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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
CCM2
Full Name:
Malcavernin
Alias:
Cerebral cavernous malformations 2; PP10187
Type:
Adaptor/scaffold
Mass (Da):
48837
Number AA:
444
UniProt ID:
Q9BSQ5
International Prot ID:
IPI00465425
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
Uniprot
OncoNet
Molecular Function:
GO:0005515
PhosphoSite+
KinaseNET
Biological Process:
GO:0007229
GO:0051403
GO:0001570
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
G
K
K
P
G
I
V
S
P
F
K
R
V
F
L
Site 2
S27
V
F
L
K
G
E
K
S
R
D
K
K
A
H
E
Site 3
T37
K
K
A
H
E
K
V
T
E
R
R
P
L
H
T
Site 4
T44
T
E
R
R
P
L
H
T
V
V
L
S
L
P
E
Site 5
S60
V
E
P
D
R
L
L
S
D
Y
I
E
K
E
V
Site 6
Y62
P
D
R
L
L
S
D
Y
I
E
K
E
V
K
Y
Site 7
Y69
Y
I
E
K
E
V
K
Y
L
G
Q
L
T
S
I
Site 8
S75
K
Y
L
G
Q
L
T
S
I
P
G
Y
L
N
P
Site 9
Y79
Q
L
T
S
I
P
G
Y
L
N
P
S
S
R
T
Site 10
S83
I
P
G
Y
L
N
P
S
S
R
T
E
I
L
H
Site 11
S84
P
G
Y
L
N
P
S
S
R
T
E
I
L
H
F
Site 12
S114
Q
E
H
D
A
V
L
S
L
S
A
Y
N
V
K
Site 13
Y144
H
D
I
A
A
V
S
Y
V
R
D
D
A
A
H
Site 14
S164
T
A
Q
D
P
G
I
S
P
S
Q
S
L
C
A
Site 15
S166
Q
D
P
G
I
S
P
S
Q
S
L
C
A
E
S
Site 16
S168
P
G
I
S
P
S
Q
S
L
C
A
E
S
S
R
Site 17
S173
S
Q
S
L
C
A
E
S
S
R
G
L
S
A
G
Site 18
S174
Q
S
L
C
A
E
S
S
R
G
L
S
A
G
S
Site 19
S178
A
E
S
S
R
G
L
S
A
G
S
L
S
E
S
Site 20
S181
S
R
G
L
S
A
G
S
L
S
E
S
A
V
G
Site 21
S224
F
Q
V
V
Y
T
E
S
T
I
D
F
L
D
R
Site 22
S238
R
A
I
F
D
G
A
S
T
P
T
H
H
L
S
Site 23
T239
A
I
F
D
G
A
S
T
P
T
H
H
L
S
L
Site 24
T241
F
D
G
A
S
T
P
T
H
H
L
S
L
H
S
Site 25
S245
S
T
P
T
H
H
L
S
L
H
S
D
D
S
S
Site 26
S248
T
H
H
L
S
L
H
S
D
D
S
S
T
K
V
Site 27
S251
L
S
L
H
S
D
D
S
S
T
K
V
D
I
K
Site 28
S252
S
L
H
S
D
D
S
S
T
K
V
D
I
K
E
Site 29
T253
L
H
S
D
D
S
S
T
K
V
D
I
K
E
T
Site 30
Y261
K
V
D
I
K
E
T
Y
E
V
E
A
S
T
F
Site 31
S266
E
T
Y
E
V
E
A
S
T
F
C
F
P
E
S
Site 32
T267
T
Y
E
V
E
A
S
T
F
C
F
P
E
S
V
Site 33
S280
S
V
D
V
G
G
A
S
P
H
S
K
T
I
S
Site 34
S283
V
G
G
A
S
P
H
S
K
T
I
S
E
S
E
Site 35
T285
G
A
S
P
H
S
K
T
I
S
E
S
E
L
S
Site 36
S287
S
P
H
S
K
T
I
S
E
S
E
L
S
A
S
Site 37
S289
H
S
K
T
I
S
E
S
E
L
S
A
S
A
T
Site 38
S294
S
E
S
E
L
S
A
S
A
T
E
L
L
Q
D
Site 39
T296
S
E
L
S
A
S
A
T
E
L
L
Q
D
Y
M
Site 40
Y302
A
T
E
L
L
Q
D
Y
M
L
T
L
R
T
K
Site 41
T305
L
L
Q
D
Y
M
L
T
L
R
T
K
L
S
S
Site 42
S311
L
T
L
R
T
K
L
S
S
Q
E
I
Q
Q
F
Site 43
S312
T
L
R
T
K
L
S
S
Q
E
I
Q
Q
F
A
Site 44
Y342
C
I
N
L
R
Q
L
Y
G
D
S
R
K
F
L
Site 45
S362
P
F
I
P
E
K
D
S
Q
H
F
E
N
F
L
Site 46
T382
K
D
G
R
G
I
I
T
D
S
F
G
R
H
R
Site 47
S384
G
R
G
I
I
T
D
S
F
G
R
H
R
R
A
Site 48
S393
G
R
H
R
R
A
L
S
T
T
S
S
S
T
T
Site 49
T394
R
H
R
R
A
L
S
T
T
S
S
S
T
T
N
Site 50
T395
H
R
R
A
L
S
T
T
S
S
S
T
T
N
G
Site 51
S396
R
R
A
L
S
T
T
S
S
S
T
T
N
G
N
Site 52
S397
R
A
L
S
T
T
S
S
S
T
T
N
G
N
R
Site 53
S398
A
L
S
T
T
S
S
S
T
T
N
G
N
R
A
Site 54
T399
L
S
T
T
S
S
S
T
T
N
G
N
R
A
T
Site 55
T400
S
T
T
S
S
S
T
T
N
G
N
R
A
T
G
Site 56
T406
T
T
N
G
N
R
A
T
G
S
S
D
D
R
S
Site 57
S408
N
G
N
R
A
T
G
S
S
D
D
R
S
A
P
Site 58
S409
G
N
R
A
T
G
S
S
D
D
R
S
A
P
S
Site 59
S413
T
G
S
S
D
D
R
S
A
P
S
E
G
D
E
Site 60
S426
D
E
W
D
R
M
I
S
D
I
S
S
D
I
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation