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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated November 2019
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Protein Info
Short Name:
DDX23
Full Name:
Probable ATP-dependent RNA helicase DDX23
Alias:
DEAD (Asp-Glu-Ala-Asp) box polypeptide 23; DEAD box protein 23; PRP28; PRPF28; PRPF28, U5-100K, prp28; U5 snRNP 100 kD; U5-100K
Type:
RNA binding protein; RNA processing; EC 3.6.1.-; Helicase
Mass (Da):
95583
Number AA:
820
UniProt ID:
Q9BUQ8
International Prot ID:
IPI00006725
Sequence:
Retrieve full protein sequence
GO Terms
External Links
Internal Links
Cellular Component:
GO:0005634
GO:0005681
GO:0005682
Uniprot
OncoNet
Molecular Function:
GO:0000166
GO:0003676
GO:0003724
PhosphoSite+
KinaseNET
Biological Process:
GO:0000354
GO:0000375
GO:0000377
Phosida
TranscriptoNet
STRING
Kinexus Products
Info Box
A variety of parameters were considered in the selection of putative P-sites. Confirmed P-Sites have lower Hydrophobicity Scores. The P-site Similarity Score is lower the more that it resembles typical confirmed corresponding P-Ser, P-Thr or P-Tyr sites. The Maximum KInase Score provides the calculated score for highest match of 500 human protein kinases for the amino acid sequence surrounding the target P-site as determined with Kinase Substrate Predictor V2. The Sum KInase Score provides the additive sum of the positive individual Kinase Substrate Predictor V2 scores from 500 human protein kinases. The Conservation Score is the average of the percent similarity of the human P-site with the equivalent P-site in 20 other diverse species. Click the coloured buttons below to retrieve this and other information in the Info Box, or click the orange buttons for relevant links.
Phosphosites
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Expt. conf.
Effect
Kinase
PPase
Kinexus Products
Ref.
Evol.
Kinase Pred.
P-site Match
Site 1
S14
D
K
K
D
R
D
A
S
P
S
K
E
E
R
K
Site 2
S16
K
D
R
D
A
S
P
S
K
E
E
R
K
R
S
Site 3
S23
S
K
E
E
R
K
R
S
R
T
P
D
R
E
R
Site 4
T25
E
E
R
K
R
S
R
T
P
D
R
E
R
D
R
Site 5
S38
D
R
D
R
D
R
K
S
S
P
S
K
D
R
K
Site 6
S39
R
D
R
D
R
K
S
S
P
S
K
D
R
K
R
Site 7
S41
R
D
R
K
S
S
P
S
K
D
R
K
R
H
R
Site 8
S49
K
D
R
K
R
H
R
S
R
D
R
R
R
G
G
Site 9
S57
R
D
R
R
R
G
G
S
R
S
R
S
R
S
R
Site 10
S59
R
R
R
G
G
S
R
S
R
S
R
S
R
S
K
Site 11
S61
R
G
G
S
R
S
R
S
R
S
R
S
K
S
A
Site 12
S63
G
S
R
S
R
S
R
S
R
S
K
S
A
E
R
Site 13
S65
R
S
R
S
R
S
R
S
K
S
A
E
R
E
R
Site 14
S67
R
S
R
S
R
S
K
S
A
E
R
E
R
R
H
Site 15
S106
R
D
K
D
R
K
R
S
S
L
S
P
G
R
G
Site 16
S107
D
K
D
R
K
R
S
S
L
S
P
G
R
G
K
Site 17
S109
D
R
K
R
S
S
L
S
P
G
R
G
K
D
F
Site 18
S118
G
R
G
K
D
F
K
S
R
K
D
R
D
S
K
Site 19
S124
K
S
R
K
D
R
D
S
K
K
D
E
E
D
E
Site 20
S143
K
P
K
A
Q
P
L
S
L
E
E
L
L
A
K
Site 21
S165
E
A
K
P
K
F
L
S
K
A
E
R
E
A
E
Site 22
T225
R
E
R
M
E
R
E
T
N
G
N
E
D
E
E
Site 23
S244
I
R
E
E
K
D
K
S
K
E
L
H
A
I
K
Site 24
T264
G
I
K
K
R
R
R
T
R
H
L
N
D
R
K
Site 25
Y286
S
E
D
T
S
I
D
Y
N
P
L
Y
K
E
R
Site 26
Y290
S
I
D
Y
N
P
L
Y
K
E
R
H
Q
V
Q
Site 27
S317
K
Q
Q
K
R
E
Q
S
R
F
Y
G
D
L
M
Site 28
Y320
K
R
E
Q
S
R
F
Y
G
D
L
M
E
K
R
Site 29
T329
D
L
M
E
K
R
R
T
L
E
E
K
E
Q
E
Site 30
Y377
W
R
I
F
R
E
D
Y
S
I
T
T
K
G
G
Site 31
S378
R
I
F
R
E
D
Y
S
I
T
T
K
G
G
K
Site 32
T380
F
R
E
D
Y
S
I
T
T
K
G
G
K
I
P
Site 33
T381
R
E
D
Y
S
I
T
T
K
G
G
K
I
P
N
Site 34
S392
K
I
P
N
P
I
R
S
W
K
D
S
S
L
P
Site 35
S396
P
I
R
S
W
K
D
S
S
L
P
P
H
I
L
Site 36
S397
I
R
S
W
K
D
S
S
L
P
P
H
I
L
E
Site 37
Y411
E
V
I
D
K
C
G
Y
K
E
P
T
P
I
Q
Site 38
T415
K
C
G
Y
K
E
P
T
P
I
Q
R
Q
A
I
Site 39
T437
D
I
I
G
V
A
E
T
G
S
G
K
T
A
A
Site 40
S465
K
I
D
R
I
E
E
S
D
Q
G
P
Y
A
I
Site 41
Y470
E
E
S
D
Q
G
P
Y
A
I
I
L
A
P
T
Site 42
S573
I
L
E
H
M
P
V
S
N
Q
K
P
D
T
D
Site 43
T579
V
S
N
Q
K
P
D
T
D
E
A
E
D
P
E
Site 44
S594
K
M
L
A
N
F
E
S
G
K
H
K
Y
R
Q
Site 45
Y599
F
E
S
G
K
H
K
Y
R
Q
T
V
M
F
T
Site 46
T602
G
K
H
K
Y
R
Q
T
V
M
F
T
A
T
M
Site 47
S619
A
V
E
R
L
A
R
S
Y
L
R
R
P
A
V
Site 48
Y620
V
E
R
L
A
R
S
Y
L
R
R
P
A
V
V
Site 49
Y628
L
R
R
P
A
V
V
Y
I
G
S
A
G
K
P
Site 50
S683
G
C
D
V
L
A
K
S
L
E
K
M
G
Y
N
Site 51
Y689
K
S
L
E
K
M
G
Y
N
A
C
T
L
H
G
Site 52
S708
E
Q
R
E
F
A
L
S
N
L
K
A
G
A
K
Site 53
Y748
M
A
K
N
I
E
D
Y
I
H
R
I
G
R
T
Site 54
T755
Y
I
H
R
I
G
R
T
G
R
A
G
K
S
G
Site 55
T766
G
K
S
G
V
A
I
T
F
L
T
K
E
D
S
Site 56
S773
T
F
L
T
K
E
D
S
A
V
F
Y
E
L
K
Site 57
Y777
K
E
D
S
A
V
F
Y
E
L
K
Q
A
I
L
Site 58
S786
L
K
Q
A
I
L
E
S
P
V
S
S
C
P
P
Site 59
S790
I
L
E
S
P
V
S
S
C
P
P
E
L
A
N
Site 60
T807
D
A
Q
H
K
P
G
T
I
L
T
K
K
R
R
Legend
Confirmed in mammals
Confirmed in related proteins or other species
Predicted by Kinexus P-Site Prediction algorithm
No data/link available
Link available
Products available
2019 Kinexus Bioinformatics Corporation