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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
TBCD
Full Name:
Tubulin-specific chaperone D
Alias:
beta-tubulin cofactor D; tubulin folding cofactor D
Type:
Mass (Da):
132528
Number AA:
1192
UniProt ID:
Q9BTW9
International Prot ID:
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005874
Uniprot
OncoNet
Molecular Function:
GO:0051087
PhosphoSite+
KinaseNET
Biological Process:
GO:0006457
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S4
_
_
_
_
M
A
L
S
D
E
P
A
A
G
G
Site 2
T20
E
E
E
A
E
D
E
T
L
A
F
G
A
A
L
Site 3
T36
A
F
G
E
S
A
E
T
R
A
L
L
G
R
L
Site 4
Y67
F
R
V
I
M
D
K
Y
Q
E
Q
P
H
L
L
Site 5
T93
L
D
I
V
Q
D
Q
T
S
P
A
S
L
V
H
Site 6
S94
D
I
V
Q
D
Q
T
S
P
A
S
L
V
H
L
Site 7
S97
Q
D
Q
T
S
P
A
S
L
V
H
L
A
F
K
Site 8
T117
T
K
V
R
G
Y
K
T
F
L
R
L
F
P
H
Site 9
T176
R
L
D
G
N
L
L
T
Q
P
G
Q
A
R
M
Site 10
S184
Q
P
G
Q
A
R
M
S
I
M
D
R
I
L
Q
Site 11
T216
V
L
V
S
R
F
I
T
R
P
D
V
K
Q
S
Site 12
T243
L
A
R
S
S
F
Q
T
M
Q
G
V
I
T
M
Site 13
Y272
K
R
E
D
C
L
P
Y
A
A
T
V
L
R
C
Site 14
S288
D
G
C
R
L
P
E
S
N
Q
T
L
L
R
K
Site 15
T291
R
L
P
E
S
N
Q
T
L
L
R
K
L
G
V
Site 16
Y318
P
K
V
A
A
W
R
Y
Q
R
G
C
R
S
L
Site 17
S324
R
Y
Q
R
G
C
R
S
L
A
A
N
L
Q
L
Site 18
T333
A
A
N
L
Q
L
L
T
Q
G
Q
S
E
Q
K
Site 19
S337
Q
L
L
T
Q
G
Q
S
E
Q
K
P
L
I
L
Site 20
T374
V
G
L
K
D
K
D
T
V
V
R
W
S
A
A
Site 21
S379
K
D
T
V
V
R
W
S
A
A
K
G
I
G
R
Site 22
S408
G
S
V
L
D
C
F
S
F
Q
E
T
D
K
A
Site 23
Y478
C
W
A
F
A
R
A
Y
E
P
Q
E
L
K
P
Site 24
S511
I
N
C
R
R
A
A
S
A
A
F
Q
E
N
V
Site 25
T523
E
N
V
G
R
Q
G
T
F
P
H
G
I
D
I
Site 26
Y536
D
I
L
T
T
A
D
Y
F
A
V
G
N
R
S
Site 27
Y559
F
I
A
G
F
P
E
Y
T
Q
P
M
I
D
H
Site 28
S573
H
L
V
T
M
K
I
S
H
W
D
G
V
I
R
Site 29
T600
Q
A
P
E
F
S
A
T
Q
V
F
P
R
L
L
Site 30
S612
R
L
L
S
M
T
L
S
P
D
L
H
M
R
H
Site 31
T644
A
Q
E
N
R
P
V
T
D
H
L
D
E
Q
A
Site 32
Y663
K
Q
I
H
Q
Q
L
Y
D
R
Q
L
Y
R
G
Site 33
Y668
Q
L
Y
D
R
Q
L
Y
R
G
L
G
G
Q
L
Site 34
S690
L
I
E
K
L
S
L
S
K
M
P
F
R
G
D
Site 35
S719
R
H
L
H
L
I
S
S
H
S
R
Q
Q
M
K
Site 36
S738
S
A
L
A
A
L
C
S
E
Y
Y
M
K
E
P
Site 37
Y740
L
A
A
L
C
S
E
Y
Y
M
K
E
P
G
E
Site 38
Y741
A
A
L
C
S
E
Y
Y
M
K
E
P
G
E
A
Site 39
T758
A
I
Q
E
E
L
I
T
Q
Y
L
A
E
L
R
Site 40
T771
L
R
N
P
E
E
M
T
R
C
G
F
S
L
A
Site 41
T796
G
R
L
Q
Q
V
L
T
G
L
R
A
V
T
H
Site 42
T802
L
T
G
L
R
A
V
T
H
T
S
P
E
D
V
Site 43
T804
G
L
R
A
V
T
H
T
S
P
E
D
V
S
F
Site 44
S805
L
R
A
V
T
H
T
S
P
E
D
V
S
F
A
Site 45
S810
H
T
S
P
E
D
V
S
F
A
E
S
R
R
D
Site 46
S814
E
D
V
S
F
A
E
S
R
R
D
G
L
K
A
Site 47
Y859
L
L
G
C
M
D
D
Y
T
T
D
S
R
G
D
Site 48
T860
L
G
C
M
D
D
Y
T
T
D
S
R
G
D
V
Site 49
T861
G
C
M
D
D
Y
T
T
D
S
R
G
D
V
G
Site 50
T869
D
S
R
G
D
V
G
T
W
V
R
K
A
A
M
Site 51
S952
L
E
K
L
F
P
R
S
D
V
A
S
V
N
W
Site 52
S956
F
P
R
S
D
V
A
S
V
N
W
S
A
P
S
Site 53
S960
D
V
A
S
V
N
W
S
A
P
S
Q
A
F
P
Site 54
S963
S
V
N
W
S
A
P
S
Q
A
F
P
R
I
T
Site 55
S996
S
L
G
G
L
T
E
S
T
I
R
H
S
T
Q
Site 56
T997
L
G
G
L
T
E
S
T
I
R
H
S
T
Q
S
Site 57
S1001
T
E
S
T
I
R
H
S
T
Q
S
L
F
E
Y
Site 58
T1002
E
S
T
I
R
H
S
T
Q
S
L
F
E
Y
M
Site 59
S1004
T
I
R
H
S
T
Q
S
L
F
E
Y
M
K
G
Site 60
Y1008
S
T
Q
S
L
F
E
Y
M
K
G
I
Q
S
D
Site 61
S1014
E
Y
M
K
G
I
Q
S
D
P
Q
A
L
G
S
Site 62
S1021
S
D
P
Q
A
L
G
S
F
S
G
T
L
L
Q
Site 63
T1127
R
F
P
L
I
R
K
T
T
A
S
Q
V
Y
E
Site 64
T1128
F
P
L
I
R
K
T
T
A
S
Q
V
Y
E
T
Site 65
S1156
D
E
V
V
T
V
L
S
D
T
A
W
D
A
E
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation