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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
PI4K2A
Full Name:
Phosphatidylinositol 4-kinase type 2-alpha
Alias:
DKFZP761G1923; EC 2.7.1.67; P4K2A; Phosphatidylinositol 4-kinase type 2 alpha; Phosphatidylinositol 4-kinase type II; PI4KII; PIK42A; Type II alpha phosphatidylinositol 4-kinase
Type:
Kinase, lipid, inositol phosphate metabolism
Mass (Da):
54022
Number AA:
479
UniProt ID:
Q9BTU6
International Prot ID:
not found
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005887
GO:0045121
GO:0016020
Uniprot
OncoNet
Molecular Function:
GO:0004430
GO:0005524
GO:0000287
PhosphoSite+
KinaseNET
Biological Process:
GO:0006661
GO:0006643
GO:0006644
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
T4
_
_
_
_
M
D
E
T
S
P
L
V
S
P
E
Site 2
S5
_
_
_
M
D
E
T
S
P
L
V
S
P
E
R
Site 3
S9
D
E
T
S
P
L
V
S
P
E
R
A
Q
P
P
Site 4
Y18
E
R
A
Q
P
P
D
Y
T
F
P
S
G
S
G
Site 5
T19
R
A
Q
P
P
D
Y
T
F
P
S
G
S
G
A
Site 6
S22
P
P
D
Y
T
F
P
S
G
S
G
A
H
F
P
Site 7
S44
R
V
A
A
A
A
G
S
G
P
S
P
P
G
S
Site 8
S47
A
A
A
G
S
G
P
S
P
P
G
S
P
G
H
Site 9
S51
S
G
P
S
P
P
G
S
P
G
H
D
R
E
R
Site 10
Y131
C
I
F
P
E
R
I
Y
Q
G
S
S
G
S
Y
Site 11
S134
P
E
R
I
Y
Q
G
S
S
G
S
Y
F
V
K
Site 12
S135
E
R
I
Y
Q
G
S
S
G
S
Y
F
V
K
D
Site 13
S137
I
Y
Q
G
S
S
G
S
Y
F
V
K
D
P
Q
Site 14
Y138
Y
Q
G
S
S
G
S
Y
F
V
K
D
P
Q
G
Site 15
S197
Y
L
S
E
A
G
A
S
L
V
D
Q
K
L
E
Site 16
Y215
V
P
R
T
K
V
V
Y
L
A
S
E
T
F
N
Site 17
Y223
L
A
S
E
T
F
N
Y
S
A
I
D
R
V
K
Site 18
S231
S
A
I
D
R
V
K
S
R
G
K
R
L
A
L
Site 19
Y272
E
G
Y
K
D
A
D
Y
W
L
R
R
F
E
A
Site 20
Y302
E
R
L
V
V
L
D
Y
I
I
R
N
T
D
R
Site 21
Y318
N
D
N
W
L
I
K
Y
D
C
P
M
D
S
S
Site 22
S324
K
Y
D
C
P
M
D
S
S
S
S
R
D
T
D
Site 23
S326
D
C
P
M
D
S
S
S
S
R
D
T
D
W
V
Site 24
T330
D
S
S
S
S
R
D
T
D
W
V
V
V
K
E
Site 25
S377
P
Q
A
K
V
P
F
S
Q
E
I
K
D
L
I
Site 26
S389
D
L
I
L
P
K
I
S
D
P
N
F
V
K
D
Site 27
Y402
K
D
L
E
E
D
L
Y
E
L
F
K
K
D
P
Site 28
T431
R
G
Q
I
L
N
L
T
Q
A
L
K
D
N
K
Site 29
S439
Q
A
L
K
D
N
K
S
P
L
H
L
V
Q
M
Site 30
S456
V
I
V
E
T
A
R
S
H
Q
R
S
S
S
E
Site 31
S460
T
A
R
S
H
Q
R
S
S
S
E
S
Y
T
Q
Site 32
S461
A
R
S
H
Q
R
S
S
S
E
S
Y
T
Q
S
Site 33
S462
R
S
H
Q
R
S
S
S
E
S
Y
T
Q
S
F
Site 34
S464
H
Q
R
S
S
S
E
S
Y
T
Q
S
F
Q
S
Site 35
Y465
Q
R
S
S
S
E
S
Y
T
Q
S
F
Q
S
R
Site 36
T466
R
S
S
S
E
S
Y
T
Q
S
F
Q
S
R
K
Site 37
S468
S
S
E
S
Y
T
Q
S
F
Q
S
R
K
P
F
Site 38
S471
S
Y
T
Q
S
F
Q
S
R
K
P
F
F
S
W
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation