G
I
I
Site 19
S342
L
L
A
A
R
G
L
S
S
K
D
K
Y
V
K
Site 20
Y347
G
L
S
S
K
D
K
Y
V
K
G
L
I
E
G
Site 21
S356
K
G
L
I
E
G
K
S
D
P
Y
A
L
V
R
Site 22
Y359
I
E
G
K
S
D
P
Y
A
L
V
R
L
G
T
Site 23
T366
Y
A
L
V
R
L
G
T
Q
T
F
C
S
R
V
Site 24
S450
H
L
R
L
E
W
L
S
L
L
S
D
A
E
K
Site 25
S453
L
E
W
L
S
L
L
S
D
A
E
K
L
E
Q
Site 26
S469
L
Q
W
N
W
G
V
S
S
R
P
D
P
P
S
Site 27
S470
Q
W
N
W
G
V
S
S
R
P
D
P
P
S
A
Site 28
S506
P
N
P
M
V
Q
L
S
I
Q
D
V
T
Q
E
Site 29
T511
Q
L
S
I
Q
D
V
T
Q
E
S
K
A
V
Y
Site 30
S514
I
Q
D
V
T
Q
E
S
K
A
V
Y
S
T
N
Site 31
Y518
T
Q
E
S
K
A
V
Y
S
T
N
C
P
V
W
Site 32
T520
E
S
K
A
V
Y
S
T
N
C
P
V
W
E
E
Site 33
S538
F
F
L
Q
D
P
Q
S
Q
E
L
D
V
Q
V
Site 34
S549
D
V
Q
V
K
D
D
S
R
A
L
T
L
G
A
Site 35
T553
K
D
D
S
R
A
L
T
L
G
A
L
T
L
P
Site 36
S579
L
D
Q
W
F
Q
L
S
S
S
G
P
N
S
R
Site 37
S580
D
Q
W
F
Q
L
S
S
S
G
P
N
S
R
L
Site 38
S581
Q
W
F
Q
L
S
S
S
G
P
N
S
R
L
Y
Site 39
S585
L
S
S
S
G
P
N
S
R
L
Y
M
K
L
V
Site 40
Y588
S
G
P
N
S
R
L
Y
M
K
L
V
M
R
I
Site 41
S619
P
G
A
W
D
V
D
S
E
N
P
Q
R
G
S
Site 42
S626
S
E
N
P
Q
R
G
S
S
V
D
A
P
P
R
Site 43
S627
E
N
P
Q
R
G
S
S
V
D
A
P
P
R
P
Site 44
T637
A
P
P
R
P
C
H
T
T
P
D
S
Q
F
G
Site 45
T638
P
P
R
P
C
H
T
T
P
D
S
Q
F
G
T
Site 46
S641
P
C
H
T
T
P
D
S
Q
F
G
T
E
H
V
Site 47
T645
T
P
D
S
Q
F
G
T
E
H
V
L
R
I
H
Site 48
S674
G
G
L
V
K
G
K
S
D
P
Y
V
K
L
K
Site 49
Y677
V
K
G
K
S
D
P
Y
V
K
L
K
L
A
G
Site 50
S686
K
L
K
L
A
G
R
S
F
R
S
H
V
V
R
Site 51
S689
L
A
G
R
S
F
R
S
H
V
V
R
E
D
L
Site 52
T752
G
F
L
D
E
W
L
T
L
E
D
V
P
S
G
Site 53
S758
L
T
L
E
D
V
P
S
G
R
L
H
L
R
L
Site 54
T769
H
L
R
L
E
R
L
T
P
R
P
T
A
A
E
Site 55
T773
E
R
L
T
P
R
P
T
A
A
E
L
E
E
V
Site 56
S785
E
E
V
L
Q
V
N
S
L
I
Q
T
Q
K
S
Site 57
T789
Q
V
N
S
L
I
Q
T
Q
K
S
A
E
L
A
Site 58
T816
D
L
P
L
R
K
G
T
K
H
L
S
P
Y
A
Site 59
S820
R
K
G
T
K
H
L
S
P
Y
A
T
L
T
V
Site 60
Y822
G
T
K
H
L
S
P
Y
A
T
L
T
V
G
D
Extended synaptotagmin-1 Y822 phosphosite-specific antibody AB-PN514#http://www.kinexusproducts.ca/ProductInfo_Antibody.aspx?Product_Number=AB-PN514#Extended synaptotagmin-1 (L819-L825, human) pY822 phosphopeptide - Powder PE-04AHJ99#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-04AHJ99
Site 61
T824
K
H
L
S
P
Y
A
T
L
T
V
G
D
S
S
Site 62
T826
L
S
P
Y
A
T
L
T
V
G
D
S
S
H
K
Site 63
S830
A
T
L
T
V
G
D
S
S
H
K
T
K
T
I
Site 64
S831
T
L
T
V
G
D
S
S
H
K
T
K
T
I
S
Site 65
T834
V
G
D
S
S
H
K
T
K
T
I
S
Q
T
S
Site 66
T836
D
S
S
H
K
T
K
T
I
S
Q
T
S
A
P
Site 67
S838
S
H
K
T
K
T
I
S
Q
T
S
A
P
V
W
Site 68
S848
S
A
P
V
W
D
E
S
A
S
F
L
I
R
K
Site 69
S850
P
V
W
D
E
S
A
S
F
L
I
R
K
P
H
Site 70
T858
F
L
I
R
K
P
H
T
E
S
L
E
L
Q
V
Site 71
T896
L
C
L
D
R
W
F
T
L
S
S
G
Q
G
Q
Site 72
S898
L
D
R
W
F
T
L
S
S
G
Q
G
Q
V
L
Site 73
S918
G
I
L
V
S
Q
H
S
G
V
E
A
H
S
H
Site 74
S924
H
S
G
V
E
A
H
S
H
S
Y
S
H
S
S
Site 75
S926
G
V
E
A
H
S
H
S
Y
S
H
S
S
S
S
Site 76
Y927
V
E
A
H
S
H
S
Y
S
H
S
S
S
S
L
Site 77
S928
E
A
H
S
H
S
Y
S
H
S
S
S
S
L
S
Site 78
S930
H
S
H
S
Y
S
H
S
S
S
S
L
S
E
E
Site 79
S931
S
H
S
Y
S
H
S
S
S
S
L
S
E
E
P
Site 80
S932
H
S
Y
S
H
S
S
S
S
L
S
E
E
P
E
Site 81
S933
S
Y
S
H
S
S
S
S
L
S
E
E
P
E
L
Site 82
S935
S
H
S
S
S
S
L
S
E
E
P
E
L
S
G
Site 83
S941
L
S
E
E
P
E
L
S
G
G
P
P
H
I
T
Site 84
T948
S
G
G
P
P
H
I
T
S
S
A
P
E
L
R
Site 85
S949
G
G
P
P
H
I
T
S
S
A
P
E
L
R
Q
Site 86
S950
G
P
P
H
I
T
S
S
A
P
E
L
R
Q
R
Site 87
T959
P
E
L
R
Q
R
L
T
H
V
D
S
P
L
E
Site 88
S963
Q
R
L
T
H
V
D
S
P
L
E
A
P
A
G
Site 89
T978
P
L
G
Q
V
K
L
T
L
W
Y
Y
S
E
E
Site 90
Y981
Q
V
K
L
T
L
W
Y
Y
S
E
E
R
K
L
Site 91
Y982
V
K
L
T
L
W
Y
Y
S
E
E
R
K
L
V
Site 92
S983
K
L
T
L
W
Y
Y
S
E
E
R
K
L
V
S
Site 93
S997
S
I
V
H
G
C
R
S
L
R
Q
N
G
R
D
Site 94
Y1009
G
R
D
P
P
D
P
Y
V
S
L
L
L
L
P
Site 95
S1011
D
P
P
D
P
Y
V
S
L
L
L
L
P
D
K
Site 96
T1022
L
P
D
K
N
R
G
T
K
R
R
T
S
Q
K
Site 97
T1026
N
R
G
T
K
R
R
T
S
Q
K
K
R
T
L
Site 98
S1027
R
G
T
K
R
R
T
S
Q
K
K
R
T
L
S
Site 99
T1032
R
T
S
Q
K
K
R
T
L
S
P
E
F
N
E
Site 100
S1034
S
Q
K
K
R
T
L
S
P
E
F
N
E
R
F
Site 101
S1058
Q
R
R
K
L
D
V
S
V
K
S
N
S
S
F
Site 102
S1061
K
L
D
V
S
V
K
S
N
S
S
F
M
S
R
Site 103
S1063
D
V
S
V
K
S
N
S
S
F
M
S
R
E
R
Site 104
S1064
V
S
V
K
S
N
S
S
F
M
S
R
E
R
E
Site 105
S1067
K
S
N
S
S
F
M
S
R
E
R
E
L
L
G
Site 106
S1086
D
L
A
E
T
D
L
S
Q
G
V
A
R
W
Y
Site 107
Y1093
S
Q
G
V
A
R
W
Y
D
L
M
D
N
K
D
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation