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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
MNK1
Full Name:
MAP kinase-interacting serine/threonine-protein kinase 1
Alias:
EC 2.7.11.1; MKNK1
Type:
Protein-serine kinase, CAMK group, MAPKAPK family, MNK subfamily
Mass (Da):
51342
Number AA:
465
UniProt ID:
Q9BUB5
International Prot ID:
IPI00187091
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005737
GO:0005634
Uniprot
OncoNet
Molecular Function:
GO:0005524
GO:0005515
GO:0004674
PhosphoSite+
KinaseNET
Biological Process:
GO:0006468
GO:0007243
GO:0006417
Phosida
TranscriptoNet
STRING
Kinexus Products
EIF2S1 (46-57) - EIF2S1 eIF2-alpha) substrate peptide - Powder PE-01ACR95#http://www.kinexusproducts.ca/ProductInfo_Peptide.aspx?Product_Number=PE-01ACR95
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S15
E
K
P
I
E
M
G
S
S
E
P
L
P
I
A
Site 2
S16
K
P
I
E
M
G
S
S
E
P
L
P
I
A
D
Site 3
T37
K
K
R
R
G
R
A
T
D
S
L
P
G
K
F
Site 4
S39
R
R
G
R
A
T
D
S
L
P
G
K
F
E
D
Site 5
Y48
P
G
K
F
E
D
M
Y
K
L
T
S
E
L
L
Site 6
S68
A
K
V
Q
G
A
V
S
L
Q
N
G
K
E
Y
Site 7
Y75
S
L
Q
N
G
K
E
Y
A
V
K
I
I
E
K
Site 8
Y99
F
R
E
V
E
T
L
Y
Q
C
Q
G
N
K
N
Site 9
Y121
F
E
D
D
T
R
F
Y
L
V
F
E
K
L
Q
Site 10
S148
H
F
N
E
R
E
A
S
R
V
V
R
D
V
A
Site 11
T187
S
G
L
T
A
A
P
T
S
L
G
S
S
D
P
Site 12
S188
G
L
T
A
A
P
T
S
L
G
S
S
D
P
P
Site 13
S191
A
A
P
T
S
L
G
S
S
D
P
P
T
S
A
Site 14
S192
A
P
T
S
L
G
S
S
D
P
P
T
S
A
S
Site 15
T196
L
G
S
S
D
P
P
T
S
A
S
Q
V
A
G
Site 16
S197
G
S
S
D
P
P
T
S
A
S
Q
V
A
G
T
Site 17
S199
S
D
P
P
T
S
A
S
Q
V
A
G
T
T
G
Site 18
S221
P
E
N
I
L
C
E
S
P
E
K
V
S
P
V
Site 19
S226
C
E
S
P
E
K
V
S
P
V
K
I
C
D
F
Site 20
S237
I
C
D
F
D
L
G
S
G
M
K
L
N
N
S
Site 21
S244
S
G
M
K
L
N
N
S
C
T
P
I
T
T
P
Site 22
T246
M
K
L
N
N
S
C
T
P
I
T
T
P
E
L
Site 23
T250
N
S
C
T
P
I
T
T
P
E
L
T
T
P
C
Site 24
T254
P
I
T
T
P
E
L
T
T
P
C
G
S
A
E
Site 25
T255
I
T
T
P
E
L
T
T
P
C
G
S
A
E
Y
Site 26
Y262
T
P
C
G
S
A
E
Y
M
A
P
E
V
V
E
Site 27
Y278
F
T
D
Q
A
T
F
Y
D
K
R
C
D
L
W
Site 28
Y333
E
S
I
Q
E
G
K
Y
E
F
P
D
K
D
W
Site 29
S344
D
K
D
W
A
H
I
S
S
E
A
K
D
L
I
Site 30
S364
R
D
A
K
Q
R
L
S
A
A
Q
V
L
Q
H
Site 31
T385
A
P
E
K
G
L
P
T
P
Q
V
L
Q
R
N
Site 32
S393
P
Q
V
L
Q
R
N
S
S
T
M
D
L
T
L
Site 33
S394
Q
V
L
Q
R
N
S
S
T
M
D
L
T
L
F
Site 34
S413
I
A
L
N
R
Q
L
S
Q
H
E
E
N
E
L
Site 35
S437
G
L
C
S
M
K
L
S
P
P
C
K
S
R
L
Site 36
S442
K
L
S
P
P
C
K
S
R
L
A
R
R
R
A
Site 37
S460
A
G
R
G
E
D
R
S
P
P
T
A
L
_
_
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation